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| TissGeneSummary for FOXA2 |
 Gene summary |
| Basic gene information | Gene symbol | FOXA2 |
| Gene name | forkhead box A2 | |
| Synonyms | HNF3B|TCF3B | |
| Cytomap | UCSC genome browser: 20p11 | |
| Type of gene | protein-coding | |
| RefGenes | NM_021784.4, NM_153675.2, | |
| Description | HNF-3-betaHNF-3BTCF-3Bforkhead box protein A2hepatic nuclear factor-3-betahepatocyte nuclear factor 3, betahepatocyte nuclear factor 3-betatranscription factor 3B | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 600288 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000125798 | ||
| HPRD : 02618 | ||
| Vega : OTTHUMG00000032041 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FOXA2 | |
| BioGPS: 3170 | ||
| Pathway | NCI Pathway Interaction Database: FOXA2 | |
| KEGG: FOXA2 | ||
| REACTOME: FOXA2 | ||
| Pathway Commons: FOXA2 | ||
| Context | iHOP: FOXA2 | |
| ligand binding site mutation search in PubMed: FOXA2 | ||
| UCL Cancer Institute: FOXA2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungStomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCSTAD | |
| Reference showing the relevant tissue of FOXA2 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006357 | regulation of transcription from RNA polymerase II promoter | 12911579 | GO:0030193 | regulation of blood coagulation | 12911579 | GO:0031018 | endocrine pancreas development | 12124776 | GO:0045893 | positive regulation of transcription, DNA-templated | 9931457 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 12124776 | GO:0006357 | regulation of transcription from RNA polymerase II promoter | 12911579 | GO:0030193 | regulation of blood coagulation | 12911579 | GO:0031018 | endocrine pancreas development | 12124776 | GO:0045893 | positive regulation of transcription, DNA-templated | 9931457 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 12124776 |
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| TissGeneExp for FOXA2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | 6.035663521 | 4.414732751 | 1.620930769 | 1.45E-06 | 7.92E-06 |
| LUAD | 4.237689913 | 6.046200258 | -1.808510345 | 1.31E-07 | 5.03E-07 |
| THCA | 0.596212152 | 4.098703677 | -3.502491525 | 1.58E-17 | 3.36E-16 |
| KICH | -3.497718018 | -0.453238018 | -3.04448 | 7.45E-07 | 2.85E-06 |
| LUSC | 1.235149041 | 5.765007864 | -4.529858824 | 1.55E-19 | 1.71E-18 |
| STAD | 4.723655107 | 2.520539482 | 2.203115625 | 0.012 | 0.03945614 |
| HNSC | -0.84474453 | -2.132479413 | 1.287734884 | 0.00171 | 0.005419014 |
| PRAD | -1.302384556 | -0.083011479 | -1.219373077 | 9.30E-05 | 0.000393232 |
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| TissGene-miRNA for FOXA2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FOXA2 |
| TissGeneSNV for FOXA2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G52S | SKCM | 1 |
| p.P112L | SKCM | 1 |
| p.G58S | SKCM | 1 |
| p.M139I | SKCM | 1 |
| p.E250K | SKCM | 1 |
| p.G15R | UCEC | 1 |
| p.S416F | SKCM | 1 |
| p.A78S | STAD | 1 |
| p.E250* | UCEC | 1 |
| p.L408H | UCEC | 1 |
| p.S66* | UCS | 1 |
| p.F223Y | UCEC | 1 |
| p.P339L | THYM | 1 |
| p.P243S | KIRP | 1 |
| p.M13I | THYM | 1 |
| p.F249S | DLBC | 1 |
| p.A66T | DLBC | 1 |
| p.T434M | THYM | 1 |
| p.G320R | SKCM | 1 |
| p.R228C | UCS | 1 |
| p.A84S | STAD | 1 |
| p.S59R | LUAD | 1 |
| p.L112F | CESC | 1 |
| p.W239R | UCEC | 1 |
| p.K184T | CHOL | 1 |
| p.S72X | UCS | 1 |
| p.E244K | SKCM | 1 |
| p.S183R | PCPG | 1 |
| p.E17X | STAD | 1 |
| p.P345L | THYM | 1 |
| p.H401Q | PAAD | 1 |
| p.S312W | BLCA | 1 |
| p.M133I | SKCM | 1 |
| p.Q179* | UCEC | 1 |
| p.Q173H | OV | 1 |
| p.S81F | SKCM | 1 |
| p.S140R | COAD | 1 |
| p.S212F | HNSC | 1 |
| p.Q180H | BLCA | 1 |
| p.M73I | LUAD | 1 |
| p.Q174H | BLCA | 1 |
| p.A171V | LGG | 1 |
| p.I213M | UCS | 1 |
| p.N44H | OV | 1 |
| p.K178T | CHOL | 1 |
| p.P358L | BLCA | 1 |
| p.S169L | UCEC | 1 |
| p.A117V | PRAD | 1 |
| p.S383F | SKCM | 1 |
| p.E184G | HNSC | 1 |
| p.P148S | SKCM | 1 |
| p.P126L | SKCM | 1 |
| p.S422F | SKCM | 1 |
| p.H395Q | PRAD | 1 |
| p.S59G | STAD | 1 |
| p.E11* | STAD | 1 |
| p.R159C | STAD | 1 |
| p.E406K | SKCM | 1 |
| p.A158S | LUAD | 1 |
| p.H395Q | SKCM | 1 |
| p.S189R | PCPG | 1 |
| p.M127V | PCPG | 1 |
| p.S390L | CESC | 1 |
| p.P154S | SKCM | 1 |
| p.T431M | SARC | 1 |
| p.H392Y | SKCM | 1 |
| p.H395Q | LGG | 1 |
| p.P339S | UCEC | 1 |
| p.R222C | UCS | 1 |
| p.A123V | PRAD | 1 |
| p.S53G | STAD | 1 |
| p.F223L | UCEC | 1 |
| p.I207M | UCS | 1 |
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| TissGeneCNV for FOXA2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FOXA2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AK075055 | GOLGA2-FOXA2 | chr9:131036195 | chr20:22561987 |
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| TissGeneNet for FOXA2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| FOXA2, ONECUT1, IGFBP1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, PROS1, OTX2, AMBP, FGB, MIP, LHX1, SLC10A1, EN2 (tumor) | FOXA2, ONECUT1, IGFBP1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, OTX2, EPHX1, AMBP, FGB, MIP, LHX1, SLC10A1, EN2 (normal) |
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| COAD (tumor) | COAD (normal) |
| FOXA2, ONECUT1, IGFBP1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, PROS1, EPHX1, AMBP, FGB, MIP, LHX1, SLC10A1, EN2 (tumor) | FOXA2, ONECUT1, IGFBP1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, OTX2, EPHX1, AMBP, FGB, MIP, LHX1, SLC10A1, EN2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| FOXA2, ONECUT1, IGFBP1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, PROS1, EPHX1, AMBP, FGB, MIP, LHX1, SLC10A1, EN2 (tumor) | FOXA2, ONECUT1, IGFBP1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, PROS1, EPHX1, AMBP, FGB, MIP, LHX1, SLC10A1, EN2 (normal) |
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| KICH (tumor) | KICH (normal) |
| FOXA2, ONECUT1, IGFBP1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, PROS1, OTX2, EPHX1, FGB, MIP, LHX1, SLC10A1, EN2 (tumor) | FOXA2, ONECUT1, IGFBP1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, PROS1, OTX2, EPHX1, FGB, MIP, LHX1, SLC10A1, EN2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| FOXA2, ONECUT1, IGFBP1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, PROS1, OTX2, EPHX1, FGB, MIP, LHX1, SLC10A1, EN2 (tumor) | FOXA2, ONECUT1, IGFBP1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, OTX2, EPHX1, AMBP, FGB, MIP, LHX1, SLC10A1, EN2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| FOXA2, ONECUT1, IGFBP1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, PROS1, OTX2, EPHX1, AMBP, FGB, MIP, LHX1, SLC10A1, EN2 (tumor) | FOXA2, ONECUT1, IGFBP1, NCOA1, CYP3A7, HOXA5, FOXA1, PDX1, F2, GSC, APOA1, TLE1, PROS1, OTX2, EPHX1, AMBP, FGB, MIP, LHX1, SLC10A1, EN2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| FOXA2, ONECUT1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, PROS1, OTX2, EPHX1, AMBP, FGB, MIP, LHX1, SLC10A1, EN2 (tumor) | FOXA2, ONECUT1, IGFBP1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, PROS1, EPHX1, AMBP, FGB, MIP, LHX1, SLC10A1, EN2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| FOXA2, ONECUT1, IGFBP1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, PROS1, OTX2, EPHX1, AMBP, FGB, MIP, LHX1, SLC10A1 (tumor) | FOXA2, ONECUT1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, PROS1, OTX2, EPHX1, AMBP, FGB, MIP, LHX1, SLC10A1, EN2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| FOXA2, ONECUT1, IGFBP1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, PROS1, OTX2, EPHX1, AMBP, FGB, MIP, LHX1, SLC10A1, EN2 (tumor) | FOXA2, ONECUT1, IGFBP1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, PROS1, OTX2, EPHX1, AMBP, FGB, MIP, LHX1, SLC10A1, EN2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| FOXA2, ONECUT1, IGFBP1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, PROS1, OTX2, EPHX1, AMBP, FGB, MIP, LHX1, SLC10A1, EN2 (tumor) | FOXA2, ONECUT1, IGFBP1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, PROS1, OTX2, EPHX1, AMBP, FGB, MIP, LHX1, SLC10A1, EN2 (normal) |
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| STAD (tumor) | STAD (normal) |
| FOXA2, ONECUT1, IGFBP1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, PROS1, OTX2, EPHX1, AMBP, FGB, MIP, SLC10A1, EN2 (tumor) | FOXA2, ONECUT1, IGFBP1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, PROS1, OTX2, AMBP, FGB, MIP, LHX1, SLC10A1, EN2 (normal) |
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| THCA (tumor) | THCA (normal) |
| FOXA2, ONECUT1, IGFBP1, NCOA1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, OTX2, EPHX1, AMBP, FGB, MIP, LHX1, SLC10A1, EN2 (tumor) | FOXA2, ONECUT1, IGFBP1, CYP3A7, HOXA5, PPARGC1B, FOXA1, PDX1, F2, GSC, APOA1, TLE1, PROS1, OTX2, EPHX1, AMBP, FGB, MIP, LHX1, SLC10A1, EN2 (normal) |
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| TissGeneProg for FOXA2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FOXA2 |
| TissGeneDrug for FOXA2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for FOXA2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C2239176 | Liver carcinoma | 7 | BeFree,LHGDN |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 6 | BeFree,GAD |
| umls:C0027627 | Neoplasm Metastasis | 5 | BeFree,LHGDN |
| umls:C0242379 | Malignant neoplasm of lung | 5 | BeFree |
| umls:C0684249 | Carcinoma of lung | 5 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 4 | BeFree |
| umls:C0011847 | Diabetes | 3 | BeFree |
| umls:C0023903 | Liver neoplasms | 3 | BeFree |
| umls:C0024115 | Lung diseases | 3 | BeFree,CTD_human |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 2 | BeFree,LHGDN |
| umls:C0238463 | Papillary thyroid carcinoma | 2 | BeFree |
| umls:C0342276 | Maturity onset diabetes mellitus in young | 2 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C0600139 | Prostate carcinoma | 2 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0001486 | Adenovirus Infections | 1 | BeFree |
| umls:C0005411 | Biliary Atresia | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0008370 | Cholestasis | 1 | BeFree |
| umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
| umls:C0019196 | Hepatitis C | 1 | BeFree |
| umls:C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
| umls:C0020615 | Hypoglycemia | 1 | BeFree |
| umls:C0023895 | Liver diseases | 1 | BeFree |
| umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0035220 | Respiratory Distress Syndrome, Newborn | 1 | BeFree |
| umls:C0035222 | Respiratory Distress Syndrome, Adult | 1 | BeFree |
| umls:C0038476 | Supernumerary structure | 1 | BeFree |
| umls:C0040136 | Thyroid Neoplasm | 1 | LHGDN |
| umls:C0079541 | Holoprosencephaly | 1 | BeFree |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0206695 | Carcinoma, Neuroendocrine | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0242422 | Parkinsonian Disorders | 1 | BeFree |
| umls:C0262584 | Carcinoma, Small Cell | 1 | BeFree |
| umls:C0263361 | Psoriasis vulgaris | 1 | BeFree |
| umls:C0278504 | Non-small cell lung cancer stage I | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0796126 | AICARDI-GOUTIERES SYNDROME 1 | 1 | BeFree |
| umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
| umls:C1800706 | Idiopathic Pulmonary Fibrosis | 1 | BeFree |
| umls:C3163918 | Tumor thrombus | 1 | BeFree |
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