TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for HNF4A

Gene summary

Basic gene information	Gene symbol	HNF4A
	Gene name	hepatocyte nuclear factor 4, alpha
	Synonyms	FRTS4\|HNF4\|HNF4a7\|HNF4a8\|HNF4a9\|HNF4alpha\|MODY\|MODY1\|NR2A1\|NR2A21\|TCF\|TCF14
	Cytomap	UCSC genome browser: 20q13.12
	Type of gene	protein-coding
	RefGenes	NM_000457.4, NM_001030003.2,NM_001030004.2,NM_001258355.1,NM_001287182.1, NM_001287183.1,NM_001287184.1,NM_175914.4,NM_178849.2, NM_178850.2,
	Description	HNF4alpha10/11/12TCF-14hepatic nuclear factor 4 alphahepatocyte nuclear factor 4-alphanuclear receptor subfamily 2 group A member 1transcription factor 14transcription factor HNF-4
	Modification date	20141222
dbXrefs	MIM : 600281
	HGNC : HGNC
	Ensembl : ENSG00000101076
	HPRD : 02612
	Vega : OTTHUMG00000032531
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_HNF4A
	BioGPS: 3172
Pathway	NCI Pathway Interaction Database: HNF4A
	KEGG: HNF4A
	REACTOME: HNF4A
	Pathway Commons: HNF4A
Context	iHOP: HNF4A
	ligand binding site mutation search in PubMed: HNF4A
	UCL Cancer Institute: HNF4A
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	ColonKidneyLiver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	COADKIRC,KIRP,KICHLIHC
Reference showing the relevant tissue of HNF4A
Description by TissGene annotations	Risk TissGene in OS Risk TissGene in RFS Cancer gene

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0006357	regulation of transcription from RNA polymerase II promoter	10330009
GO:0007596	blood coagulation	12911579
GO:0019216	regulation of lipid metabolic process	10551874
GO:0045893	positive regulation of transcription, DNA-templated	16488887
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	7615825
GO:0006357	regulation of transcription from RNA polymerase II promoter	10330009
GO:0007596	blood coagulation	12911579
GO:0019216	regulation of lipid metabolic process	10551874
GO:0045893	positive regulation of transcription, DNA-templated	16488887
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	7615825

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TissGeneExp for HNF4A

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
KICH	-1.014649219	4.345010781	-5.35966	6.40E-12	6.38E-11
KIRP	4.352852406	6.222155531	-1.869303125	0.00924	0.020430059
HNSC	-2.267150428	-3.370866707	1.103716279	0.000431	0.001635329
STAD	6.624893031	3.163149281	3.46174375	0.00019	0.001331184

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TissGene-miRNA for HNF4A

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for HNF4A

TissGeneSNV for HNF4A

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.E472K	SKCM	4
p.F294L	UCEC	2
p.P409S	UCEC	1
p.P42T	PRAD	1
p.Y94H	STAD	1
p.A58V	LUAD	1
p.A185T	BLCA	1
p.H387Y	GBM	1
p.D11N	SKCM	1
p.R263Q	GBM	1
p.G9W	LUAD	1
p.G37D	HNSC	1
p.V88L	LUAD	1
p.P405S	SKCM	1
p.P437S	SKCM	1
p.H386N	ACC	1
p.M398V	KIRC	1
p.R326H	GBM	1
p.R177P	BLCA	1
p.A154V	UCEC	1
p.G415R	STAD	1
p.G415E	SKCM	1
p.E226V	LUAD	1
p.D260N	SKCM	1
p.R333C	SKCM	1
p.R89Q	BLCA	1
p.E278K	SKCM	1
p.T400A	CESC	1
p.D381N	HNSC	1
p.P401S	SKCM	1
p.A158V	UCEC	1
p.D85Y	READ	1
p.L213M	LUAD	1
p.A287V	KIRP	1
p.G69C	LUAD	1
p.T400I	SKCM	1
p.V130I	CESC	1
p.T35M	ESCA	1
p.D304N	SKCM	1
p.S401L	SKCM	1
p.M191I	LUAD	1
p.E226K	BLCA	1
p.E472V	LIHC	1
p.E256K	SKCM	1
p.G410E	SKCM	1
p.I152F	BRCA	1
p.A185V	HNSC	1
p.L412F	UCEC	1
p.E440K	SKCM	1
p.S358N	SKCM	1
p.R235K	SKCM	1
p.G174D	SKCM	1
p.Y94C	UCEC	1
p.C418S	LUAD	1
p.W201R	THCA	1
p.R331C	LUAD	1
p.N91K	OV	1
p.A10T	SKCM	1
p.P212L	SKCM	1
p.V453I	STAD	1
p.R94W	UCEC	1
p.S53N	SKCM	1
p.R89Q	SKCM	1
p.G399E	SKCM	1
p.I176L	ESCA	1
p.L34M	SKCM	1
p.Q334X	SKCM	1
p.G174S	LUAD	1
p.S330L	UCEC	1
p.E200K	BLCA	1
p.T432I	SKCM	1
p.G231E	SKCM	1
p.D381V	THCA	1
p.R113G	BRCA	1
p.R263Q	MESO	1
p.P7S	SKCM	1
p.D299N	SKCM	1
p.A178V	UCEC	1
p.R415Q	SKCM	1
p.G209E	SKCM	1
p.S443Y	LUAD	1
p.C115W	UCEC	1
p.W179R	THCA	1
p.M237I	ESCA	1
p.H92N	LUAD	1
p.D282N	SKCM	1
p.G393R	READ	1
p.R422X	STAD	1
p.Q292X	SKCM	1
p.V8I	HNSC	1
p.K290T	LUAD	1
p.P190L	SKCM	1
p.G399R	LUAD	1
p.G354R	SKCM	1
p.A154V	LGG	1
p.P433S	SKCM	1
p.D135N	SKCM	1
p.A58T	STAD	1
p.D175N	UCEC	1
p.R2Q	SKCM	1
p.G376R	SKCM	1
p.G9W	KIRP	1
p.R422Q	SKCM	1
p.A13V	LGG	1
p.G393E	SKCM	1
p.I21L	STAD	1
p.S313F	SKCM	1
p.G68E	BRCA	1
p.S380G	STAD	1
p.A61P	LUAD	1
p.R113C	LIHC	1
p.R331C	LGG	1
p.G442E	SKCM	1
p.G64V	LUAD	1
p.D321N	SKCM	1
p.R422*	STAD	1
p.G393A	LUAD	1
p.G425R	SKCM	1
p.S380N	SKCM	1
p.D113N	SKCM	1
p.H384N	LUAD	1
p.Q356*	SKCM	1
p.H379N	ACC	1
p.T35K	LUSC	1
p.R331G	UCEC	1
p.G55C	LUAD	1
p.A123V	UCEC	1
p.Q314*	SKCM	1
p.G399R	SARC	1
p.G69V	LUAD	1
p.D9N	UCEC	1
p.H397R	COAD	1
p.E44Q	HNSC	1
p.R140*	GBM	1
p.M417I	LUSC	1
p.S408F	SKCM	1
p.P7L	SKCM	1
p.F121L	KIRP	1
p.A58T	CESC	1
p.P378S	SKCM	1
p.S170C	HNSC	1
p.P51R	OV	1

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TissGeneCNV for HNF4A

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for HNF4A

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
TCGAfusionPortal	PRADA	KIRC	TCGA-AS-3777-01A	SLCO2B1-HNF4A	5UTR-CDS	Chr11:74870949	Chr20:43034698

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TissGeneNet for HNF4A

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
HNF4A, ONECUT1, GPX2, ALDH3A1, TRIM15, SLC22A1, ABCG5, SERPINB3, PZP, APOH, SHH, AQP3, AGA, HNF1B, AP4B1, CYP2B6, TBRG1, TM4SF4, CYP4F3, FABP2, CLCN6 (tumor)	HNF4A, APCS, CPB2, F2, KNG1, APOA2, AHSG, UGT2A3, APOH, F9, A1CF, APOC3, G6PC, CYP4F2, HNF1B, SULT2A1, INHBE, SLC10A1, SLC17A2, APOA4, PLA2G12B (normal)

COAD (tumor)	COAD (normal)
HNF4A, EID1, NR5A2, NR1I2, EPB41L4B, VDR, LSR, CETN2, IRF6, P2RY2, SLC35D1, KIF3B, PARP4, PITPNB, C11orf73, KDELC1, ABCC3, FRK, REXO2, RPS6KC1, GPR39 (tumor)	HNF4A, YWHAB, TRPC4AP, UBE2V1, SPATA2, NR1I2, NCOA6, PPP1R3D, MOCS3, ZFP64, RBM39, DDX27, SLMO2, DHX35, PLAGL2, RPRD1B, CYP4F2, KIF3B, PARP4, TP53RK, TM9SF4 (normal)

HNSC (tumor)	HNSC (normal)
HNF4A, MDM2, TBC1D17, EFTUD2, GADD45G, SERPINA5, PSME3, MPP1, FGF13, AGT, PRPF4, KDM5C, DIS3, TMOD2, DDX47, RASL12, MGST3, HAAO, MSRB2, GDAP2, FIGF (tumor)	HNF4A, GSTK1, RAP1GAP, AHSA1, C14orf1, CPB2, F2, GPX2, HHLA2, ABCC2, SNAPC1, TXNDC12, PNO1, ABCG8, PNMA1, ABCG5, CXXC1, RPRD1B, WDR12, GFM1, ABCC3 (normal)

KICH (tumor)	KICH (normal)
HNF4A, GIPC2, DPF3, ADH6, HNF1A, ACY3, ANPEP, ABCC2, GLYAT, SLC22A3, AGXT2, BHMT, SLC22A18AS, A1CF, ALDH1L1, G6PC, CYP4F2, FCAMR, RBP5, CYP4F3, PLA2G12B (tumor)	HNF4A, PSAT1, FAS, NEDD8, SHFM1, COPZ1, ACTR3, SPAST, SDR39U1, UXT, NDUFA7, GCHFR, HIRIP3, HSD17B2, MRPL11, RSL24D1, ALDH2, TIMM17B, ATP6V1F, OGFOD2, TPCN1 (normal)

KIRC (tumor)	KIRC (normal)
HNF4A, GIPC2, ADH6, HNF1A, ACY3, ANPEP, PCK1, ABCC2, TRIM15, GLYAT, CYP27A1, AGXT2, BHMT, A1CF, ALDH1L1, G6PC, RBP5, NAT8, APOM, SLC22A7, PLA2G12B (tumor)	HNF4A, TRIM55, GIPC2, HNF1A, GJB1, CLDN2, ACY3, ANPEP, ABCC2, AGT, TRIM15, UGT2A3, GLYAT, AGXT2, ABCC6, IL22RA1, BHMT, A1CF, RBP5, NAT8, PLA2G12B (normal)

KIRP (tumor)	KIRP (normal)
HNF4A, GIPC2, ADH6, HNF1A, CLDN2, ACY3, ANPEP, ABCC2, PRLR, TRIM15, GLYAT, CYP27A1, AGXT2, BHMT, A1CF, ALDH1L1, FCAMR, RBP5, NAT8, CYP4F3, SLC22A7 (tumor)	HNF4A, GIPC2, HNF1A, ACY3, HHLA2, ANPEP, AGT, TRIM15, UGT2A3, GLYAT, AGXT2, ABCC6, IL22RA1, GPT, TMEM176A, HAAO, ABHD6, NAT8, TMEM176B, KLF15, BPHL (normal)

LIHC (tumor)	LIHC (normal)
HNF4A, ARPC5, SUB1, UBE2I, NR1I2, WTAP, RASSF1, BACE1, PGM1, FTSJ1, MED10, SRP19, CYTH2, ABCC6, A1CF, DCAF13, DCAF11, L2HGDH, UTP11L, SLC26A1, CYP4F3 (tumor)	HNF4A, ADH6, HNF1A, APOB, GJB1, CPB2, F2, KNG1, TF, ABCC2, F11, SERPINA10, SERPINC1, ABCC6, A1CF, HGD, F12, CYP2J2, HAO1, CYP4F3, KLF15 (normal)

LUAD (tumor)	LUAD (normal)
HNF4A, ADH6, HNF1A, HHLA2, HSPA4L, UGT2B15, NME7, PZP, BAI2, RDH11, SPATS2L, SLC39A6, CHST9, TTC26, TSNAXIP1, C22orf23, CYP2J2, TMTC4, EFCAB1, LRRC6, CLCNKA (tumor)	HNF4A, NR1I2, ADH6, HNF1A, F2, GPX2, CYP2C9, TRIM15, UGT2B15, UGT2A3, MYO1A, SERPINA4, A1CF, HGD, GUCY2C, SGK2, TM4SF4, CYP3A5, AKR1C4, CYP4F3, PDE11A (normal)

LUSC (tumor)	LUSC (normal)
HNF4A, TRIM55, RUVBL2, ADH6, STAM, HNF1A, UFM1, DACH2, MTTP, PNMA1, PZP, USPL1, CHST9, TTC26, ATF6B, TSNAXIP1, C22orf23, LRRC6, LHX6, IFT122, FUZ (tumor)	HNF4A, SERPINA1, APOB, ASGR2, GJB1, F2, F10, HABP2, TRIM15, AMBP, ABCC6, APOH, SERPINA4, A1CF, ORM1, ANG, HGD, GUCY2C, HNF1B, ORM2, TM4SF4 (normal)

PRAD (tumor)	PRAD (normal)
HNF4A, EPHA2, CD55, GTF2H4, PIP5K1A, SF3B1, SLC5A3, UGT2A3, GLYAT, AGXT2, PAN2, SHH, SULT1C2, ALDH1L1, ZNF747, SGK2, CYP2C8, SLC17A2, TM4SF4, CYP4F3, PRICKLE4 (tumor)	HNF4A, APCS, F2, APOA1, KNG1, APOA2, CYP2C9, AHSG, TAT, SERPINA10, AMBP, UGT2B15, SERPINC1, AGXT2, APOH, F9, BHMT, APOC3, G6PC, TM4SF4, AKR1C4 (normal)

STAD (tumor)	STAD (normal)
HNF4A, NR0B2, SERPINA1, NR1I2, EPB41L4B, HNF1A, GJB1, ACY3, HHLA2, TRIM15, MYO1A, TNFSF13, SULT1C2, SSTR1, HGD, HNF1B, REG1A, SGK2, HLA-F, TMEM53, AKR1C4 (tumor)	HNF4A, SPATA2, NR1I2, MAP7, EPB41L4B, HNF1A, GJB1, GPX2, ELF3, TRIM15, MYO1A, IL22RA1, A1CF, HGD, GATA6, GUCY2C, HNF1B, SGK2, C4orf19, CYP2B6, TMEM63A (normal)

THCA (tumor)	THCA (normal)
HNF4A, FOXO1, TMEM33, CBX5, CLDN2, HABP2, TSN, TMBIM6, PPP6C, LZTR1, UGT2A3, DCTN4, AGXT2, BHMT, HNF1B, NCBP2, REG1A, NAT8, SLC17A2, HBS1L, SLC39A9 (tumor)	HNF4A, SLC25A5, SESN2, SRPRB, F2, GHITM, HABP2, FH, PCK1, CS, SUPV3L1, UGT2A3, GLYAT, AGXT2, GOT1, A1CF, G6PC, INHBE, NAT8, SLC43A1, SLC22A7 (normal)

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TissGeneProg for HNF4A

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for HNF4A

TissGeneDrug for HNF4A

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for HNF4A

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0011860	Diabetes Mellitus, Non-Insulin-Dependent	153	BeFree,CLINVAR,CTD_human,GAD,GWASCAT,LHGDN,UNIPROT
umls:C0011849	Diabetes Mellitus	108	BeFree,GAD
umls:C0011847	Diabetes	100	BeFree
umls:C0342276	Maturity onset diabetes mellitus in young	85	BeFree,CTD_human,GAD
umls:C2239176	Liver carcinoma	31	BeFree,LHGDN
umls:C0009402	Colorectal Carcinoma	17	BeFree
umls:C0023903	Liver neoplasms	17	BeFree
umls:C0011854	Diabetes Mellitus, Insulin-Dependent	14	BeFree,GAD
umls:C1527249	Colorectal Cancer	14	BeFree
umls:C0596263	Carcinogenesis	13	BeFree
umls:C0020456	Hyperglycemia	11	BeFree
umls:C0020615	Hypoglycemia	11	BeFree,GAD,LHGDN
umls:C0699790	Colon Carcinoma	11	BeFree
umls:C0007102	Malignant tumor of colon	10	BeFree
umls:C0085207	Gestational Diabetes	10	BeFree,GAD
umls:C1852093	Maturity-Onset Diabetes of the Young, Type 1	10	BeFree,CLINVAR,CTD_human,MGD,UNIPROT
umls:C0027627	Neoplasm Metastasis	8	BeFree,LHGDN
umls:C0009324	Ulcerative Colitis	7	BeFree,CTD_human,GAD
umls:C0019163	Hepatitis B	7	BeFree,LHGDN
umls:C0020459	Hyperinsulinism	7	BeFree,CLINVAR,GAD
umls:C0032580	Adenomatous Polyposis Coli	7	BeFree
umls:C0024623	Malignant neoplasm of stomach	6	BeFree
umls:C0158981	Neonatal diabetes mellitus	6	BeFree
umls:C0699791	Stomach Carcinoma	6	BeFree
umls:C0025202	melanoma	5	BeFree
umls:C0271650	Impaired glucose tolerance	5	BeFree
umls:C0524620	Metabolic Syndrome X	5	BeFree
umls:C0010346	Crohn Disease	4	BeFree
umls:C0020474	Hyperlipidemia, Familial Combined	4	BeFree
umls:C0028754	Obesity	4	BeFree
umls:C0178874	Tumor Progression	4	BeFree
umls:C0001418	Adenocarcinoma	3	BeFree,LHGDN
umls:C0002793	Anaplasia	3	BeFree
umls:C0006142	Malignant neoplasm of breast	3	BeFree
umls:C0007134	Renal Cell Carcinoma	3	BeFree
umls:C0011881	Diabetic Nephropathy	3	BeFree,LHGDN,RGD
umls:C0015503	Factor VII Deficiency	3	BeFree
umls:C0021390	Inflammatory Bowel Diseases	3	BeFree
umls:C0022658	Kidney Diseases	3	BeFree
umls:C0025517	Metabolic Diseases	3	BeFree
umls:C0026764	Multiple Myeloma	3	BeFree
umls:C0279000	Liver and Intrahepatic Biliary Tract Carcinoma	3	BeFree
umls:C0279626	Squamous cell carcinoma of esophagus	3	BeFree
umls:C0342277	Diabetes mellitus autosomal dominant type II (disorder)	3	BeFree
umls:C0345904	Malignant neoplasm of liver	3	BeFree
umls:C0376358	Malignant neoplasm of prostate	3	BeFree
umls:C0600139	Prostate carcinoma	3	BeFree
umls:C0678222	Breast Carcinoma	3	BeFree
umls:C0004153	Atherosclerosis	2	BeFree,GAD
umls:C0005684	Malignant neoplasm of urinary bladder	2	BeFree
umls:C0007103	Malignant neoplasm of endometrium	2	BeFree
umls:C0008312	Primary biliary cirrhosis	2	BeFree
umls:C0009319	Colitis	2	BeFree
umls:C0015624	Fanconi Syndrome	2	BeFree
umls:C0015625	Fanconi Anemia	2	BeFree
umls:C0015938	Fetal Macrosomia	2	BeFree
umls:C0019693	HIV Infections	2	BeFree
umls:C0022661	Kidney Failure, Chronic	2	BeFree,GAD
umls:C0027819	Neuroblastoma	2	BeFree
umls:C0029925	Ovarian Carcinoma	2	BeFree
umls:C0205734	Diabetes, Autoimmune	2	BeFree
umls:C0442874	Neuropathy	2	BeFree
umls:C0476089	Endometrial Carcinoma	2	BeFree
umls:C0699885	Carcinoma of bladder	2	BeFree
umls:C0700095	Central neuroblastoma	2	BeFree
umls:C0740457	Malignant neoplasm of kidney	2	BeFree
umls:C1140680	Malignant neoplasm of ovary	2	BeFree
umls:C1368683	Epithelioma	2	BeFree
umls:C1378703	Renal carcinoma	2	BeFree
umls:C1857395	De Toni-Debre-Fanconi Syndrome	2	BeFree
umls:C1883486	Uterine Corpus Cancer	2	BeFree
umls:C0000768	Congenital Abnormality	1	BeFree
umls:C0001430	Adenoma	1	BeFree
umls:C0002395	Alzheimer's Disease	1	GAD
umls:C0003850	Arteriosclerosis	1	BeFree
umls:C0004114	Astrocytoma	1	BeFree
umls:C0005779	Blood Coagulation Disorders	1	BeFree
umls:C0005967	Bone neoplasms	1	BeFree
umls:C0006625	Cachexia	1	BeFree
umls:C0007131	Non-Small Cell Lung Carcinoma	1	BeFree
umls:C0007222	Cardiovascular Diseases	1	BeFree
umls:C0008350	Cholelithiasis	1	BeFree
umls:C0008370	Cholestasis	1	BeFree
umls:C0011853	Diabetes Mellitus, Experimental	1	RGD
umls:C0011859	Lipoatrophic Diabetes Mellitus	1	BeFree
umls:C0011880	Diabetic Ketoacidosis	1	BeFree
umls:C0014544	Epilepsy	1	BeFree
umls:C0014556	Epilepsy, Temporal Lobe	1	BeFree
umls:C0015645	Fasciitis	1	BeFree
umls:C0017638	Glioma	1	BeFree
umls:C0018799	Heart Diseases	1	BeFree
umls:C0019069	Hemophilia A	1	BeFree
umls:C0020538	Hypertensive disease	1	BeFree
umls:C0021670	insulinoma	1	BeFree
umls:C0023467	Leukemia, Myelocytic, Acute	1	BeFree
umls:C0023470	Myeloid Leukemia	1	BeFree
umls:C0023530	Leukopenia	1	BeFree
umls:C0023890	Liver Cirrhosis	1	BeFree
umls:C0024121	Lung Neoplasms	1	BeFree
umls:C0025149	Medulloblastoma	1	BeFree
umls:C0027709	Nephrocalcinosis	1	BeFree
umls:C0027773	Nesidioblastosis	1	BeFree
umls:C0027947	Neutropenia	1	BeFree,GAD
umls:C0029002	Onchocerciasis, Ocular	1	BeFree
umls:C0029408	Degenerative polyarthritis	1	BeFree
umls:C0029463	Osteosarcoma	1	BeFree
umls:C0030567	Parkinson Disease	1	BeFree
umls:C0032584	polyps	1	BeFree
umls:C0036572	Seizures	1	BeFree
umls:C0040336	Tobacco Use Disorder	1	GAD
umls:C0151747	Renal tubular disorder	1	BeFree
umls:C0153676	Secondary malignant neoplasm of lung	1	BeFree
umls:C0162429	Malnutrition	1	BeFree
umls:C0205851	Germ cell tumor	1	BeFree
umls:C0206624	Hepatoblastoma	1	BeFree
umls:C0221032	Familial generalized lipodystrophy	1	BeFree
umls:C0221715	Intestinal carcinoma	1	BeFree
umls:C0233794	Memory impairment	1	BeFree
umls:C0238052	Xanthomatosis, Cerebrotendinous	1	BeFree
umls:C0239946	Fibrosis, Liver	1	BeFree
umls:C0242339	Dyslipidemias	1	GAD
umls:C0262401	Carcinoma of ampulla of Vater	1	BeFree
umls:C0268800	Simple renal cyst	1	BeFree
umls:C0271694	Familial partial lipodystrophy	1	BeFree
umls:C0280100	Solid tumour	1	BeFree
umls:C0346429	Multiple malignancy	1	BeFree
umls:C0362046	Prediabetes syndrome	1	BeFree
umls:C0376544	Hematopoietic Neoplasms	1	BeFree
umls:C0400966	Non-alcoholic Fatty Liver Disease	1	BeFree
umls:C0497406	Overweight	1	BeFree
umls:C0524909	Hepatitis B, Chronic	1	BeFree
umls:C0585442	Osteosarcoma of bone	1	BeFree
umls:C0684275	Hemophilia, NOS	1	BeFree
umls:C0687120	Nephronophthisis	1	BeFree
umls:C0750952	Biliary Tract Cancer	1	BeFree
umls:C0947622	Cholecystolithiasis	1	BeFree
umls:C1458155	Mammary Neoplasms	1	GAD
umls:C1512409	Hepatocarcinogenesis	1	BeFree
umls:C1569637	Adenocarcinoma, Endometrioid	1	BeFree
umls:C1623038	Cirrhosis	1	BeFree
umls:C1720860	Familial Partial Lipodystrophy, Type 2	1	BeFree
umls:C1838100	MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)	1	BeFree
umls:C2316810	Chronic kidney disease stage 5	1	BeFree
umls:C2718001	Protein Misfolding Disorders	1	BeFree
umls:C2931833	Hyperinsulinemic hypoglycemia, familial, 2	1	BeFree
umls:C3825462	Diabetes in youth	1	BeFree
umls:C3826457	Diabetes in children	1	BeFree
umls:C3888018	Congenital Hyperinsulinism	1	GAD
umls:C4014962	FANCONI RENOTUBULAR SYNDROME 4 WITH MATURITY-ONSET DIABETES OF THE YOUNG	1	UNIPROT