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TissGeneSummary for APOF |
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Basic gene information | Gene symbol | APOF |
Gene name | apolipoprotein F | |
Synonyms | Apo-F|LTIP | |
Cytomap | UCSC genome browser: 12q13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001638.2, | |
Description | lipid transfer inhibitor protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 107760 | |
HGNC : HGNC | ||
Ensembl : ENSG00000175336 | ||
HPRD : 00137 | ||
Vega : OTTHUMG00000170715 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_APOF | |
BioGPS: 319 | ||
Pathway | NCI Pathway Interaction Database: APOF | |
KEGG: APOF | ||
REACTOME: APOF | ||
Pathway Commons: APOF | ||
Context | iHOP: APOF | |
ligand binding site mutation search in PubMed: APOF | ||
UCL Cancer Institute: APOF | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of APOF | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for APOF |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 5.326591555 | 10.07206356 | -4.745472 | 3.19E-15 | 9.84E-14 |
PRAD | 3.800429555 | 0.704314171 | 3.096115385 | 4.45E-15 | 5.87E-13 |
KICH | -3.244932445 | -2.101160445 | -1.143772 | 2.63E-07 | 1.10E-06 |
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TissGene-miRNA for APOF |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for APOF |
TissGeneSNV for APOF |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.Q42E | ACC | 1 |
p.P50S | SKCM | 1 |
p.Y306C | STAD | 1 |
p.R215* | SARC | 1 |
p.P50L | SKCM | 1 |
p.A266T | GBM | 1 |
p.P50L | LUSC | 1 |
p.A80P | GBM | 1 |
p.A280T | THYM | 1 |
p.I219M | UCEC | 1 |
p.S55F | SKCM | 1 |
p.A230S | THYM | 1 |
p.E172Q | CESC | 1 |
p.L245F | PAAD | 1 |
p.T273I | LIHC | 1 |
p.D265H | BRCA | 1 |
p.D216N | SKCM | 1 |
p.D316A | UCEC | 1 |
p.S59F | SKCM | 1 |
p.P271L | SKCM | 1 |
p.L245F | SKCM | 1 |
p.G252W | SKCM | 1 |
p.M232I | GBM | 1 |
p.K209N | BLCA | 1 |
p.L207M | UCEC | 1 |
p.L166F | SKCM | 1 |
p.R128* | UCEC | 1 |
p.A119V | SARC | 1 |
p.Q157K | BRCA | 1 |
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TissGeneCNV for APOF |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for APOF |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for APOF |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for APOF |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for APOF |
TissGeneDrug for APOF |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for APOF |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002395 | Alzheimer's Disease | 1 | GAD |
umls:C0010068 | Coronary heart disease | 1 | GAD |
umls:C0019196 | Hepatitis C | 1 | GAD |
umls:C0020443 | Hypercholesterolemia | 1 | BeFree |
umls:C0020473 | Hyperlipidemia | 1 | BeFree |
umls:C0021368 | Inflammation | 1 | GAD |
umls:C0021655 | Insulin Resistance | 1 | GAD |
umls:C0023903 | Liver neoplasms | 1 | BeFree |
umls:C1956346 | Coronary Artery Disease | 1 | GAD |
umls:C2239176 | Liver carcinoma | 1 | BeFree |