TissGeneSummary for TLX2 |
Gene summary |
Basic gene information | Gene symbol | TLX2 |
Gene name | T-cell leukemia homeobox 2 | |
Synonyms | HOX11L1|NCX | |
Cytomap | UCSC genome browser: 2p13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_016170.4, | |
Description | T-cell leukemia homeobox protein 2homeo box 11-like 1homeobox protein Hox-11L1neural crest homeobox protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 604240 | |
HGNC : HGNC | ||
Ensembl : ENSG00000115297 | ||
HPRD : 07254 | ||
Vega : OTTHUMG00000129960 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TLX2 | |
BioGPS: 3196 | ||
Pathway | NCI Pathway Interaction Database: TLX2 | |
KEGG: TLX2 | ||
REACTOME: TLX2 | ||
Pathway Commons: TLX2 | ||
Context | iHOP: TLX2 | |
ligand binding site mutation search in PubMed: TLX2 | ||
UCL Cancer Institute: TLX2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUVM | |
Reference showing the relevant tissue of TLX2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TLX2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | -0.752887638 | -2.09641322 | 1.343525581 | 1.25E-06 | 9.25E-06 |
COAD | -1.206116976 | 0.657809947 | -1.863926923 | 3.77E-11 | 6.07E-10 |
LUSC | -0.463385906 | -2.040483945 | 1.577098039 | 4.68E-07 | 1.22E-06 |
BLCA | -0.572212118 | -1.826601592 | 1.254389474 | 0.0114 | 0.049134884 |
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TissGene-miRNA for TLX2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TLX2 |
TissGeneSNV for TLX2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A199T | COAD | 1 |
p.V284L | COAD | 1 |
p.H147N | LGG | 1 |
p.A63T | READ | 1 |
p.R39H | BLCA | 1 |
p.A261V | STAD | 1 |
p.R152W | PAAD | 1 |
p.D198G | HNSC | 1 |
p.Q206H | UCEC | 1 |
p.R144H | PRAD | 1 |
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TissGeneCNV for TLX2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TLX2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TLX2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TLX2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TLX2 |
TissGeneDrug for TLX2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TLX2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0018801 | Heart failure | 2 | BeFree |
umls:C0018802 | Congestive heart failure | 2 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
umls:C0038454 | Cerebrovascular accident | 2 | BeFree |
umls:C0345244 | Neuronal intestinal dysplasia | 2 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 2 | BeFree |
umls:C0002063 | Alkalosis | 1 | BeFree |
umls:C0008626 | Congenital chromosomal disease | 1 | BeFree |
umls:C0011570 | Mental Depression | 1 | BeFree |
umls:C0011581 | Depressive disorder | 1 | BeFree |
umls:C0014544 | Epilepsy | 1 | BeFree |
umls:C0020538 | Hypertensive disease | 1 | BeFree |
umls:C0023492 | Leukemia, T-Cell | 1 | BeFree |
umls:C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | BeFree |
umls:C0026266 | Mitral Valve Insufficiency | 1 | BeFree |
umls:C0026269 | Mitral Valve Stenosis | 1 | BeFree |
umls:C0036572 | Seizures | 1 | BeFree |
umls:C0238198 | Gastrointestinal Stromal Tumors | 1 | BeFree,LHGDN |
umls:C0241910 | Hepatitis, Autoimmune | 1 | BeFree |
umls:C0264766 | Rheumatic mitral stenosis | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
umls:C1832589 | Neuronal Intestinal Dysplasia, Type B | 0 | MGD |
umls:C1855733 | Neuronal intestinal pseudoobstruction | 0 | MGD |