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| TissGeneSummary for HOXA11 |
 Gene summary |
| Basic gene information | Gene symbol | HOXA11 |
| Gene name | homeobox A11 | |
| Synonyms | HOX1|HOX1I | |
| Cytomap | UCSC genome browser: 7p15.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005523.5, | |
| Description | homeo box 1Ihomeobox protein HOXA11homeobox protein Hox-1Ihomeobox protein Hox-A11 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 142958 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000005073 | ||
| HPRD : 00846 | ||
| Vega : OTTHUMG00000023437 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HOXA11 | |
| BioGPS: 3207 | ||
| Pathway | NCI Pathway Interaction Database: HOXA11 | |
| KEGG: HOXA11 | ||
| REACTOME: HOXA11 | ||
| Pathway Commons: HOXA11 | ||
| Context | iHOP: HOXA11 | |
| ligand binding site mutation search in PubMed: HOXA11 | ||
| UCL Cancer Institute: HOXA11 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Uterus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | UCEC,UCS | |
| Reference showing the relevant tissue of HOXA11 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for HOXA11 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | -3.015148634 | -4.393895186 | 1.378746552 | 1.77E-05 | 5.02E-05 |
| LUSC | -0.845710061 | -4.445878688 | 3.600168627 | 6.86E-16 | 4.81E-15 |
| STAD | 0.911110957 | -3.927617168 | 4.838728125 | 1.17E-12 | 3.76E-10 |
| HNSC | -0.807071529 | -4.21189711 | 3.404825581 | 1.89E-16 | 2.50E-14 |
| KIRC | -0.156240779 | 1.860238387 | -2.016479167 | 2.07E-20 | 1.70E-19 |
| ESCA | 0.692370332 | -3.789466032 | 4.481836364 | 0.000211 | 0.005586476 |
| LIHC | -3.684721668 | -4.774497668 | 1.089776 | 0.00042 | 0.001245421 |
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| TissGene-miRNA for HOXA11 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for HOXA11 |
| TissGeneSNV for HOXA11 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.N300I | LUAD | 1 |
| p.Q138* | UCEC | 1 |
| p.F126L | UCEC | 1 |
| p.I266M | BLCA | 1 |
| p.A233V | UCEC | 1 |
| p.S10P | LIHC | 1 |
| p.M294I | BLCA | 1 |
| p.V22I | UCEC | 1 |
| p.S111L | BLCA | 1 |
| p.P69A | LGG | 1 |
| p.Y307C | DLBC | 1 |
| p.M294I | ESCA | 1 |
| p.Q290* | SKCM | 1 |
| p.S308L | SKCM | 1 |
| p.R41H | UCEC | 1 |
| p.Q95H | HNSC | 1 |
| p.Q290X | SKCM | 1 |
| p.H90N | ESCA | 1 |
| p.Q142K | LUAD | 1 |
| p.P137Q | LUAD | 1 |
| p.N300L | LUAD | 1 |
| p.R293K | HNSC | 1 |
| p.P8T | LUAD | 1 |
| p.K250R | LIHC | 1 |
| p.R41C | LGG | 1 |
| p.N300H | LUAD | 1 |
| p.P97A | LIHC | 1 |
| p.F143I | CESC | 1 |
| p.F126L | BLCA | 1 |
| p.A99V | STAD | 1 |
| p.P31L | STAD | 1 |
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| TissGeneCNV for HOXA11 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for HOXA11 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for HOXA11 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (tumor) | HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (normal) |
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| COAD (tumor) | COAD (normal) |
| HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (tumor) | HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (tumor) | HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (normal) |
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| KICH (tumor) | KICH (normal) |
| HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (tumor) | HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (tumor) | HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (tumor) | HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (tumor) | HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (tumor) | HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (tumor) | HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (tumor) | HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (normal) |
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| STAD (tumor) | STAD (normal) |
| HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (tumor) | HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (normal) |
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| THCA (tumor) | THCA (normal) |
| HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (tumor) | HOXA11, HDAC2, HDAC1, CREBBP, YY1, GMNN, FOXO1, MEIS1, PGBD3 (normal) |
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| TissGeneProg for HOXA11 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for HOXA11 |
| TissGeneDrug for HOXA11 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for HOXA11 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0014175 | Endometriosis | 4 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 3 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 3 | BeFree |
| umls:C0023418 | leukemia | 2 | BeFree |
| umls:C0023473 | Myeloid Leukemia, Chronic | 2 | BeFree,LHGDN |
| umls:C0024117 | Chronic Obstructive Airway Disease | 2 | BeFree |
| umls:C0265306 | Greig cephalopolysyndactyly syndrome | 2 | BeFree |
| umls:C0000768 | Congenital Abnormality | 1 | BeFree,GAD |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0009081 | Congenital clubfoot | 1 | GAD |
| umls:C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0022658 | Kidney Diseases | 1 | CTD_human |
| umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
| umls:C0023470 | Myeloid Leukemia | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0027086 | Myoma | 1 | BeFree |
| umls:C0027960 | Nevus | 1 | BeFree |
| umls:C0027962 | Melanocytic nevus | 1 | BeFree |
| umls:C0032987 | Ectopic Pregnancy | 1 | LHGDN |
| umls:C0085669 | Acute leukemia | 1 | BeFree |
| umls:C0156369 | Uterine Polyp | 1 | BeFree |
| umls:C0175703 | Thrombocytopenia-Absent Radius Syndrome | 1 | BeFree |
| umls:C0206762 | Limb Deformities, Congenital | 1 | CTD_human |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0280255 | stage, endometrial cancer | 1 | BeFree |
| umls:C0349639 | Juvenile Myelomonocytic Leukemia | 1 | BeFree |
| umls:C0598766 | Leukemogenesis | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0740268 | Pelvic prolapse | 1 | BeFree |
| umls:C0877015 | Pelvic Organ Prolapse | 1 | BeFree |
| umls:C1153706 | Endometrial adenocarcinoma | 1 | BeFree |
| umls:C1292769 | Precursor B-cell lymphoblastic leukemia | 1 | BeFree |
| umls:C1456781 | Benign melanocytic nevus | 1 | BeFree |
| umls:C1709246 | Non-Neoplastic Disorder | 1 | BeFree |
| umls:C1720887 | Female Urogenital Diseases | 1 | CTD_human |
| umls:C1854273 | Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia | 1 | CLINVAR,CTD_human,ORPHANET |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | LHGDN |
| umls:C3665593 | Melanocytic nevus of skin | 1 | BeFree |
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