TissGeneSummary for HOXB8 |
Gene summary |
Basic gene information | Gene symbol | HOXB8 |
Gene name | homeobox B8 | |
Synonyms | HOX2|HOX2D|Hox-2.4 | |
Cytomap | UCSC genome browser: 17q21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_024016.3, | |
Description | homeo box 2Dhomeo box B8homeobox protein Hox-2.4homeobox protein Hox-2Dhomeobox protein Hox-B8 | |
Modification date | 20141207 | |
dbXrefs | MIM : 142963 | |
HGNC : HGNC | ||
Ensembl : ENSG00000120068 | ||
HPRD : 00851 | ||
Vega : OTTHUMG00000159904 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HOXB8 | |
BioGPS: 3218 | ||
Pathway | NCI Pathway Interaction Database: HOXB8 | |
KEGG: HOXB8 | ||
REACTOME: HOXB8 | ||
Pathway Commons: HOXB8 | ||
Context | iHOP: HOXB8 | |
ligand binding site mutation search in PubMed: HOXB8 | ||
UCL Cancer Institute: HOXB8 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonKidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADKIRC,KIRP,KICH | |
Reference showing the relevant tissue of HOXB8 | ||
Description by TissGene annotations | Protective TissGene in OS Protective TissGene in RFS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for HOXB8 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 1.948635999 | 5.066219332 | -3.117583333 | 3.46E-28 | 5.58E-27 |
HNSC | -1.809604602 | -3.649406927 | 1.839802326 | 2.24E-07 | 2.01E-06 |
LUAD | -0.688002076 | -1.707040007 | 1.019037931 | 0.00548 | 0.010346498 |
COAD | 3.995965166 | 2.295699781 | 1.700265385 | 0.00343 | 0.008598547 |
LUSC | -0.660542677 | -1.83517405 | 1.174631373 | 0.00191 | 0.003408336 |
PRAD | -2.381021373 | -0.622536757 | -1.758484615 | 0.000558 | 0.001917911 |
KICH | 4.404861166 | 5.605141166 | -1.20028 | 0.000432 | 0.001001186 |
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TissGene-miRNA for HOXB8 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for HOXB8 |
TissGeneSNV for HOXB8 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.Q55E | UVM | 1 |
p.L96I | PAAD | 1 |
p.Q141* | LUSC | 1 |
p.L225V | DLBC | 1 |
p.E226D | BRCA | 1 |
p.V6I | PRAD | 1 |
p.D31N | BLCA | 1 |
p.E216K | BLCA | 1 |
p.G184R | SKCM | 1 |
p.P129S | SKCM | 1 |
p.P136S | LGG | 1 |
p.D101N | SKCM | 1 |
p.V76M | BLCA | 1 |
p.D101G | STAD | 1 |
p.E219D | LUAD | 1 |
p.Y153C | LUSC | 1 |
p.Q30P | LUAD | 1 |
p.K243Q | SKCM | 1 |
p.G80R | SKCM | 1 |
p.G16A | GBM | 1 |
p.E234K | BLCA | 1 |
p.G119D | SKCM | 1 |
p.A237E | LUSC | 1 |
p.P68L | LGG | 1 |
p.R188K | HNSC | 1 |
p.Q127H | BLCA | 1 |
p.P51L | SKCM | 1 |
p.S180W | HNSC | 1 |
p.G45C | LUAD | 1 |
p.Y107C | STAD | 1 |
p.L91M | LUSC | 1 |
p.Y86N | LIHC | 1 |
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TissGeneCNV for HOXB8 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for HOXB8 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BX951816 | HOXB8-DIAPH1 | chr17:46690096 | chr5:140910549 |
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TissGeneNet for HOXB8 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for HOXB8 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for HOXB8 |
TissGeneDrug for HOXB8 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for HOXB8 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0028768 | Obsessive-Compulsive Disorder | 2 | BeFree,CTD_human |
umls:C0040953 | Trichotillomania | 2 | BeFree,CTD_human,MGD |
umls:C0206659 | Embryonal Carcinoma | 2 | BeFree |
umls:C1861922 | CAMPOMELIC DYSPLASIA | 2 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
umls:C0023440 | Acute Erythroblastic Leukemia | 1 | BeFree |
umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
umls:C0027831 | Neurofibromatosis 1 | 1 | BeFree |
umls:C1378703 | Renal carcinoma | 1 | BeFree |