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| TissGeneSummary for HOXC11 |
 Gene summary |
| Basic gene information | Gene symbol | HOXC11 |
| Gene name | homeobox C11 | |
| Synonyms | HOX3H | |
| Cytomap | UCSC genome browser: 12q13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_014212.3, | |
| Description | homeo box C11homeobox protein Hox-3Hhomeobox protein Hox-C11 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605559 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000123388 | ||
| HPRD : 09275 | ||
| Vega : OTTHUMG00000160011 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HOXC11 | |
| BioGPS: 3227 | ||
| Pathway | NCI Pathway Interaction Database: HOXC11 | |
| KEGG: HOXC11 | ||
| REACTOME: HOXC11 | ||
| Pathway Commons: HOXC11 | ||
| Context | iHOP: HOXC11 | |
| ligand binding site mutation search in PubMed: HOXC11 | ||
| UCL Cancer Institute: HOXC11 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixSkin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCSKCM | |
| Reference showing the relevant tissue of HOXC11 | ||
| Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 9582375 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 9582375 |
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| TissGeneExp for HOXC11 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| STAD | 3.460610805 | -1.95190482 | 5.412515625 | 5.77E-20 | 6.49E-17 |
| HNSC | 1.621863639 | -2.148071244 | 3.769934884 | 2.57E-17 | 5.78E-15 |
| LUAD | -0.893647708 | -3.086321846 | 2.192674138 | 1.16E-07 | 4.49E-07 |
| KIRP | 2.44269518 | 0.74802018 | 1.694675 | 8.99E-06 | 3.81E-05 |
| BRCA | 2.24143257 | -0.368737605 | 2.610170175 | 5.10E-17 | 2.99E-16 |
| KICH | -1.15709357 | 1.43269043 | -2.589784 | 1.93E-10 | 1.39E-09 |
| LUSC | 1.156689175 | -3.071702982 | 4.228392157 | 1.57E-15 | 1.05E-14 |
| COAD | -0.571654339 | -2.703958185 | 2.132303846 | 0.00294 | 0.007507622 |
| ESCA | 2.872817339 | -2.536628115 | 5.409445455 | 1.81E-06 | 0.000664023 |
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| TissGene-miRNA for HOXC11 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-27a-3p | MIMAT0000084 | 0.013 | -0.28 | 78 |
| ACC | hsa-miR-27a-3p | MIMAT0000084 | 0.013 | -0.28 | 78 |
| ACC | hsa-miR-501-3p | MIMAT0004774 | 0.0036 | -0.34 | 78 |
| ACC | hsa-miR-501-3p | MIMAT0004774 | 0.0036 | -0.34 | 78 |
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| TissGeneMut for HOXC11 |
| TissGeneSNV for HOXC11 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.A135T | PAAD | 1 |
| p.E180* | BLCA | 1 |
| p.F154L | UCEC | 1 |
| p.G188E | LUAD | 1 |
| p.S88R | LUSC | 1 |
| p.V5A | UCEC | 1 |
| p.S120T | KIRC | 1 |
| p.E17K | SKCM | 1 |
| p.K288N | LUAD | 1 |
| p.S64W | LUAD | 1 |
| p.P169L | SKCM | 1 |
| p.C308G | LIHC | 1 |
| p.P148L | SKCM | 1 |
| p.A94E | LUSC | 1 |
| p.R86W | COAD | 1 |
| p.A265S | LUAD | 1 |
| p.L295P | PRAD | 1 |
| p.D245N | SKCM | 1 |
| p.E194K | BLCA | 1 |
| p.P184L | LIHC | 1 |
| p.C171G | HNSC | 1 |
| p.E278K | LUAD | 1 |
| p.P107L | SKCM | 1 |
| p.S12Y | THCA | 1 |
| p.E78* | LUAD | 1 |
| p.R309T | ESCA | 1 |
| p.S191F | ACC | 1 |
| p.T133P | GBM | 1 |
| p.G224R | OV | 1 |
| p.F251S | STAD | 1 |
| p.R267W | COAD | 1 |
| p.E43K | PAAD | 1 |
| p.R102Q | BLCA | 1 |
| p.G123D | UCEC | 1 |
| p.S145R | LUAD | 1 |
| p.R102L | KIRP | 1 |
| p.L247Q | LUAD | 1 |
| p.R25Q | GBM | 1 |
| p.P42H | LIHC | 1 |
| p.K223X | DLBC | 1 |
| p.V110I | PAAD | 1 |
| p.M115I | CESC | 1 |
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| TissGeneCNV for HOXC11 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for HOXC11 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for HOXC11 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (tumor) | HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (normal) |
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| COAD (tumor) | COAD (normal) |
| HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (tumor) | HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (tumor) | HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (normal) |
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| KICH (tumor) | KICH (normal) |
| HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (tumor) | HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (tumor) | HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (tumor) | HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (tumor) | HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (tumor) | HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (tumor) | HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (tumor) | HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (normal) |
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| STAD (tumor) | STAD (normal) |
| HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (tumor) | HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (normal) |
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| THCA (tumor) | THCA (normal) |
| HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (tumor) | HOXC11, SMAD3, ELAVL1, SP1, STAT3, SOX8, HDAC5, GTF2A1L, GTF2H1, IRF4, CD2AP, MEIS1, TBX21 (normal) |
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| TissGeneProg for HOXC11 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for HOXC11 |
| TissGeneDrug for HOXC11 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for HOXC11 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0023448 | Lymphoid leukemia | 1 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0027819 | Neuroblastoma | 1 | LHGDN |
| umls:C0220615 | Adult Acute Myeloblastic Leukemia | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0598766 | Leukemogenesis | 1 | BeFree |
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