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| TissGeneSummary for HOXD8 |
 Gene summary |
| Basic gene information | Gene symbol | HOXD8 |
| Gene name | homeobox D8 | |
| Synonyms | HOX4|HOX4E|HOX5.4 | |
| Cytomap | UCSC genome browser: 2q31.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001199746.1, NM_001199747.1,NM_019558.3, | |
| Description | Hox-4.5homeo box 4Ehomeo box D8homeobox protein 5.4homeobox protein Hox-4Ehomeobox protein Hox-5.4homeobox protein Hox-D8 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 142985 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000175879 | ||
| HPRD : 00868 | ||
| Vega : OTTHUMG00000132513 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HOXD8 | |
| BioGPS: 3234 | ||
| Pathway | NCI Pathway Interaction Database: HOXD8 | |
| KEGG: HOXD8 | ||
| REACTOME: HOXD8 | ||
| Pathway Commons: HOXD8 | ||
| Context | iHOP: HOXD8 | |
| ligand binding site mutation search in PubMed: HOXD8 | ||
| UCL Cancer Institute: HOXD8 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
| Reference showing the relevant tissue of HOXD8 | ||
| Description by TissGene annotations | Protective TissGene in OS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 1756725 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 1756725 |
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| TissGeneExp for HOXD8 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | 3.999906085 | 5.697718085 | -1.697812 | 1.84E-07 | 8.03E-07 |
| KIRC | 3.867662696 | 5.663944641 | -1.796281944 | 1.03E-34 | 2.68E-33 |
| HNSC | 1.009851294 | -0.561292892 | 1.571144186 | 1.84E-08 | 2.09E-07 |
| KIRP | 2.51847971 | 5.48569846 | -2.96721875 | 1.54E-11 | 2.06E-10 |
| LIHC | -0.860393915 | -3.784935915 | 2.924542 | 2.99E-19 | 1.75E-17 |
| LUSC | 0.341474869 | -0.94789768 | 1.289372549 | 8.03E-05 | 0.000168219 |
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| TissGene-miRNA for HOXD8 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for HOXD8 |
| TissGeneSNV for HOXD8 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q67H | KIRP | 2 |
| p.R198* | LUSC | 1 |
| p.Q192K | STAD | 1 |
| p.G98R | PAAD | 1 |
| p.P120A | STAD | 1 |
| p.P116T | HNSC | 1 |
| p.S179N | UCEC | 1 |
| p.K274N | UCEC | 1 |
| p.E279D | LGG | 1 |
| p.Q192K | PRAD | 1 |
| p.H175N | LUAD | 1 |
| p.A18T | DLBC | 1 |
| p.Q143K | LUAD | 1 |
| p.Q184E | BRCA | 1 |
| p.S164L | HNSC | 1 |
| p.L288R | PRAD | 1 |
| p.Q178H | LUAD | 1 |
| p.D75E | ACC | 1 |
| p.P101L | SKCM | 1 |
| p.D259E | ACC | 1 |
| p.L236F | SKCM | 1 |
| p.D75G | COAD | 1 |
| p.P122S | ESCA | 1 |
| p.Q152* | LUAD | 1 |
| p.E286K | HNSC | 1 |
| p.R227I | UCEC | 1 |
| p.R198Q | LUAD | 1 |
| p.G88S | HNSC | 1 |
| p.G98W | LUAD | 1 |
| p.E286K | SKCM | 1 |
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| TissGeneCNV for HOXD8 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for HOXD8 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for HOXD8 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (tumor) | HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (normal) |
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| COAD (tumor) | COAD (normal) |
| HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (tumor) | HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (tumor) | HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (tumor) | HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (tumor) | HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (tumor) | HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (tumor) | HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (tumor) | HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (tumor) | HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (tumor) | HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (tumor) | HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (normal) |
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| THCA (tumor) | THCA (normal) |
| HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (tumor) | HOXD8, HMGB1, RCC1, CDKN1A, ANXA7, PFDN1 (normal) |
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| TissGeneProg for HOXD8 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for HOXD8 |
| TissGeneDrug for HOXD8 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for HOXD8 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0009081 | Congenital clubfoot | 1 | GAD |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
| umls:C0027819 | Neuroblastoma | 1 | BeFree |
| umls:C0349566 | Squamous cell carcinoma of tongue | 1 | BeFree |
| umls:C0700095 | Central neuroblastoma | 1 | BeFree |
| umls:C1861367 | Synpolydactyly 1 | 1 | BeFree |
| umls:C2699746 | Syndactyly, type 2 | 1 | BeFree |
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