TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for HP

Gene summary

Basic gene information	Gene symbol	HP
	Gene name	haptoglobin
	Synonyms	BP\|HP2ALPHA2\|HPA1S
	Cytomap	UCSC genome browser: 16q22.2
	Type of gene	protein-coding
	RefGenes	NM_001126102.1, NM_005143.3,
	Description	binding peptidehaptoglobin alpha(1S)-betahaptoglobin alpha(2FS)-betahaptoglobin, alpha polypeptidehaptoglobin, beta polypeptidezonulin
	Modification date	20141219
dbXrefs	MIM : 140100
	HGNC : HGNC
	Ensembl : ENSG00000257017
	HPRD : 00772
	Vega : OTTHUMG00000173009
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_HP
	BioGPS: 3240
Pathway	NCI Pathway Interaction Database: HP
	KEGG: HP
	REACTOME: HP
	Pathway Commons: HP
Context	iHOP: HP
	ligand binding site mutation search in PubMed: HP
	UCL Cancer Institute: HP
Assigned class in TissGDB*	A
Included tissue-specific gene expression resources	HPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	LIHC
Reference showing the relevant tissue of HP	Extrahepatic expression of plasma protein genes during inflammation. Kalmovarin N, Friedrichs WE, O'Brien HV, Linehan LA, Bowman BH, Yang F. Inflammation. 1991 Oct;15(5):369-79. (pmid:1757124) go to article
Description by TissGene annotations	TissgsKTS

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0010942	positive regulation of cell death	19740759
GO:0042542	response to hydrogen peroxide	19740759
GO:0051354	negative regulation of oxidoreductase activity	19740759
GO:2000296	negative regulation of hydrogen peroxide catabolic process	19740759
GO:0010942	positive regulation of cell death	19740759
GO:0042542	response to hydrogen peroxide	19740759
GO:0051354	negative regulation of oxidoreductase activity	19740759
GO:2000296	negative regulation of hydrogen peroxide catabolic process	19740759

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TissGeneExp for HP

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
BRCA	-0.468758451	1.233852952	-1.702611404	1.47E-07	4.35E-07
LIHC	13.44160811	16.44140811	-2.9998	3.51E-09	3.42E-08
HNSC	-1.042129239	1.712277738	-2.754406977	4.50E-06	2.84E-05
LUSC	2.830779836	6.337101404	-3.506321569	4.30E-08	1.26E-07
THCA	-0.608767788	-2.02152711	1.412759322	3.25E-06	1.15E-05
LUAD	4.808450593	6.059529903	-1.25107931	0.00837	0.015164709
KIRC	1.107688332	-0.425867223	1.533555556	0.000639	0.00122813

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TissGene-miRNA for HP

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for HP

TissGeneSNV for HP

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.R286Q	UCEC	2
p.F377L	THYM	1
p.S47L	CESC	1
p.W369*	SKCM	1
p.A371G	UCS	1
p.R3Q	UCEC	1
p.V262A	STAD	1
p.T372A	KIRP	1
p.N128K	SARC	1
p.L11P	LUAD	1
p.K112N	UCEC	1
p.I374T	UCEC	1
p.I217T	PCPG	1
p.D31N	CESC	1
p.D248Y	COAD	1
p.D304N	SKCM	1
p.R286L	ESCA	1
p.K72M	READ	1
p.L35V	BRCA	1
p.A355V	ESCA	1
p.V302I	COAD	1
p.W284*	SKCM	1
p.Y125H	HNSC	1
p.G387D	SKCM	1
p.I28V	LGG	1
p.G328D	SKCM	1
p.P205H	COAD	1
p.D271N	PAAD	1
p.D363N	SKCM	1
p.L221S	ESCA	1
p.I274V	READ	1

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TissGeneCNV for HP

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for HP

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database

Src

Cancer type

Sample

Fusion gene

ORF

5'-gene BP

3'-gene BP

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TissGeneNet for HP

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
HP, TP63, SMAD3, GRB2, RBBP6, APOE, LAMC3, PITX3, ALB, ADAMTS4, TGM2, WASL, ITGB2, MVP, ITGAM, MIS12, RPL11, HBB, CD22, CD163, C1RL (tumor)	HP, TP63, APOE, TBL1X, LAMC3, PITX3, ADAMTS4, TGM2, WASL, GADD45G, APOA1, ITGB2, CD40LG, MVP, ITGAM, MIS12, RPL11, HBB, CD22, CD163, C1RL (normal)

COAD (tumor)	COAD (normal)
HP, TP63, SMAD3, GRB2, RBBP6, APOE, TBL1X, LAMC3, PITX3, ALB, ADAMTS4, TGM2, WASL, ITGB2, MVP, ITGAM, MIS12, RPL11, HBB, CD163, C1RL (tumor)	HP, TP63, SMAD3, GRB2, APOE, TBL1X, LAMC3, PITX3, ALB, ADAMTS4, TGM2, GADD45G, APOA1, ITGB2, CD40LG, MVP, ITGAM, HBB, CD22, CD163, C1RL (normal)

HNSC (tumor)	HNSC (normal)
HP, TP63, GRB2, RBBP6, APOE, TBL1X, LAMC3, ALB, ADAMTS4, TGM2, GADD45G, APOA1, ITGB2, CD40LG, MVP, ITGAM, MIS12, HBB, CD22, CD163, C1RL (tumor)	HP, SMAD3, GRB2, RBBP6, APOE, TBL1X, LAMC3, PITX3, ALB, ADAMTS4, TGM2, GADD45G, APOA1, ITGB2, CD40LG, ITGAM, MIS12, HBB, CD22, CD163, C1RL (normal)

KICH (tumor)	KICH (normal)
HP, SMAD3, GRB2, RBBP6, LAMC3, PITX3, ALB, ADAMTS4, TGM2, GADD45G, APOA1, ITGB2, CD40LG, MVP, ITGAM, MIS12, RPL11, HBB, CD22, CD163, C1RL (tumor)	HP, TP63, GRB2, RBBP6, APOE, TBL1X, PITX3, ALB, ADAMTS4, TGM2, WASL, GADD45G, APOA1, ITGB2, CD40LG, ITGAM, MIS12, RPL11, HBB, CD163, C1RL (normal)

KIRC (tumor)	KIRC (normal)
HP, TP63, SMAD3, GRB2, TBL1X, LAMC3, ALB, ADAMTS4, TGM2, WASL, GADD45G, ITGB2, CD40LG, MVP, ITGAM, MIS12, RPL11, HBB, CD22, CD163, C1RL (tumor)	HP, TP63, SMAD3, GRB2, RBBP6, APOE, TBL1X, LAMC3, PITX3, ALB, ADAMTS4, TGM2, WASL, APOA1, ITGB2, CD40LG, MVP, ITGAM, RPL11, CD163, C1RL (normal)

KIRP (tumor)	KIRP (normal)
HP, TP63, SMAD3, GRB2, RBBP6, APOE, TBL1X, LAMC3, PITX3, ADAMTS4, TGM2, GADD45G, ITGB2, CD40LG, MVP, ITGAM, MIS12, RPL11, CD22, CD163, C1RL (tumor)	HP, TP63, SMAD3, RBBP6, APOE, TBL1X, LAMC3, ALB, ADAMTS4, TGM2, WASL, GADD45G, APOA1, ITGB2, CD40LG, ITGAM, MIS12, RPL11, HBB, CD163, C1RL (normal)

LIHC (tumor)	LIHC (normal)
HP, TP63, SMAD3, GRB2, RBBP6, APOE, TBL1X, ALB, ADAMTS4, TGM2, WASL, GADD45G, ITGB2, CD40LG, MVP, ITGAM, RPL11, HBB, CD22, CD163, C1RL (tumor)	HP, SMAD3, GRB2, RBBP6, APOE, PITX3, ALB, ADAMTS4, TGM2, WASL, GADD45G, APOA1, ITGB2, CD40LG, MVP, ITGAM, MIS12, HBB, CD22, CD163, C1RL (normal)

LUAD (tumor)	LUAD (normal)
HP, TP63, SMAD3, RBBP6, TBL1X, LAMC3, PITX3, ALB, ADAMTS4, TGM2, WASL, GADD45G, APOA1, CD40LG, MVP, ITGAM, MIS12, RPL11, HBB, CD22, C1RL (tumor)	HP, TP63, GRB2, RBBP6, LAMC3, PITX3, ADAMTS4, TGM2, WASL, GADD45G, APOA1, ITGB2, CD40LG, MVP, ITGAM, MIS12, RPL11, HBB, CD22, CD163, C1RL (normal)

LUSC (tumor)	LUSC (normal)
HP, SMAD3, GRB2, RBBP6, APOE, TBL1X, LAMC3, PITX3, ALB, ADAMTS4, TGM2, GADD45G, APOA1, ITGB2, CD40LG, MVP, ITGAM, MIS12, RPL11, CD163, C1RL (tumor)	HP, SMAD3, GRB2, RBBP6, APOE, TBL1X, LAMC3, PITX3, ADAMTS4, TGM2, GADD45G, APOA1, ITGB2, CD40LG, MVP, ITGAM, RPL11, HBB, CD22, CD163, C1RL (normal)

PRAD (tumor)	PRAD (normal)
HP, TP63, SMAD3, GRB2, APOE, TBL1X, PITX3, ALB, ADAMTS4, TGM2, WASL, GADD45G, ITGB2, CD40LG, MVP, ITGAM, MIS12, HBB, CD22, CD163, C1RL (tumor)	HP, TP63, SMAD3, RBBP6, APOE, PITX3, ALB, ADAMTS4, TGM2, WASL, GADD45G, APOA1, ITGB2, CD40LG, MVP, ITGAM, RPL11, HBB, CD22, CD163, C1RL (normal)

STAD (tumor)	STAD (normal)
HP, TP63, SMAD3, GRB2, RBBP6, APOE, TBL1X, LAMC3, PITX3, ALB, ADAMTS4, TGM2, WASL, APOA1, ITGB2, ITGAM, MIS12, RPL11, HBB, CD163, C1RL (tumor)	HP, SMAD3, GRB2, APOE, PITX3, ALB, ADAMTS4, TGM2, WASL, GADD45G, APOA1, ITGB2, CD40LG, MVP, ITGAM, MIS12, RPL11, HBB, CD22, CD163, C1RL (normal)

THCA (tumor)	THCA (normal)
HP, TP63, SMAD3, GRB2, RBBP6, APOE, TBL1X, LAMC3, TGM2, WASL, APOA1, ITGB2, CD40LG, MVP, ITGAM, MIS12, RPL11, HBB, CD22, CD163, C1RL (tumor)	HP, TP63, SMAD3, GRB2, APOE, TBL1X, PITX3, ALB, TGM2, WASL, GADD45G, APOA1, ITGB2, CD40LG, MVP, ITGAM, RPL11, HBB, CD22, CD163, C1RL (normal)

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TissGeneProg for HP

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for HP

TissGeneDrug for HP

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for HP

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0011849	Diabetes Mellitus	28	BeFree,GAD,LHGDN
umls:C0007222	Cardiovascular Diseases	27	BeFree,CTD_human,GAD,LHGDN
umls:C0011860	Diabetes Mellitus, Non-Insulin-Dependent	21	BeFree,CTD_human,GAD
umls:C0011847	Diabetes	20	BeFree
umls:C0024530	Malaria	19	BeFree,CTD_human,GAD
umls:C0010054	Coronary Arteriosclerosis	16	BeFree,GAD
umls:C0011854	Diabetes Mellitus, Insulin-Dependent	14	BeFree,CTD_human,GAD
umls:C0010068	Coronary heart disease	13	BeFree,GAD
umls:C1956346	Coronary Artery Disease	12	BeFree,GAD
umls:C0004153	Atherosclerosis	11	BeFree,CTD_human,GAD
umls:C0019693	HIV Infections	11	BeFree,CTD_human,GAD
umls:C0027051	Myocardial Infarction	11	BeFree,CTD_human,GAD,LHGDN
umls:C0020538	Hypertensive disease	10	BeFree,CTD_human,GAD,LHGDN
umls:C0014175	Endometriosis	9	BeFree,LHGDN
umls:C0238339	Hereditary pancreatitis	9	BeFree
umls:C2239176	Liver carcinoma	9	BeFree
umls:C0003850	Arteriosclerosis	7	BeFree
umls:C0006142	Malignant neoplasm of breast	7	BeFree,GAD
umls:C0011875	Diabetic Angiopathies	7	BeFree,CTD_human,GAD
umls:C0678222	Breast Carcinoma	7	BeFree
umls:C0002895	Anemia, Sickle Cell	6	BeFree,CTD_human,GAD
umls:C0023903	Liver neoplasms	6	BeFree
umls:C0004364	Autoimmune Diseases	5	BeFree,CTD_human
umls:C0011881	Diabetic Nephropathy	5	BeFree,GAD
umls:C0024535	Malaria, Falciparum	5	BeFree,GAD
umls:C0027627	Neoplasm Metastasis	5	BeFree,LHGDN
umls:C0028754	Obesity	5	BeFree,GAD,RGD
umls:C0036341	Schizophrenia	5	BeFree,CTD_human,GAD
umls:C0155626	Acute myocardial infarction	5	BeFree
umls:C0002312	alpha-Thalassemia	4	BeFree,GAD
umls:C0002395	Alzheimer's Disease	4	BeFree,GAD
umls:C0003873	Rheumatoid Arthritis	4	BeFree
umls:C0004096	Asthma	4	BeFree,GAD
umls:C0023418	leukemia	4	BeFree,CTD_human
umls:C0023473	Myeloid Leukemia, Chronic	4	BeFree
umls:C0041696	Unipolar Depression	4	BeFree
umls:C0085580	Essential Hypertension	4	BeFree
umls:C0235574	Intravascular hemolysis	4	BeFree
umls:C0333186	Restenosis	4	BeFree,GAD
umls:C0600139	Prostate carcinoma	4	BeFree
umls:C1456873	alpha^+^ Thalassemia	4	BeFree
umls:C1458155	Mammary Neoplasms	4	BeFree,CTD_human,LHGDN
umls:C0002871	Anemia	3	BeFree,CTD_human,GAD
umls:C0007134	Renal Cell Carcinoma	3	BeFree
umls:C0011884	Diabetic Retinopathy	3	BeFree
umls:C0014548	Epilepsy, Generalized	3	BeFree,GAD,LHGDN
umls:C0015230	Exanthema	3	BeFree
umls:C0017636	Glioblastoma	3	BeFree
umls:C0018801	Heart failure	3	BeFree,GAD
umls:C0018802	Congestive heart failure	3	BeFree
umls:C0018995	Hemochromatosis	3	BeFree,CTD_human
umls:C0019163	Hepatitis B	3	BeFree,CTD_human
umls:C0023890	Liver Cirrhosis	3	BeFree
umls:C0038454	Cerebrovascular accident	3	BeFree
umls:C0038525	Subarachnoid Hemorrhage	3	BeFree
umls:C0041234	Chagas Disease	3	BeFree
umls:C0041296	Tuberculosis	3	BeFree,CTD_human,LHGDN
umls:C0042373	Vascular Diseases	3	BeFree
umls:C0086543	Cataract	3	BeFree
umls:C0235974	Pancreatic carcinoma	3	BeFree
umls:C0346647	Malignant neoplasm of pancreas	3	BeFree
umls:C0848332	Spots on skin	3	BeFree
umls:C1269683	Major Depressive Disorder	3	BeFree
umls:C2939465	Deficiency of glucose-6-phosphate dehydrogenase	3	BeFree,GAD
umls:C3279786	ANHAPTOGLOBINEMIA	3	BeFree,CLINVAR,UNIPROT
umls:C0001925	Albuminuria	2	GAD
umls:C0003969	Ascorbic Acid Deficiency	2	BeFree,GAD
umls:C0007570	Celiac Disease	2	BeFree,GAD,LHGDN
umls:C0011570	Mental Depression	2	BeFree
umls:C0011581	Depressive disorder	2	BeFree
umls:C0012860	DNA Damage	2	GAD
umls:C0021368	Inflammation	2	GAD,RGD
umls:C0022658	Kidney Diseases	2	BeFree,GAD
umls:C0022661	Kidney Failure, Chronic	2	BeFree
umls:C0024623	Malignant neoplasm of stomach	2	BeFree
umls:C0030319	Panic Disorder	2	BeFree
umls:C0034065	Pulmonary Embolism	2	RGD
umls:C0035309	Retinal Diseases	2	BeFree
umls:C0036572	Seizures	2	BeFree,GAD
umls:C0037054	Sickle Cell Trait	2	BeFree
umls:C0038013	Ankylosing spondylitis	2	BeFree
umls:C0039730	Thalassemia	2	BeFree
umls:C0242231	Coronary Stenosis	2	BeFree
umls:C0242339	Dyslipidemias	2	BeFree,CTD_human
umls:C0270850	Idiopathic generalized epilepsy	2	BeFree
umls:C0302592	Cervix carcinoma	2	BeFree,GAD
umls:C0342257	Complications of Diabetes Mellitus	2	CTD_human,GAD
umls:C0376358	Malignant neoplasm of prostate	2	BeFree
umls:C0403447	Chronic Kidney Insufficiency	2	BeFree
umls:C0494165	Secondary malignant neoplasm of liver	2	BeFree
umls:C0524910	Hepatitis C, Chronic	2	BeFree,CTD_human
umls:C0525045	Mood Disorders	2	BeFree
umls:C0677886	Epithelial ovarian cancer	2	BeFree
umls:C0699791	Stomach Carcinoma	2	BeFree
umls:C0751383	Juvenile Neuronal Ceroid Lipofuscinosis	2	BeFree
umls:C0850803	Anaphylaxis (non medication)	2	BeFree
umls:C0856169	Endothelial dysfunction	2	BeFree
umls:C0993582	Arthritis, Experimental	2	RGD
umls:C1168401	Squamous cell carcinoma of the head and neck	2	BeFree
umls:C1290884	Inflammatory disorder	2	BeFree
umls:C1561643	Chronic Kidney Diseases	2	BeFree
umls:C1623038	Cirrhosis	2	BeFree
umls:C1868649	PANIC DISORDER 1	2	BeFree
umls:C0000786	Spontaneous abortion	1	GAD
umls:C0002726	Amyloidosis	1	BeFree
umls:C0002940	Aneurysm	1	BeFree
umls:C0003130	Anoxia	1	RGD
umls:C0003486	Aortic Aneurysm	1	BeFree
umls:C0003864	Arthritis	1	CTD_human
umls:C0007137	Squamous cell carcinoma	1	GAD
umls:C0007282	Carotid Stenosis	1	BeFree
umls:C0008370	Cholestasis	1	RGD
umls:C0009319	Colitis	1	BeFree
umls:C0009691	Congenital cataract	1	BeFree
umls:C0010346	Crohn Disease	1	BeFree
umls:C0010674	Cystic Fibrosis	1	BeFree
umls:C0011853	Diabetes Mellitus, Experimental	1	RGD
umls:C0013264	Muscular Dystrophy, Duchenne	1	BeFree
umls:C0014544	Epilepsy	1	BeFree,GAD
umls:C0014549	Tonic-Clonic Epilepsy	1	GAD
umls:C0015695	Fatty Liver	1	BeFree,GAD
umls:C0015696	Fatty Liver, Alcoholic	1	GAD
umls:C0015944	Fetal Membranes, Premature Rupture	1	GAD
umls:C0017416	Genital Neoplasms, Female	1	CTD_human
umls:C0017638	Glioma	1	BeFree
umls:C0018133	Graft-vs-Host Disease	1	BeFree
umls:C0018671	Head and Neck Neoplasms	1	GAD
umls:C0019054	Hemolysis (disorder)	1	CTD_human
umls:C0019196	Hepatitis C	1	BeFree
umls:C0020473	Hyperlipidemia	1	BeFree
umls:C0020517	Hypersensitivity	1	CTD_human
umls:C0021390	Inflammatory Bowel Diseases	1	BeFree
umls:C0021400	Influenza	1	BeFree
umls:C0022660	Kidney Failure, Acute	1	BeFree
umls:C0023343	Leprosy	1	BeFree
umls:C0023891	Liver Cirrhosis, Alcoholic	1	GAD
umls:C0023893	Liver Cirrhosis, Experimental	1	RGD
umls:C0024121	Lung Neoplasms	1	LHGDN
umls:C0024141	Lupus Erythematosus, Systemic	1	BeFree
umls:C0024305	Lymphoma, Non-Hodgkin	1	GAD
umls:C0025202	melanoma	1	BeFree
umls:C0025268	Multiple Endocrine Neoplasia Type 2a	1	BeFree
umls:C0026691	Mucocutaneous Lymph Node Syndrome	1	BeFree
umls:C0026850	Muscular Dystrophy	1	BeFree
umls:C0027439	Nasopharyngeal Neoplasms	1	GAD
umls:C0029408	Degenerative polyarthritis	1	BeFree
umls:C0029458	Osteoporosis, Postmenopausal	1	LHGDN
umls:C0030297	Pancreatic Neoplasm	1	LHGDN
umls:C0030567	Parkinson Disease	1	GAD,LHGDN
umls:C0032285	Pneumonia	1	BeFree
umls:C0032460	Polycystic Ovary Syndrome	1	GAD
umls:C0032768	Postherpetic neuralgia	1	BeFree
umls:C0032914	Pre-Eclampsia	1	GAD,LHGDN
umls:C0033687	Proteinuria	1	LHGDN
umls:C0033860	Psoriasis	1	BeFree
umls:C0035078	Kidney Failure	1	BeFree
umls:C0035305	Retinal Detachment	1	CTD_human
umls:C0035412	Rhabdomyosarcoma	1	BeFree
umls:C0036421	Systemic Scleroderma	1	BeFree
umls:C0036474	Scurvy	1	BeFree
umls:C0036982	Shock, Hemorrhagic	1	RGD
umls:C0037315	Sleep Apnea Syndromes	1	GAD
umls:C0039743	Thanatophoric Dysplasia	1	BeFree
umls:C0040592	Trachoma	1	BeFree,GAD
umls:C0041227	Trypanosomiasis	1	BeFree
umls:C0042769	Virus Diseases	1	BeFree
umls:C0085084	Motor Neuron Disease	1	BeFree
umls:C0085207	Gestational Diabetes	1	LHGDN
umls:C0085397	Pasteurellaceae Infections	1	CTD_human
umls:C0085413	Polycystic Kidney, Autosomal Dominant	1	BeFree
umls:C0153381	Malignant neoplasm of mouth	1	BeFree
umls:C0205734	Diabetes, Autoimmune	1	BeFree
umls:C0206669	Hepatocellular Adenoma	1	RGD
umls:C0220641	Lip and Oral Cavity Carcinoma	1	BeFree
umls:C0234972	Convulsive disorder	1	BeFree
umls:C0242383	Age related macular degeneration	1	LHGDN
umls:C0242723	Parasitemia	1	GAD
umls:C0268419	Acatalasia	1	BeFree
umls:C0271650	Impaired glucose tolerance	1	GAD
umls:C0276275	Disease due to Parvoviridae	1	BeFree
umls:C0278488	Carcinoma breast stage IV	1	BeFree
umls:C0278996	Cancer of Head and Neck	1	BeFree
umls:C0333559	Infarction, Lacunar	1	BeFree
umls:C0340629	Aortic aneurysm without mention of rupture NOS	1	BeFree
umls:C0342623	Senile systemic amyloidosis	1	BeFree
umls:C0343804	Chronic Chagas' disease	1	BeFree
umls:C0392514	Hereditary hemochromatosis	1	BeFree
umls:C0400966	Non-alcoholic Fatty Liver Disease	1	BeFree
umls:C0520679	Sleep Apnea, Obstructive	1	BeFree
umls:C0524909	Hepatitis B, Chronic	1	CTD_human
umls:C0566602	Primary sclerosing cholangitis	1	BeFree
umls:C0577631	Carotid Atherosclerosis	1	BeFree
umls:C0679360	Foodborne Disease	1	CTD_human
umls:C0685938	Malignant neoplasm of gastrointestinal tract	1	BeFree
umls:C0741923	cardiac event	1	BeFree
umls:C0741975	carotid disease	1	BeFree
umls:C0836924	Thrombocytosis	1	BeFree
umls:C0852036	Pregnancy associated hypertension	1	CTD_human
umls:C0867389	Chronic graft-versus-host disease	1	BeFree
umls:C1292769	Precursor B-cell lymphoblastic leukemia	1	BeFree
umls:C1306889	Peripheral arterial occlusive disease	1	BeFree
umls:C1561505	Haptoglobin Adverse Event	1	GAD
umls:C1704272	Benign Prostatic Hyperplasia	1	BeFree
umls:C1868678	THANATOPHORIC DYSPLASIA, TYPE I (disorder)	1	BeFree
umls:C2717961	Thrombotic Microangiopathies	1	BeFree
umls:C2931788	Atypical Hemolytic Uremic Syndrome	1	BeFree
umls:C2931868	Catalase deficiency	1	BeFree
umls:C3178801	Stroke, Lacunar	1	BeFree