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| TissGeneSummary for APCS |
 Gene summary |
| Basic gene information | Gene symbol | APCS |
| Gene name | amyloid P component, serum | |
| Synonyms | HEL-S-92n|PTX2|SAP | |
| Cytomap | UCSC genome browser: 1q21-q23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001639.3, | |
| Description | 9.5S alpha-1-glycoproteinepididymis secretory sperm binding protein Li 92npentaxin-relatedserum amyloid P-component | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 104770 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000132703 | ||
| HPRD : 00101 | ||
| Vega : OTTHUMG00000022741 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_APCS | |
| BioGPS: 325 | ||
| Pathway | NCI Pathway Interaction Database: APCS | |
| KEGG: APCS | ||
| REACTOME: APCS | ||
| Pathway Commons: APCS | ||
| Context | iHOP: APCS | |
| ligand binding site mutation search in PubMed: APCS | ||
| UCL Cancer Institute: APCS | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of APCS | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0044869 | negative regulation by host of viral exo-alpha-sialidase activity | 23544079 | GO:0044871 | negative regulation by host of viral glycoprotein metabolic process | 23544079 | GO:0045087 | innate immune response | 23544079 | GO:0045656 | negative regulation of monocyte differentiation | 14607961 | GO:0046597 | negative regulation of viral entry into host cell | 23544079 | GO:0048525 | negative regulation of viral process | 23544079 | GO:1903016 | negative regulation of exo-alpha-sialidase activity | 23544079 | GO:1903019 | negative regulation of glycoprotein metabolic process | 23544079 | GO:0044869 | negative regulation by host of viral exo-alpha-sialidase activity | 23544079 | GO:0044871 | negative regulation by host of viral glycoprotein metabolic process | 23544079 | GO:0045087 | innate immune response | 23544079 | GO:0045656 | negative regulation of monocyte differentiation | 14607961 | GO:0046597 | negative regulation of viral entry into host cell | 23544079 | GO:0048525 | negative regulation of viral process | 23544079 | GO:1903016 | negative regulation of exo-alpha-sialidase activity | 23544079 | GO:1903019 | negative regulation of glycoprotein metabolic process | 23544079 |
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| TissGeneExp for APCS |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 10.62909154 | 12.99013954 | -2.361048 | 2.09E-07 | 1.35E-06 |
| KICH | -2.595884456 | -0.000348456 | -2.595536 | 0.000107 | 0.000277445 |
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| TissGene-miRNA for APCS |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for APCS |
| TissGeneSNV for APCS |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E155K | SKCM | 3 |
| p.S158F | SKCM | 3 |
| p.E125K | SKCM | 2 |
| p.S34F | SKCM | 2 |
| p.G141S | SKCM | 2 |
| p.S121L | LUSC | 1 |
| p.P196L | SKCM | 1 |
| p.Y159N | LUAD | 1 |
| p.G122S | SKCM | 1 |
| p.E125K | CESC | 1 |
| p.D77N | SKCM | 1 |
| p.A58S | LUAD | 1 |
| p.W7* | SKCM | 1 |
| p.Y71C | UCEC | 1 |
| p.S121L | SKCM | 1 |
| p.G213E | SKCM | 1 |
| p.S166I | THYM | 1 |
| p.S91C | LUAD | 1 |
| p.E105K | SKCM | 1 |
| p.D164N | BLCA | 1 |
| p.S67I | LUAD | 1 |
| p.K106N | LUAD | 1 |
| p.D37H | BLCA | 1 |
| p.G130E | SKCM | 1 |
| p.R139X | COAD | 1 |
| p.E85Q | HNSC | 1 |
| p.G160E | UCEC | 1 |
| p.V221M | SKCM | 1 |
| p.P31S | SKCM | 1 |
| p.T195P | UCEC | 1 |
| p.L202P | UCEC | 1 |
| p.A17T | UCEC | 1 |
| p.S9F | SKCM | 1 |
| p.E210K | SKCM | 1 |
| p.D157N | SKCM | 1 |
| p.Y93H | LIHC | 1 |
| p.G141D | SKCM | 1 |
| p.G130V | SKCM | 1 |
| p.S67C | LIHC | 1 |
| p.H97Q | LUAD | 1 |
| p.E210Q | BLCA | 1 |
| p.T100I | LUAD | 1 |
| p.T195P | KIRP | 1 |
| p.Y66C | LIHC | 1 |
| p.L133F | LUAD | 1 |
| p.D180E | OV | 1 |
| p.W127* | SKCM | 1 |
| p.I216M | HNSC | 1 |
| p.F169S | UCEC | 1 |
| p.Y59H | ACC | 1 |
| p.P132T | LUAD | 1 |
| p.T131A | CESC | 1 |
| p.W127X | SKCM | 1 |
| p.R139* | LUAD | 1 |
| p.Q140H | LUAD | 1 |
| p.E85K | SKCM | 1 |
| p.F69L | LUAD | 1 |
| p.V170L | SKCM | 1 |
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| TissGeneCNV for APCS |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for APCS |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | CB164297 | APCS-APCS | chr1:159557968 | chr1:159557963 |
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| TissGeneNet for APCS |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| APCS, HNF4A, ONECUT1, GRB2, FN1, GK, FCGR1A, COPS5, FCGR2B, PITX3, HNF1A, COL4A1, CRP, HES1, C4BPA, GOT2, MBL2, C1QA, FCGR3A, LAMA1, FCAR (tumor) | APCS, HNF4A, ONECUT1, GRB2, FN1, GK, FCGR1A, COPS5, PITX3, HNF1A, COL4A1, CRP, HES1, C4BPA, GOT2, MBL2, FCGR3A, FCAR, TG, CALU, FCGR3B (normal) |
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| COAD (tumor) | COAD (normal) |
| APCS, HNF4A, ONECUT1, GRB2, FN1, GK, COPS5, FCGR2B, PITX3, HNF1A, COL4A1, CRP, HES1, C4BPA, MBL2, C1QA, FCGR3A, LAMA1, FCAR, TG, CALU (tumor) | APCS, ONECUT1, GRB2, FN1, GK, FCGR1A, FCGR2B, PITX3, HNF1A, COL4A1, CRP, HES1, C4BPA, GOT2, MBL2, C1QA, FCGR3A, FCAR, TG, CALU, FCGR3B (normal) |
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| HNSC (tumor) | HNSC (normal) |
| APCS, HNF4A, ONECUT1, GRB2, FCGR1A, COPS5, FCGR2B, PITX3, HNF1A, COL4A1, CRP, HES1, C4BPA, GOT2, MBL2, C1QA, FCGR3A, LAMA1, TG, CALU, FCGR3B (tumor) | APCS, HNF4A, ONECUT1, GRB2, FN1, GK, FCGR1A, COPS5, FCGR2B, PITX3, COL4A1, CRP, HES1, C4BPA, GOT2, MBL2, LAMA1, FCAR, TG, CALU, FCGR3B (normal) |
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| KICH (tumor) | KICH (normal) |
| APCS, HNF4A, ONECUT1, GRB2, FN1, GK, FCGR2B, PITX3, HNF1A, COL4A1, CRP, HES1, GOT2, MBL2, C1QA, FCGR3A, LAMA1, FCAR, TG, CALU, FCGR3B (tumor) | APCS, HNF4A, ONECUT1, GRB2, FN1, COPS5, FCGR2B, PITX3, HNF1A, COL4A1, HES1, C4BPA, GOT2, MBL2, C1QA, FCGR3A, LAMA1, FCAR, TG, CALU, FCGR3B (normal) |
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| KIRC (tumor) | KIRC (normal) |
| APCS, HNF4A, ONECUT1, GRB2, FN1, GK, COPS5, FCGR2B, PITX3, HNF1A, CRP, HES1, C4BPA, GOT2, MBL2, C1QA, LAMA1, FCAR, TG, CALU, FCGR3B (tumor) | APCS, HNF4A, ONECUT1, GRB2, FN1, GK, FCGR1A, FCGR2B, PITX3, COL4A1, CRP, HES1, C4BPA, GOT2, MBL2, C1QA, FCGR3A, LAMA1, FCAR, TG, CALU (normal) |
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| KIRP (tumor) | KIRP (normal) |
| APCS, HNF4A, ONECUT1, GRB2, GK, COPS5, FCGR2B, PITX3, HNF1A, COL4A1, CRP, HES1, C4BPA, MBL2, C1QA, FCGR3A, LAMA1, FCAR, TG, CALU, FCGR3B (tumor) | APCS, HNF4A, ONECUT1, GRB2, FN1, GK, FCGR1A, COPS5, PITX3, HNF1A, COL4A1, CRP, C4BPA, GOT2, MBL2, C1QA, FCGR3A, LAMA1, TG, CALU, FCGR3B (normal) |
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| LIHC (tumor) | LIHC (normal) |
| APCS, ONECUT1, GRB2, FN1, GK, FCGR1A, COPS5, FCGR2B, COL4A1, CRP, HES1, C4BPA, GOT2, MBL2, C1QA, FCGR3A, LAMA1, FCAR, TG, CALU, FCGR3B (tumor) | APCS, HNF4A, ONECUT1, GRB2, FN1, GK, COPS5, FCGR2B, PITX3, HNF1A, COL4A1, CRP, HES1, C4BPA, GOT2, MBL2, C1QA, LAMA1, TG, CALU, FCGR3B (normal) |
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| LUAD (tumor) | LUAD (normal) |
| APCS, HNF4A, ONECUT1, GRB2, FN1, GK, FCGR1A, COPS5, FCGR2B, PITX3, HNF1A, COL4A1, CRP, HES1, C4BPA, GOT2, MBL2, C1QA, FCGR3A, LAMA1, FCAR (tumor) | APCS, HNF4A, ONECUT1, GRB2, FN1, GK, FCGR1A, COPS5, FCGR2B, PITX3, HNF1A, COL4A1, CRP, HES1, GOT2, MBL2, C1QA, FCGR3A, FCAR, CALU, FCGR3B (normal) |
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| LUSC (tumor) | LUSC (normal) |
| APCS, HNF4A, ONECUT1, GRB2, FN1, GK, COPS5, FCGR2B, PITX3, HNF1A, CRP, C4BPA, GOT2, MBL2, C1QA, FCGR3A, LAMA1, FCAR, TG, CALU, FCGR3B (tumor) | APCS, HNF4A, ONECUT1, GRB2, FN1, FCGR1A, COPS5, FCGR2B, PITX3, HNF1A, CRP, HES1, C4BPA, GOT2, MBL2, C1QA, FCGR3A, LAMA1, FCAR, TG, FCGR3B (normal) |
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| PRAD (tumor) | PRAD (normal) |
| APCS, HNF4A, ONECUT1, GRB2, FN1, GK, FCGR1A, COPS5, FCGR2B, PITX3, HNF1A, COL4A1, CRP, C4BPA, GOT2, MBL2, FCGR3A, LAMA1, FCAR, TG, CALU (tumor) | APCS, HNF4A, ONECUT1, FN1, GK, FCGR1A, COPS5, FCGR2B, COL4A1, CRP, HES1, C4BPA, GOT2, MBL2, C1QA, FCGR3A, LAMA1, FCAR, TG, CALU, FCGR3B (normal) |
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| STAD (tumor) | STAD (normal) |
| APCS, HNF4A, ONECUT1, GRB2, GK, FCGR1A, COPS5, PITX3, HNF1A, COL4A1, CRP, HES1, GOT2, MBL2, C1QA, FCGR3A, LAMA1, FCAR, TG, CALU, FCGR3B (tumor) | APCS, ONECUT1, GRB2, FN1, GK, COPS5, FCGR2B, PITX3, HNF1A, COL4A1, CRP, HES1, C4BPA, GOT2, MBL2, C1QA, LAMA1, FCAR, TG, CALU, FCGR3B (normal) |
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| THCA (tumor) | THCA (normal) |
| APCS, HNF4A, ONECUT1, GRB2, FN1, GK, FCGR1A, COPS5, FCGR2B, PITX3, HNF1A, COL4A1, CRP, HES1, C4BPA, GOT2, MBL2, C1QA, FCGR3A, LAMA1, FCAR (tumor) | APCS, HNF4A, ONECUT1, FN1, GK, FCGR1A, COPS5, FCGR2B, PITX3, HNF1A, COL4A1, CRP, HES1, C4BPA, GOT2, MBL2, C1QA, FCGR3A, TG, CALU, FCGR3B (normal) |
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| TissGeneProg for APCS |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for APCS |
| TissGeneDrug for APCS |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for APCS |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0549463 | X-Linked Lymphoproliferative Disorder | 46 | BeFree |
| umls:C2936349 | Plaque, Amyloid | 20 | BeFree |
| umls:C0149678 | Epstein-Barr Virus Infections | 11 | BeFree |
| umls:C0002726 | Amyloidosis | 8 | BeFree |
| umls:C1845076 | Lymphoproliferative Syndrome, X-Linked, 2 | 6 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 5 | BeFree,CTD_human |
| umls:C0006413 | Burkitt Lymphoma | 4 | BeFree |
| umls:C0006849 | Oral candidiasis | 4 | BeFree |
| umls:C0024291 | Lymphohistiocytosis, Hemophagocytic | 4 | BeFree |
| umls:C0024299 | Lymphoma | 4 | BeFree |
| umls:C0004153 | Atherosclerosis | 3 | GAD,LHGDN |
| umls:C0021053 | Immune System Diseases | 3 | BeFree |
| umls:C0024141 | Lupus Erythematosus, Systemic | 3 | BeFree,GAD |
| umls:C0079731 | B-Cell Lymphomas | 3 | BeFree |
| umls:C0004364 | Autoimmune Diseases | 2 | BeFree,LHGDN |
| umls:C0006852 | Candidiasis of vagina | 2 | BeFree |
| umls:C0011847 | Diabetes | 2 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 2 | BeFree |
| umls:C0017658 | Glomerulonephritis | 2 | BeFree |
| umls:C0021345 | Infectious Mononucleosis | 2 | BeFree |
| umls:C0021400 | Influenza | 2 | BeFree,LHGDN |
| umls:C0027051 | Myocardial Infarction | 2 | BeFree |
| umls:C0155626 | Acute myocardial infarction | 2 | BeFree |
| umls:C0206245 | Amyloid Neuropathies, Familial | 2 | BeFree,GAD |
| umls:C0221014 | Reactive systemic amyloidosis | 2 | BeFree |
| umls:C0276680 | Infection by Candida albicans | 2 | BeFree |
| umls:C0340293 | Anterior myocardial infarction | 2 | BeFree |
| umls:C2239176 | Liver carcinoma | 2 | BeFree,CTD_human |
| umls:C3536715 | AA amyloidosis | 2 | BeFree |
| umls:C0001768 | Agammaglobulinemia | 1 | BeFree |
| umls:C0004623 | Bacterial Infections | 1 | BeFree |
| umls:C0006840 | Candidiasis | 1 | BeFree |
| umls:C0006846 | Cutaneous Candidiasis | 1 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 1 | LHGDN |
| umls:C0009447 | Common Variable Immunodeficiency | 1 | BeFree |
| umls:C0013374 | Dysgammaglobulinemia | 1 | BeFree |
| umls:C0014836 | Escherichia coli Infections | 1 | BeFree |
| umls:C0018801 | Heart failure | 1 | CTD_human |
| umls:C0019061 | Hemolytic-Uremic Syndrome | 1 | BeFree |
| umls:C0019163 | Hepatitis B | 1 | BeFree |
| umls:C0021051 | Immunologic Deficiency Syndromes | 1 | BeFree |
| umls:C0021368 | Inflammation | 1 | LHGDN |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0023462 | Acute Megakaryocytic Leukemias | 1 | BeFree |
| umls:C0023903 | Liver neoplasms | 1 | CTD_human |
| umls:C0024131 | Lupus Vulgaris | 1 | BeFree |
| umls:C0024138 | Lupus Erythematosus, Discoid | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0030305 | Pancreatitis | 1 | BeFree |
| umls:C0031069 | Familial Mediterranean Fever | 1 | BeFree |
| umls:C0032000 | Pituitary Adenoma | 1 | BeFree |
| umls:C0032002 | Pituitary Diseases | 1 | BeFree |
| umls:C0033375 | Prolactinoma | 1 | BeFree |
| umls:C0041234 | Chagas Disease | 1 | BeFree |
| umls:C0041296 | Tuberculosis | 1 | BeFree |
| umls:C0042769 | Virus Diseases | 1 | BeFree |
| umls:C0086438 | Hypogammaglobulinemia | 1 | BeFree |
| umls:C0153252 | Systemic candidiasis | 1 | BeFree |
| umls:C0162534 | Prion Diseases | 1 | BeFree |
| umls:C0206247 | Amyloid Neuropathies | 1 | LHGDN |
| umls:C0242994 | Hantavirus Infections | 1 | BeFree |
| umls:C0243026 | Sepsis | 1 | BeFree |
| umls:C0268380 | Systemic amyloidosis | 1 | BeFree |
| umls:C0268392 | Localized amyloidosis | 1 | BeFree |
| umls:C0281479 | Primary Systemic Amyloidosis | 1 | BeFree |
| umls:C0302810 | Uremia syndrome | 1 | BeFree |
| umls:C0333463 | Senile Plaques | 1 | BeFree |
| umls:C0346302 | Growth Hormone-Secreting Pituitary Adenoma | 1 | BeFree |
| umls:C0409974 | Lupus Erythematosus | 1 | BeFree |
| umls:C0521158 | Recurrent tumor | 1 | BeFree |
| umls:C0524910 | Hepatitis C, Chronic | 1 | BeFree |
| umls:C3714514 | Infection | 1 | LHGDN |
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