TissGeneSummary for HRG |
Gene summary |
Basic gene information | Gene symbol | HRG |
Gene name | histidine-rich glycoprotein | |
Synonyms | HPRG|HRGP|THPH11 | |
Cytomap | UCSC genome browser: 3q27 | |
Type of gene | protein-coding | |
RefGenes | NM_000412.3, | |
Description | histidine-proline-rich glycoprotein | |
Modification date | 20141207 | |
dbXrefs | MIM : 142640 | |
HGNC : HGNC | ||
Ensembl : ENSG00000113905 | ||
HPRD : 00812 | ||
Vega : OTTHUMG00000156578 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HRG | |
BioGPS: 3273 | ||
Pathway | NCI Pathway Interaction Database: HRG | |
KEGG: HRG | ||
REACTOME: HRG | ||
Pathway Commons: HRG | ||
Context | iHOP: HRG | |
ligand binding site mutation search in PubMed: HRG | ||
UCL Cancer Institute: HRG | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of HRG | ||
Description by TissGene annotations | TissgsKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0002839 | positive regulation of immune response to tumor cell | 21215706 | GO:0007162 | negative regulation of cell adhesion | 14744774 | GO:0008285 | negative regulation of cell proliferation | 14744774 | GO:0010468 | regulation of gene expression | 21215706 | GO:0010593 | negative regulation of lamellipodium assembly | 16489009 | GO:0016525 | negative regulation of angiogenesis | 14744774 | GO:0030168 | platelet activation | 19903770 | GO:0030193 | regulation of blood coagulation | 21304106 | GO:0030308 | negative regulation of cell growth | 21215706 | GO:0032956 | regulation of actin cytoskeleton organization | 16489009 | GO:0033629 | negative regulation of cell adhesion mediated by integrin | 16489009 | GO:0043065 | positive regulation of apoptotic process | 14744774 | GO:0043254 | regulation of protein complex assembly | 16489009 | GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 16489009 | GO:0050832 | defense response to fungus | 18797515 | GO:0051894 | positive regulation of focal adhesion assembly | 14744774 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway | 16489009 | GO:2000504 | positive regulation of blood vessel remodeling | 21215706 | GO:2001027 | negative regulation of endothelial cell chemotaxis | 14744774 | GO:0002839 | positive regulation of immune response to tumor cell | 21215706 | GO:0007162 | negative regulation of cell adhesion | 14744774 | GO:0008285 | negative regulation of cell proliferation | 14744774 | GO:0010468 | regulation of gene expression | 21215706 | GO:0010593 | negative regulation of lamellipodium assembly | 16489009 | GO:0016525 | negative regulation of angiogenesis | 14744774 | GO:0030168 | platelet activation | 19903770 | GO:0030193 | regulation of blood coagulation | 21304106 | GO:0030308 | negative regulation of cell growth | 21215706 | GO:0032956 | regulation of actin cytoskeleton organization | 16489009 | GO:0033629 | negative regulation of cell adhesion mediated by integrin | 16489009 | GO:0043065 | positive regulation of apoptotic process | 14744774 | GO:0043254 | regulation of protein complex assembly | 16489009 | GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 16489009 | GO:0050832 | defense response to fungus | 18797515 | GO:0051894 | positive regulation of focal adhesion assembly | 14744774 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway | 16489009 | GO:2000504 | positive regulation of blood vessel remodeling | 21215706 | GO:2001027 | negative regulation of endothelial cell chemotaxis | 14744774 |
Top |
TissGeneExp for HRG |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -1.033007271 | 8.026128729 | -9.059136 | 3.44E-28 | 2.47E-25 |
KIRP | -0.635462146 | 8.367062854 | -9.002525 | 3.06E-39 | 2.29E-36 |
KIRC | -0.221686105 | 8.052377784 | -8.274063889 | 7.93E-56 | 2.22E-53 |
LIHC | 12.32904073 | 15.37351273 | -3.044472 | 4.39E-06 | 2.04E-05 |
LUSC | 0.30196316 | -1.391454487 | 1.693417647 | 4.62E-09 | 1.49E-08 |
Top |
TissGene-miRNA for HRG |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for HRG |
TissGeneSNV for HRG |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G336E | SKCM | 2 |
p.R153H | LUAD | 1 |
p.P289L | SKCM | 1 |
p.C89R | HNSC | 1 |
p.F147L | UCEC | 1 |
p.H261N | GBM | 1 |
p.R52W | BRCA | 1 |
p.P204S | COAD | 1 |
p.S132F | LUAD | 1 |
p.E248K | SKCM | 1 |
p.P262T | LUAD | 1 |
p.S174F | SKCM | 1 |
p.S76L | BLCA | 1 |
p.P256L | PRAD | 1 |
p.I180T | COAD | 1 |
p.T334I | LIHC | 1 |
p.P386H | LUAD | 1 |
p.S79L | COAD | 1 |
p.H382Y | SKCM | 1 |
p.F263L | LUAD | 1 |
p.P462S | SKCM | 1 |
p.E115K | SKCM | 1 |
p.G403E | SKCM | 1 |
p.P298Q | LUAD | 1 |
p.P483L | PRAD | 1 |
p.E294K | UCEC | 1 |
p.R460L | LUAD | 1 |
p.S129R | UCEC | 1 |
p.Q494* | SKCM | 1 |
p.E190K | SKCM | 1 |
p.P234L | READ | 1 |
p.P301S | SKCM | 1 |
p.R42* | BLCA | 1 |
p.S503T | COAD | 1 |
p.E294K | SKCM | 1 |
p.E373K | LUAD | 1 |
p.E303K | READ | 1 |
p.F172V | UCEC | 1 |
p.R441Q | CESC | 1 |
p.R441X | SKCM | 1 |
p.I5V | LIHC | 1 |
p.R52Q | STAD | 1 |
p.L461F | STAD | 1 |
p.Q247_splice | UCEC | 1 |
p.P421R | LUSC | 1 |
p.Y46F | KIRP | 1 |
p.V515F | ESCA | 1 |
p.R179X | COAD | 1 |
p.R52Q | SKCM | 1 |
p.N251H | SKCM | 1 |
p.D146Y | BLCA | 1 |
p.E303* | KICH | 1 |
p.P310S | SKCM | 1 |
p.S16L | SKCM | 1 |
p.P513S | HNSC | 1 |
p.A330D | ESCA | 1 |
p.P481L | SKCM | 1 |
p.R441* | SKCM | 1 |
p.G432S | BRCA | 1 |
p.P317H | UCEC | 1 |
p.P21L | SKCM | 1 |
p.V143I | UCEC | 1 |
p.R441X | PAAD | 1 |
p.H258Y | LUAD | 1 |
p.R201W | GBM | 1 |
p.P462S | LUAD | 1 |
p.T65N | UCEC | 1 |
p.P277L | SKCM | 1 |
p.P396T | LUAD | 1 |
p.P204L | SKCM | 1 |
p.H426Y | STAD | 1 |
p.E90Q | ACC | 1 |
p.P406H | STAD | 1 |
p.R179Q | SKCM | 1 |
p.F147L | COAD | 1 |
p.E373* | HNSC | 1 |
p.H367Y | LUAD | 1 |
p.E32K | BLCA | 1 |
p.P316L | BLCA | 1 |
p.P317S | SKCM | 1 |
p.P262H | BLCA | 1 |
p.H397N | ACC | 1 |
p.Q247R | UCEC | 1 |
p.E181Q | BRCA | 1 |
p.K2N | LUSC | 1 |
p.G103R | ESCA | 1 |
p.L464V | BLCA | 1 |
p.F477C | SKCM | 1 |
p.R441* | PAAD | 1 |
p.R304I | READ | 1 |
p.P300S | SKCM | 1 |
p.S346F | SKCM | 1 |
p.R201W | STAD | 1 |
p.G363R | SKCM | 1 |
p.C408Y | STAD | 1 |
p.Q494X | SKCM | 1 |
p.R448H | STAD | 1 |
p.R179Q | UCEC | 1 |
Top |
TissGeneCNV for HRG |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for HRG |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for HRG |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for HRG |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for HRG |
TissGeneDrug for HRG |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for HRG |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 7 | BeFree |
umls:C0678222 | Breast Carcinoma | 7 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 4 | BeFree |
umls:C0398623 | Thrombophilia | 3 | BeFree |
umls:C0600433 | Activated Protein C Resistance | 2 | BeFree |
umls:C1458155 | Mammary Neoplasms | 2 | BeFree,CTD_human |
umls:C1861171 | THROMBOPHILIA DUE TO ACTIVATED PROTEIN C RESISTANCE (disorder) | 2 | BeFree |
umls:C2751090 | Thrombophilia Due To Histidine-Rich Glycoprotein Deficiency | 2 | CLINVAR,ORPHANET,UNIPROT |
umls:C0004623 | Bacterial Infections | 1 | BeFree |
umls:C0006118 | Brain Neoplasms | 1 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
umls:C0017636 | Glioblastoma | 1 | BeFree |
umls:C0017638 | Glioma | 1 | BeFree |
umls:C0027051 | Myocardial Infarction | 1 | BeFree |
umls:C0036690 | Septicemia | 1 | BeFree |
umls:C0040053 | Thrombosis | 1 | GAD |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0243026 | Sepsis | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0555198 | Malignant Glioma | 1 | BeFree |
umls:C0584960 | Factor V Leiden mutation | 1 | BeFree |
umls:C0852077 | Blood Coagulation Disorders, Inherited | 1 | GAD |
umls:C0853879 | Invasive breast carcinoma | 1 | BeFree |
umls:C0854917 | Rhabdoid Tumor of the Kidney | 1 | BeFree |
umls:C1519670 | Tumor Angiogenesis | 1 | BeFree |
umls:C2751091 | Thrombophilia Due To Elevated Histidine-Rich Glycoprotein | 0 | CTD_human |