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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for HSD11B1
check button Gene summary
Basic gene informationGene symbolHSD11B1
Gene namehydroxysteroid (11-beta) dehydrogenase 1
Synonyms11-DH|11-beta-HSD1|CORTRD2|HDL|HSD11|HSD11B|HSD11L|SDR26C1
CytomapUCSC genome browser: 1q32-q41
Type of geneprotein-coding
RefGenesNM_001206741.1,
NM_005525.3,NM_181755.2,
Descriptioncorticosteroid 11-beta-dehydrogenase isozyme 1short chain dehydrogenase/reductase family 26C, member 1
Modification date20141207
dbXrefs MIM : 600713
HGNC : HGNC
Ensembl : ENSG00000117594
HPRD : 07042
Vega : OTTHUMG00000036481
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HSD11B1
BioGPS: 3290
PathwayNCI Pathway Interaction Database: HSD11B1
KEGG: HSD11B1
REACTOME: HSD11B1
Pathway Commons: HSD11B1
ContextiHOP: HSD11B1
ligand binding site mutation search in PubMed: HSD11B1
UCL Cancer Institute: HSD11B1
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)LiverOvary
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHCOV
Reference showing the relevant tissue of HSD11B1
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for HSD11B1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC0.2198644092.079346762-1.8594823531.53E-137.76E-13
KICH-2.518233160.41637884-2.9346121.18E-086.21E-08
KIRP-3.099422785-0.796291535-2.303131258.74E-085.32E-07
LIHC5.259034847.84301284-2.5839784.33E-072.56E-06
BRCA-1.1981957561.228160384-2.426356141.75E-211.40E-20
KIRC-2.302011326-0.080652993-2.2213583332.33E-131.04E-12
BLCA-1.2776834750.08994284-1.3676263160.001430.009579277
PRAD-0.3239802370.780144763-1.1041258.59E-050.000365279
THCA-2.380016482-1.150467329-1.2295491536.57E-050.000184594


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TissGene-miRNA for HSD11B1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for HSD11B1
TissGeneSNV for HSD11B1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G34ESKCM2
p.E69KSKCM2
p.G45WLUAD1
p.Y19HSTAD1
p.D191NSKCM1
p.H130YSKCM1
p.R48KLUAD1
p.G58ESKCM1
p.C272*LUAD1
p.R252CLUAD1
p.A51GLUAD1
p.E200KSKCM1
p.L109FLUSC1
p.K44EPAAD1
p.A99PLUAD1
p.G112RSTAD1
p.S125CBRCA1
p.G58RSKCM1
p.R137CSKCM1
p.S196YUCEC1
p.E221*UCEC1
p.G45RSKCM1
p.G192VACC1
p.A99TCOAD1
p.E254*UCEC1
p.T92PSKCM1
p.L128FSKCM1
p.A226ELUSC1
p.G248ESKCM1
p.H232YSKCM1
p.E26KSKCM1
p.L215PSTAD1
p.R252CGBM1
p.F193LUCEC1
p.L128IUCEC1
p.K187NSTAD1
p.L267PLUSC1
p.G45VBRCA1
p.A154SUCEC1
p.G45ESKCM1


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TissGeneCNV for HSD11B1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for HSD11B1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABG954179HNRNPH3-HSD11B1chr10:70099312chr1:209897701
TCGAfusionPortalPRADAOVTCGA-09-1667-01CJAK1-HSD11B15UTR-5UTRChr1:65432016Chr1:209878262


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TissGeneNet for HSD11B1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (tumor)HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (normal)
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COAD (tumor)COAD (normal)
HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (tumor)HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (normal)
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HNSC (tumor)HNSC (normal)
HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (tumor)HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (normal)
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KICH (tumor)KICH (normal)
HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (tumor)HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (normal)
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KIRC (tumor)KIRC (normal)
HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (tumor)HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (normal)
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KIRP (tumor)KIRP (normal)
HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (tumor)HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (normal)
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LIHC (tumor)LIHC (normal)
HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (tumor)HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (normal)
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LUAD (tumor)LUAD (normal)
HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (tumor)HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (normal)
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LUSC (tumor)LUSC (normal)
HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (tumor)HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (normal)
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PRAD (tumor)PRAD (normal)
HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (tumor)HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (normal)
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STAD (tumor)STAD (normal)
HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (tumor)HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (normal)
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THCA (tumor)THCA (normal)
HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (tumor)HSD11B1, HNF4A, HNF1A, CD36, GKAP1 (normal)
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TissGeneProg for HSD11B1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for HSD11B1
TissGeneDrug for HSD11B1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB00635PrednisoneLigandSmall moleculeApproved|Vet_approved


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TissGeneDisease for HSD11B1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0028754Obesity30BeFree,CTD_human,GAD,RGD
umls:C0524620Metabolic Syndrome X16BeFree,GAD,RGD
umls:C0020538Hypertensive disease13BeFree,CTD_human,GAD,LHGDN
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent10BeFree,GAD,LHGDN,RGD
umls:C1291245Cortisone reductase deficiency9BeFree,CTD_human
umls:C0032460Polycystic Ovary Syndrome6BeFree,GAD
umls:C0029456Osteoporosis4BeFree,LHGDN
umls:C0029928Ovarian Diseases4BeFree
umls:C0007222Cardiovascular Diseases3BeFree
umls:C0010054Coronary Arteriosclerosis3BeFree
umls:C0010481Cushing Syndrome3BeFree,GAD
umls:C0151526Premature Birth3GAD
umls:C0311277Obesity, Abdominal3BeFree,CTD_human
umls:C1956346Coronary Artery Disease3BeFree
umls:C0001430Adenoma2BeFree,LHGDN
umls:C0001622Adrenal Gland Hyperfunction2BeFree
umls:C0002395Alzheimer's Disease2GAD
umls:C0003873Rheumatoid Arthritis2BeFree,CTD_human
umls:C0006142Malignant neoplasm of breast2BeFree,GAD
umls:C0010068Coronary heart disease2BeFree
umls:C0021368Inflammation2GAD
umls:C0032002Pituitary Diseases2BeFree
umls:C0037274Dermatologic disorders2BeFree,GAD
umls:C0400966Non-alcoholic Fatty Liver Disease2BeFree
umls:C2936861Cortisol 11-beta-ketoreductase deficiency2BeFree
umls:C0001403Addison Disease1GAD
umls:C0001418Adenocarcinoma1BeFree
umls:C0001624Adrenal Gland Neoplasms1BeFree
umls:C0001787Osteoporosis, Age-Related1BeFree
umls:C0004352Autistic Disorder1GAD
umls:C0009402Colorectal Carcinoma1BeFree
umls:C0009404Colorectal Neoplasms1LHGDN
umls:C0009782Connective Tissue Diseases1GAD
umls:C0011570Mental Depression1BeFree
umls:C0011581Depressive disorder1BeFree
umls:C0011853Diabetes Mellitus, Experimental1CTD_human
umls:C0014130Endocrine System Diseases1GAD
umls:C0015929Fetal Diseases1GAD
umls:C0020456Hyperglycemia1CTD_human
umls:C0020473Hyperlipidemia1RGD
umls:C0021655Insulin Resistance1CTD_human
umls:C0022661Kidney Failure, Chronic1BeFree
umls:C0025517Metabolic Diseases1BeFree
umls:C0026857Musculoskeletal Diseases1GAD
umls:C0028756Obesity, Morbid1GAD
umls:C0029463Osteosarcoma1BeFree
umls:C0032019Pituitary Neoplasms1BeFree
umls:C0032964Pregnancy Complications, Hematologic1GAD
umls:C0033845Pseudotumor Cerebri1BeFree
umls:C0149721Left Ventricular Hypertrophy1BeFree
umls:C0162309Adrenoleukodystrophy1BeFree
umls:C0162820Dermatitis, Allergic Contact1CTD_human
umls:C0206081Hyperandrogenism1BeFree
umls:C0238052Xanthomatosis, Cerebrotendinous1BeFree
umls:C0271650Impaired glucose tolerance1LHGDN
umls:C0271885Hypothalamic obesity1BeFree
umls:C0333516Tumor necrosis1BeFree
umls:C0338656Impaired cognition1BeFree
umls:C0342488Mineralocorticoid Excess Syndrome, Apparent1BeFree
umls:C0518010body mass1GAD
umls:C0585442Osteosarcoma of bone1BeFree
umls:C0678222Breast Carcinoma1BeFree
umls:C1306214ACTH-Secreting Pituitary Adenoma1BeFree
umls:C1527249Colorectal Cancer1BeFree
umls:C2316810Chronic kidney disease stage 51BeFree
umls:C2362324Pediatric Obesity1BeFree
umls:C3714514Infection1GAD
umls:C3553382CORTISONE REDUCTASE DEFICIENCY 20CLINVAR,MGD