TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for BIRC5

Gene summary

Basic gene information	Gene symbol	BIRC5
	Gene name	baculoviral IAP repeat containing 5
	Synonyms	API4\|EPR-1
	Cytomap	UCSC genome browser: 17q25
	Type of gene	protein-coding
	RefGenes	NM_001012270.1, NM_001012271.1,NM_001168.2,
	Description	apoptosis inhibitor 4apoptosis inhibitor survivinbaculoviral IAP repeat-containing protein 5survivin variant 3 alpha
	Modification date	20141222
dbXrefs	MIM : 603352
	HGNC : HGNC
	Ensembl : ENSG00000089685
	HPRD : 04520
	Vega : OTTHUMG00000177505
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_BIRC5
	BioGPS: 332
Pathway	NCI Pathway Interaction Database: BIRC5
	KEGG: BIRC5
	REACTOME: BIRC5
	Pathway Commons: BIRC5
Context	iHOP: BIRC5
	ligand binding site mutation search in PubMed: BIRC5
	UCL Cancer Institute: BIRC5
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	TestisThymus
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	TGCTTHYM
Reference showing the relevant tissue of BIRC5
Description by TissGene annotations	Protective TissGene in OS Cancer gene

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0000086	G2/M transition of mitotic cell cycle	9859993
GO:0006468	protein phosphorylation	21252625
GO:0043066	negative regulation of apoptotic process	10626797
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	12773388
GO:0000086	G2/M transition of mitotic cell cycle	9859993
GO:0006468	protein phosphorylation	21252625
GO:0043066	negative regulation of apoptotic process	10626797
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	12773388

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TissGeneExp for BIRC5

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
LUSC	1.154328771	-3.968922209	5.12325098	1.72E-39	9.68E-37
HNSC	1.055704239	-0.924260878	1.979965116	4.31E-11	9.60E-10
LUAD	-0.289757469	-4.150726435	3.860968966	1.18E-28	9.13E-27
STAD	0.297741884	-2.341711241	2.639453125	5.00E-06	6.43E-05
KIRP	-2.576626866	-5.782811241	3.206184375	5.16E-11	6.35E-10
BRCA	-0.322943313	-3.857252085	3.534308772	8.99E-43	3.32E-41
COAD	0.713116403	-0.568425904	1.281542308	3.31E-08	2.59E-07
KIRC	-2.578275477	-5.366526866	2.788251389	1.11E-24	1.29E-23
PRAD	-2.849731674	-4.776227828	1.926496154	5.43E-11	1.29E-09
LIHC	-1.194752366	-5.273290366	4.078538	3.30E-26	1.22E-23
KICH	-3.739718366	-5.301754366	1.562036	0.002	0.004100465
ESCA	0.108831089	-3.220778002	3.329609091	0.00014	0.004096842
BLCA	0.98799616	-2.799935419	3.787931579	1.20E-05	0.000226169
THCA	-3.901571993	-5.26223301	1.360661017	6.68E-05	0.000187209

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TissGene-miRNA for BIRC5

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for BIRC5

TissGeneSNV for BIRC5

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.Y81H	CESC	3
p.T85P	CESC	2
p.E95K	KIRP	1
p.Q120*	SKCM	1
p.G77D	UCEC	1
p.E116K	BLCA	1
p.L110F	SKCM	1
p.Y81H	THCA	1
p.P26S	COAD	1
p.A163V	SKCM	1
p.T85P	HNSC	1
p.S109N	THYM	1
p.P69L	LUAD	1
p.G66C	LUAD	1
p.T78A	CESC	1
p.E117K	BLCA	1
p.A105S	ACC	1
p.E139K	BLCA	1
p.I74V	UCEC	1
p.M141V	STAD	1
p.S137Y	UCEC	1
p.R91*	PRAD	1
p.D128Y	PRAD	1
p.P130S	SKCM	1
p.E118K	KIRP	1
p.P76L	UVM	1
p.L100P	STAD	1
p.P52Q	UCEC	1

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TissGeneCNV for BIRC5

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for BIRC5

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	ChiTaRs	NA	AA600810	STX17-BIRC5		chr9:102734584	chr17:76212763
Chimerdb3.0	ChiTaRs	NA	DB443041	BIRC5-SPDYA		chr17:76210826	chr2:29050056
TCGAfusionPortal	PRADA	BRCA	TCGA-EW-A1PB-01A	PGS1-BIRC5	Out-of-frame	Chr17:76395618	Chr17:76219546

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TissGeneNet for BIRC5

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
BIRC5, MAP3K5, PPP1CC, BIRC3, CASP3, ELAVL1, HSPA4, CDK1, CDK2, AURKA, CDCA8, USP9X, CDK4, AURKB, INCENP, H2AFX, CASP9, DIABLO, LEF1, KLF5, EVI5 (tumor)	BIRC5, UFD1L, ELAVL1, SP1, CDK1, EGR1, CDK2, XPO1, AURKA, MYB, MDC1, CDCA8, XIAP, CDK4, AURKB, RASA1, INCENP, H2AFX, CASP9, XRCC6, EVI5 (normal)

COAD (tumor)	COAD (normal)
BIRC5, UFD1L, CASP3, UBC, SP1, CDK1, CDK2, KCNJ6, AURKA, HSP90AA1, MYB, CDCA8, USP9X, CDK4, AURKB, INCENP, H2AFX, XRCC6, DIABLO, EVI5, JTB (tumor)	BIRC5, UFD1L, PPP1CC, ELAVL1, SP1, BIRC6, CDK1, CDK2, XPO1, AURKA, HSP90AA1, CDCA8, XIAP, CDK4, AURKB, RASA1, INCENP, H2AFX, XRCC6, DIABLO, LEF1 (normal)

HNSC (tumor)	HNSC (normal)
BIRC5, UFD1L, BIRC3, CASP3, HSPA4, CDK1, CDK2, XPO1, AURKA, BIRC2, MYB, USF2, CDCA8, CDK4, AURKB, INCENP, H2AFX, XRCC6, LEF1, KLF5, EVI5 (tumor)	BIRC5, UFD1L, MAP3K5, ELAVL1, SP1, STAT3, BIRC6, CDK1, AURKA, HSP90AA1, CDCA8, USP9X, XIAP, CDK4, AURKB, RASA1, H2AFX, XRCC6, DIABLO, EVI5, JTB (normal)

KICH (tumor)	KICH (normal)
BIRC5, UFD1L, BIRC3, CASP3, HDAC6, CDK1, CDK2, AURKA, BIRC2, HSP90AA1, MDC1, CDCA8, USP9X, CDK4, AURKB, H2AFX, CASP9, CASP7, XRCC6, DIABLO, JTB (tumor)	BIRC5, UFD1L, MAP3K5, UBC, CDK1, CDK2, XPO1, AURKA, BIRC2, MYB, MDC1, BECN1, CDCA8, XIAP, CDK4, AURKB, INCENP, PRKDC, H2AFX, XRCC6, DIABLO (normal)

KIRC (tumor)	KIRC (normal)
BIRC5, MAP3K5, PPP1CC, BIRC3, CASP3, CDK1, EGR1, CDK2, XPO1, AURKA, BIRC2, MYB, MDC1, USF2, CDCA8, CDK4, AURKB, RASA1, H2AFX, CASP9, LEF1 (tumor)	BIRC5, UFD1L, MAP3K5, BIRC3, CASP3, ELAVL1, BIRC6, CDK1, CDK2, KCNJ6, AURKA, MYB, USF2, CDCA8, CDK4, AURKB, AURKC, H2AFX, DIABLO, LEF1, JTB (normal)

KIRP (tumor)	KIRP (normal)
BIRC5, BIRC3, CASP3, UBC, HDAC6, HSPA4, STAT3, CDK1, CDK2, KCNJ6, XPO1, HSP90AA1, MYB, BECN1, USF2, CDCA8, USP9X, XIAP, AURKB, CASP7, XRCC6 (tumor)	BIRC5, UFD1L, PPP1CC, BIRC3, CASP3, ELAVL1, UBC, HDAC6, BIRC6, CDK1, CDK2, AURKA, MYB, CDCA8, CDK4, AURKB, RASA1, H2AFX, DIABLO, LEF1, JTB (normal)

LIHC (tumor)	LIHC (normal)
BIRC5, UFD1L, MAP3K5, PPP1CC, CASP3, STAT3, CDK1, XPO1, AURKA, MYB, BECN1, CDCA8, USP9X, CDK4, AURKB, INCENP, AURKC, H2AFX, XRCC6, DIABLO, LEF1 (tumor)	BIRC5, UFD1L, PPP1CC, HDAC6, STAT3, BIRC6, CDK1, CDK2, AURKA, MYB, MDC1, CDCA8, XIAP, CDK4, AURKB, RASA1, INCENP, H2AFX, XRCC6, DIABLO, JTB (normal)

LUAD (tumor)	LUAD (normal)
BIRC5, UFD1L, PPP1CC, CASP3, SP1, HSPA4, BIRC6, CDK1, AURKA, MDC1, CDCA8, USP9X, XIAP, CDK4, AURKB, RASA1, H2AFX, XRCC6, DIABLO, EVI5, JTB (tumor)	BIRC5, UFD1L, PPP1CC, CASP3, ELAVL1, STAT3, CDK1, EGR1, CDK2, XPO1, AURKA, HSP90AA1, CDCA8, XIAP, CDK4, AURKB, INCENP, PRKDC, H2AFX, DIABLO, EVI5 (normal)

LUSC (tumor)	LUSC (normal)
BIRC5, UFD1L, MAP3K5, PPP1CC, CASP3, UBC, HSPA4, STAT3, CDK1, EGR1, XPO1, AURKA, CDCA8, CDK4, AURKB, INCENP, PRKDC, H2AFX, LEF1, KLF5, EVI5 (tumor)	BIRC5, UFD1L, MAP3K5, PPP1CC, ELAVL1, CDK1, EGR1, CDK2, XPO1, AURKA, HSP90AA1, CDCA8, CDK4, AURKB, RASA1, INCENP, H2AFX, XRCC6, DIABLO, EVI5, JTB (normal)

PRAD (tumor)	PRAD (normal)
BIRC5, UFD1L, MAP3K5, PPP1CC, ELAVL1, SP1, HDAC6, BIRC6, CDK1, AURKA, MYB, MDC1, CDCA8, USP9X, CDK4, AURKB, RASA1, H2AFX, DIABLO, LEF1, EVI5 (tumor)	BIRC5, UFD1L, PPP1CC, CASP3, SP1, STAT3, BIRC6, CDK1, EGR1, AURKA, USF2, CDCA8, XIAP, CDK4, AURKB, RASA1, H2AFX, DIABLO, KLF5, EVI5, JTB (normal)

STAD (tumor)	STAD (normal)
BIRC5, UFD1L, MAP3K5, CASP3, ELAVL1, STAT3, CDK1, EGR1, AURKA, MYB, MDC1, BECN1, CDCA8, AURKB, INCENP, H2AFX, CASP7, LEF1, KLF5, EVI5, JTB (tumor)	BIRC5, UFD1L, CASP3, ELAVL1, STAT3, CDK1, CDK2, XPO1, AURKA, HSP90AA1, MYB, CDCA8, CDK4, AURKB, RASA1, INCENP, PRKDC, H2AFX, XRCC6, DIABLO, EVI5 (normal)

THCA (tumor)	THCA (normal)
BIRC5, UFD1L, PPP1CC, BIRC3, CASP3, HDAC6, CDK1, KCNJ6, AURKA, MYB, USF2, CDCA8, XIAP, AURKB, RASA1, AURKC, H2AFX, CASP7, XRCC6, LEF1, EVI5 (tumor)	BIRC5, UFD1L, BIRC3, CASP3, ELAVL1, BIRC6, CDK1, KCNJ6, AURKA, MYB, MDC1, CDCA8, USP9X, XIAP, AURKB, INCENP, AURKC, H2AFX, CASP7, LEF1, EVI5 (normal)

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TissGeneProg for BIRC5

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for BIRC5

TissGeneDrug for BIRC5

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for BIRC5

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C2239176	Liver carcinoma	35	BeFree,CTD_human,LHGDN
umls:C0007131	Non-Small Cell Lung Carcinoma	18	BeFree,CTD_human
umls:C0024623	Malignant neoplasm of stomach	18	BeFree
umls:C0678222	Breast Carcinoma	18	BeFree
umls:C0699791	Stomach Carcinoma	18	BeFree
umls:C0006142	Malignant neoplasm of breast	16	BeFree
umls:C1458155	Mammary Neoplasms	15	BeFree,CTD_human,LHGDN
umls:C0009402	Colorectal Carcinoma	13	BeFree
umls:C0242379	Malignant neoplasm of lung	13	BeFree,GAD
umls:C0017638	Glioma	12	BeFree,LHGDN,RGD
umls:C0684249	Carcinoma of lung	12	BeFree
umls:C0024121	Lung Neoplasms	11	CTD_human,LHGDN
umls:C1527249	Colorectal Cancer	11	BeFree,GAD
umls:C0025202	melanoma	10	BeFree,LHGDN
umls:C0038356	Stomach Neoplasms	10	CTD_human,GAD,LHGDN,RGD
umls:C0007137	Squamous cell carcinoma	9	BeFree,GAD,LHGDN
umls:C0235974	Pancreatic carcinoma	9	BeFree
umls:C0346647	Malignant neoplasm of pancreas	9	BeFree
umls:C0027627	Neoplasm Metastasis	8	BeFree,LHGDN
umls:C0027819	Neuroblastoma	8	BeFree,LHGDN
umls:C0596263	Carcinogenesis	8	BeFree
umls:C0007134	Renal Cell Carcinoma	7	BeFree,CTD_human,LHGDN
umls:C0009404	Colorectal Neoplasms	7	BeFree,CTD_human,LHGDN
umls:C0919267	ovarian neoplasm	7	CTD_human,LHGDN
umls:C0009375	Colonic Neoplasms	6	CTD_human,LHGDN
umls:C0023473	Myeloid Leukemia, Chronic	6	BeFree,CTD_human,GAD
umls:C0302592	Cervix carcinoma	6	BeFree
umls:C0686619	Secondary malignant neoplasm of lymph node	6	BeFree
umls:C0699885	Carcinoma of bladder	6	BeFree
umls:C0001418	Adenocarcinoma	5	BeFree,GAD,LHGDN
umls:C0005684	Malignant neoplasm of urinary bladder	5	BeFree
umls:C0005695	Bladder Neoplasm	5	LHGDN
umls:C0007847	Malignant tumor of cervix	5	BeFree
umls:C0023449	Acute lymphocytic leukemia	5	BeFree
umls:C0024299	Lymphoma	5	BeFree,LHGDN
umls:C0029925	Ovarian Carcinoma	5	BeFree
umls:C0030297	Pancreatic Neoplasm	5	GAD,LHGDN
umls:C0376358	Malignant neoplasm of prostate	5	BeFree
umls:C0600139	Prostate carcinoma	5	BeFree
umls:C0700095	Central neuroblastoma	5	BeFree
umls:C1140680	Malignant neoplasm of ovary	5	BeFree,GAD
umls:C0014175	Endometriosis	4	BeFree,LHGDN,RGD
umls:C0014859	Esophageal Neoplasms	4	BeFree,GAD,LHGDN
umls:C0023418	leukemia	4	LHGDN
umls:C0023467	Leukemia, Myelocytic, Acute	4	BeFree,GAD
umls:C0023493	Adult T-Cell Lymphoma/Leukemia	4	BeFree,CTD_human
umls:C0033578	Prostatic Neoplasms	4	LHGDN
umls:C0595989	Carcinoma of larynx	4	BeFree
umls:C2931822	Nasopharyngeal carcinoma	4	BeFree
umls:C3714514	Infection	4	LHGDN
umls:C0007102	Malignant tumor of colon	3	BeFree
umls:C0017636	Glioblastoma	3	LHGDN
umls:C0023903	Liver neoplasms	3	BeFree
umls:C0024232	Lymphatic Metastasis	3	BeFree,GAD
umls:C0025149	Medulloblastoma	3	BeFree,LHGDN
umls:C0026764	Multiple Myeloma	3	BeFree,LHGDN
umls:C0206698	Cholangiocarcinoma	3	BeFree
umls:C0476089	Endometrial Carcinoma	3	BeFree
umls:C0677886	Epithelial ovarian cancer	3	BeFree
umls:C0699790	Colon Carcinoma	3	BeFree
umls:C0751690	Malignant Peripheral Nerve Sheath Tumor	3	BeFree
umls:C1261473	Sarcoma	3	BeFree
umls:C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	3	BeFree
umls:C0003873	Rheumatoid Arthritis	2	BeFree,LHGDN
umls:C0007103	Malignant neoplasm of endometrium	2	BeFree
umls:C0011065	Cessation of life	2	LHGDN
umls:C0023055	Laryngeal neoplasm	2	LHGDN
umls:C0023434	Chronic Lymphocytic Leukemia	2	BeFree,GAD
umls:C0023492	Leukemia, T-Cell	2	BeFree
umls:C0025286	Meningioma	2	LHGDN
umls:C0025500	Mesothelioma	2	LHGDN
umls:C0028945	oligodendroglioma	2	BeFree
umls:C0032580	Adenomatous Polyposis Coli	2	BeFree
umls:C0035126	Reperfusion Injury	2	RGD
umls:C0040136	Thyroid Neoplasm	2	BeFree,LHGDN
umls:C0079731	B-Cell Lymphomas	2	LHGDN
umls:C0079744	Diffuse Large B-Cell Lymphoma	2	BeFree
umls:C0086692	Benign Neoplasm	2	BeFree
umls:C0149925	Small cell carcinoma of lung	2	LHGDN
umls:C0152018	Esophageal carcinoma	2	BeFree
umls:C0178874	Tumor Progression	2	BeFree
umls:C0238463	Papillary thyroid carcinoma	2	BeFree
umls:C0278488	Carcinoma breast stage IV	2	BeFree
umls:C0278996	Cancer of Head and Neck	2	BeFree
umls:C0279000	Liver and Intrahepatic Biliary Tract Carcinoma	2	BeFree
umls:C0280324	Laryngeal Squamous Cell Carcinoma	2	BeFree
umls:C0345904	Malignant neoplasm of liver	2	BeFree
umls:C0546837	Malignant neoplasm of esophagus	2	BeFree
umls:C0555198	Malignant Glioma	2	BeFree
umls:C0751396	Well Differentiated Oligodendroglioma	2	BeFree
umls:C1883486	Uterine Corpus Cancer	2	BeFree
umls:C3539878	Triple Negative Breast Neoplasms	2	BeFree
umls:C0001430	Adenoma	1	LHGDN
umls:C0003130	Anoxia	1	LHGDN
umls:C0004096	Asthma	1	BeFree
umls:C0004114	Astrocytoma	1	BeFree
umls:C0006118	Brain Neoplasms	1	BeFree
umls:C0007124	Noninfiltrating Intraductal Carcinoma	1	BeFree
umls:C0007129	Merkel cell carcinoma	1	LHGDN
umls:C0007138	Carcinoma, Transitional Cell	1	BeFree,GAD
umls:C0007785	Cerebral Infarction	1	BeFree
umls:C0007873	Uterine Cervical Neoplasm	1	LHGDN
umls:C0008479	Chondrosarcoma	1	BeFree
umls:C0010709	Cyst	1	BeFree
umls:C0014170	Endometrial Neoplasms	1	CTD_human
umls:C0017661	IGA Glomerulonephritis	1	CTD_human
umls:C0018671	Head and Neck Neoplasms	1	GAD
umls:C0018801	Heart failure	1	RGD
umls:C0019163	Hepatitis B	1	LHGDN
umls:C0019693	HIV Infections	1	BeFree
umls:C0021368	Inflammation	1	LHGDN
umls:C0022408	Arthropathy	1	BeFree
umls:C0023462	Acute Megakaryocytic Leukemias	1	CTD_human
umls:C0023470	Myeloid Leukemia	1	LHGDN
umls:C0023480	Leukemia, Myelomonocytic, Chronic	1	LHGDN
umls:C0023893	Liver Cirrhosis, Experimental	1	RGD
umls:C0023895	Liver diseases	1	LHGDN
umls:C0023904	Liver Neoplasms, Experimental	1	RGD
umls:C0024305	Lymphoma, Non-Hodgkin	1	LHGDN
umls:C0027051	Myocardial Infarction	1	RGD
umls:C0027430	Nasal Polyps	1	BeFree,LHGDN
umls:C0027643	Neoplasm Recurrence, Local	1	GAD
umls:C0027658	Neoplasms, Germ Cell and Embryonal	1	LHGDN
umls:C0027686	Pathologic Neovascularization	1	GAD
umls:C0027766	Nervous System Neoplasms	1	BeFree
umls:C0027831	Neurofibromatosis 1	1	BeFree
umls:C0029172	Oral Submucous Fibrosis	1	LHGDN
umls:C0031099	Periodontitis	1	GWASCAT
umls:C0031511	Pheochromocytoma	1	LHGDN
umls:C0032927	Precancerous Conditions	1	BeFree
umls:C0034885	Rectal Neoplasms	1	LHGDN
umls:C0035335	Retinoblastoma	1	BeFree
umls:C0038454	Cerebrovascular accident	1	BeFree
umls:C0039538	Teratoma	1	BeFree
umls:C0040137	Thyroid Nodule	1	BeFree
umls:C0042076	Urologic Neoplasms	1	GAD
umls:C0085183	Neoplasms, Second Primary	1	GAD
umls:C0152013	Adenocarcinoma of lung (disorder)	1	BeFree
umls:C0153381	Malignant neoplasm of mouth	1	BeFree
umls:C0153452	Malignant neoplasm of gallbladder	1	BeFree
umls:C0153567	Uterine Cancer	1	BeFree
umls:C0153676	Secondary malignant neoplasm of lung	1	BeFree
umls:C0155880	Intrinsic asthma	1	BeFree
umls:C0206623	Adenosquamous carcinoma	1	GAD
umls:C0206708	Cervical Intraepithelial Neoplasia	1	BeFree
umls:C0206720	Squamous Cell Neoplasms	1	LHGDN
umls:C0220621	pediatric acute myeloblastic leukemia	1	BeFree
umls:C0220641	Lip and Oral Cavity Carcinoma	1	BeFree
umls:C0235782	Gallbladder Carcinoma	1	BeFree
umls:C0262584	Carcinoma, Small Cell	1	CTD_human
umls:C0267941	Pancreatitis, Acute Necrotizing	1	RGD
umls:C0279626	Squamous cell carcinoma of esophagus	1	BeFree
umls:C0279987	childhood neurofibrosarcoma	1	BeFree
umls:C0334590	Anaplastic Oligodendroglioma	1	BeFree
umls:C0346109	Malignant Mesothelioma of Peritoneum	1	BeFree
umls:C0346153	Breast Cancer, Familial	1	BeFree
umls:C0549473	Thyroid carcinoma	1	BeFree
umls:C0598766	Leukemogenesis	1	BeFree
umls:C0600327	Toxic Shock Syndrome	1	BeFree
umls:C0677932	Progressive Neoplastic Disease	1	BeFree
umls:C0677936	Refractory cancer	1	BeFree
umls:C0740457	Malignant neoplasm of kidney	1	BeFree
umls:C0858252	Breast adenocarcinoma	1	BeFree
umls:C0878544	Cardiomyopathies	1	LHGDN
umls:C0948008	Ischemic stroke	1	BeFree
umls:C1134719	Invasive Ductal Breast Carcinoma	1	BeFree
umls:C1153706	Endometrial adenocarcinoma	1	BeFree
umls:C1292753	Primary Effusion Lymphoma	1	LHGDN
umls:C1292769	Precursor B-cell lymphoblastic leukemia	1	BeFree
umls:C1334956	Neuroepithelial, Perineurial, and Schwann Cell Neoplasm	1	BeFree
umls:C1336527	Carcinoma of urinary bladder, superficial	1	BeFree
umls:C1336753	Thyroid Lymphoma	1	BeFree
umls:C1378703	Renal carcinoma	1	BeFree
umls:C1516170	Cancer Cell Growth	1	BeFree
umls:C3272363	Ischemic Cerebrovascular Accident	1	BeFree
umls:C3539781	Progressive cGVHD	1	BeFree
umls:C0020542	Pulmonary Hypertension	0	RGD