TissGeneSummary for PPM1J |
Gene summary |
Basic gene information | Gene symbol | PPM1J |
Gene name | protein phosphatase, Mg2+/Mn2+ dependent, 1J | |
Synonyms | PP2CZ|PP2Czeta|PPP2CZ | |
Cytomap | UCSC genome browser: 1p13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_005167.5, | |
Description | PP2C-zetaprotein phosphatase 1Jprotein phosphatase 1J (PP2C domain containing)protein phosphatase 2C isoform zetaprotein phosphatase 2C zetaprotein phosphatase 2a, catalytic subunit, zeta isoform | |
Modification date | 20141207 | |
dbXrefs | MIM : 609957 | |
HGNC : HGNC | ||
Ensembl : ENSG00000155367 | ||
HPRD : 15171 | ||
Vega : OTTHUMG00000012019 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PPM1J | |
BioGPS: 333926 | ||
Pathway | NCI Pathway Interaction Database: PPM1J | |
KEGG: PPM1J | ||
REACTOME: PPM1J | ||
Pathway Commons: PPM1J | ||
Context | iHOP: PPM1J | |
ligand binding site mutation search in PubMed: PPM1J | ||
UCL Cancer Institute: PPM1J | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of PPM1J | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PPM1J |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | 1.0473332 | -0.546477326 | 1.593810526 | 6.84E-16 | 3.78E-15 |
KIRC | -2.614992896 | -0.725070674 | -1.889922222 | 2.06E-26 | 2.81E-25 |
LUSC | -0.397653435 | -2.06399069 | 1.666337255 | 4.79E-14 | 2.58E-13 |
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TissGene-miRNA for PPM1J |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PPM1J |
TissGeneSNV for PPM1J |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P193R | CHOL | 1 |
p.I496T | UCEC | 1 |
p.D411H | BLCA | 1 |
p.R273H | LGG | 1 |
p.V272M | UCEC | 1 |
p.I111M | CESC | 1 |
p.R479H | GBM | 1 |
p.P399R | CHOL | 1 |
p.V139I | READ | 1 |
p.G164R | COAD | 1 |
p.K224T | COAD | 1 |
p.P191L | UCEC | 1 |
p.G146D | THCA | 1 |
p.R286W | COAD | 1 |
p.D238H | LUAD | 1 |
p.D444H | LUAD | 1 |
p.P267T | BLCA | 1 |
p.R251Q | GBM | 1 |
p.L324I | STAD | 1 |
p.P497L | STAD | 1 |
p.D73N | LGG | 1 |
p.E90Q | BLCA | 1 |
p.E237D | UCEC | 1 |
p.R175H | READ | 1 |
p.E320A | UCEC | 1 |
p.H180Y | LUAD | 1 |
p.S393F | ESCA | 1 |
p.L308M | ESCA | 1 |
p.F115I | SKCM | 1 |
p.M243T | KIRC | 1 |
p.G159E | PRAD | 1 |
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TissGeneCNV for PPM1J |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PPM1J |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for PPM1J |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PPM1J |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PPM1J |
TissGeneDrug for PPM1J |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PPM1J |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |