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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for APOA1
check button Gene summary
Basic gene informationGene symbolAPOA1
Gene nameapolipoprotein A-I
Synonyms-
CytomapUCSC genome browser: 11q23-q24
Type of geneprotein-coding
RefGenesNM_000039.1,
Descriptionapo-AI
Modification date20141222
dbXrefs MIM : 107680
HGNC : HGNC
Ensembl : ENSG00000118137
HPRD : 02517
Vega : OTTHUMG00000046112
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_APOA1
BioGPS: 335
PathwayNCI Pathway Interaction Database: APOA1
KEGG: APOA1
REACTOME: APOA1
Pathway Commons: APOA1
ContextiHOP: APOA1
ligand binding site mutation search in PubMed: APOA1
UCL Cancer Institute: APOA1
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of APOA1
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0002740negative regulation of cytokine secretion involved in immune response12458630
GO:0006656phosphatidylcholine biosynthetic process4335615
GO:0007179transforming growth factor beta receptor signaling pathway23726972
GO:0007186G-protein coupled receptor signaling pathway16443932
GO:0007229integrin-mediated signaling pathway23726972
GO:0010804negative regulation of tumor necrosis factor-mediated signaling pathway21571275
GO:0010873positive regulation of cholesterol esterification4335615
GO:0010903negative regulation of very-low-density lipoprotein particle remodeling14967812
GO:0018158protein oxidation12576517
GO:0018206peptidyl-methionine modification12576517
GO:0030301cholesterol transport10559507
GO:0032489regulation of Cdc42 protein signal transduction16443932
GO:0033344cholesterol efflux11162594
GO:0033700phospholipid efflux11162594
GO:0034115negative regulation of heterotypic cell-cell adhesion21571275
GO:0034380high-density lipoprotein particle assembly190223
GO:0035025positive regulation of Rho protein signal transduction23726972
GO:0042632cholesterol homeostasis21571275
GO:0050713negative regulation of interleukin-1 beta secretion12458630
GO:0050728negative regulation of inflammatory response21571275
GO:0050821protein stabilization17655203
GO:0050919negative chemotaxis23726972
GO:0051345positive regulation of hydrolase activity7638166
GO:0051496positive regulation of stress fiber assembly23726972
GO:0055091phospholipid homeostasis21571275
GO:0060354negative regulation of cell adhesion molecule production21571275
GO:0060761negative regulation of response to cytokine stimulus21571275
GO:0070328triglyceride homeostasis21571275
GO:0070371ERK1 and ERK2 cascade23726972
GO:1900026positive regulation of substrate adhesion-dependent cell spreading23726972
GO:0002740negative regulation of cytokine secretion involved in immune response12458630
GO:0006656phosphatidylcholine biosynthetic process4335615
GO:0007179transforming growth factor beta receptor signaling pathway23726972
GO:0007186G-protein coupled receptor signaling pathway16443932
GO:0007229integrin-mediated signaling pathway23726972
GO:0010804negative regulation of tumor necrosis factor-mediated signaling pathway21571275
GO:0010873positive regulation of cholesterol esterification4335615
GO:0010903negative regulation of very-low-density lipoprotein particle remodeling14967812
GO:0018158protein oxidation12576517
GO:0018206peptidyl-methionine modification12576517
GO:0030301cholesterol transport10559507
GO:0032489regulation of Cdc42 protein signal transduction16443932
GO:0033344cholesterol efflux11162594
GO:0033700phospholipid efflux11162594
GO:0034115negative regulation of heterotypic cell-cell adhesion21571275
GO:0034380high-density lipoprotein particle assembly190223
GO:0035025positive regulation of Rho protein signal transduction23726972
GO:0042632cholesterol homeostasis21571275
GO:0050713negative regulation of interleukin-1 beta secretion12458630
GO:0050728negative regulation of inflammatory response21571275
GO:0050821protein stabilization17655203
GO:0050919negative chemotaxis23726972
GO:0051345positive regulation of hydrolase activity7638166
GO:0051496positive regulation of stress fiber assembly23726972
GO:0055091phospholipid homeostasis21571275
GO:0060354negative regulation of cell adhesion molecule production21571275
GO:0060761negative regulation of response to cytokine stimulus21571275
GO:0070328triglyceride homeostasis21571275
GO:0070371ERK1 and ERK2 cascade23726972
GO:1900026positive regulation of substrate adhesion-dependent cell spreading23726972


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TissGeneExp for APOA1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
PRAD-3.891120457-2.731808918-1.1593115385.84E-097.65E-08
THCA-0.9057135471.172235606-2.0779491531.61E-076.79E-07
KICH-4.057597072-2.197793072-1.8598041.49E-076.62E-07
LUSC-3.101881543-0.714330562-2.387550982.75E-213.87E-20
KIRC-3.353730072-1.902135628-1.4515944449.87E-082.75E-07
LUAD-3.156415417-0.487180934-2.6692344835.21E-262.60E-24
KIRP-3.528351947-1.200795697-2.327556251.42E-091.29E-08
LIHC11.5247689314.07846493-2.5536961.71E-071.13E-06


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TissGene-miRNA for APOA1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for APOA1
TissGeneSNV for APOA1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.Q162PLIHC1
p.Q17LLIHC1
p.S49NUCEC1
p.E26KLUAD1
p.Q93RSKCM1
p.R34*UCEC1
p.E258QLUAD1
p.L71ISTAD1
p.S191NESCA1
p.S79PDLBC1
p.W96*SKCM1
p.G63ESKCM1
p.R85HSTAD1
p.Q267KESCA1
p.V35LBLCA1
p.Q141EMESO1
p.E94KLGG1
p.A4VSTAD1
p.R19WKICH1
p.V77AUCEC1
p.A234TPCPG1
p.D237ETHYM1
p.R177CSTAD1
p.A18VBLCA1
p.R173HSTAD1
p.A256SSTAD1
p.K64ESTAD1


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TissGeneCNV for APOA1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for APOA1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABJ995037APOA1-DRAP1chr11:116708338chr11:65686958


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TissGeneNet for APOA1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
APOA1, SP1, RARA, VCP, RARB, ABCA1, UCHL5, IL7R, LGALS8, NR2F1, PPARA, MAPK6, TOMM20, ZNRD1, NR1H4, PCMT1, MAP7D1, GPLD1, APOC1, APOA1BP, SPG11 (tumor)APOA1, SP1, SPP1, RARA, RXRA, APP, ABCA1, UCHL5, AKT2, IL7R, TNFRSF10C, TTR, PPARA, MAPK6, CLEC4G, ZNRD1, NR1H4, LCAT, HPR, APOF, APOA1BP (normal)
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COAD (tumor)COAD (normal)
APOA1, RARA, VCP, APP, ABCA1, APOB, JAK3, TNFRSF10C, TTR, NR2F1, PPARA, CETP, MAPK6, FBLN1, CLEC4G, ZNRD1, ABCA13, NR1H4, FOXA2, APOF, PON1 (tumor)APOA1, HNF4A, RARA, RXRA, APP, ALB, UCHL5, AKT2, APOB, TTR, NR2F1, TF, HP, ZNRD1, NR1H4, LCAT, LBP, APOF, APOL1, CFHR1, SPG11 (normal)
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HNSC (tumor)HNSC (normal)
APOA1, SP1, VCP, RARB, ALB, UCHL5, APOB, JAK3, TTR, PPARA, CETP, CLEC4G, LCAT, HPR, SCARB1, GPLD1, PON1, APOC1, APOA1BP, CFHR1, SPG11 (tumor)APOA1, SP1, APP, ALB, ABCA1, UCHL5, APOB, IL7R, TTR, PPARA, CETP, MAPK6, HP, ZNRD1, NR1H4, LCAT, HPR, APOF, PON1, APOA1BP, SPG11 (normal)
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KICH (tumor)KICH (normal)
APOA1, HNF4A, SP1, SPP1, APP, ALB, AKT2, APOB, IL7R, TTR, CETP, MAPK6, ABCA13, NR1H4, FOXA2, HPR, LBP, PLTP, APOF, APOC1, CFHR1 (tumor)APOA1, SP1, RARA, RARB, UCHL5, JAK3, TNFRSF10C, LGALS8, NR2F1, PPARA, ATP5B, ZNRD1, PCMT1, MAP7D1, FOXA2, LCAT, LBP, PLTP, APOF, PDE1A, SPG11 (normal)
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KIRC (tumor)KIRC (normal)
APOA1, HNF4A, RXRA, APP, PITX3, ALB, AKT2, APOB, TNFRSF10C, TTR, PPARA, CETP, MAPK6, TF, ABCA13, FOXA2, HPR, LBP, PDE1A, APOC1, SPG11 (tumor)APOA1, LGALS3, RARB, ALB, UCHL5, APOB, TTR, LGALS8, SAA1, TF, HP, ZNRD1, SAA2, HPR, LBP, APOF, PON1, APOC1, APOA1BP, CFHR1, SPG11 (normal)
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KIRP (tumor)KIRP (normal)
APOA1, HNF4A, RXRA, APP, PITX3, ALB, AKT2, APOB, TNFRSF10C, TTR, PPARA, CETP, MAPK6, ABCA13, PCMT1, FOXA2, LCAT, HPR, LBP, SCARB1, PDE1A (tumor)APOA1, HNF4A, SPP1, LGALS3, APP, ALB, AKT2, APOB, TTR, NR2F2, TF, CLEC4G, HP, PCMT1, HPR, LBP, SCARB1, APOL1, PON1, APOC1, SPG11 (normal)
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LIHC (tumor)LIHC (normal)
APOA1, SP1, ALB, ABCA1, IL7R, JAK3, TTR, LGALS8, NR2F1, CETP, CD40LG, TF, CLEC4G, MIS12, LCAT, PLTP, APOL1, PDE1A, APOC1, APOA1BP, SPG11 (tumor)APOA1, HNF4A, SP1, RXRA, ALB, APOB, TTR, NR2F2, TF, HP, NR1H4, MAP7D1, FOXA2, LCAT, HPR, SCARB1, GPLD1, APOF, PON1, APOC1, CFHR1 (normal)
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LUAD (tumor)LUAD (normal)
APOA1, HNF4A, SP1, LGALS3, UCHL5, IL7R, TNFRSF10C, LGALS8, PPARA, CETP, ATP5B, FBLN1, TF, PCMT1, MAP7D1, FOXA2, GPLD1, PDE1A, APOC1, APOA1BP, SPG11 (tumor)APOA1, HNF4A, SPP1, APP, ALB, UCHL5, APOB, TTR, CETP, SAA1, TF, NR1H4, SAA2, FOXA2, LCAT, HPR, LBP, SCARB1, APOF, APOC1, CFHR1 (normal)
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LUSC (tumor)LUSC (normal)
APOA1, HNF4A, SP1, ALB, IL7R, PPARA, TOMM20, CD40LG, ZNRD1, ABCA13, SAA2, MAP7D1, FOXA2, LCAT, PLTP, SCARB1, APOF, APOL1, PDE1A, APOA1BP, SPG11 (tumor)APOA1, HNF4A, SP1, SPP1, APP, ALB, APOB, TTR, PPARA, TF, ZNRD1, ABCA13, NR1H4, HPR, LBP, APOF, APOL1, PON1, APOC1, APOA1BP, SPG11 (normal)
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PRAD (tumor)PRAD (normal)
APOA1, HNF4A, RARA, APP, IL7R, TTR, NR2F1, PPARA, ATP5B, NR2F2, MAPK6, ABCA13, SAA2, FOXA2, LCAT, HPR, SCARB1, APOF, APOL1, PON1, SPG11 (tumor)APOA1, HNF4A, SP1, ALB, ABCA1, UCHL5, APOB, JAK3, TTR, PPARA, MAPK6, SAA1, HP, ZNRD1, MAP7D1, LCAT, HPR, LBP, APOA1BP, CFHR1, SPG11 (normal)
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STAD (tumor)STAD (normal)
APOA1, HNF4A, SP1, RARA, LGALS3, RARB, ABCA1, AKT2, APOB, TNFRSF10C, TTR, ATP5B, TOMM20, TF, NR1H4, FOXA2, LCAT, SCARB1, GPLD1, APOL1, SPG11 (tumor)APOA1, HNF4A, RARB, ALB, APOB, TTR, SAA1, TF, HP, ZNRD1, ABCA13, NR1H4, FOXA2, HPR, LBP, PLTP, SCARB1, GPLD1, APOF, PON1, APOA1BP (normal)
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THCA (tumor)THCA (normal)
APOA1, SP1, VCP, LGALS3, RARB, ALB, ABCA1, UCHL5, IL7R, LGALS8, PPARA, ATP5B, MAPK6, FBLN1, TF, ABCA13, NR1H4, FOXA2, GPLD1, APOA1BP, SPG11 (tumor)APOA1, SPP1, RXRA, LGALS3, RARB, PITX3, ALB, AKT2, IL7R, JAK3, TTR, LGALS8, NR2F1, CETP, ATP5B, MIS12, MAP7D1, FOXA2, LCAT, SCARB1, APOL1 (normal)
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TissGeneProg for APOA1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for APOA1
TissGeneDrug for APOA1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for APOA1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0004153Atherosclerosis65BeFree,GAD,LHGDN
umls:C0003850Arteriosclerosis62BeFree,LHGDN,RGD
umls:C0010054Coronary Arteriosclerosis50BeFree,GAD
umls:C0010068Coronary heart disease50BeFree,GAD,LHGDN
umls:C1956346Coronary Artery Disease43BeFree,GAD,LHGDN
umls:C0002726Amyloidosis23BeFree,LHGDN
umls:C0007222Cardiovascular Diseases23BeFree,GAD,LHGDN
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent22BeFree,GAD
umls:C0020474Hyperlipidemia, Familial Combined20BeFree,GAD,LHGDN
umls:C0027051Myocardial Infarction20BeFree,GAD,LHGDN
umls:C2239176Liver carcinoma16BeFree,CTD_human
umls:C0039292Tangier Disease15BeFree,LHGDN
umls:C0524620Metabolic Syndrome X15BeFree,GAD,RGD
umls:C0028754Obesity14BeFree,GAD
umls:C0020473Hyperlipidemia12BeFree,GAD
umls:C0023903Liver neoplasms10BeFree
umls:C0242339Dyslipidemias9BeFree,GAD
umls:C0020538Hypertensive disease8BeFree,CTD_human,GAD,LHGDN,RGD
umls:C0268380Systemic amyloidosis8BeFree
umls:C0281479Primary Systemic Amyloidosis8BeFree
umls:C0342883Cholesteryl Ester Transfer Protein Deficiency8BeFree,GAD
umls:C1704429Hypoalphalipoproteinemia, Familial8BeFree,CLINVAR,ORPHANET
umls:C2936349Plaque, Amyloid8BeFree
umls:C0002395Alzheimer's Disease7BeFree,GAD
umls:C0011849Diabetes Mellitus7BeFree
umls:C0020445Hypercholesterolemia, Familial7BeFree,LHGDN
umls:C0948089Acute Coronary Syndrome7BeFree,GAD,LHGDN
umls:C2931838Familial HDL deficiency6BeFree
umls:C0006142Malignant neoplasm of breast5BeFree
umls:C0011847Diabetes5BeFree
umls:C0020443Hypercholesterolemia5BeFree,GAD
umls:C0038454Cerebrovascular accident5CTD_human,GAD,LHGDN
umls:C0678222Breast Carcinoma5BeFree
umls:C3165209High density lipoprotein deficiency5BeFree
umls:C0019693HIV Infections4BeFree,CTD_human
umls:C0023195Lecithin Acyltransferase Deficiency4BeFree
umls:C0023895Liver diseases4BeFree,GAD
umls:C0042373Vascular Diseases4BeFree,LHGDN
umls:C0151744Myocardial Ischemia4BeFree,GAD,LHGDN
umls:C0497327Dementia4BeFree,GAD,LHGDN
umls:C0011265Presenile dementia3BeFree
umls:C0020557Hypertriglyceridemia3GAD,LHGDN
umls:C0021368Inflammation3CTD_human,GAD,LHGDN
umls:C0027720Nephrosis3BeFree
umls:C0027726Nephrotic Syndrome3BeFree,RGD
umls:C0029925Ovarian Carcinoma3BeFree
umls:C0033860Psoriasis3BeFree
umls:C0035309Retinal Diseases3BeFree,GAD
umls:C0038356Stomach Neoplasms3BeFree,CTD_human
umls:C0206246Amyloidosis, Hereditary3BeFree
umls:C0206624Hepatoblastoma3BeFree
umls:C0268389Amyloidosis, familial visceral3BeFree,CLINVAR,CTD_human,UNIPROT
umls:C0342895Fish-Eye Disease3BeFree
umls:C1522137Hypertriglyceridemia result3GAD
umls:C2712907Combined hyperlipidemia3BeFree
umls:C3149462HYPERALPHALIPOPROTEINEMIA 13BeFree
umls:C0001418Adenocarcinoma2CTD_human,LHGDN
umls:C0008350Cholelithiasis2BeFree,GAD
umls:C0011884Diabetic Retinopathy2BeFree,LHGDN
umls:C0013080Down Syndrome2BeFree
umls:C0015230Exanthema2BeFree
umls:C0015695Fatty Liver2BeFree
umls:C0016977Gall Bladder Diseases2BeFree,LHGDN
umls:C0019196Hepatitis C2BeFree,GAD
umls:C0020476Hyperlipoproteinemias2BeFree
umls:C0020480Hyperlipoproteinemia Type IV2BeFree
umls:C0022661Kidney Failure, Chronic2BeFree,GAD
umls:C0022876Premature Obstetric Labor2GAD
umls:C0023890Liver Cirrhosis2BeFree
umls:C0024121Lung Neoplasms2CTD_human,LHGDN
umls:C0026769Multiple Sclerosis2BeFree,GAD
umls:C0027627Neoplasm Metastasis2BeFree,LHGDN
umls:C0029408Degenerative polyarthritis2BeFree
umls:C0029928Ovarian Diseases2BeFree
umls:C0032460Polycystic Ovary Syndrome2BeFree
umls:C0032580Adenomatous Polyposis Coli2BeFree
umls:C0036341Schizophrenia2LHGDN
umls:C0085220Cerebral Amyloid Angiopathy2BeFree
umls:C0178874Tumor Progression2BeFree
umls:C0206245Amyloid Neuropathies, Familial2BeFree
umls:C0233794Memory impairment2BeFree
umls:C0243026Sepsis2BeFree,RGD
umls:C0302314Xanthoma2BeFree
umls:C0311277Obesity, Abdominal2BeFree,GAD
umls:C0338656Impaired cognition2BeFree
umls:C0473527Hypoalphalipoproteinemias2CTD_human,GAD,LHGDN
umls:C0497406Overweight2BeFree
umls:C0577631Carotid Atherosclerosis2GAD
umls:C0848332Spots on skin2BeFree
umls:C0947622Cholecystolithiasis2GAD
umls:C0947751Vascular inflammations2BeFree
umls:C1140680Malignant neoplasm of ovary2BeFree
umls:C1272641Systemic arterial pressure2GAD
umls:C2711227Steatohepatitis2BeFree
umls:C0002895Anemia, Sickle Cell1GAD
umls:C0003130Anoxia1CTD_human
umls:C0003742Arcus Senilis1BeFree
umls:C0003864Arthritis1BeFree
umls:C0003868Arthritis, Gouty1BeFree
umls:C0003873Rheumatoid Arthritis1BeFree
umls:C0004096Asthma1BeFree
umls:C0004364Autoimmune Diseases1LHGDN
umls:C0004943Behcet Syndrome1CTD_human
umls:C0006111Brain Diseases1BeFree
umls:C0007102Malignant tumor of colon1BeFree
umls:C0007138Carcinoma, Transitional Cell1RGD
umls:C0007282Carotid Stenosis1BeFree
umls:C0007785Cerebral Infarction1GAD
umls:C0007820Cerebrovascular Disorders1GAD
umls:C0008495Chorioamnionitis1GAD
umls:C0010346Crohn Disease1BeFree
umls:C0011065Cessation of life1CTD_human
umls:C0011609Drug Eruptions1CTD_human
umls:C0011853Diabetes Mellitus, Experimental1RGD
umls:C0013604Edema1CTD_human
umls:C0015814Femur Head Necrosis1GAD
umls:C0015944Fetal Membranes, Premature Rupture1GAD
umls:C0017636Glioblastoma1BeFree
umls:C0017665Membranous glomerulonephritis1CTD_human
umls:C0018099Gout1GAD
umls:C0018801Heart failure1BeFree
umls:C0018802Congestive heart failure1BeFree
umls:C0019163Hepatitis B1LHGDN
umls:C0020479Hyperlipoproteinemia Type III1BeFree
umls:C0020542Pulmonary Hypertension1BeFree
umls:C0020550Hyperthyroidism1RGD
umls:C0020639Hypoproteinemia1RGD
umls:C0021390Inflammatory Bowel Diseases1GAD
umls:C0021655Insulin Resistance1GAD
umls:C0023891Liver Cirrhosis, Alcoholic1BeFree
umls:C0023893Liver Cirrhosis, Experimental1RGD
umls:C0024141Lupus Erythematosus, Systemic1BeFree
umls:C0024623Malignant neoplasm of stomach1BeFree
umls:C0025286Meningioma1BeFree
umls:C0025517Metabolic Diseases1BeFree
umls:C0028259Nodule1BeFree
umls:C0029445Bone necrosis1GAD
umls:C0032285Pneumonia1BeFree
umls:C0032914Pre-Eclampsia1GAD
umls:C0034069Pulmonary Fibrosis1BeFree
umls:C0036572Seizures1BeFree
umls:C0037116Silicosis1BeFree
umls:C0040028Thrombocythemia, Essential1BeFree
umls:C0041349Nephritis, Tubulointerstitial1BeFree
umls:C0041948Uremia1BeFree
umls:C0043119Werner Syndrome1BeFree
umls:C0149896Primary gout1BeFree
umls:C0149940Sciatic Neuropathy1RGD
umls:C0151526Premature Birth1GAD
umls:C0152013Adenocarcinoma of lung (disorder)1CTD_human
umls:C0152025Polyneuropathy1BeFree
umls:C0152096Complete trisomy 18 syndrome1BeFree
umls:C0155626Acute myocardial infarction1BeFree
umls:C0155668Old myocardial infarction1BeFree
umls:C0206701Cystadenocarcinoma, Serous1BeFree
umls:C0242216Biliary calculi1LHGDN
umls:C0242488Acute Lung Injury1CTD_human
umls:C0264683Coronary artery atheroma1BeFree
umls:C0266258Congenital absence of liver1BeFree
umls:C0268381Primary amyloidosis1BeFree
umls:C0268392Localized amyloidosis1BeFree
umls:C0268407Senile cardiac amyloidosis1BeFree
umls:C0271650Impaired glucose tolerance1BeFree
umls:C0333463Senile Plaques1BeFree
umls:C0340288Stable angina1BeFree
umls:C0375023Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site1BeFree
umls:C0376358Malignant neoplasm of prostate1BeFree
umls:C0376618Endotoxemia1RGD
umls:C0518010body mass1GAD
umls:C0524909Hepatitis B, Chronic1LHGDN
umls:C0553573Primary infertility1BeFree
umls:C0553692Brain hemorrhage1GAD
umls:C0600139Prostate carcinoma1BeFree
umls:C0677886Epithelial ovarian cancer1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0699791Stomach Carcinoma1BeFree
umls:C0740394Hyperuricemia1GAD,LHGDN
umls:C0751003Brain Aneurysm1GAD
umls:C0751955Brain Infarction1BeFree
umls:C0795956Chylomicron retention disease1BeFree
umls:C0853897Diabetic Cardiomyopathies1BeFree,CTD_human
umls:C0860207Drug-Induced Liver Injury1CTD_human
umls:C0948008Ischemic stroke1GAD
umls:C0948896Primary hypogonadism1BeFree
umls:C1269683Major Depressive Disorder1RGD
umls:C1271104Blood pressure finding1GAD
umls:C1335177Ovarian Serous Adenocarcinoma1BeFree
umls:C1519670Tumor Angiogenesis1BeFree
umls:C1520166Xenograft Model1BeFree
umls:C1527249Colorectal Cancer1GAD
umls:C1623038Cirrhosis1BeFree
umls:C1704417Hyperlipoproteinemia Type IIb1BeFree
umls:C1719315Hereditary cardiac amyloidosis1BeFree
umls:C1800706Idiopathic Pulmonary Fibrosis1BeFree
umls:C1848533Ataxia with vitamin E deficiency1CTD_human
umls:C1867403Pyloric Stenosis, Infantile Hypertrophic 11BeFree
umls:C2062908Gout acute1BeFree
umls:C2316810Chronic kidney disease stage 51BeFree
umls:C2711472Infection by Trypanosoma brucei brucei1BeFree
umls:C2919032Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified1GAD
umls:C3665444Neutrophilia (disorder)1BeFree
umls:C3714514Infection1LHGDN
umls:C0342898Apolipoprotein A-I deficiency0CLINVAR,ORPHANET