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| TissGeneSummary for HTR2C |
 Gene summary |
| Basic gene information | Gene symbol | HTR2C |
| Gene name | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | |
| Synonyms | 5-HT2C|5-HTR2C|5HTR2C|HTR1C | |
| Cytomap | UCSC genome browser: Xq24 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000868.2, NM_001256760.1,NM_001256761.1, | |
| Description | 5-HT-1C5-HT-2C5-HT1C5-hydroxytryptamine receptor 1C5-hydroxytryptamine receptor 2C5-hydroxytryptamine receptor-1cserotonin 5-HT-2C receptorserotonin receptor 2C | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 312861 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000147246 | ||
| HPRD : 02429 | ||
| Vega : OTTHUMG00000022226 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HTR2C | |
| BioGPS: 3358 | ||
| Pathway | NCI Pathway Interaction Database: HTR2C | |
| KEGG: HTR2C | ||
| REACTOME: HTR2C | ||
| Pathway Commons: HTR2C | ||
| Context | iHOP: HTR2C | |
| ligand binding site mutation search in PubMed: HTR2C | ||
| UCL Cancer Institute: HTR2C | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGTGCT | |
| Reference showing the relevant tissue of HTR2C | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA Fused withOncogene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006182 | cGMP biosynthetic process | 12970106 | GO:0006874 | cellular calcium ion homeostasis | 19057895 | GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway | 12970106 | GO:0010513 | positive regulation of phosphatidylinositol biosynthetic process | 19057895 | GO:0042493 | response to drug | 18703043 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 19057895 | GO:0006182 | cGMP biosynthetic process | 12970106 | GO:0006874 | cellular calcium ion homeostasis | 19057895 | GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway | 12970106 | GO:0010513 | positive regulation of phosphatidylinositol biosynthetic process | 19057895 | GO:0042493 | response to drug | 18703043 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 19057895 |
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| TissGeneExp for HTR2C |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| HNSC | 2.257524137 | -0.708394468 | 2.965918605 | 2.93E-09 | 4.15E-08 |
| LUSC | 2.835026599 | -0.929993009 | 3.765019608 | 2.20E-14 | 1.24E-13 |
| BLCA | 3.068509571 | 0.863493782 | 2.205015789 | 0.0108 | 0.047657143 |
| ESCA | 2.956705743 | -0.771194257 | 3.7279 | 0.00211 | 0.02334099 |
| STAD | 0.006242959 | -1.065385166 | 1.071628125 | 0.00488 | 0.018857595 |
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| TissGene-miRNA for HTR2C |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-382-3p | MIMAT0022697 | 0.023 | -0.32 | 56 |
| UCS | hsa-miR-26b-5p | MIMAT0000083 | 0.0025 | -0.4 | 56 |
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| TissGeneMut for HTR2C |
| TissGeneSNV for HTR2C |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R183C | SKCM | 8 |
| p.P232S | SKCM | 2 |
| p.G164R | SKCM | 2 |
| p.W130X | SKCM | 2 |
| p.W130* | SKCM | 2 |
| p.E306K | SKCM | 2 |
| p.S149L | SKCM | 2 |
| p.R170C | SKCM | 2 |
| p.S132Y | UCEC | 2 |
| p.E255K | SKCM | 2 |
| p.F317L | UCEC | 2 |
| p.L73F | SKCM | 1 |
| p.R219W | STAD | 1 |
| p.M1L | COAD | 1 |
| p.R168W | PRAD | 1 |
| p.I64T | SARC | 1 |
| p.G408W | LUAD | 1 |
| p.A32G | LIHC | 1 |
| p.W55R | OV | 1 |
| p.R168Q | UCEC | 1 |
| p.C146S | LUSC | 1 |
| p.A180V | LGG | 1 |
| p.V74L | KIRC | 1 |
| p.L333Q | PAAD | 1 |
| p.P280S | LUSC | 1 |
| p.I65L | READ | 1 |
| p.D174N | SKCM | 1 |
| p.R288Q | SKCM | 1 |
| p.G43A | STAD | 1 |
| p.T228M | HNSC | 1 |
| p.L95I | READ | 1 |
| p.T228R | LIHC | 1 |
| p.P29T | HNSC | 1 |
| p.P365H | UCEC | 1 |
| p.S310L | BRCA | 1 |
| p.K348E | STAD | 1 |
| p.W161X | SKCM | 1 |
| p.S110P | UCEC | 1 |
| p.V208M | OV | 1 |
| p.R157H | BRCA | 1 |
| p.G193A | MESO | 1 |
| p.W55G | LUAD | 1 |
| p.E425* | LIHC | 1 |
| p.P211Q | LUAD | 1 |
| p.A195T | UCEC | 1 |
| p.P121S | ESCA | 1 |
| p.V215I | BLCA | 1 |
| p.L336H | SKCM | 1 |
| p.F328V | PAAD | 1 |
| p.V389I | SKCM | 1 |
| p.Q244P | SKCM | 1 |
| p.S167L | SKCM | 1 |
| p.P393L | OV | 1 |
| p.A7V | LGG | 1 |
| p.I181S | UCEC | 1 |
| p.S167L | PAAD | 1 |
| p.I181M | STAD | 1 |
| p.R243Q | UCEC | 1 |
| p.G251S | COAD | 1 |
| p.S310L | COAD | 1 |
| p.R417W | SKCM | 1 |
| p.F214L | UCEC | 1 |
| p.V221I | STAD | 1 |
| p.A77S | STAD | 1 |
| p.N204S | UCEC | 1 |
| p.R45C | PRAD | 1 |
| p.V129I | LGG | 1 |
| p.C235G | LUAD | 1 |
| p.R287C | HNSC | 1 |
| p.D151Y | UCEC | 1 |
| p.L104I | LUAD | 1 |
| p.C325R | COAD | 1 |
| p.E197D | STAD | 1 |
| p.M230V | UCEC | 1 |
| p.R297S | LUSC | 1 |
| p.E425K | COAD | 1 |
| p.E197K | SKCM | 1 |
| p.T228M | UCEC | 1 |
| p.G44E | SKCM | 1 |
| p.T271M | STAD | 1 |
| p.L321P | READ | 1 |
| p.M1I | LUSC | 1 |
| p.E425X | LIHC | 1 |
| p.R417L | UCEC | 1 |
| p.P447S | SKCM | 1 |
| p.V221I | SKCM | 1 |
| p.P56S | STAD | 1 |
| p.R168Q | GBM | 1 |
| p.M323I | LUAD | 1 |
| p.R170C | ACC | 1 |
| p.L73I | LUAD | 1 |
| p.P432S | UCEC | 1 |
| p.L441* | UCEC | 1 |
| p.V202M | SKCM | 1 |
| p.P188L | OV | 1 |
| p.E197K | CESC | 1 |
| p.K82N | LUAD | 1 |
| p.W161* | SKCM | 1 |
| p.P188S | SKCM | 1 |
| p.H250Q | LUAD | 1 |
| p.D36N | PRAD | 1 |
| p.Q22K | OV | 1 |
| p.L336V | OV | 1 |
| p.R400T | HNSC | 1 |
| p.I148K | UCEC | 1 |
| p.N304K | LUAD | 1 |
| p.C23S | COAD | 1 |
| p.R152W | STAD | 1 |
| p.G240S | COAD | 1 |
| p.D160N | SKCM | 1 |
| p.R152W | LUSC | 1 |
| p.V395D | STAD | 1 |
| p.F263V | UCEC | 1 |
| p.P280L | LIHC | 1 |
| p.A286T | SARC | 1 |
| p.M436I | CESC | 1 |
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| TissGeneCNV for HTR2C |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for HTR2C |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | HNSC | TCGA-D6-6827-01A | RB1-HTR2C | Out-of-Frame | chr13:48881542 | chrX:114141151 |
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| TissGeneNet for HTR2C |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (tumor) | HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (normal) |
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| COAD (tumor) | COAD (normal) |
| HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (tumor) | HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (tumor) | HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (normal) |
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| KICH (tumor) | KICH (normal) |
| HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (tumor) | HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (tumor) | HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (tumor) | HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (tumor) | HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (tumor) | HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (tumor) | HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (tumor) | HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (normal) |
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| STAD (tumor) | STAD (normal) |
| HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (tumor) | HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (normal) |
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| THCA (tumor) | THCA (normal) |
| HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (tumor) | HTR2C, GNAQ, DLG4, CALM1, ARRB2, LIN7C, SIRT2, APBA1, MPDZ, SNTA1 (normal) |
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| TissGeneProg for HTR2C |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for HTR2C |
| TissGeneDrug for HTR2C |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00247 | Methysergide | Antagonist | Small molecule | Approved |
| DB00321 | Amitriptyline | Binder | Small molecule | Approved |
| DB00543 | Amoxapine | Antagonist | Small molecule | Approved |
| DB00589 | Lisuride | Agonist | Small molecule | Approved |
| DB00696 | Ergotamine | Agonist | Small molecule | Approved |
| DB00726 | Trimipramine | Antagonist | Small molecule | Approved |
| DB04871 | Lorcaserin | Small molecule | Approved | |
| DB01191 | Dexfenfluramine | Agonist | Small molecule | Approved|Illicit|Withdrawn |
| DB00193 | Tramadol | Antagonist | Small molecule | Approved|Investigational |
| DB00268 | Ropinirole | Agonist | Small molecule | Approved|Investigational |
| DB00413 | Pramipexole | Unknown | Small molecule | Approved|Investigational |
| DB00714 | Apomorphine | Agonist | Small molecule | Approved|Investigational |
| DB00734 | Risperidone | Antagonist | Small molecule | Approved|Investigational |
| DB06594 | Agomelatine | Antagonist | Small molecule | Approved|Investigational |
| DB09014 | Captodiame | Antagonist | Small molecule | Approved|Investigational |
| DB01242 | Clomipramine | Antagonist | Small molecule | Approved|Vet_approved |
| DB01392 | Yohimbine | Antagonist | Small molecule | Approved|Vet_approved |
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| TissGeneDisease for HTR2C |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0036341 | Schizophrenia | 30 | BeFree,GAD,LHGDN |
| umls:C0028754 | Obesity | 21 | BeFree,CTD_human,GAD |
| umls:C0043094 | Weight Gain | 15 | CTD_human,GAD |
| umls:C2911647 | Weight Gain Adverse Event | 13 | GAD |
| umls:C0011570 | Mental Depression | 12 | BeFree,GAD |
| umls:C1269683 | Major Depressive Disorder | 11 | BeFree,GAD,RGD |
| umls:C0004936 | Mental disorders | 9 | BeFree |
| umls:C0005586 | Bipolar Disorder | 9 | BeFree,GAD |
| umls:C0011581 | Depressive disorder | 9 | BeFree |
| umls:C0041696 | Unipolar Depression | 7 | BeFree,GAD |
| umls:C0524620 | Metabolic Syndrome X | 7 | BeFree,CTD_human,GAD |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 6 | BeFree,GAD |
| umls:C0003469 | Anxiety Disorders | 6 | BeFree,GAD,RGD |
| umls:C0525045 | Mood Disorders | 6 | BeFree |
| umls:C0149931 | Migraine Disorders | 5 | BeFree,GAD |
| umls:C0152115 | Lingual-Facial-Buccal Dyskinesia | 5 | BeFree,GAD |
| umls:C0686347 | Tardive Dyskinesia | 5 | BeFree,GAD |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 4 | BeFree,GAD,MGD |
| umls:C1263846 | Attention deficit hyperactivity disorder | 4 | BeFree,GAD |
| umls:C0003125 | Anorexia Nervosa | 3 | BeFree,GAD,LHGDN |
| umls:C0004352 | Autistic Disorder | 3 | BeFree,GAD |
| umls:C0013473 | Eating Disorders | 3 | BeFree |
| umls:C0032897 | Prader-Willi Syndrome | 3 | BeFree,MGD |
| umls:C0038580 | Substance Dependence | 3 | BeFree |
| umls:C0154723 | Migraine with Aura | 3 | BeFree,GAD,LHGDN |
| umls:C0233565 | Bradykinesia | 3 | BeFree |
| umls:C0242422 | Parkinsonian Disorders | 3 | BeFree |
| umls:C0520679 | Sleep Apnea, Obstructive | 3 | BeFree,GAD |
| umls:C1510472 | Drug Dependence | 3 | BeFree |
| umls:C1524032 | Depression and Suicide | 3 | BeFree |
| umls:C2267227 | Bulimia Nervosa | 3 | BeFree,LHGDN |
| umls:C0002395 | Alzheimer's Disease | 2 | GAD,LHGDN |
| umls:C0003123 | Anorexia | 2 | BeFree |
| umls:C0003944 | As If Personality | 2 | GAD |
| umls:C0006012 | Borderline Personality Disorder | 2 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 2 | BeFree |
| umls:C0013386 | Dyskinesia, Drug-Induced | 2 | BeFree,GAD |
| umls:C0027819 | Neuroblastoma | 2 | BeFree |
| umls:C0030193 | Pain | 2 | BeFree,RGD |
| umls:C0032002 | Pituitary Diseases | 2 | BeFree |
| umls:C0033038 | Premature Ejaculation | 2 | BeFree |
| umls:C0033975 | Psychotic Disorders | 2 | BeFree,GAD |
| umls:C0036572 | Seizures | 2 | BeFree |
| umls:C0038587 | Substance Withdrawal Syndrome | 2 | CTD_human,GAD |
| umls:C0040517 | Gilles de la Tourette syndrome | 2 | BeFree,GAD |
| umls:C0085762 | Alcohol abuse | 2 | GAD |
| umls:C0233849 | Personality Traits | 2 | GAD |
| umls:C0349204 | Nonorganic psychosis | 2 | BeFree |
| umls:C0700095 | Central neuroblastoma | 2 | BeFree |
| umls:C0871189 | Psychotic symptom | 2 | BeFree |
| umls:C1839839 | MAJOR AFFECTIVE DISORDER 2 | 2 | BeFree,GAD |
| umls:C1852197 | MAJOR AFFECTIVE DISORDER 1 | 2 | BeFree,GAD |
| umls:C1970943 | MAJOR AFFECTIVE DISORDER 4 | 2 | BeFree,GAD |
| umls:C1970944 | MAJOR AFFECTIVE DISORDER 5 | 2 | BeFree,GAD |
| umls:C1970945 | MAJOR AFFECTIVE DISORDER 6 | 2 | BeFree,GAD |
| umls:C2700438 | MAJOR AFFECTIVE DISORDER 7 | 2 | BeFree,GAD |
| umls:C2700439 | MAJOR AFFECTIVE DISORDER 8 | 2 | BeFree,GAD |
| umls:C2700440 | MAJOR AFFECTIVE DISORDER 9 | 2 | BeFree,GAD |
| umls:C0004782 | Basal Ganglia Diseases | 1 | GAD |
| umls:C0006287 | Bronchopulmonary Dysplasia | 1 | BeFree |
| umls:C0006370 | Bulimia | 1 | GAD |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0013146 | Drug abuse | 1 | BeFree |
| umls:C0013384 | Dyskinetic syndrome | 1 | BeFree |
| umls:C0014130 | Endocrine System Diseases | 1 | GAD |
| umls:C0014556 | Epilepsy, Temporal Lobe | 1 | GAD |
| umls:C0015371 | Extrapyramidal Disorders | 1 | BeFree |
| umls:C0015672 | Fatigue | 1 | GAD |
| umls:C0015674 | Chronic Fatigue Syndrome | 1 | GAD |
| umls:C0018817 | Atrial Septal Defects | 1 | BeFree |
| umls:C0020459 | Hyperinsulinism | 1 | BeFree |
| umls:C0023904 | Liver Neoplasms, Experimental | 1 | RGD |
| umls:C0026837 | Muscle Rigidity | 1 | BeFree |
| umls:C0027796 | Neuralgia | 1 | BeFree |
| umls:C0030567 | Parkinson Disease | 1 | GAD |
| umls:C0034040 | Puerperal Disorders | 1 | GAD |
| umls:C0038443 | Stress, Psychological | 1 | BeFree |
| umls:C0041341 | Tuberous Sclerosis | 1 | BeFree,GAD |
| umls:C0085159 | Seasonal Affective Disorder | 1 | BeFree,GAD |
| umls:C0085271 | Self-Injurious Behavior | 1 | BeFree |
| umls:C0085631 | Agitation | 1 | BeFree |
| umls:C0086132 | Depressive Symptoms | 1 | BeFree |
| umls:C0086209 | Emotional Stress | 1 | BeFree |
| umls:C0152025 | Polyneuropathy | 1 | BeFree |
| umls:C0154409 | Recurrent major depressive episodes | 1 | BeFree |
| umls:C0162550 | Akathisia, Drug-Induced | 1 | GAD |
| umls:C0221765 | Chronic schizophrenia | 1 | BeFree |
| umls:C0233397 | Psychological symptom | 1 | BeFree |
| umls:C0233777 | Hallucinosis | 1 | BeFree |
| umls:C0234379 | Resting Tremor | 1 | BeFree |
| umls:C0236969 | Substance-Related Disorders | 1 | RGD |
| umls:C0237873 | Physiological Sexual Disorders | 1 | GAD |
| umls:C0302847 | major affective disorder | 1 | BeFree |
| umls:C0338614 | Psychotic episode | 1 | BeFree |
| umls:C0338715 | Drug-induced depressive state | 1 | BeFree |
| umls:C0424295 | Hyperactive behavior | 1 | CTD_human |
| umls:C0458960 | Peripheral neuropathic pain | 1 | BeFree |
| umls:C0518010 | body mass | 1 | GAD |
| umls:C0524528 | Pervasive Development Disorder | 1 | BeFree |
| umls:C0600427 | Cocaine Dependence | 1 | BeFree |
| umls:C0740858 | Substance abuse problem | 1 | BeFree |
| umls:C0746556 | metabolic disturbance | 1 | BeFree |
| umls:C0851578 | Sleep Disorders | 1 | GAD |
| umls:C0853193 | Bipolar I disorder | 1 | BeFree |
| umls:C1510586 | Autism Spectrum Disorders | 1 | BeFree |
| umls:C2911645 | Weight Loss Adverse Event | 1 | GAD |
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