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| TissGeneSummary for IAPP |
 Gene summary |
| Basic gene information | Gene symbol | IAPP |
| Gene name | islet amyloid polypeptide | |
| Synonyms | DAP|IAP | |
| Cytomap | UCSC genome browser: 12p12.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000415.2, | |
| Description | Islet amyloid polypeptide (diabetes-associated peptide; amylin)amylindiabetes-associated peptideinsulinoma amyloid peptide | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 147940 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000121351 | ||
| HPRD : 01005 | ||
| Vega : OTTHUMG00000169128 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_IAPP | |
| BioGPS: 3375 | ||
| Pathway | NCI Pathway Interaction Database: IAPP | |
| KEGG: IAPP | ||
| REACTOME: IAPP | ||
| Pathway Commons: IAPP | ||
| Context | iHOP: IAPP | |
| ligand binding site mutation search in PubMed: IAPP | ||
| UCL Cancer Institute: IAPP | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
| Reference showing the relevant tissue of IAPP | Early changes in islet hormone secretion in the hamster pancreatic cancer model. Permert J, Herrington M, Kazakoff K, Pour PM, Adrian TE. Teratog Carcinog Mutagen. 2001;21(1):59-67. (pmid:11135321) go to article | |
| Description by TissGene annotations | TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for IAPP |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for IAPP |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for IAPP |
| TissGeneSNV for IAPP |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.L87M | STAD | 2 |
| p.T42A | COAD | 1 |
| p.V15I | LUAD | 1 |
| p.R33Q | CESC | 1 |
| p.L60V | PAAD | 1 |
| p.I3M | STAD | 1 |
| p.N85K | LUAD | 1 |
| p.L87M | LUAD | 1 |
| p.I59M | BLCA | 1 |
| p.I11L | ACC | 1 |
| p.R60T | LUAD | 1 |
| p.L20M | STAD | 1 |
| p.L17F | BRCA | 1 |
| p.E26X | CHOL | 1 |
| p.E82X | THYM | 1 |
| p.R81K | SKCM | 1 |
| p.L10I | UCEC | 1 |
| p.R44C | UCEC | 1 |
| p.S14Y | STAD | 1 |
| p.N55S | LGG | 1 |
| p.P88T | STAD | 1 |
| p.L10I | PAAD | 1 |
| p.N64S | UCEC | 1 |
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| TissGeneCNV for IAPP |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for IAPP |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-E2-A1L8-01A | ANO6-IAPP | Out-of-Frame | chr12:45816845 | chr12:21531170 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-E2-A1L8-01A | ANO6-IAPP | Out-of-Frame | chr12:45816844 | chr12:21531170 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-E2-A1L8-01A | ANO6-IAPP | Out-of-frame | Chr12:45816845 | Chr12:21531171 |
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| TissGeneNet for IAPP |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (tumor) | IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (normal) |
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| COAD (tumor) | COAD (normal) |
| IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (tumor) | IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (tumor) | IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (normal) |
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| KICH (tumor) | KICH (normal) |
| IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (tumor) | IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (tumor) | IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (tumor) | IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (tumor) | IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (tumor) | IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (tumor) | IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (tumor) | IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (normal) |
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| STAD (tumor) | STAD (normal) |
| IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (tumor) | IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (normal) |
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| THCA (tumor) | THCA (normal) |
| IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (tumor) | IAPP, CAND1, KIAA0101, CUL1, COPS5, PDX1, PCSK1, RAMP1, RAMP2, PCSK2, COL25A1 (normal) |
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| TissGeneProg for IAPP |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for IAPP |
| TissGeneDrug for IAPP |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for IAPP |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 79 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0011849 | Diabetes Mellitus | 23 | BeFree,GAD,LHGDN |
| umls:C2936349 | Plaque, Amyloid | 23 | BeFree |
| umls:C0011847 | Diabetes | 16 | BeFree |
| umls:C0028754 | Obesity | 11 | BeFree |
| umls:C0021670 | insulinoma | 9 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 7 | BeFree |
| umls:C0596263 | Carcinogenesis | 7 | BeFree |
| umls:C0002726 | Amyloidosis | 6 | BeFree,LHGDN |
| umls:C0178874 | Tumor Progression | 6 | BeFree |
| umls:C2239176 | Liver carcinoma | 6 | BeFree |
| umls:C0020456 | Hyperglycemia | 5 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 5 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 4 | BeFree |
| umls:C0376545 | Hematologic Neoplasms | 4 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 4 | BeFree |
| umls:C1527249 | Colorectal Cancer | 4 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 3 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 3 | BeFree |
| umls:C0024299 | Lymphoma | 3 | BeFree |
| umls:C0025202 | melanoma | 3 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 3 | BeFree |
| umls:C0302592 | Cervix carcinoma | 3 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 3 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree |
| umls:C0600139 | Prostate carcinoma | 3 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 3 | BeFree |
| umls:C1709246 | Non-Neoplastic Disorder | 3 | BeFree |
| umls:C2931822 | Nasopharyngeal carcinoma | 3 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 2 | BeFree |
| umls:C0020538 | Hypertensive disease | 2 | BeFree,LHGDN |
| umls:C0023418 | leukemia | 2 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 2 | BeFree |
| umls:C0024301 | Lymphoma, Follicular | 2 | BeFree |
| umls:C0026764 | Multiple Myeloma | 2 | BeFree |
| umls:C0079731 | B-Cell Lymphomas | 2 | BeFree |
| umls:C0271650 | Impaired glucose tolerance | 2 | BeFree |
| umls:C0282577 | Congenital Disorders of Glycosylation | 2 | BeFree |
| umls:C0684249 | Carcinoma of lung | 2 | BeFree |
| umls:C0699790 | Colon Carcinoma | 2 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 2 | BeFree |
| umls:C0751882 | Myasthenic Syndromes, Congenital | 2 | BeFree |
| umls:C0812413 | Malignant Pleural Mesothelioma | 2 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
| umls:C0003123 | Anorexia | 1 | BeFree |
| umls:C0003864 | Arthritis | 1 | BeFree |
| umls:C0004509 | Azoospermia | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007125 | Carcinoma, Ehrlich Tumor | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 1 | BeFree |
| umls:C0011065 | Cessation of life | 1 | LHGDN |
| umls:C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
| umls:C0011881 | Diabetic Nephropathy | 1 | LHGDN |
| umls:C0013537 | Eclampsia | 1 | BeFree |
| umls:C0014544 | Epilepsy | 1 | BeFree |
| umls:C0014553 | Absence Epilepsy | 1 | BeFree |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0017689 | Glucagonoma | 1 | BeFree |
| umls:C0019829 | Hodgkin Disease | 1 | BeFree |
| umls:C0020479 | Hyperlipoproteinemia Type III | 1 | BeFree |
| umls:C0022661 | Kidney Failure, Chronic | 1 | GAD |
| umls:C0023269 | leiomyosarcoma | 1 | BeFree |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | BeFree |
| umls:C0023452 | Leukemia, Lymphocytic, Acute, L1 | 1 | BeFree |
| umls:C0023470 | Myeloid Leukemia | 1 | BeFree |
| umls:C0023895 | Liver diseases | 1 | BeFree |
| umls:C0026847 | Spinal Muscular Atrophy | 1 | BeFree |
| umls:C0027533 | Neck Neoplasms | 1 | BeFree |
| umls:C0031154 | Peritonitis | 1 | BeFree |
| umls:C0032019 | Pituitary Neoplasms | 1 | BeFree |
| umls:C0035412 | Rhabdomyosarcoma | 1 | BeFree |
| umls:C0038358 | Gastric ulcer | 1 | CTD_human |
| umls:C0085207 | Gestational Diabetes | 1 | BeFree |
| umls:C0151744 | Myocardial Ischemia | 1 | BeFree |
| umls:C0162534 | Prion Diseases | 1 | BeFree |
| umls:C0206754 | Neuroendocrine Tumors | 1 | BeFree |
| umls:C0220615 | Adult Acute Myeloblastic Leukemia | 1 | BeFree |
| umls:C0221014 | Reactive systemic amyloidosis | 1 | BeFree |
| umls:C0232197 | Fibrillation | 1 | BeFree |
| umls:C0238462 | Medullary carcinoma of thyroid | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0242647 | Mucosa-Associated Lymphoid Tissue Lymphoma | 1 | BeFree |
| umls:C0278519 | recurrent childhood acute lymphoblastic leukemia | 1 | BeFree |
| umls:C0278601 | Inflammatory Breast Carcinoma | 1 | BeFree |
| umls:C0278883 | Metastatic melanoma | 1 | BeFree |
| umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 1 | BeFree |
| umls:C0279680 | Transitional cell carcinoma of bladder | 1 | BeFree |
| umls:C0342276 | Maturity onset diabetes mellitus in young | 1 | BeFree |
| umls:C0343401 | MRSA - Methicillin resistant Staphylococcus aureus infection | 1 | BeFree |
| umls:C0345904 | Malignant neoplasm of liver | 1 | BeFree |
| umls:C0362046 | Prediabetes syndrome | 1 | BeFree |
| umls:C0518010 | body mass | 1 | GAD |
| umls:C0598766 | Leukemogenesis | 1 | BeFree |
| umls:C0677607 | Hashimoto Disease | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0687120 | Nephronophthisis | 1 | BeFree |
| umls:C0700323 | Observation of Neuromuscular Block | 1 | BeFree |
| umls:C0917713 | Becker Muscular Dystrophy | 1 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
| umls:C1261473 | Sarcoma | 1 | BeFree |
| umls:C1336527 | Carcinoma of urinary bladder, superficial | 1 | BeFree |
| umls:C1336753 | Thyroid Lymphoma | 1 | BeFree |
| umls:C1800706 | Idiopathic Pulmonary Fibrosis | 1 | BeFree |
| umls:C1851710 | LATERAL MENINGOCELE SYNDROME | 1 | BeFree |
| umls:C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | BeFree |
| umls:C3536715 | AA amyloidosis | 1 | BeFree |
| umls:C3539878 | Triple Negative Breast Neoplasms | 1 | BeFree |
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