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| TissGeneSummary for APOB |
 Gene summary |
| Basic gene information | Gene symbol | APOB |
| Gene name | apolipoprotein B | |
| Synonyms | FLDB|LDLCQ4 | |
| Cytomap | UCSC genome browser: 2p24-p23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000384.2, | |
| Description | apo B-100apoB-100apoB-48apolipoprotein B (including Ag(x) antigen)apolipoprotein B-100apolipoprotein B48mutant Apo B 100 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 107730 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000084674 | ||
| HPRD : 00133 | ||
| Vega : OTTHUMG00000090785 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_APOB | |
| BioGPS: 338 | ||
| Pathway | NCI Pathway Interaction Database: APOB | |
| KEGG: APOB | ||
| REACTOME: APOB | ||
| Pathway Commons: APOB | ||
| Context | iHOP: APOB | |
| ligand binding site mutation search in PubMed: APOB | ||
| UCL Cancer Institute: APOB | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of APOB | ||
| Description by TissGene annotations | TissgsKTS CNV gained TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0010744 | positive regulation of macrophage derived foam cell differentiation | 17244792 | GO:0010884 | positive regulation of lipid storage | 18322245 | GO:0010886 | positive regulation of cholesterol storage | 19114110 | GO:0010744 | positive regulation of macrophage derived foam cell differentiation | 17244792 | GO:0010884 | positive regulation of lipid storage | 18322245 | GO:0010886 | positive regulation of cholesterol storage | 19114110 |
| Top |
| TissGeneExp for APOB |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 4.881917857 | 2.107510912 | 2.774406944 | 2.95E-10 | 9.99E-10 |
| BRCA | -0.373681997 | 4.225157477 | -4.598839474 | 2.91E-40 | 8.86E-39 |
| COAD | -1.125980647 | 0.975138583 | -2.101119231 | 8.62E-07 | 4.92E-06 |
| PRAD | 0.413021276 | 1.800444353 | -1.387423077 | 3.55E-06 | 2.23E-05 |
| KIRP | 0.340113343 | 1.463932093 | -1.12381875 | 0.0192 | 0.039097548 |
| BLCA | -0.881803927 | 1.175738179 | -2.057542105 | 0.000907 | 0.006506994 |
| LIHC | 13.94888997 | 15.18680797 | -1.237918 | 0.00015 | 0.000496498 |
| Top |
| TissGene-miRNA for APOB |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for APOB |
| TissGeneSNV for APOB |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.F3102L | UCEC | 4 |
| p.R1388C | SKCM | 4 |
| p.G3972E | SKCM | 3 |
| p.E4256K | SKCM | 3 |
| p.S4244F | SKCM | 3 |
| p.R3059C | SKCM | 3 |
| p.G493E | SKCM | 3 |
| p.S1848L | SKCM | 2 |
| p.P2734S | SKCM | 2 |
| p.M3458I | SKCM | 2 |
| p.T3448N | LUAD | 2 |
| p.S2980F | SKCM | 2 |
| p.E2909K | SKCM | 2 |
| p.G2872R | SKCM | 2 |
| p.D3728N | SKCM | 2 |
| p.E2786K | SKCM | 2 |
| p.E2079K | SKCM | 2 |
| p.S3284F | SKCM | 2 |
| p.F2890L | LIHC | 2 |
| p.D4146N | SKCM | 2 |
| p.E2531K | SKCM | 2 |
| p.L973M | LUAD | 2 |
| p.M1749I | SKCM | 2 |
| p.S3561F | SKCM | 2 |
| p.G2797R | SKCM | 2 |
| p.W2929* | SKCM | 2 |
| p.S1401F | SKCM | 2 |
| p.D3231G | BLCA | 2 |
| p.M1391I | SKCM | 2 |
| p.W2929X | SKCM | 2 |
| p.H4236Y | SKCM | 2 |
| p.P2896L | LIHC | 2 |
| p.E4475K | SKCM | 2 |
| p.M2178I | SKCM | 2 |
| p.G694E | SKCM | 2 |
| p.E3154K | SKCM | 2 |
| p.P2642S | SKCM | 2 |
| p.Q3601* | SKCM | 2 |
| p.E1564D | COAD | 1 |
| p.D4033Y | LUAD | 1 |
| p.S3503L | COAD | 1 |
| p.S365Y | UCEC | 1 |
| p.S2068Y | HNSC | 1 |
| p.L827I | CHOL | 1 |
| p.S2815T | UCEC | 1 |
| p.L2357X | ESCA | 1 |
| p.E323K | COAD | 1 |
| p.E3195D | GBM | 1 |
| p.E1260D | LUAD | 1 |
| p.S3402R | ESCA | 1 |
| p.H2891N | PRAD | 1 |
| p.M1391V | SKCM | 1 |
| p.P927L | SKCM | 1 |
| p.R3527P | HNSC | 1 |
| p.V3725F | LUAD | 1 |
| p.K3627N | OV | 1 |
| p.R1599H | UCEC | 1 |
| p.Y3489H | LUAD | 1 |
| p.V3857M | COAD | 1 |
| p.L2014M | LUAD | 1 |
| p.A2465S | LUAD | 1 |
| p.L3062X | LGG | 1 |
| p.P1509S | SKCM | 1 |
| p.Q4449K | STAD | 1 |
| p.S909L | GBM | 1 |
| p.T3512N | LUAD | 1 |
| p.C186F | UCEC | 1 |
| p.A2475D | HNSC | 1 |
| p.R1024G | STAD | 1 |
| p.G709E | SKCM | 1 |
| p.S4233L | UCEC | 1 |
| p.P3275S | SKCM | 1 |
| p.M522I | SKCM | 1 |
| p.A2810E | PRAD | 1 |
| p.L3062* | LGG | 1 |
| p.P2689S | SKCM | 1 |
| p.N868D | CESC | 1 |
| p.K3682N | BLCA | 1 |
| p.L944F | KIRC | 1 |
| p.D1432N | LAML | 1 |
| p.I2179M | UCEC | 1 |
| p.R3136C | COAD | 1 |
| p.T3338A | UCEC | 1 |
| p.N4431S | SKCM | 1 |
| p.E2445D | LUAD | 1 |
| p.E2842K | SKCM | 1 |
| p.E3582K | SKCM | 1 |
| p.E3888Q | BLCA | 1 |
| p.D1908N | UCEC | 1 |
| p.C1505F | HNSC | 1 |
| p.E2798Q | BLCA | 1 |
| p.W1920X | SKCM | 1 |
| p.M566P | BRCA | 1 |
| p.L1385F | SKCM | 1 |
| p.A251T | DLBC | 1 |
| p.G3157S | SKCM | 1 |
| p.R3212K | SKCM | 1 |
| p.S1407F | LUAD | 1 |
| p.D1945A | SKCM | 1 |
| p.S3294* | LIHC | 1 |
| p.H3987Y | SKCM | 1 |
| p.T3897I | SKCM | 1 |
| p.N456S | STAD | 1 |
| p.R3638W | READ | 1 |
| p.N2239K | COAD | 1 |
| p.S644F | READ | 1 |
| p.L1819M | STAD | 1 |
| p.S1524P | CHOL | 1 |
| p.Q387T | LUAD | 1 |
| p.M1905I | LUAD | 1 |
| p.G3006C | COAD | 1 |
| p.S1613R | LUAD | 1 |
| p.D2993N | SKCM | 1 |
| p.E2667Q | BRCA | 1 |
| p.F4039L | LUAD | 1 |
| p.V3758F | LGG | 1 |
| p.L4081H | BLCA | 1 |
| p.R3389G | LUAD | 1 |
| p.I3331V | LIHC | 1 |
| p.S3506F | SKCM | 1 |
| p.F2617C | UCEC | 1 |
| p.G2940R | TGCT | 1 |
| p.D3319N | BLCA | 1 |
| p.A4112D | STAD | 1 |
| p.G2847V | HNSC | 1 |
| p.L4081I | PRAD | 1 |
| p.A2463V | READ | 1 |
| p.D1196A | STAD | 1 |
| p.R2534Q | SKCM | 1 |
| p.E1085K | BLCA | 1 |
| p.F4322C | COAD | 1 |
| p.N1884K | LUAD | 1 |
| p.D2203H | BLCA | 1 |
| p.R2907C | GBM | 1 |
| p.G1512C | LUAD | 1 |
| p.P4004Q | LUAD | 1 |
| p.S127Y | LUAD | 1 |
| p.R3136C | SKCM | 1 |
| p.N2727S | SKCM | 1 |
| p.N3569T | LUAD | 1 |
| p.F2711L | HNSC | 1 |
| p.T1102S | SKCM | 1 |
| p.R4496K | SKCM | 1 |
| p.Q571* | KIRP | 1 |
| p.K3097T | STAD | 1 |
| p.P4391L | SKCM | 1 |
| p.G4174S | KIRC | 1 |
| p.S3641Y | HNSC | 1 |
| p.S4434Y | SKCM | 1 |
| p.Q2173H | ESCA | 1 |
| p.F2073S | HNSC | 1 |
| p.A3004D | STAD | 1 |
| p.K1099N | BLCA | 1 |
| p.P971T | UCEC | 1 |
| p.P224S | LIHC | 1 |
| p.F1612L | BRCA | 1 |
| p.A3950S | READ | 1 |
| p.S684X | COAD | 1 |
| p.L3315I | LUAD | 1 |
| p.A440V | STAD | 1 |
| p.S3742A | UCEC | 1 |
| p.S1425P | STAD | 1 |
| p.K304R | STAD | 1 |
| p.D4169V | OV | 1 |
| p.M672K | LUAD | 1 |
| p.Q1489K | COAD | 1 |
| p.S1242Y | UCEC | 1 |
| p.S2870N | UCEC | 1 |
| p.F2633V | UCEC | 1 |
| p.D4504N | LUAD | 1 |
| p.Q2989X | SKCM | 1 |
| p.I2276T | STAD | 1 |
| p.Q2448H | LUAD | 1 |
| p.G2952E | SKCM | 1 |
| p.R3136H | GBM | 1 |
| p.M1682V | UCEC | 1 |
| p.L502V | STAD | 1 |
| p.T1019A | SKCM | 1 |
| p.G277R | LUAD | 1 |
| p.E689G | LIHC | 1 |
| p.M1717I | SKCM | 1 |
| p.V383A | HNSC | 1 |
| p.E2153K | SKCM | 1 |
| p.E2332K | LUSC | 1 |
| p.E472* | STAD | 1 |
| p.P405T | LUAD | 1 |
| p.E3459K | SKCM | 1 |
| p.R1333Q | BRCA | 1 |
| p.E2047K | LUAD | 1 |
| p.S1325Y | UCEC | 1 |
| p.F1896I | UCEC | 1 |
| p.P1127L | STAD | 1 |
| p.P3262S | OV | 1 |
| p.S878F | SKCM | 1 |
| p.H1944R | PAAD | 1 |
| p.K1967N | STAD | 1 |
| p.A3235D | LUSC | 1 |
| p.A448V | SKCM | 1 |
| p.M1742T | SKCM | 1 |
| p.Q3247X | SKCM | 1 |
| p.A1241P | LGG | 1 |
| p.S119P | LIHC | 1 |
| p.S1723I | SARC | 1 |
| p.E3817K | BLCA | 1 |
| p.R1867W | HNSC | 1 |
| p.E1707K | ESCA | 1 |
| p.F2806V | UCEC | 1 |
| p.R207I | SKCM | 1 |
| p.R4046Q | LGG | 1 |
| p.Q2608R | UCEC | 1 |
| p.A2045V | UCEC | 1 |
| p.F705S | LIHC | 1 |
| p.H2918R | STAD | 1 |
| p.S714I | UCEC | 1 |
| p.L4436F | SKCM | 1 |
| p.V3255D | COAD | 1 |
| p.A552D | UCEC | 1 |
| p.R219C | UCEC | 1 |
| p.D1945N | SKCM | 1 |
| p.V1440L | OV | 1 |
| p.A679T | UCEC | 1 |
| p.R2012X | PRAD | 1 |
| p.T3798R | LIHC | 1 |
| p.L1568M | UCEC | 1 |
| p.G2395E | SKCM | 1 |
| p.D2772V | THCA | 1 |
| p.S1433L | STAD | 1 |
| p.Q3088K | OV | 1 |
| p.G4225R | COAD | 1 |
| p.Q2972K | LUAD | 1 |
| p.E865* | LIHC | 1 |
| p.L3659F | SKCM | 1 |
| p.K934N | HNSC | 1 |
| p.G1651R | SKCM | 1 |
| p.S1494L | READ | 1 |
| p.L2844M | UCEC | 1 |
| p.L4352V | THYM | 1 |
| p.S1433X | LIHC | 1 |
| p.K876N | THCA | 1 |
| p.G1451C | COAD | 1 |
| p.K3501N | LUAD | 1 |
| p.R635Q | PAAD | 1 |
| p.Q1044H | LUAD | 1 |
| p.E2826G | BRCA | 1 |
| p.L2099M | UCEC | 1 |
| p.E1517K | SKCM | 1 |
| p.I3538S | PAAD | 1 |
| p.G997A | HNSC | 1 |
| p.R1388P | LIHC | 1 |
| p.K654* | SKCM | 1 |
| p.E3016X | THCA | 1 |
| p.D1151N | KIRP | 1 |
| p.D743N | BLCA | 1 |
| p.R2522* | UCEC | 1 |
| p.D824N | SKCM | 1 |
| p.G2917S | LUAD | 1 |
| p.R2705T | THYM | 1 |
| p.N2123Y | LUAD | 1 |
| p.A561S | LIHC | 1 |
| p.K3097R | LUAD | 1 |
| p.G1761S | LUAD | 1 |
| p.F3577I | STAD | 1 |
| p.I3997L | LUAD | 1 |
| p.L4197M | READ | 1 |
| p.A4001E | LUAD | 1 |
| p.L827V | CESC | 1 |
| p.G3502D | SKCM | 1 |
| p.R2012* | GBM | 1 |
| p.N2654K | LUAD | 1 |
| p.V4045I | LUAD | 1 |
| p.P2724T | STAD | 1 |
| p.A835P | LUAD | 1 |
| p.S3036Y | UCEC | 1 |
| p.E4060D | ESCA | 1 |
| p.R2085Q | SKCM | 1 |
| p.E2786K | HNSC | 1 |
| p.P3262L | SKCM | 1 |
| p.A1387P | LUAD | 1 |
| p.N1804D | LUSC | 1 |
| p.G4079E | STAD | 1 |
| p.L3702I | UCEC | 1 |
| p.A3354S | COAD | 1 |
| p.H453Y | SKCM | 1 |
| p.G2584R | SKCM | 1 |
| p.S1956Y | READ | 1 |
| p.F2957L | THYM | 1 |
| p.T3352I | SKCM | 1 |
| p.S3294L | SKCM | 1 |
| p.W1920* | SKCM | 1 |
| p.N3549H | STAD | 1 |
| p.E137K | SKCM | 1 |
| p.V3758A | SKCM | 1 |
| p.S4470F | HNSC | 1 |
| p.H2288L | LUSC | 1 |
| p.R2012* | PRAD | 1 |
| p.D3340H | BLCA | 1 |
| p.Y3251C | UCEC | 1 |
| p.V1731I | SKCM | 1 |
| p.W2686L | HNSC | 1 |
| p.A1018T | LGG | 1 |
| p.E2751K | SKCM | 1 |
| p.S1460F | SKCM | 1 |
| p.E865X | LIHC | 1 |
| p.R635W | LUSC | 1 |
| p.S4423F | SKCM | 1 |
| p.Q1860H | LUAD | 1 |
| p.L4276V | UCEC | 1 |
| p.P1509S | SARC | 1 |
| p.R2520* | LUSC | 1 |
| p.G1576W | LUAD | 1 |
| p.L3883Q | LUAD | 1 |
| p.Q2613K | LUAD | 1 |
| p.N3052H | STAD | 1 |
| p.N1361K | THCA | 1 |
| p.D2527N | SKCM | 1 |
| p.L2736F | SKCM | 1 |
| p.I2354L | COAD | 1 |
| p.D435G | LIHC | 1 |
| p.S2537Y | UCEC | 1 |
| p.S3103A | UCEC | 1 |
| p.A3075E | THYM | 1 |
| p.D744N | CESC | 1 |
| p.H2942R | LGG | 1 |
| p.R4270G | COAD | 1 |
| p.R3703C | SKCM | 1 |
| p.H3603N | LUAD | 1 |
| p.Q4165H | LUAD | 1 |
| p.K859N | LUSC | 1 |
| p.G1861V | UCEC | 1 |
| p.H1866N | THYM | 1 |
| p.I597V | PAAD | 1 |
| p.S2544R | CESC | 1 |
| p.A440S | LUSC | 1 |
| p.Q3802E | CESC | 1 |
| p.S3369* | LUAD | 1 |
| p.E331X | COAD | 1 |
| p.S1332C | LIHC | 1 |
| p.S3409R | LIHC | 1 |
| p.F2181C | COAD | 1 |
| p.P3892S | SKCM | 1 |
| p.L288R | UCEC | 1 |
| p.P3133S | SKCM | 1 |
| p.A43V | STAD | 1 |
| p.D3022Y | STAD | 1 |
| p.S1621F | SKCM | 1 |
| p.S3832X | ESCA | 1 |
| p.S1142L | STAD | 1 |
| p.S2980C | ESCA | 1 |
| p.D4033N | HNSC | 1 |
| p.I1096V | HNSC | 1 |
| p.F3341L | UCEC | 1 |
| p.A2704V | STAD | 1 |
| p.R1388H | UCEC | 1 |
| p.L1550M | BRCA | 1 |
| p.S72R | STAD | 1 |
| p.L3576I | BLCA | 1 |
| p.Q1528* | LUAD | 1 |
| p.I854V | GBM | 1 |
| p.A173D | LUAD | 1 |
| p.C3194F | HNSC | 1 |
| p.Q3247* | SKCM | 1 |
| p.D3612N | LUAD | 1 |
| p.R3558H | PRAD | 1 |
| p.S2831Y | ACC | 1 |
| p.P3310S | SKCM | 1 |
| p.D2677A | ESCA | 1 |
| p.G1617R | SKCM | 1 |
| p.V2587L | READ | 1 |
| p.A3885V | STAD | 1 |
| p.D3240N | SKCM | 1 |
| p.P668L | LGG | 1 |
| p.L112W | LGG | 1 |
| p.V1481D | LUAD | 1 |
| p.G3011E | SKCM | 1 |
| p.S4233L | COAD | 1 |
| p.A787V | KIRC | 1 |
| p.E289G | LUAD | 1 |
| p.E3303K | CESC | 1 |
| p.S2643F | SKCM | 1 |
| p.E4271K | SKCM | 1 |
| p.S1306P | COAD | 1 |
| p.V2752L | STAD | 1 |
| p.G221C | COAD | 1 |
| p.S4020F | SKCM | 1 |
| p.P3759Q | UCEC | 1 |
| p.E1835K | SKCM | 1 |
| p.G2847R | BRCA | 1 |
| p.L1819Q | LUAD | 1 |
| p.P2739L | COAD | 1 |
| p.R3632G | UCEC | 1 |
| p.S3222F | SKCM | 1 |
| p.S2504Y | UCEC | 1 |
| p.R2012Q | SKCM | 1 |
| p.A3004S | READ | 1 |
| p.E3407D | LIHC | 1 |
| p.D1081N | SKCM | 1 |
| p.G4209R | PAAD | 1 |
| p.R3558C | READ | 1 |
| p.S3491F | SKCM | 1 |
| p.Q571X | KIRP | 1 |
| p.R2219H | PRAD | 1 |
| p.K51E | LIHC | 1 |
| p.T2596S | OV | 1 |
| p.F3204L | LUSC | 1 |
| p.P2049S | HNSC | 1 |
| p.E1670* | HNSC | 1 |
| p.D2441N | BRCA | 1 |
| p.S3529L | SKCM | 1 |
| p.S3641A | UCEC | 1 |
| p.V4176I | BRCA | 1 |
| p.D1908Y | PRAD | 1 |
| p.R2935K | SKCM | 1 |
| p.D290N | ESCA | 1 |
| p.E3649K | CESC | 1 |
| p.E3564K | SKCM | 1 |
| p.P668S | SKCM | 1 |
| p.L2450V | LUAD | 1 |
| p.D2228N | HNSC | 1 |
| p.T1419A | OV | 1 |
| p.N1914S | COAD | 1 |
| p.T1114I | HNSC | 1 |
| p.G459W | COAD | 1 |
| p.I3696M | LUAD | 1 |
| p.K51R | READ | 1 |
| p.S1548F | SKCM | 1 |
| p.D4127N | LUAD | 1 |
| p.N3411K | BRCA | 1 |
| p.F3869L | UCEC | 1 |
| p.G3502C | KIRC | 1 |
| p.L544I | LUAD | 1 |
| p.T2837M | COAD | 1 |
| p.V4231L | LUAD | 1 |
| p.R3558H | PAAD | 1 |
| p.S644Y | UCEC | 1 |
| p.W1167* | UCEC | 1 |
| p.D4049E | OV | 1 |
| p.R4385C | LGG | 1 |
| p.P3189S | SKCM | 1 |
| p.K3430N | SKCM | 1 |
| p.G1516R | SARC | 1 |
| p.P3243R | LUAD | 1 |
| p.S391F | SKCM | 1 |
| p.A651D | STAD | 1 |
| p.A3942T | GBM | 1 |
| p.A4063D | ACC | 1 |
| p.S3345L | SKCM | 1 |
| p.R2012Q | LIHC | 1 |
| p.M1266I | STAD | 1 |
| p.E1025D | LUAD | 1 |
| p.L3902F | ESCA | 1 |
| p.A1320P | HNSC | 1 |
| p.Q387K | LUAD | 1 |
| p.S2902C | LIHC | 1 |
| p.F2057C | STAD | 1 |
| p.H3308Y | SKCM | 1 |
| p.V3789I | LUSC | 1 |
| p.E1116* | BLCA | 1 |
| p.K537E | LIHC | 1 |
| p.K1043N | COAD | 1 |
| p.H2280Y | PRAD | 1 |
| p.P3722S | SKCM | 1 |
| p.V1448I | LAML | 1 |
| p.Q96R | LUAD | 1 |
| p.P712S | GBM | 1 |
| p.R1078K | SKCM | 1 |
| p.H2745Y | SKCM | 1 |
| p.N3211S | SKCM | 1 |
| p.D1908N | THYM | 1 |
| p.V2992I | ACC | 1 |
| p.E4537K | SKCM | 1 |
| p.W2573C | LUAD | 1 |
| p.Y993C | HNSC | 1 |
| p.E2346K | SKCM | 1 |
| p.Q588* | UCEC | 1 |
| p.L3763R | STAD | 1 |
| p.P3787A | SKCM | 1 |
| p.Y1373* | LGG | 1 |
| p.R558X | READ | 1 |
| p.S95I | LUAD | 1 |
| p.A3587T | HNSC | 1 |
| p.Y2432C | UCEC | 1 |
| p.P2734T | ESCA | 1 |
| p.A527T | CESC | 1 |
| p.H2227Y | SKCM | 1 |
| p.K3178N | LUAD | 1 |
| p.G4206E | SKCM | 1 |
| p.T4484M | DLBC | 1 |
| p.G3116R | KICH | 1 |
| p.N2779I | HNSC | 1 |
| p.R4106K | SKCM | 1 |
| p.S553Y | UCEC | 1 |
| p.D791G | LUAD | 1 |
| p.E2041Q | CESC | 1 |
| p.K2255T | STAD | 1 |
| p.G3498R | SKCM | 1 |
| p.H1470Y | SKCM | 1 |
| p.L1570F | LUSC | 1 |
| p.A895T | STAD | 1 |
| p.L3297S | COAD | 1 |
| p.S3609T | UCEC | 1 |
| p.S2031C | LUAD | 1 |
| p.Q2173H | LUAD | 1 |
| p.D1700N | CESC | 1 |
| p.M471I | PRAD | 1 |
| p.L2604F | SKCM | 1 |
| p.L355M | SARC | 1 |
| p.W1981* | SKCM | 1 |
| p.Q2134H | LUAD | 1 |
| p.G1979V | ESCA | 1 |
| p.S1372F | SKCM | 1 |
| p.R1957M | UCEC | 1 |
| p.T3821S | BLCA | 1 |
| p.S622Y | ESCA | 1 |
| p.T2949I | SKCM | 1 |
| p.Q343H | CESC | 1 |
| p.R233C | BLCA | 1 |
| p.P1246T | SKCM | 1 |
| p.A1846S | LUAD | 1 |
| p.E2406* | LUSC | 1 |
| p.L2607V | LUSC | 1 |
| p.S1433L | UCEC | 1 |
| p.M2358I | SKCM | 1 |
| p.V3843L | LUAD | 1 |
| p.A4370V | SKCM | 1 |
| p.R2085* | HNSC | 1 |
| p.D1807N | SKCM | 1 |
| p.T98I | COAD | 1 |
| p.A3974V | STAD | 1 |
| p.A527V | STAD | 1 |
| p.V2095I | GBM | 1 |
| p.E2075V | STAD | 1 |
| p.E146K | SKCM | 1 |
| p.E2649K | STAD | 1 |
| p.A775T | SKCM | 1 |
| p.D3124G | HNSC | 1 |
| p.L1358I | LUAD | 1 |
| p.N2638T | COAD | 1 |
| p.S3592F | UCEC | 1 |
| p.A913D | PAAD | 1 |
| p.P3145L | SKCM | 1 |
| p.P582S | SKCM | 1 |
| p.G841R | SKCM | 1 |
| p.L3158F | LUAD | 1 |
| p.Q585H | READ | 1 |
| p.T1417M | UCEC | 1 |
| p.T2304A | LUSC | 1 |
| p.P2588H | PRAD | 1 |
| p.A787D | BLCA | 1 |
| p.A1878T | SKCM | 1 |
| p.I3329T | SARC | 1 |
| p.G1711R | SKCM | 1 |
| p.E1483X | READ | 1 |
| p.W3087L | LUSC | 1 |
| p.G1074E | SKCM | 1 |
| p.Q2448E | BRCA | 1 |
| p.R635W | PAAD | 1 |
| p.T3397I | COAD | 1 |
| p.W3633X | SKCM | 1 |
| p.G1074R | SKCM | 1 |
| p.A1105T | COAD | 1 |
| p.W2686* | LUSC | 1 |
| p.E4223Q | OV | 1 |
| p.G1948C | LUAD | 1 |
| p.E1171K | SKCM | 1 |
| p.Q343X | LIHC | 1 |
| p.S3036Y | READ | 1 |
| p.K2671N | HNSC | 1 |
| p.G307S | SKCM | 1 |
| p.L4348S | SARC | 1 |
| p.T4226M | COAD | 1 |
| p.R804H | GBM | 1 |
| p.A3235T | SKCM | 1 |
| p.R558Q | COAD | 1 |
| p.D4264E | LUAD | 1 |
| p.T378I | LUSC | 1 |
| p.S2956F | SKCM | 1 |
| p.L1426Q | SKCM | 1 |
| p.W2931* | LGG | 1 |
| p.Y3233C | HNSC | 1 |
| p.E3927K | SKCM | 1 |
| p.M3421I | SKCM | 1 |
| p.G3552R | GBM | 1 |
| p.L619M | UCEC | 1 |
| p.I848T | UCEC | 1 |
| p.E3788K | LUSC | 1 |
| p.E2589K | SKCM | 1 |
| p.Q1239R | UCEC | 1 |
| p.E3812Q | LGG | 1 |
| p.V879M | UCS | 1 |
| p.E3382D | LUAD | 1 |
| p.Q2268H | SKCM | 1 |
| p.L3616F | SKCM | 1 |
| p.T2941I | LUAD | 1 |
| p.L1550M | LUAD | 1 |
| p.P646S | UCEC | 1 |
| p.H3658P | LUAD | 1 |
| p.R1128C | LGG | 1 |
| p.V1859F | SARC | 1 |
| p.G2116E | SKCM | 1 |
| p.E2863K | SKCM | 1 |
| p.L2357* | ESCA | 1 |
| p.K1450N | COAD | 1 |
| p.G1735R | SKCM | 1 |
| p.E2649K | SKCM | 1 |
| p.F1176S | SKCM | 1 |
| p.R1513Q | READ | 1 |
| p.R437C | LGG | 1 |
| p.E698Q | BLCA | 1 |
| p.H1952Q | STAD | 1 |
| p.H1390N | LUSC | 1 |
| p.R3507L | KIRP | 1 |
| p.G2927W | SKCM | 1 |
| p.I2165N | ACC | 1 |
| p.S2244I | LUSC | 1 |
| p.Q4158* | SKCM | 1 |
| p.K4346E | SKCM | 1 |
| p.L268P | PRAD | 1 |
| p.R1867W | THYM | 1 |
| p.A3354G | ESCA | 1 |
| p.L873M | LUAD | 1 |
| p.G3475A | BLCA | 1 |
| p.S553F | SKCM | 1 |
| p.Y3958C | KIRP | 1 |
| p.R2219C | SKCM | 1 |
| p.Q1249P | SKCM | 1 |
| p.R2513* | LUSC | 1 |
| p.T941R | STAD | 1 |
| p.R1006K | SKCM | 1 |
| p.D3539N | SKCM | 1 |
| p.S3036Y | UCS | 1 |
| p.D2016Y | LUAD | 1 |
| p.E2868Q | LUAD | 1 |
| p.T2837M | UCEC | 1 |
| p.L3744I | UCEC | 1 |
| p.R2520X | ESCA | 1 |
| p.S1384N | COAD | 1 |
| p.D1741N | SKCM | 1 |
| p.R3952H | THYM | 1 |
| p.E1136* | PAAD | 1 |
| p.E420K | STAD | 1 |
| p.V3115I | LUAD | 1 |
| p.N4023S | SKCM | 1 |
| p.H2137D | LUAD | 1 |
| p.I3492F | BLCA | 1 |
| p.S2628L | LUAD | 1 |
| p.S3742L | SKCM | 1 |
| p.G1761V | LUAD | 1 |
| p.I2325F | BLCA | 1 |
| p.A1139T | GBM | 1 |
| p.P3803S | STAD | 1 |
| p.N2221H | CESC | 1 |
| p.D3149N | SKCM | 1 |
| p.S4233L | SKCM | 1 |
| p.S3870F | SKCM | 1 |
| p.P3614T | THYM | 1 |
| p.L4151P | STAD | 1 |
| p.R2513Q | READ | 1 |
| p.A3780D | LUSC | 1 |
| p.Q546L | LUAD | 1 |
| p.L4167F | HNSC | 1 |
| p.I1872N | BRCA | 1 |
| p.S3664F | SKCM | 1 |
| p.G1632S | SKCM | 1 |
| p.S4233L | UCS | 1 |
| p.E747Q | BLCA | 1 |
| p.L1983F | SKCM | 1 |
| p.D1722N | UCEC | 1 |
| p.L1806M | UCEC | 1 |
| p.G1462R | LUSC | 1 |
| p.L1471V | STAD | 1 |
| p.E689K | BLCA | 1 |
| p.L544I | ESCA | 1 |
| p.S1584C | LUAD | 1 |
| p.D1423N | SKCM | 1 |
| p.I4525M | PAAD | 1 |
| p.T1419S | HNSC | 1 |
| p.K2148N | BLCA | 1 |
| p.Q748K | LUAD | 1 |
| p.D1508N | GBM | 1 |
| p.K2930N | SKCM | 1 |
| p.F924C | UCEC | 1 |
| p.D1800N | SKCM | 1 |
| p.Q387P | LUAD | 1 |
| p.L2913R | CESC | 1 |
| p.L3147V | SARC | 1 |
| p.A2122D | LUAD | 1 |
| p.E2290* | LUAD | 1 |
| p.R1599H | HNSC | 1 |
| p.M4013I | SKCM | 1 |
| p.I2334S | CESC | 1 |
| p.K763E | UCEC | 1 |
| p.N2494K | BRCA | 1 |
| p.Q2765H | CESC | 1 |
| p.A4383S | LUSC | 1 |
| p.M2358L | SKCM | 1 |
| p.M1234I | SKCM | 1 |
| p.D2162Y | BRCA | 1 |
| p.K2170N | COAD | 1 |
| p.F1766L | LUAD | 1 |
| p.E3804K | STAD | 1 |
| p.S909* | LUAD | 1 |
| p.G898E | SKCM | 1 |
| p.A3075T | BRCA | 1 |
| p.N3180S | BLCA | 1 |
| p.S595F | SKCM | 1 |
| p.G3663E | SKCM | 1 |
| p.R4496T | BLCA | 1 |
| p.R2520* | ESCA | 1 |
| p.I926M | BRCA | 1 |
| p.D3022N | SKCM | 1 |
| p.Y1169C | UCEC | 1 |
| p.D2993N | STAD | 1 |
| p.V3253A | LUAD | 1 |
| p.A2606T | HNSC | 1 |
| p.G3408V | ESCA | 1 |
| p.E4387K | SKCM | 1 |
| p.A2812E | STAD | 1 |
| p.D3149Y | READ | 1 |
| p.T1906I | STAD | 1 |
| p.V2046I | THYM | 1 |
| p.E3195Q | LUSC | 1 |
| p.S3915F | SKCM | 1 |
| p.F4024L | LIHC | 1 |
| p.Q4247H | COAD | 1 |
| p.A4280V | LUAD | 1 |
| p.K1344M | LUAD | 1 |
| p.E2438K | SKCM | 1 |
| p.W3633R | STAD | 1 |
| p.E472X | STAD | 1 |
| p.Y4509X | COAD | 1 |
| p.P3747A | LUSC | 1 |
| p.A1156V | KIRP | 1 |
| p.E1692K | SKCM | 1 |
| p.S1433* | LIHC | 1 |
| p.D208N | SKCM | 1 |
| p.R4044M | LUAD | 1 |
| p.Y776* | SARC | 1 |
| p.I3696V | LGG | 1 |
| p.Q3601X | SKCM | 1 |
| p.H3021N | COAD | 1 |
| p.E1175Q | BLCA | 1 |
| p.D2038N | LUAD | 1 |
| p.D2521G | SKCM | 1 |
| p.I660T | LUAD | 1 |
| p.E2079K | BLCA | 1 |
| p.D2735H | HNSC | 1 |
| p.A3982V | ESCA | 1 |
| p.L3381S | LUAD | 1 |
| p.Q2989* | SKCM | 1 |
| p.G4118R | SKCM | 1 |
| p.D1270Y | STAD | 1 |
| p.D1070H | BRCA | 1 |
| p.R2836K | SKCM | 1 |
| p.G657V | LUAD | 1 |
| p.P994L | STAD | 1 |
| p.S296I | LUAD | 1 |
| p.D4125Y | LUAD | 1 |
| p.E1567K | SKCM | 1 |
| p.R233S | THYM | 1 |
| p.A43V | READ | 1 |
| p.D180N | SKCM | 1 |
| p.F4513C | UCEC | 1 |
| p.I1647M | SKCM | 1 |
| p.R3638Q | COAD | 1 |
| p.W3633* | SKCM | 1 |
| p.H4092Q | LUAD | 1 |
| p.R3212T | CESC | 1 |
| p.G781E | SKCM | 1 |
| p.D4014N | SKCM | 1 |
| p.P2033S | BRCA | 1 |
| p.Q4372E | BLCA | 1 |
| p.Q3199H | CESC | 1 |
| p.P3129L | UCEC | 1 |
| p.D4457N | SKCM | 1 |
| p.L1353P | COAD | 1 |
| p.T2955A | HNSC | 1 |
| p.P554L | CESC | 1 |
| p.E1674D | LUAD | 1 |
| p.H1214Y | SKCM | 1 |
| p.G2302E | SKCM | 1 |
| p.L1527H | OV | 1 |
| p.N2166T | ESCA | 1 |
| p.P4254S | SKCM | 1 |
| p.E3767K | LUAD | 1 |
| p.E951Q | BRCA | 1 |
| p.E3016* | THCA | 1 |
| p.L12P | KIRP | 1 |
| p.L2968I | ACC | 1 |
| p.K3724R | LIHC | 1 |
| p.P4004Q | STAD | 1 |
| p.A651V | LUSC | 1 |
| p.F4130C | COAD | 1 |
| p.K4087N | LUSC | 1 |
| p.T1032S | DLBC | 1 |
| p.I2185L | SKCM | 1 |
| p.R1210T | STAD | 1 |
| p.S570A | STAD | 1 |
| p.L4452H | UCEC | 1 |
| p.M901I | SKCM | 1 |
| p.A111T | SKCM | 1 |
| p.S1844F | STAD | 1 |
| p.R4385H | COAD | 1 |
| p.K654X | SKCM | 1 |
| p.R3136H | STAD | 1 |
| p.S1493F | SKCM | 1 |
| p.A3354V | SKCM | 1 |
| p.K1635N | STAD | 1 |
| p.V4080D | UCEC | 1 |
| p.T3047M | SKCM | 1 |
| p.E339* | GBM | 1 |
| p.F711L | UCEC | 1 |
| p.E2909D | LUAD | 1 |
| p.A200S | STAD | 1 |
| p.V3789I | SKCM | 1 |
| p.V4416L | LUAD | 1 |
| p.K2195T | PRAD | 1 |
| p.D3907N | BLCA | 1 |
| p.A4467S | UCEC | 1 |
| p.E1863Q | HNSC | 1 |
| p.S1433L | SKCM | 1 |
| p.A448V | UCEC | 1 |
| p.N868K | LUAD | 1 |
| p.Q4230K | LUAD | 1 |
| p.K3501N | COAD | 1 |
| p.R4177Q | SKCM | 1 |
| p.E3590Q | ESCA | 1 |
| p.D629N | SKCM | 1 |
| p.D4018N | SKCM | 1 |
| p.S3282N | SKCM | 1 |
| p.F3779L | SARC | 1 |
| p.A1105S | LUAD | 1 |
| p.Y3509D | UCEC | 1 |
| p.F1591I | HNSC | 1 |
| p.D2993H | BLCA | 1 |
| p.F2633L | UCEC | 1 |
| p.R1897H | READ | 1 |
| p.L3009Q | LGG | 1 |
| p.E3303* | LUSC | 1 |
| p.K4553N | HNSC | 1 |
| p.H1693N | LUAD | 1 |
| p.D2431G | GBM | 1 |
| p.E331K | LUAD | 1 |
| p.E2851K | SKCM | 1 |
| p.P1194H | LGG | 1 |
| p.A4286T | SKCM | 1 |
| p.I4266M | OV | 1 |
| p.R2712S | HNSC | 1 |
| p.M3267L | LIHC | 1 |
| p.R3527W | COAD | 1 |
| p.P3133S | LGG | 1 |
| p.G1108D | LUSC | 1 |
| p.S1546P | LUAD | 1 |
| p.H2737N | UCEC | 1 |
| p.G3116E | SKCM | 1 |
| p.R1333X | READ | 1 |
| p.R1815L | LUAD | 1 |
| p.G3105A | BLCA | 1 |
| p.M628L | COAD | 1 |
| p.Q4149* | SKCM | 1 |
| p.Q2742* | SKCM | 1 |
| p.Q1038* | BRCA | 1 |
| p.E2349K | SKCM | 1 |
| p.E4061K | HNSC | 1 |
| p.Q2455* | HNSC | 1 |
| p.R4201I | ESCA | 1 |
| p.G2979C | ACC | 1 |
| p.E1040K | CESC | 1 |
| p.V3751A | STAD | 1 |
| p.S1621Y | LUAD | 1 |
| p.Q3088X | ESCA | 1 |
| p.M522I | CESC | 1 |
| p.D1472Y | LUAD | 1 |
| p.N2221H | LUAD | 1 |
| p.R3989H | STAD | 1 |
| p.A980V | HNSC | 1 |
| p.H737L | STAD | 1 |
| p.K4087M | READ | 1 |
| p.E3160K | SKCM | 1 |
| p.P1274L | SKCM | 1 |
| p.A2610T | SKCM | 1 |
| p.K3097M | THYM | 1 |
| p.T2010I | COAD | 1 |
| p.S1125F | SKCM | 1 |
| p.P3318Q | LUAD | 1 |
| p.E4279* | UCEC | 1 |
| p.I754M | SKCM | 1 |
| p.K3057I | SKCM | 1 |
| p.T1924N | LUAD | 1 |
| p.S1618L | SKCM | 1 |
| p.E3355K | ESCA | 1 |
| p.E3937K | LUAD | 1 |
| p.I848L | HNSC | 1 |
| p.G3287S | SKCM | 1 |
| p.Y1501C | LIHC | 1 |
| p.R1078T | TGCT | 1 |
| p.D4083N | SKCM | 1 |
| p.G2302V | STAD | 1 |
| p.E1991K | SKCM | 1 |
| p.I1630M | BLCA | 1 |
| p.K3314R | SKCM | 1 |
| p.G2925V | LUAD | 1 |
| p.Q2880* | HNSC | 1 |
| p.G841E | SARC | 1 |
| Top |
| TissGeneCNV for APOB |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for APOB |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BG562874 | APOB-ALB | chr2:21228146 | chr4:74279174 | |
| Chimerdb3.0 | ChiTaRs | NA | BX091114 | APOB-SLBP | chr2:21262094 | chr4:1699179 | |
| Chimerdb3.0 | ChiTaRs | NA | AI052800 | SUPT6H-APOB | chr17:27029248 | chr2:21234785 | |
| Chimerdb3.0 | ChiTaRs | NA | AF119905 | MALAT1-APOB | chr11:65270612 | chr2:21228718 | |
| Chimerdb3.0 | ChiTaRs | NA | BP238983 | DDX19B-APOB | chr16:70406156 | chr2:21226053 | |
| Chimerdb3.0 | TopHat-Fusion | CHOL | TCGA-W5-AA34-11A | APOB-ALB | 3'UTR-CDS | chr2:21224340 | chr4:74280795 |
| Chimerdb3.0 | TopHat-Fusion | CHOL | TCGA-W5-AA30-11A | APOB-ALB | Out-of-Frame | chr2:21224898 | chr4:74285314 |
| Chimerdb3.0 | TopHat-Fusion | CHOL | TCGA-ZU-A8S4-11A | APOB-ALB | Out-of-Frame | chr2:21233781 | chr4:74285332 |
| Top |
| TissGeneNet for APOB |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| APOB, TFAP2A, CTCF, LGALS3, ARFGAP1, CEBPA, HSP90AA1, CALR, AKT2, HNF1A, FOXA1, HSPA5, PDIA4, PPIB, NR2F6, MTTP, PLIN2, LRP2, SEC61A1, SEC61A2, DERL1 (tumor) | APOB, HNF4A, SMAD3, SP1, SUMO2, HSP90B1, VCP, LGALS3, ARFGAP1, CEBPA, HSP90AA1, HSPA1A, CALR, CALCR, NR2F1, PDIA4, LIPC, NR2F6, BGN, PLIN2, SEC61B (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| APOB, SMAD3, UBC, PRDX4, HSP90B1, RAD21, CALR, HNF1A, FOXA1, HSPA5, SYVN1, PDIA4, APOA1, NR2F2, PPIB, MTTP, BGN, PLIN2, LRP6, SEC61B, DERL1 (tumor) | APOB, SMAD3, SUMO2, HSP90B1, HSPA8, LGALS3, ARFGAP1, HSP90AA1, UCHL5, CALR, AKT2, HSPA5, NR2F1, PDIA4, LIPC, APOA1, NR2F2, MTTP, BGN, LRP2, LRP6 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| APOB, TFAP2A, SMAD3, UBC, SUMO2, LGALS3, PITX3, CALR, AKT2, FOXA1, HSPA5, CALCR, NR2F1, APOA1, NR2F2, NR2F6, MTTP, BGN, PLIN2, LRP6, SEC61A2 (tumor) | APOB, HNF4A, TFAP2A, UBC, SUMO2, HSP90B1, HSPA8, CTCF, PITX3, RAD21, CALCR, NR2F1, APOA1, NR2F2, ZNF148, NR2F6, BGN, PLIN2, LRP2, LRP6, SEC61B (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| APOB, HNF4A, TFAP2A, SUMO2, VCP, HSPA8, CTCF, PITX3, CEBPA, HSP90AA1, AKT2, HNF1A, CANX, CALCR, PDIA4, APOA1, NR2F6, MTTP, PLIN2, LRP2, SEC61A2 (tumor) | APOB, HNF4A, SMAD3, SUMO2, HSP90B1, VCP, HSPA8, CTCF, FAF2, LGALS3, ARFGAP1, HSP90AA1, CANX, CALCR, LIPC, ZNF148, NFIC, LRP2, SEC61A1, SEC61A2, SEC61B (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| APOB, HNF4A, SMAD3, SUMO2, HSP90B1, FAF2, PITX3, CEBPA, UCHL5, HSPA1A, AKT2, HNF1A, CANX, CALCR, PDIA4, APOA1, NR2F2, MTTP, PLIN2, LRP2, SEC61A2 (tumor) | APOB, HNF4A, UBC, SP1, PRDX4, HSP90B1, FAF2, CEBPA, HSP90AA1, CALR, AKT2, HNF1A, CANX, PDIA4, APOA1, MTTP, PLIN2, LRP2, SEC61A1, LDLR, DERL1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| APOB, HNF4A, TFAP2A, UBC, SUMO2, PRDX4, HSPA8, PITX3, CEBPA, HSP90AA1, AKT2, HNF1A, CANX, CALCR, NR2F1, APOA1, MTTP, PLIN2, LRP2, SEC61A2, DERL1 (tumor) | APOB, HNF4A, TFAP2A, SMAD3, SUMO2, PRDX4, VCP, HSPA8, CEBPA, RAD21, CALR, AKT2, HNF1A, CANX, APOA1, NR2F2, MTTP, BGN, PLIN2, LRP2, SEC61A2 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| APOB, HNF4A, SUMO2, CTCF, FAF2, LGALS3, ARFGAP1, RAD21, UCHL5, FOXA1, CANX, SYVN1, PDIA4, ZNF148, MTTP, NFIC, LRP2, LRP6, SEC61A2, SEC61B, DERL1 (tumor) | APOB, HNF4A, TFAP2A, SUMO2, LGALS3, ARFGAP1, PITX3, CEBPA, UCHL5, HNF1A, FOXA1, CANX, SYVN1, LIPC, APOA1, NR2F6, MTTP, NFIC, PLIN2, LRP6, LDLR (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| APOB, TFAP2A, SMAD3, SP1, SUMO2, PRDX4, HSPA8, CTCF, LGALS3, PITX3, CEBPA, CALR, HNF1A, NR2F1, NR2F2, PPIB, BGN, NFIC, LRP6, SEC61B, DERL1 (tumor) | APOB, HNF4A, UBC, SP1, SUMO2, PRDX4, HSP90AA1, CALR, HNF1A, FOXA1, CALCR, NR2F1, LIPC, APOA1, NR2F2, NR2F6, MTTP, BGN, LRP2, LRP6, SEC61B (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| APOB, HNF4A, SP1, SUMO2, PRDX4, VCP, HSPA8, CTCF, FAF2, LGALS3, AKT2, NR2F1, SYVN1, PDIA4, NR2F2, BGN, NFIC, LRP6, SEC61A1, SEC61A2, SEC61B (tumor) | APOB, HNF4A, TFAP2A, SMAD3, SUMO2, HSP90AA1, UCHL5, HSPA1A, HNF1A, CALCR, NR2F1, SYVN1, LIPC, APOA1, NR2F2, PPIB, MTTP, BGN, PLIN2, LRP2, SEC61A2 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| APOB, SP1, SUMO2, HSPA8, FAF2, LGALS3, CEBPA, HSP90AA1, HSPA1A, CALR, HSPA5, NR2F1, PDIA4, LIPC, NR2F2, ZNF148, PPIB, BGN, NFIC, LRP6, SEC61B (tumor) | APOB, SMAD3, SP1, PRDX4, LGALS3, ARFGAP1, CALR, FOXA1, CALCR, NR2F1, LIPC, APOA1, NR2F2, ZNF148, PPIB, NR2F6, MTTP, PLIN2, LRP6, SEC61A1, SEC61B (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| APOB, HNF4A, SMAD3, SUMO2, HSP90B1, HSPA8, LGALS3, ARFGAP1, CEBPA, RAD21, AKT2, HNF1A, HSPA5, PDIA4, LIPC, APOA1, NR2F6, MTTP, NFIC, PLIN2, SEC61A2 (tumor) | APOB, HNF4A, TFAP2A, SMAD3, SUMO2, PRDX4, HSP90B1, CEBPA, UCHL5, HNF1A, CALCR, NR2F1, LIPC, APOA1, NR2F2, MTTP, PLIN2, LRP2, LRP6, LDLR, DERL1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| APOB, HNF4A, SMAD3, SP1, SUMO2, PRDX4, CTCF, FAF2, RAD21, FOXA1, NR2F1, NR2F2, ZNF148, PPIB, MTTP, BGN, NFIC, LRP2, LRP6, SEC61B, DERL1 (tumor) | APOB, HNF4A, SMAD3, HSP90B1, LGALS3, PITX3, CEBPA, HSP90AA1, CALR, AKT2, HNF1A, FOXA1, HSPA5, CANX, SYVN1, PDIA4, NR2F2, PLIN2, LDLR, SEC61B, DERL1 (normal) |
 |  |
| Top |
| TissGeneProg for APOB |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for APOB |
| TissGeneDrug for APOB |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for APOB |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0020445 | Hypercholesterolemia, Familial | 139 | BeFree,CLINVAR,CTD_human,GAD,LHGDN |
| umls:C0010068 | Coronary heart disease | 90 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0020597 | Hypobetalipoproteinemias | 82 | BeFree,CLINVAR,GAD,LHGDN |
| umls:C0010054 | Coronary Arteriosclerosis | 78 | BeFree,GAD |
| umls:C0020443 | Hypercholesterolemia | 67 | BeFree,CTD_human,GAD,LHGDN,RGD |
| umls:C1956346 | Coronary Artery Disease | 64 | BeFree,GAD,LHGDN |
| umls:C0004153 | Atherosclerosis | 61 | BeFree,GAD,LHGDN |
| umls:C1862596 | Familial hypobetalipoproteinemia | 60 | BeFree,CLINVAR,UNIPROT |
| umls:C0003850 | Arteriosclerosis | 56 | BeFree |
| umls:C1704417 | Hyperlipoproteinemia Type IIb | 38 | BeFree,CLINVAR,UNIPROT |
| umls:C0007222 | Cardiovascular Diseases | 31 | BeFree,CTD_human,GAD,GWASCAT |
| umls:C0020474 | Hyperlipidemia, Familial Combined | 31 | BeFree,GAD,LHGDN |
| umls:C0000744 | Abetalipoproteinemia | 27 | BeFree,LHGDN |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 27 | BeFree,GAD |
| umls:C0027051 | Myocardial Infarction | 27 | BeFree,GAD,LHGDN |
| umls:C0028754 | Obesity | 27 | BeFree,GAD |
| umls:C0745103 | Hyperlipoproteinemia Type IIa | 25 | BeFree |
| umls:C0242339 | Dyslipidemias | 22 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0020473 | Hyperlipidemia | 21 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0015695 | Fatty Liver | 19 | BeFree,CTD_human,RGD |
| umls:C2239176 | Liver carcinoma | 17 | BeFree |
| umls:C0023903 | Liver neoplasms | 15 | BeFree |
| umls:C0020538 | Hypertensive disease | 13 | BeFree,GAD |
| umls:C0524620 | Metabolic Syndrome X | 13 | BeFree,GAD,GWASCAT |
| umls:C0019693 | HIV Infections | 12 | BeFree |
| umls:C0151744 | Myocardial Ischemia | 11 | BeFree,GAD,LHGDN |
| umls:C0008350 | Cholelithiasis | 9 | BeFree,GAD |
| umls:C0019196 | Hepatitis C | 8 | BeFree |
| umls:C0947622 | Cholecystolithiasis | 8 | BeFree,GAD |
| umls:C0018799 | Heart Diseases | 7 | BeFree,GAD |
| umls:C0038454 | Cerebrovascular accident | 7 | BeFree,GAD,LHGDN |
| umls:C0085096 | Peripheral Vascular Diseases | 7 | BeFree,GAD |
| umls:C0154251 | Lipid Metabolism Disorders | 7 | BeFree |
| umls:C0577631 | Carotid Atherosclerosis | 7 | BeFree,GAD |
| umls:C0011849 | Diabetes Mellitus | 6 | BeFree |
| umls:C0019163 | Hepatitis B | 6 | BeFree |
| umls:C0042373 | Vascular Diseases | 6 | BeFree,GAD |
| umls:C0242383 | Age related macular degeneration | 6 | BeFree,GAD |
| umls:C1704436 | Peripheral Arterial Diseases | 6 | BeFree,GAD |
| umls:C0020479 | Hyperlipoproteinemia Type III | 5 | BeFree |
| umls:C0524910 | Hepatitis C, Chronic | 5 | BeFree,GAD |
| umls:C0948008 | Ischemic stroke | 5 | BeFree |
| umls:C0011847 | Diabetes | 4 | BeFree |
| umls:C0020557 | Hypertriglyceridemia | 4 | CTD_human,GAD |
| umls:C0153452 | Malignant neoplasm of gallbladder | 4 | BeFree,GAD |
| umls:C0311277 | Obesity, Abdominal | 4 | BeFree |
| umls:C0497406 | Overweight | 4 | BeFree |
| umls:C0856727 | Cholesterol gallstones | 4 | BeFree |
| umls:C1522137 | Hypertriglyceridemia result | 4 | GAD |
| umls:C1704299 | Hypobetalipoproteinemia, Familial, Apolipoprotein B | 4 | BeFree,CTD_human |
| umls:C2711227 | Steatohepatitis | 4 | BeFree |
| umls:C2936179 | Obesity, Visceral | 4 | BeFree |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 4 | BeFree |
| umls:C0002895 | Anemia, Sickle Cell | 3 | BeFree,GAD |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 3 | GAD |
| umls:C0007273 | Carotid Artery Diseases | 3 | GAD,LHGDN |
| umls:C0016977 | Gall Bladder Diseases | 3 | BeFree,GAD,LHGDN |
| umls:C0022116 | Ischemia | 3 | BeFree,GAD |
| umls:C0023890 | Liver Cirrhosis | 3 | BeFree |
| umls:C0024523 | Malabsorption Syndrome | 3 | BeFree |
| umls:C0027726 | Nephrotic Syndrome | 3 | BeFree,GAD |
| umls:C0039292 | Tangier Disease | 3 | BeFree |
| umls:C0042769 | Virus Diseases | 3 | BeFree |
| umls:C0235782 | Gallbladder Carcinoma | 3 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 2 | GAD |
| umls:C0003507 | Aortic Valve Stenosis | 2 | BeFree,LHGDN |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0007785 | Cerebral Infarction | 2 | BeFree,GAD |
| umls:C0015814 | Femur Head Necrosis | 2 | GAD |
| umls:C0020456 | Hyperglycemia | 2 | BeFree |
| umls:C0020459 | Hyperinsulinism | 2 | BeFree |
| umls:C0020480 | Hyperlipoproteinemia Type IV | 2 | BeFree |
| umls:C0021364 | Male infertility | 2 | BeFree,LHGDN |
| umls:C0021390 | Inflammatory Bowel Diseases | 2 | GAD |
| umls:C0021655 | Insulin Resistance | 2 | GAD |
| umls:C0022661 | Kidney Failure, Chronic | 2 | BeFree,LHGDN |
| umls:C0031117 | Peripheral Neuropathy | 2 | BeFree,CTD_human |
| umls:C0033860 | Psoriasis | 2 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 2 | GAD |
| umls:C0040053 | Thrombosis | 2 | GAD |
| umls:C0085580 | Essential Hypertension | 2 | BeFree |
| umls:C0155210 | Eyelid Xanthoma | 2 | BeFree |
| umls:C0155626 | Acute myocardial infarction | 2 | BeFree |
| umls:C0155668 | Old myocardial infarction | 2 | BeFree |
| umls:C0242231 | Coronary Stenosis | 2 | BeFree,GAD |
| umls:C0271650 | Impaired glucose tolerance | 2 | BeFree |
| umls:C0302314 | Xanthoma | 2 | BeFree |
| umls:C0400966 | Non-alcoholic Fatty Liver Disease | 2 | BeFree |
| umls:C0497327 | Dementia | 2 | BeFree,GAD |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C0948089 | Acute Coronary Syndrome | 2 | GAD,LHGDN |
| umls:C1272641 | Systemic arterial pressure | 2 | GAD |
| umls:C1623038 | Cirrhosis | 2 | BeFree |
| umls:C1863512 | HYPERCHOLESTEROLEMIA, AUTOSOMAL RECESSIVE | 2 | BeFree |
| umls:C2937358 | Cerebral Hemorrhage | 2 | GAD,LHGDN |
| umls:C3714514 | Infection | 2 | LHGDN |
| umls:C3714619 | Insulin resistance syndrome | 2 | BeFree |
| umls:C0000786 | Spontaneous abortion | 1 | GAD |
| umls:C0001486 | Adenovirus Infections | 1 | BeFree |
| umls:C0002351 | Altitude Sickness | 1 | GAD |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | GAD |
| umls:C0003076 | Aniridia | 1 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
| umls:C0004134 | Ataxia | 1 | BeFree |
| umls:C0004509 | Azoospermia | 1 | GAD |
| umls:C0004943 | Behcet Syndrome | 1 | CTD_human |
| umls:C0005283 | beta Thalassemia | 1 | GAD |
| umls:C0005396 | Bile Duct Neoplasms | 1 | LHGDN |
| umls:C0005426 | Biliary Tract Neoplasm | 1 | GAD |
| umls:C0005586 | Bipolar Disorder | 1 | BeFree |
| umls:C0006370 | Bulimia | 1 | BeFree |
| umls:C0006663 | Calcinosis | 1 | GAD |
| umls:C0007282 | Carotid Stenosis | 1 | BeFree |
| umls:C0007570 | Celiac Disease | 1 | BeFree |
| umls:C0007786 | Brain Ischemia | 1 | GAD |
| umls:C0008354 | Cholera | 1 | BeFree |
| umls:C0008495 | Chorioamnionitis | 1 | GAD |
| umls:C0008626 | Congenital chromosomal disease | 1 | GAD |
| umls:C0008732 | Chylous Ascites | 1 | BeFree |
| umls:C0011265 | Presenile dementia | 1 | BeFree |
| umls:C0011269 | Dementia, Vascular | 1 | BeFree |
| umls:C0011570 | Mental Depression | 1 | GAD |
| umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
| umls:C0011875 | Diabetic Angiopathies | 1 | GAD |
| umls:C0011881 | Diabetic Nephropathy | 1 | LHGDN |
| umls:C0011882 | Diabetic Neuropathies | 1 | GAD |
| umls:C0015934 | Fetal Growth Retardation | 1 | GAD |
| umls:C0015944 | Fetal Membranes, Premature Rupture | 1 | GAD |
| umls:C0016978 | gallbladder neoplasm | 1 | LHGDN |
| umls:C0017920 | Glycogen Storage Disease Type I | 1 | BeFree |
| umls:C0020217 | Hydatidiform Mole | 1 | BeFree |
| umls:C0020550 | Hyperthyroidism | 1 | BeFree |
| umls:C0020676 | Hypothyroidism | 1 | BeFree |
| umls:C0021368 | Inflammation | 1 | GAD |
| umls:C0022658 | Kidney Diseases | 1 | BeFree |
| umls:C0022876 | Premature Obstetric Labor | 1 | GAD |
| umls:C0023195 | Lecithin Acyltransferase Deficiency | 1 | BeFree |
| umls:C0023646 | Lichen Planus | 1 | BeFree |
| umls:C0023817 | Hyperlipoproteinemia Type I | 1 | BeFree |
| umls:C0023891 | Liver Cirrhosis, Alcoholic | 1 | BeFree |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | GAD |
| umls:C0027831 | Neurofibromatosis 1 | 1 | LHGDN |
| umls:C0028960 | Oligospermia | 1 | GAD |
| umls:C0029445 | Bone necrosis | 1 | GAD |
| umls:C0032002 | Pituitary Diseases | 1 | BeFree |
| umls:C0032460 | Polycystic Ovary Syndrome | 1 | BeFree |
| umls:C0032461 | Polycythemia | 1 | BeFree |
| umls:C0032787 | Postoperative Complications | 1 | GAD |
| umls:C0032914 | Pre-Eclampsia | 1 | GAD |
| umls:C0035334 | Retinitis Pigmentosa | 1 | BeFree |
| umls:C0035528 | Riboflavin Deficiency | 1 | LHGDN |
| umls:C0036341 | Schizophrenia | 1 | GAD |
| umls:C0037917 | Spina Bifida Cystica | 1 | GAD,LHGDN |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0040715 | Chromosomal translocation | 1 | GAD |
| umls:C0042755 | Virilism | 1 | GAD |
| umls:C0079541 | Holoprosencephaly | 1 | GAD |
| umls:C0079680 | Lentivirus Infections | 1 | BeFree |
| umls:C0149721 | Left Ventricular Hypertrophy | 1 | GAD |
| umls:C0151526 | Premature Birth | 1 | GAD |
| umls:C0155733 | Atherosclerosis of aorta | 1 | BeFree |
| umls:C0155765 | Disease of capillaries | 1 | BeFree |
| umls:C0238062 | Chronic intestinal pseudo-obstruction | 1 | BeFree |
| umls:C0238286 | Mucolipidosis Type IV | 1 | BeFree |
| umls:C0239549 | Fat intolerance | 1 | BeFree |
| umls:C0242084 | Ruptured cerebral aneurysm | 1 | BeFree |
| umls:C0242216 | Biliary calculi | 1 | LHGDN |
| umls:C0242350 | Erectile dysfunction | 1 | GAD |
| umls:C0259771 | Steatocystoma multiplex | 1 | BeFree |
| umls:C0270736 | Essential Tremor | 1 | BeFree,GAD |
| umls:C0271980 | beta^0^ Thalassemia | 1 | BeFree |
| umls:C0333186 | Restenosis | 1 | GAD |
| umls:C0333463 | Senile Plaques | 1 | BeFree |
| umls:C0342257 | Complications of Diabetes Mellitus | 1 | GAD |
| umls:C0342883 | Cholesteryl Ester Transfer Protein Deficiency | 1 | BeFree |
| umls:C0376286 | Avitaminosis | 1 | BeFree |
| umls:C0376618 | Endotoxemia | 1 | RGD |
| umls:C0403823 | Asthenozoospermia | 1 | GAD |
| umls:C0678213 | Complete hydatidiform mole | 1 | BeFree |
| umls:C0687150 | Parathyroid Gland Adenocarcinoma | 1 | BeFree |
| umls:C0687751 | Acanthocytosis | 1 | BeFree |
| umls:C0740277 | Bile duct carcinoma | 1 | BeFree |
| umls:C0752308 | Hypoxia-Ischemia, Brain | 1 | GAD |
| umls:C0795956 | Chylomicron retention disease | 1 | BeFree |
| umls:C0852077 | Blood Coagulation Disorders, Inherited | 1 | GAD |
| umls:C0856738 | Triple vessel disease | 1 | BeFree |
| umls:C0878544 | Cardiomyopathies | 1 | BeFree |
| umls:C1096293 | Macroangiopathy | 1 | BeFree |
| umls:C1260959 | Drusen | 1 | BeFree |
| umls:C1271104 | Blood pressure finding | 1 | GAD |
| umls:C1318973 | Staphylococcus aureus infection | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
| umls:C1510471 | Vitamin Deficiency | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | GAD |
| umls:C1561643 | Chronic Kidney Diseases | 1 | BeFree |
| umls:C1704429 | Hypoalphalipoproteinemia, Familial | 1 | BeFree |
| umls:C1720505 | Adult growth hormone deficiency | 1 | BeFree |
| umls:C1842372 | ASPIRIN RESISTANCE | 1 | GAD |
| umls:C1848533 | Ataxia with vitamin E deficiency | 1 | CTD_human |
| umls:C1861172 | Venous Thromboembolism | 1 | GAD |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | GAD |
| umls:C2316810 | Chronic kidney disease stage 5 | 1 | BeFree |
| umls:C2718067 | Alcoholic Steatohepatitis | 1 | BeFree |
| umls:C2919032 | Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 1 | GAD |
| umls:C2919414 | Low density lipoprotein receptor mutation | 1 | BeFree |
| umls:C2919796 | Glycogen storage disease type Ia | 1 | BeFree |
| umls:C2921106 | Recurrent pregnancy loss | 1 | GAD |
| umls:C2936349 | Plaque, Amyloid | 1 | BeFree |
| umls:C3149462 | HYPERALPHALIPOPROTEINEMIA 1 | 1 | BeFree |
| umls:C3151466 | HEPATIC LIPASE DEFICIENCY (disorder) | 1 | BeFree |
| umls:C3463897 | HYDATIDIFORM MOLE, RECURRENT, 1 | 1 | BeFree |
| umls:C3542024 | AORTIC VALVE DISEASE 2 | 1 | BeFree |
| umls:C1857970 | Hypobetalipoproteinemia, Familial, 2 | 0 | MGD |
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