TissGeneSummary for NLRP10 |
Gene summary |
Basic gene information | Gene symbol | NLRP10 |
Gene name | NLR family, pyrin domain containing 10 | |
Synonyms | CLR11.1|NALP10|NOD8|PAN5|PYNOD | |
Cytomap | UCSC genome browser: 11p15.4 | |
Type of gene | protein-coding | |
RefGenes | NM_176821.3, | |
Description | NACHT, LRR and PYD domains-containing protein 10NACHT, leucine rich repeat and PYD containing 10nucleotide-binding oligomerization domain protein 8nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10 | |
Modification date | 20141207 | |
dbXrefs | MIM : 609662 | |
HGNC : HGNC | ||
Ensembl : ENSG00000182261 | ||
HPRD : 14802 | ||
Vega : OTTHUMG00000165673 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NLRP10 | |
BioGPS: 338322 | ||
Pathway | NCI Pathway Interaction Database: NLRP10 | |
KEGG: NLRP10 | ||
REACTOME: NLRP10 | ||
Pathway Commons: NLRP10 | ||
Context | iHOP: NLRP10 | |
ligand binding site mutation search in PubMed: NLRP10 | ||
UCL Cancer Institute: NLRP10 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
Reference showing the relevant tissue of NLRP10 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for NLRP10 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -0.571374641 | -1.803153073 | 1.231778431 | 1.50E-07 | 4.15E-07 |
HNSC | 1.329188423 | -0.978230182 | 2.307418605 | 1.40E-07 | 1.32E-06 |
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TissGene-miRNA for NLRP10 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for NLRP10 |
TissGeneSNV for NLRP10 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.H474Y | SKCM | 4 |
p.P354S | SKCM | 4 |
p.E648K | SKCM | 4 |
p.G440S | SKCM | 2 |
p.V389I | UCEC | 2 |
p.E114K | SKCM | 2 |
p.A183T | UCEC | 2 |
p.T36I | SKCM | 2 |
p.K594N | UCEC | 2 |
p.S477F | SKCM | 2 |
p.E403K | SKCM | 2 |
p.E637K | SKCM | 2 |
p.E593K | SKCM | 2 |
p.E490K | SKCM | 1 |
p.R107H | UCS | 1 |
p.D396Y | LUAD | 1 |
p.Q145H | SKCM | 1 |
p.A321V | STAD | 1 |
p.A431V | SKCM | 1 |
p.L416I | HNSC | 1 |
p.R33W | STAD | 1 |
p.C357F | COAD | 1 |
p.R408W | LIHC | 1 |
p.M552I | SKCM | 1 |
p.S167Y | ESCA | 1 |
p.G250V | LUAD | 1 |
p.P162L | SKCM | 1 |
p.D330Y | BRCA | 1 |
p.M555I | SKCM | 1 |
p.P539L | SKCM | 1 |
p.D157N | SKCM | 1 |
p.S603Y | UCEC | 1 |
p.Q484K | STAD | 1 |
p.E111K | SKCM | 1 |
p.Y205H | READ | 1 |
p.G250D | BLCA | 1 |
p.E160K | SKCM | 1 |
p.S18I | LUAD | 1 |
p.P130L | LUAD | 1 |
p.L164M | LUAD | 1 |
p.C618* | PAAD | 1 |
p.N582K | LUAD | 1 |
p.R492C | PRAD | 1 |
p.L37P | THYM | 1 |
p.P269H | ACC | 1 |
p.A350E | LUAD | 1 |
p.E509* | LUSC | 1 |
p.L347I | PAAD | 1 |
p.R406W | COAD | 1 |
p.E114G | UCEC | 1 |
p.A457V | BLCA | 1 |
p.L608F | BLCA | 1 |
p.R279W | LUAD | 1 |
p.K628E | LIHC | 1 |
p.K573N | UCEC | 1 |
p.G66R | SKCM | 1 |
p.R265S | LUAD | 1 |
p.L223F | HNSC | 1 |
p.V206E | LUAD | 1 |
p.R293Q | STAD | 1 |
p.S477C | LUSC | 1 |
p.E85K | SKCM | 1 |
p.T36I | LUSC | 1 |
p.K264N | LUAD | 1 |
p.T513I | UCEC | 1 |
p.G228R | UCS | 1 |
p.E500G | LUAD | 1 |
p.R293W | CESC | 1 |
p.A350V | COAD | 1 |
p.L109P | STAD | 1 |
p.A175T | THYM | 1 |
p.L28V | SKCM | 1 |
p.T329M | HNSC | 1 |
p.L289F | SKCM | 1 |
p.S639P | PAAD | 1 |
p.G159V | LUSC | 1 |
p.K261Q | KIRP | 1 |
p.T329M | STAD | 1 |
p.P539H | OV | 1 |
p.S606N | LGG | 1 |
p.E647Q | BLCA | 1 |
p.F446S | DLBC | 1 |
p.M81I | SKCM | 1 |
p.R243Q | KICH | 1 |
p.C401* | LUAD | 1 |
p.E48K | SKCM | 1 |
p.R99K | SKCM | 1 |
p.R336H | COAD | 1 |
p.S63L | SKCM | 1 |
p.E503D | BLCA | 1 |
p.Q367H | LUSC | 1 |
p.R465S | OV | 1 |
p.E144K | SKCM | 1 |
p.G641E | SKCM | 1 |
p.Q580K | LUAD | 1 |
p.P166A | STAD | 1 |
p.P539S | SKCM | 1 |
p.L304M | LUAD | 1 |
p.T181A | CESC | 1 |
p.L447V | LUAD | 1 |
p.E48K | OV | 1 |
p.E260* | UCEC | 1 |
p.S381N | UCEC | 1 |
p.S554F | SKCM | 1 |
p.Q551H | BLCA | 1 |
p.E482K | SKCM | 1 |
p.G355D | UCEC | 1 |
p.Y98H | COAD | 1 |
p.D544N | SKCM | 1 |
p.N450K | SARC | 1 |
p.Y462* | LUAD | 1 |
p.A457D | ESCA | 1 |
p.K502N | COAD | 1 |
p.S463R | LUAD | 1 |
p.E550* | UCEC | 1 |
p.S134N | SKCM | 1 |
p.G77D | UCS | 1 |
p.L126V | LUAD | 1 |
p.S415F | SKCM | 1 |
p.V74F | COAD | 1 |
p.Y121C | HNSC | 1 |
p.L416P | LUSC | 1 |
p.G399R | SKCM | 1 |
p.D629Y | UCEC | 1 |
p.M386T | LUAD | 1 |
p.S554Y | READ | 1 |
p.A154T | UCS | 1 |
p.F25S | COAD | 1 |
p.S566F | SKCM | 1 |
p.V106M | CESC | 1 |
p.G645E | SKCM | 1 |
p.L83M | OV | 1 |
p.R465H | COAD | 1 |
p.L289P | SARC | 1 |
p.S606T | SKCM | 1 |
p.M81R | SKCM | 1 |
p.E593* | SKCM | 1 |
p.L454V | KIRC | 1 |
p.A387S | LUAD | 1 |
p.R406Q | SKCM | 1 |
p.E369K | SKCM | 1 |
p.E550* | LUAD | 1 |
p.E22K | SKCM | 1 |
p.E100D | UCS | 1 |
p.E376D | PRAD | 1 |
p.T235K | LUAD | 1 |
p.T646R | LUAD | 1 |
p.P130T | LUAD | 1 |
p.G193S | LUAD | 1 |
p.S326F | BLCA | 1 |
p.V480M | SKCM | 1 |
p.E301G | LUAD | 1 |
p.E626K | SKCM | 1 |
p.S174L | BRCA | 1 |
p.R103Q | UCEC | 1 |
p.T151M | STAD | 1 |
p.M552K | LUAD | 1 |
p.S174L | PRAD | 1 |
p.S149F | LUAD | 1 |
p.D544V | SKCM | 1 |
p.D396N | STAD | 1 |
p.G77D | SKCM | 1 |
p.D451N | UCEC | 1 |
p.R320M | LGG | 1 |
p.Q453* | LUAD | 1 |
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TissGeneCNV for NLRP10 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NLRP10 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for NLRP10 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NLRP10 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NLRP10 |
TissGeneDrug for NLRP10 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NLRP10 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0010346 | Crohn Disease | 1 | GAD |
umls:C0011847 | Diabetes | 1 | BeFree |
umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
umls:C0021368 | Inflammation | 1 | LHGDN |