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TissGeneSummary for KLHL17 |
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Basic gene information | Gene symbol | KLHL17 |
Gene name | kelch-like family member 17 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 1p36.33 | |
Type of gene | protein-coding | |
RefGenes | NM_198317.2, | |
Description | actinfilinkelch-like 17kelch-like protein 17 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000187961 | ||
HPRD : 13926 | ||
Vega : OTTHUMG00000040721 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KLHL17 | |
BioGPS: 339451 | ||
Pathway | NCI Pathway Interaction Database: KLHL17 | |
KEGG: KLHL17 | ||
REACTOME: KLHL17 | ||
Pathway Commons: KLHL17 | ||
Context | iHOP: KLHL17 | |
ligand binding site mutation search in PubMed: KLHL17 | ||
UCL Cancer Institute: KLHL17 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTUVM | |
Reference showing the relevant tissue of KLHL17 | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for KLHL17 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | -0.043924898 | -1.451340283 | 1.407415385 | 4.81E-11 | 7.53E-10 |
BLCA | 0.60449413 | -0.484495343 | 1.088989474 | 1.37E-05 | 0.00024375 |
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TissGene-miRNA for KLHL17 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KLHL17 |
TissGeneSNV for KLHL17 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P418R | BLCA | 1 |
p.V326I | UCEC | 1 |
p.D576Y | BLCA | 1 |
p.G196C | LUAD | 1 |
p.V267M | LGG | 1 |
p.V582M | STAD | 1 |
p.M125I | BLCA | 1 |
p.E240K | UCEC | 1 |
p.V133M | BRCA | 1 |
p.Q188* | CESC | 1 |
p.R390L | BLCA | 1 |
p.D457N | HNSC | 1 |
p.E124K | BLCA | 1 |
p.S421F | SKCM | 1 |
p.R472L | LIHC | 1 |
p.S244C | SKCM | 1 |
p.R600K | KIRC | 1 |
p.R368C | LUAD | 1 |
p.P629S | STAD | 1 |
p.R390W | LGG | 1 |
p.E407K | KIRP | 1 |
p.R477X | STAD | 1 |
p.R477* | STAD | 1 |
p.A380S | HNSC | 1 |
p.R381W | SKCM | 1 |
p.A467T | STAD | 1 |
p.V371M | DLBC | 1 |
p.V343M | LIHC | 1 |
p.S631F | SKCM | 1 |
p.R178* | PAAD | 1 |
p.A607V | UCEC | 1 |
p.A479V | STAD | 1 |
p.R333H | LUSC | 1 |
p.A606T | STAD | 1 |
p.P458L | SKCM | 1 |
p.G357E | SKCM | 1 |
p.D266Y | ESCA | 1 |
p.G196C | KIRC | 1 |
p.A433T | STAD | 1 |
p.T480M | STAD | 1 |
p.E454Q | BLCA | 1 |
p.G395D | PRAD | 1 |
p.G196C | STAD | 1 |
p.R86H | HNSC | 1 |
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TissGeneCNV for KLHL17 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KLHL17 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | DA497127 | OGFR-KLHL17 | chr20:61439670 | chr1:897600 |
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TissGeneNet for KLHL17 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KLHL17 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KLHL17 |
TissGeneDrug for KLHL17 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KLHL17 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0014544 | Epilepsy | 1 | BeFree |
umls:C0037769 | West Syndrome | 1 | BeFree |
umls:C2931919 | X-linked infantile spasm syndrome | 1 | BeFree |