TissGeneSummary for FAM170A |
Gene summary |
Basic gene information | Gene symbol | FAM170A |
Gene name | family with sequence similarity 170, member A | |
Synonyms | ZNFD | |
Cytomap | UCSC genome browser: 5q23.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001163991.1, NM_182761.3, | |
Description | Znf domain containing proteinprotein FAM170Azinc finger domain-containing proteinzinc finger protein ZNFD | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000164334 | ||
HPRD : 14174 | ||
Vega : OTTHUMG00000162946 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FAM170A | |
BioGPS: 340069 | ||
Pathway | NCI Pathway Interaction Database: FAM170A | |
KEGG: FAM170A | ||
REACTOME: FAM170A | ||
Pathway Commons: FAM170A | ||
Context | iHOP: FAM170A | |
ligand binding site mutation search in PubMed: FAM170A | ||
UCL Cancer Institute: FAM170A | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FAM170A | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006366 | transcription from RNA polymerase II promoter | 20162441 | GO:0045893 | positive regulation of transcription, DNA-templated | 20162441 | GO:0006366 | transcription from RNA polymerase II promoter | 20162441 | GO:0045893 | positive regulation of transcription, DNA-templated | 20162441 |
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TissGeneExp for FAM170A |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for FAM170A |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FAM170A |
TissGeneSNV for FAM170A |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G285E | SKCM | 2 |
p.G93R | SKCM | 2 |
p.V176A | KIRC | 1 |
p.D327N | SKCM | 1 |
p.G301E | COAD | 1 |
p.Q277E | LUSC | 1 |
p.P204S | STAD | 1 |
p.E11K | SKCM | 1 |
p.M271T | ESCA | 1 |
p.V61I | STAD | 1 |
p.Q277X | SKCM | 1 |
p.Q134K | STAD | 1 |
p.Q83* | SKCM | 1 |
p.S108L | ESCA | 1 |
p.P213L | SKCM | 1 |
p.R328K | SKCM | 1 |
p.G269V | LUSC | 1 |
p.M224I | SKCM | 1 |
p.R65L | LUAD | 1 |
p.S26L | CESC | 1 |
p.H76L | LUAD | 1 |
p.P173S | COAD | 1 |
p.R98H | PRAD | 1 |
p.E283K | SKCM | 1 |
p.R171K | UCEC | 1 |
p.H258Q | KIRC | 1 |
p.S55F | SKCM | 1 |
p.S59C | HNSC | 1 |
p.E144K | SKCM | 1 |
p.G319V | HNSC | 1 |
p.E281Q | UCEC | 1 |
p.H261Y | SKCM | 1 |
p.R98S | SKCM | 1 |
p.D31N | SKCM | 1 |
p.G47E | SKCM | 1 |
p.R4X | TGCT | 1 |
p.R4* | TGCT | 1 |
p.D31H | LUSC | 1 |
p.A296E | LUAD | 1 |
p.R3* | PAAD | 1 |
p.R3Q | UCEC | 1 |
p.R74K | SKCM | 1 |
p.E225K | SKCM | 1 |
p.R98H | ESCA | 1 |
p.V209I | ACC | 1 |
p.A19T | STAD | 1 |
p.D201N | SKCM | 1 |
p.M126I | COAD | 1 |
p.R65H | THYM | 1 |
p.S164F | SKCM | 1 |
p.P80L | SKCM | 1 |
p.C58R | STAD | 1 |
p.Q277* | SKCM | 1 |
p.R214K | SKCM | 1 |
p.R77Q | HNSC | 1 |
p.V209I | GBM | 1 |
p.S109F | SKCM | 1 |
p.R3Q | COAD | 1 |
p.A296E | PRAD | 1 |
p.R77* | LUAD | 1 |
p.E191K | SKCM | 1 |
p.M126I | STAD | 1 |
p.W143* | SKCM | 1 |
p.M271V | LUSC | 1 |
p.R311K | SKCM | 1 |
p.E282D | ESCA | 1 |
p.W143X | SKCM | 1 |
p.R77* | SKCM | 1 |
p.E305* | UCEC | 1 |
p.P218A | BLCA | 1 |
p.D78E | BLCA | 1 |
p.P97L | SKCM | 1 |
p.V119L | LUAD | 1 |
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TissGeneCNV for FAM170A |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FAM170A |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for FAM170A |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FAM170A |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FAM170A |
TissGeneDrug for FAM170A |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FAM170A |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |