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| TissGeneSummary for AQP8 |
 Gene summary |
| Basic gene information | Gene symbol | AQP8 |
| Gene name | aquaporin 8 | |
| Synonyms | AQP-8 | |
| Cytomap | UCSC genome browser: 16p12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001169.2, | |
| Description | aquaporin-8 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603750 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000103375 | ||
| HPRD : 04778 | ||
| Vega : OTTHUMG00000097013 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_AQP8 | |
| BioGPS: 343 | ||
| Pathway | NCI Pathway Interaction Database: AQP8 | |
| KEGG: AQP8 | ||
| REACTOME: AQP8 | ||
| Pathway Commons: AQP8 | ||
| Context | iHOP: AQP8 | |
| ligand binding site mutation search in PubMed: AQP8 | ||
| UCL Cancer Institute: AQP8 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonPancreas | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADPAAD | |
| Reference showing the relevant tissue of AQP8 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for AQP8 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | 3.822075056 | 11.78904429 | -7.966969231 | 8.04E-13 | 2.17E-11 |
| LIHC | 2.489972441 | 0.817304441 | 1.672668 | 0.00104 | 0.002837641 |
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| TissGene-miRNA for AQP8 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for AQP8 |
| TissGeneSNV for AQP8 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.C53F | STAD | 1 |
| p.E134V | UCEC | 1 |
| p.G124R | COAD | 1 |
| p.T82M | BLCA | 1 |
| p.N92S | SKCM | 1 |
| p.G52R | STAD | 1 |
| p.G52E | STAD | 1 |
| p.A260P | COAD | 1 |
| p.G242* | LUAD | 1 |
| p.E161K | SKCM | 1 |
| p.A6T | UCEC | 1 |
| p.V108L | LUSC | 1 |
| p.A69V | ESCA | 1 |
| p.A218V | STAD | 1 |
| p.M209I | SKCM | 1 |
| p.E41K | SKCM | 1 |
| p.R33W | STAD | 1 |
| p.G183C | LUAD | 1 |
| p.R27Q | SKCM | 1 |
| p.G124R | STAD | 1 |
| p.W30* | HNSC | 1 |
| p.S116* | BLCA | 1 |
| p.S116L | CESC | 1 |
| p.A221D | STAD | 1 |
| p.A218V | HNSC | 1 |
| p.R213H | UCEC | 1 |
| p.G183C | LUSC | 1 |
| p.G73R | SKCM | 1 |
| p.G103R | GBM | 1 |
| p.W138X | COAD | 1 |
| p.G44D | PAAD | 1 |
| p.R33L | LUAD | 1 |
| p.R213H | COAD | 1 |
| p.P112S | SKCM | 1 |
| p.G88A | STAD | 1 |
| p.C38F | BRCA | 1 |
| p.T61M | STAD | 1 |
| p.G84E | STAD | 1 |
| p.G242V | LUSC | 1 |
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| TissGeneCNV for AQP8 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for AQP8 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for AQP8 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for AQP8 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for AQP8 |
| TissGeneDrug for AQP8 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for AQP8 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0008370 | Cholestasis | 2 | BeFree |
| umls:C0009324 | Ulcerative Colitis | 2 | BeFree,LHGDN |
| umls:C0302592 | Cervix carcinoma | 2 | BeFree |
| umls:C0007786 | Brain Ischemia | 1 | RGD |
| umls:C0020503 | Hyperparathyroidism, Secondary | 1 | GAD |
| umls:C0021368 | Inflammation | 1 | LHGDN |
| umls:C0029928 | Ovarian Diseases | 1 | BeFree |
| umls:C0032460 | Polycystic Ovary Syndrome | 1 | BeFree |
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