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| TissGeneSummary for OR6F1 |
 Gene summary |
| Basic gene information | Gene symbol | OR6F1 |
| Gene name | olfactory receptor, family 6, subfamily F, member 1 | |
| Synonyms | OR1-34|OR1-38|OST731 | |
| Cytomap | UCSC genome browser: 1q44 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001005286.1, | |
| Description | olfactory receptor 6F1olfactory receptor OR1-34 pseudogeneolfactory receptor OR1-38 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000169214 | ||
| HPRD : 17777 | ||
| Vega : OTTHUMG00000040213 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_OR6F1 | |
| BioGPS: 343169 | ||
| Pathway | NCI Pathway Interaction Database: OR6F1 | |
| KEGG: OR6F1 | ||
| REACTOME: OR6F1 | ||
| Pathway Commons: OR6F1 | ||
| Context | iHOP: OR6F1 | |
| ligand binding site mutation search in PubMed: OR6F1 | ||
| UCL Cancer Institute: OR6F1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of OR6F1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for OR6F1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for OR6F1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for OR6F1 |
| TissGeneSNV for OR6F1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E296K | SKCM | 3 |
| p.G307E | SKCM | 2 |
| p.D269N | SKCM | 2 |
| p.R293C | SKCM | 2 |
| p.W251* | LGG | 2 |
| p.F238L | UCS | 1 |
| p.P9L | LUAD | 1 |
| p.R122C | UCEC | 1 |
| p.P79L | LIHC | 1 |
| p.F12V | ESCA | 1 |
| p.Q24H | STAD | 1 |
| p.T214I | LUAD | 1 |
| p.H53Q | LUAD | 1 |
| p.Y290N | LUSC | 1 |
| p.F177L | BLCA | 1 |
| p.F200L | BLCA | 1 |
| p.G253W | LUAD | 1 |
| p.L85P | LUSC | 1 |
| p.T51P | HNSC | 1 |
| p.V216F | LUSC | 1 |
| p.R293H | LUSC | 1 |
| p.S167F | SKCM | 1 |
| p.A273V | SKCM | 1 |
| p.R293C | UCEC | 1 |
| p.F153L | KIRC | 1 |
| p.A134V | HNSC | 1 |
| p.I92M | HNSC | 1 |
| p.M118I | LUAD | 1 |
| p.M59I | HNSC | 1 |
| p.R234W | HNSC | 1 |
| p.G152C | SKCM | 1 |
| p.A203S | LUAD | 1 |
| p.S67Y | BLCA | 1 |
| p.L226I | LIHC | 1 |
| p.R293L | LUAD | 1 |
| p.R261H | PAAD | 1 |
| p.R122H | STAD | 1 |
| p.R172S | LUAD | 1 |
| p.Y112X | COAD | 1 |
| p.T110R | LUSC | 1 |
| p.Q21E | BLCA | 1 |
| p.S52F | SKCM | 1 |
| p.E299V | LUAD | 1 |
| p.F288L | UCEC | 1 |
| p.V280L | LUAD | 1 |
| p.T110S | LUAD | 1 |
| p.S93L | SKCM | 1 |
| p.K272N | STAD | 1 |
| p.L82M | LUAD | 1 |
| p.R293C | READ | 1 |
| p.T291M | BLCA | 1 |
| p.Y35C | STAD | 1 |
| p.R293H | GBM | 1 |
| p.L270M | HNSC | 1 |
| p.H53Y | SKCM | 1 |
| p.K295R | SKCM | 1 |
| p.G87E | SKCM | 1 |
| p.C97R | LUAD | 1 |
| p.T7A | STAD | 1 |
| p.R172G | HNSC | 1 |
| p.A117T | THYM | 1 |
| p.I174V | LUSC | 1 |
| p.N278I | LUAD | 1 |
| p.W184L | LUAD | 1 |
| p.V201L | LUAD | 1 |
| p.F215V | CHOL | 1 |
| p.S67F | SKCM | 1 |
| p.G253V | LUAD | 1 |
| p.S164R | LUAD | 1 |
| p.P129L | STAD | 1 |
| p.V150L | BRCA | 1 |
| p.R88K | SKCM | 1 |
| p.D121G | LIHC | 1 |
| p.P287S | SKCM | 1 |
| p.R227S | LUAD | 1 |
| p.L277Q | LUAD | 1 |
| p.R234L | BLCA | 1 |
| p.D121G | UCEC | 1 |
| p.L245I | LUSC | 1 |
| p.Y252N | LUAD | 1 |
| p.A83V | COAD | 1 |
| p.L37I | LGG | 1 |
| p.F177L | LUSC | 1 |
| p.T240K | LUAD | 1 |
| p.L249P | KIRC | 1 |
| p.G233C | LUSC | 1 |
| p.R261C | BLCA | 1 |
| p.F215L | COAD | 1 |
| p.G307R | BLCA | 1 |
| p.G253E | HNSC | 1 |
| p.S64N | SKCM | 1 |
| p.N65T | STAD | 1 |
| p.C189F | LUSC | 1 |
| p.S232R | LUAD | 1 |
| p.L27F | SKCM | 1 |
| p.Y102H | COAD | 1 |
| p.A157G | LUAD | 1 |
| p.E196* | LUAD | 1 |
| p.D180V | LUSC | 1 |
| p.E111K | SKCM | 1 |
| p.C127* | UCEC | 1 |
| p.C241F | LUAD | 1 |
| p.A145T | SKCM | 1 |
| p.R172G | LUAD | 1 |
| p.I45F | STAD | 1 |
| p.S254F | SKCM | 1 |
| p.L25I | LUSC | 1 |
| p.V274A | LIHC | 1 |
| p.L197F | SKCM | 1 |
| p.I222S | GBM | 1 |
| p.W251X | LGG | 1 |
| p.G108C | LUSC | 1 |
| p.K295X | LIHC | 1 |
| p.V260I | KICH | 1 |
| p.G307R | SKCM | 1 |
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| TissGeneCNV for OR6F1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for OR6F1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for OR6F1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for OR6F1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for OR6F1 |
| TissGeneDrug for OR6F1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for OR6F1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 2 | BeFree |
| umls:C0001430 | Adenoma | 1 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0022658 | Kidney Diseases | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C1709457 | Papillary Thyroid Microcarcinoma | 1 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 1 | BeFree |
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