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| TissGeneSummary for KCNT2 |
 Gene summary |
| Basic gene information | Gene symbol | KCNT2 |
| Gene name | potassium channel, subfamily T, member 2 | |
| Synonyms | KCa4.2|SLICK|SLO2.1 | |
| Cytomap | UCSC genome browser: 1q31.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001287819.1, NM_001287820.1,NM_198503.3, | |
| Description | potassium channel subfamily T member 2sequence like an intermediate conductance potassium channel subunitsodium and chloride-activated ATP-sensitive potassium channel Slo2.1sodium-and chloride-activated ATP-sensitive potassium channel (SLICK) | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 610044 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000162687 | ||
| HPRD : 11584 | ||
| Vega : OTTHUMG00000035611 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KCNT2 | |
| BioGPS: 343450 | ||
| Pathway | NCI Pathway Interaction Database: KCNT2 | |
| KEGG: KCNT2 | ||
| REACTOME: KCNT2 | ||
| Pathway Commons: KCNT2 | ||
| Context | iHOP: KCNT2 | |
| ligand binding site mutation search in PubMed: KCNT2 | ||
| UCL Cancer Institute: KCNT2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LiverOvary | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHCOV | |
| Reference showing the relevant tissue of KCNT2 | ||
| Description by TissGene annotations | Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for KCNT2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | -1.299074309 | 0.136054639 | -1.435128947 | 3.07E-21 | 2.39E-20 |
| KICH | -2.879884975 | 0.443523025 | -3.323408 | 3.66E-19 | 2.18E-17 |
| LUAD | -0.444413389 | 2.981071094 | -3.425484483 | 2.23E-28 | 1.56E-26 |
| COAD | -1.848502514 | -0.383560206 | -1.464942308 | 2.30E-07 | 1.51E-06 |
| LUSC | -1.03270176 | 3.077339417 | -4.110041176 | 3.39E-27 | 1.00E-25 |
| STAD | -0.819072225 | 0.35284965 | -1.171921875 | 0.00117 | 0.00602135 |
| LIHC | 1.557143025 | 2.746513025 | -1.18937 | 0.000426 | 0.001261528 |
| BLCA | -1.57781466 | 0.438422182 | -2.016236842 | 9.17E-05 | 0.001024828 |
| HNSC | -2.135152603 | -1.023636324 | -1.111516279 | 0.000206 | 0.000841198 |
| PRAD | -1.04440636 | 0.113405178 | -1.157811538 | 3.77E-05 | 0.000176379 |
| Top |
| TissGene-miRNA for KCNT2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for KCNT2 |
| TissGeneSNV for KCNT2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E143K | SKCM | 4 |
| p.H5Y | SKCM | 3 |
| p.E1048K | SKCM | 3 |
| p.R345* | SKCM | 3 |
| p.R995Q | SKCM | 2 |
| p.S807F | SKCM | 2 |
| p.R63H | ESCA | 2 |
| p.G679E | SKCM | 2 |
| p.E7K | SKCM | 2 |
| p.E1072K | SKCM | 2 |
| p.D316N | SKCM | 2 |
| p.R541* | HNSC | 2 |
| p.R345X | SKCM | 2 |
| p.R356Q | SKCM | 2 |
| p.D19Y | UCEC | 2 |
| p.L966R | ESCA | 2 |
| p.R222Q | SKCM | 2 |
| p.L942R | ESCA | 2 |
| p.Q343H | LUAD | 2 |
| p.S831F | SKCM | 2 |
| p.L125V | KIRP | 1 |
| p.R345L | BLCA | 1 |
| p.A609S | HNSC | 1 |
| p.Y234C | PCPG | 1 |
| p.R987W | LUAD | 1 |
| p.D341N | SKCM | 1 |
| p.A609E | LUAD | 1 |
| p.D1051N | SKCM | 1 |
| p.C606F | LUAD | 1 |
| p.P984L | SKCM | 1 |
| p.F230L | SKCM | 1 |
| p.L233F | SKCM | 1 |
| p.Y77* | UCEC | 1 |
| p.G679R | LUAD | 1 |
| p.E748X | SKCM | 1 |
| p.E838* | BRCA | 1 |
| p.S58* | LUSC | 1 |
| p.I534V | UCEC | 1 |
| p.R387C | PRAD | 1 |
| p.W980X | SKCM | 1 |
| p.G26E | SKCM | 1 |
| p.F858S | PRAD | 1 |
| p.L1055P | STAD | 1 |
| p.R698G | STAD | 1 |
| p.T806S | PRAD | 1 |
| p.F163I | SKCM | 1 |
| p.R879Q | SKCM | 1 |
| p.A373E | SARC | 1 |
| p.P984S | LUAD | 1 |
| p.E962G | STAD | 1 |
| p.L457R | READ | 1 |
| p.G224E | SKCM | 1 |
| p.N531D | HNSC | 1 |
| p.E339G | STAD | 1 |
| p.K879M | HNSC | 1 |
| p.S232F | SKCM | 1 |
| p.P751R | LUAD | 1 |
| p.C550* | UCEC | 1 |
| p.D391N | SKCM | 1 |
| p.Q328* | BRCA | 1 |
| p.R1019Q | PAAD | 1 |
| p.T119S | LUSC | 1 |
| p.P325S | SKCM | 1 |
| p.H294N | HNSC | 1 |
| p.L739I | UCEC | 1 |
| p.S101R | STAD | 1 |
| p.R993S | HNSC | 1 |
| p.Q1053L | LUAD | 1 |
| p.E709K | SKCM | 1 |
| p.H1062Q | PAAD | 1 |
| p.R999G | LUAD | 1 |
| p.C1122* | HNSC | 1 |
| p.T782S | PRAD | 1 |
| p.E1108K | SKCM | 1 |
| p.L966P | ESCA | 1 |
| p.G581* | LUAD | 1 |
| p.A380G | STAD | 1 |
| p.V1100G | STAD | 1 |
| p.Y707* | UCEC | 1 |
| p.S455F | SKCM | 1 |
| p.L159* | BLCA | 1 |
| p.S577L | STAD | 1 |
| p.V521I | UCEC | 1 |
| p.H580P | LUAD | 1 |
| p.R18* | SKCM | 1 |
| p.L966I | STAD | 1 |
| p.R765T | HNSC | 1 |
| p.S73I | LUAD | 1 |
| p.S949Y | UCEC | 1 |
| p.G216R | SKCM | 1 |
| p.K225N | LUSC | 1 |
| p.P538S | SKCM | 1 |
| p.P657R | HNSC | 1 |
| p.E133K | HNSC | 1 |
| p.L966P | STAD | 1 |
| p.E502K | BRCA | 1 |
| p.D854E | LIHC | 1 |
| p.G505E | SKCM | 1 |
| p.E275K | UCEC | 1 |
| p.Q566K | LUAD | 1 |
| p.E438* | LUAD | 1 |
| p.R1093* | SKCM | 1 |
| p.L233I | GBM | 1 |
| p.L942R | SKCM | 1 |
| p.H514N | LUAD | 1 |
| p.G611S | SKCM | 1 |
| p.L1019F | SKCM | 1 |
| p.E143K | SARC | 1 |
| p.I144K | SKCM | 1 |
| p.G23E | SKCM | 1 |
| p.T1133N | LUAD | 1 |
| p.Q1038H | GBM | 1 |
| p.W956* | SKCM | 1 |
| p.W171X | SKCM | 1 |
| p.S1005* | LUAD | 1 |
| p.D757Y | SKCM | 1 |
| p.E1114V | ESCA | 1 |
| p.R969S | HNSC | 1 |
| p.M315I | SKCM | 1 |
| p.N531S | LGG | 1 |
| p.P631H | COAD | 1 |
| p.A728T | SKCM | 1 |
| p.S455C | LUAD | 1 |
| p.T886R | BLCA | 1 |
| p.S101R | ESCA | 1 |
| p.R1117Q | LAML | 1 |
| p.L942P | ESCA | 1 |
| p.A859V | LUAD | 1 |
| p.L912R | STAD | 1 |
| p.L754M | READ | 1 |
| p.M1015I | COAD | 1 |
| p.V521I | SARC | 1 |
| p.A725D | SARC | 1 |
| p.R969S | LUAD | 1 |
| p.E283K | SKCM | 1 |
| p.S926Y | HNSC | 1 |
| p.Q361X | STAD | 1 |
| p.L833I | COAD | 1 |
| p.A1029S | LUAD | 1 |
| p.R973H | HNSC | 1 |
| p.P738S | CHOL | 1 |
| p.A843T | UCEC | 1 |
| p.K1011N | HNSC | 1 |
| p.L227M | SARC | 1 |
| p.R1023T | STAD | 1 |
| p.F426Y | BLCA | 1 |
| p.G581E | SKCM | 1 |
| p.G791V | LUAD | 1 |
| p.P818H | LUAD | 1 |
| p.E748* | SKCM | 1 |
| p.Q361E | HNSC | 1 |
| p.A453T | BLCA | 1 |
| p.G89* | SKCM | 1 |
| p.R914T | LUAD | 1 |
| p.E5A | LUAD | 1 |
| p.P1111S | LGG | 1 |
| p.D812Y | BRCA | 1 |
| p.E938G | STAD | 1 |
| p.E988* | BRCA | 1 |
| p.D761Y | PRAD | 1 |
| p.M39I | SKCM | 1 |
| p.T205A | LUSC | 1 |
| p.G847C | LUAD | 1 |
| p.G679E | SARC | 1 |
| p.M848R | LIHC | 1 |
| p.G288R | LUAD | 1 |
| p.S994R | SKCM | 1 |
| p.M824V | BLCA | 1 |
| p.L585* | CESC | 1 |
| p.L834I | LUAD | 1 |
| p.H516Y | SKCM | 1 |
| p.R789T | HNSC | 1 |
| p.P540A | SKCM | 1 |
| p.R1040X | COAD | 1 |
| p.H580Y | SKCM | 1 |
| p.R879X | KIRC | 1 |
| p.R137* | THYM | 1 |
| p.S990N | LUAD | 1 |
| p.S473L | COAD | 1 |
| p.E558K | SKCM | 1 |
| p.S115G | SKCM | 1 |
| p.G539C | HNSC | 1 |
| p.D603N | STAD | 1 |
| p.T613N | LUSC | 1 |
| p.V243L | LUAD | 1 |
| p.Q569H | BLCA | 1 |
| p.L890F | LUAD | 1 |
| p.R938I | KIRC | 1 |
| p.R63H | PRAD | 1 |
| p.R997H | HNSC | 1 |
| p.F694C | UCEC | 1 |
| p.H1038Q | PAAD | 1 |
| p.S101C | DLBC | 1 |
| p.V306I | SKCM | 1 |
| p.G1040C | LUAD | 1 |
| p.D985V | HNSC | 1 |
| p.E379K | ESCA | 1 |
| p.A767V | STAD | 1 |
| p.S561L | CESC | 1 |
| p.R1117Q | UCEC | 1 |
| p.E1090* | LUAD | 1 |
| p.R18X | SKCM | 1 |
| p.L1086V | LIHC | 1 |
| p.Q418H | HNSC | 1 |
| p.P1087S | LGG | 1 |
| p.W171* | SKCM | 1 |
| p.G679R | SARC | 1 |
| p.G486R | LUAD | 1 |
| p.K669N | ESCA | 1 |
| p.Q273_splice | LUSC | 1 |
| p.V1032L | LUAD | 1 |
| p.Q361* | STAD | 1 |
| p.R1011W | COAD | 1 |
| p.N798K | LUAD | 1 |
| p.R844Q | STAD | 1 |
| p.T1109N | LUAD | 1 |
| p.K1013T | UCEC | 1 |
| p.P337S | SKCM | 1 |
| p.E748K | SKCM | 1 |
| p.S971Y | UCEC | 1 |
| p.G486W | LUAD | 1 |
| p.D530N | SKCM | 1 |
| p.G482V | LUAD | 1 |
| p.P86R | HNSC | 1 |
| p.S512Y | UCEC | 1 |
| p.V521I | SKCM | 1 |
| p.H968D | LUAD | 1 |
| p.V166A | COAD | 1 |
| p.P1106T | COAD | 1 |
| p.E133K | SKCM | 1 |
| p.H763R | BRCA | 1 |
| p.E654K | SKCM | 1 |
| p.T556N | LUAD | 1 |
| p.N783H | KIRP | 1 |
| p.V111L | LUAD | 1 |
| p.T638K | COAD | 1 |
| p.P693S | SKCM | 1 |
| p.R18Q | SKCM | 1 |
| p.H967L | LUAD | 1 |
| p.S1096T | LUAD | 1 |
| p.L1063S | UCEC | 1 |
| p.T910R | BLCA | 1 |
| p.L665V | STAD | 1 |
| p.D530N | BLCA | 1 |
| p.R1011Q | KIRP | 1 |
| p.E320K | SKCM | 1 |
| p.R1019Q | SKCM | 1 |
| p.L834F | LGG | 1 |
| p.E488D | STAD | 1 |
| p.Y714H | COAD | 1 |
| p.G885V | PAAD | 1 |
| p.Y714C | HNSC | 1 |
| p.S110L | SKCM | 1 |
| p.H689Y | SKCM | 1 |
| p.R372K | BRCA | 1 |
| p.I934M | LGG | 1 |
| p.R626K | SKCM | 1 |
| p.C1098* | HNSC | 1 |
| p.I135N | SKCM | 1 |
| p.M824R | LIHC | 1 |
| p.R855Q | SKCM | 1 |
| p.S561L | LUSC | 1 |
| p.T1037A | STAD | 1 |
| p.R1079L | LUAD | 1 |
| p.P842H | LUAD | 1 |
| p.S577L | SKCM | 1 |
| p.R345* | UCEC | 1 |
| p.R1019Q | STAD | 1 |
| p.E726* | BRCA | 1 |
| p.Y331* | LUAD | 1 |
| p.D961V | HNSC | 1 |
| p.S561* | HNSC | 1 |
| p.G915V | BRCA | 1 |
| p.H992D | LUAD | 1 |
| p.V248A | STAD | 1 |
| p.M928V | LGG | 1 |
| p.V1048M | BRCA | 1 |
| p.E5K | SKCM | 1 |
| p.H686R | ACC | 1 |
| p.S651X | THYM | 1 |
| p.P1008L | SKCM | 1 |
| p.L1110V | LIHC | 1 |
| p.E559D | READ | 1 |
| p.Q192H | LUAD | 1 |
| p.R995Q | PAAD | 1 |
| p.K256E | UCEC | 1 |
| p.V1056L | LUAD | 1 |
| p.E938Q | BLCA | 1 |
| p.E1051* | LUAD | 1 |
| p.L1031P | STAD | 1 |
| p.W105* | SKCM | 1 |
| p.G289E | SKCM | 1 |
| p.W97S | LIHC | 1 |
| p.L697S | LGG | 1 |
| p.N554D | UCEC | 1 |
| p.R868Q | STAD | 1 |
| p.E1027* | LUAD | 1 |
| p.D312H | BLCA | 1 |
| p.L688F | SKCM | 1 |
| p.Y775C | UCEC | 1 |
| p.R570I | READ | 1 |
| p.P351S | SKCM | 1 |
| p.S110L | CESC | 1 |
| p.E475D | STAD | 1 |
| p.I79F | ESCA | 1 |
| p.K865N | PRAD | 1 |
| p.S1014N | LUAD | 1 |
| p.L966H | STAD | 1 |
| p.Q569* | BLCA | 1 |
| p.E299K | SKCM | 1 |
| p.D329N | SKCM | 1 |
| p.L461M | CESC | 1 |
| p.G611D | SKCM | 1 |
| p.N179H | ESCA | 1 |
| p.P12S | UCEC | 1 |
| p.G767V | LUAD | 1 |
| p.D766G | SKCM | 1 |
| p.S981* | LUAD | 1 |
| p.R63P | LUSC | 1 |
| p.I641T | HNSC | 1 |
| p.K286R | ESCA | 1 |
| p.E1090V | ESCA | 1 |
| p.A828S | HNSC | 1 |
| p.V1124G | STAD | 1 |
| p.L75V | STAD | 1 |
| p.W253L | PRAD | 1 |
| p.L1043F | SKCM | 1 |
| p.L858I | LUAD | 1 |
| p.C948W | OV | 1 |
| p.E41K | SKCM | 1 |
| p.G581V | LUAD | 1 |
| p.L913V | UCEC | 1 |
| p.N169K | LUAD | 1 |
| p.G482R | LUAD | 1 |
| p.A364D | THYM | 1 |
| p.Y124N | READ | 1 |
| p.N822D | READ | 1 |
| p.H1052N | LUAD | 1 |
| p.P751A | HNSC | 1 |
| p.T547K | LUSC | 1 |
| p.S970R | SKCM | 1 |
| p.C550X | READ | 1 |
| p.Y667C | BRCA | 1 |
| Top |
| TissGeneCNV for KCNT2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KCNT2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | CN286506 | KCNT2-KCNT2 | chr1:196249484 | chr1:196248990 | |
| Chimerdb3.0 | ChiTaRs | NA | BU741757 | PNPO-KCNT2 | chr17:46025641 | chr1:196441331 | |
| TCGAfusionPortal | PRADA | BRCA | TCGA-D8-A27F-01A | SKI-KCNT2 | Out-of-frame | Chr1:2161174 | Chr1:196461471 |
| Top |
| TissGeneNet for KCNT2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| Top |
| TissGeneProg for KCNT2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Top |
| TissGeneClin for KCNT2 |
| TissGeneDrug for KCNT2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KCNT2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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