TissGeneSummary for XKR7 |
Gene summary |
Basic gene information | Gene symbol | XKR7 |
Gene name | XK, Kell blood group complex subunit-related family, member 7 | |
Synonyms | C20orf159|dJ310O13.4 | |
Cytomap | UCSC genome browser: 20q11.21 | |
Type of gene | protein-coding | |
RefGenes | NM_001011718.1, | |
Description | X Kell blood group precursor-related family, member 7XK-related protein 7 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
HPRD : 17359 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_XKR7 | |
BioGPS: 343702 | ||
Pathway | NCI Pathway Interaction Database: XKR7 | |
KEGG: XKR7 | ||
REACTOME: XKR7 | ||
Pathway Commons: XKR7 | ||
Context | iHOP: XKR7 | |
ligand binding site mutation search in PubMed: XKR7 | ||
UCL Cancer Institute: XKR7 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainLung | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGLUAD,LUSC | |
Reference showing the relevant tissue of XKR7 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for XKR7 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for XKR7 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for XKR7 |
TissGeneSNV for XKR7 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R517Q | COAD | 1 |
p.R484W | LUSC | 1 |
p.R382H | ESCA | 1 |
p.G428S | SKCM | 1 |
p.T558M | STAD | 1 |
p.G346E | SKCM | 1 |
p.A35V | KIRP | 1 |
p.A468S | LUAD | 1 |
p.E483X | ESCA | 1 |
p.F67L | COAD | 1 |
p.F67L | BLCA | 1 |
p.K354Q | ESCA | 1 |
p.H538D | CESC | 1 |
p.C58F | HNSC | 1 |
p.R524Q | CESC | 1 |
p.R383H | STAD | 1 |
p.R484Q | STAD | 1 |
p.M417I | SKCM | 1 |
p.R504Q | GBM | 1 |
p.G490E | SKCM | 1 |
p.D290N | SKCM | 1 |
p.M339L | LUAD | 1 |
p.C351F | LUAD | 1 |
p.G494W | LUAD | 1 |
p.A489V | BLCA | 1 |
p.R517W | BRCA | 1 |
p.G136V | LUAD | 1 |
p.V323I | ESCA | 1 |
p.L393Q | HNSC | 1 |
p.V323I | BLCA | 1 |
p.D115N | BLCA | 1 |
p.A63V | LIHC | 1 |
p.G400V | LUAD | 1 |
p.P528S | STAD | 1 |
p.L83V | KIRC | 1 |
p.G400D | LUAD | 1 |
p.T410N | LUAD | 1 |
p.R382C | COAD | 1 |
p.T276M | LGG | 1 |
p.S80F | SKCM | 1 |
p.A426V | HNSC | 1 |
p.I523F | LIHC | 1 |
p.R382H | COAD | 1 |
p.W342C | HNSC | 1 |
p.L184I | LUAD | 1 |
p.D289N | LUSC | 1 |
p.D290N | LUAD | 1 |
p.A318V | GBM | 1 |
p.W372* | BLCA | 1 |
p.R382H | STAD | 1 |
p.R529H | UCEC | 1 |
p.A147V | SKCM | 1 |
p.W535X | LIHC | 1 |
p.A226T | COAD | 1 |
p.S69F | BLCA | 1 |
p.A489E | LUAD | 1 |
p.R285W | STAD | 1 |
p.Y563C | UCEC | 1 |
p.R529C | CESC | 1 |
p.L398F | UCEC | 1 |
p.P556S | LGG | 1 |
p.R560Q | HNSC | 1 |
p.R456C | SKCM | 1 |
p.P461H | LUAD | 1 |
p.R529G | BLCA | 1 |
p.A278T | LUSC | 1 |
p.G567V | STAD | 1 |
p.A468T | UCEC | 1 |
p.A397T | STAD | 1 |
p.R492C | SARC | 1 |
p.G447V | LUAD | 1 |
p.W336L | SARC | 1 |
p.R292W | PRAD | 1 |
p.E574K | BLCA | 1 |
p.E53K | LUAD | 1 |
p.G71S | COAD | 1 |
p.R382S | LUAD | 1 |
p.E571Q | SKCM | 1 |
p.E483K | LUAD | 1 |
p.Q562* | BLCA | 1 |
p.A312T | STAD | 1 |
p.A557S | STAD | 1 |
p.E519K | UCEC | 1 |
p.G447C | LUAD | 1 |
p.G191D | SKCM | 1 |
p.R292Q | MESO | 1 |
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TissGeneCNV for XKR7 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for XKR7 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A1FD-01A | ASXL1-XKR7 | Out-of-frame | Chr20:30956926 | Chr20:30582871 |
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TissGeneNet for XKR7 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for XKR7 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for XKR7 |
TissGeneDrug for XKR7 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for XKR7 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |