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TissGeneSummary for CDKL4 |
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Basic gene information | Gene symbol | CDKL4 |
Gene name | cyclin-dependent kinase-like 4 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 2p22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001009565.1, | |
Description | - | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000205111 | ||
HPRD : 16698 | ||
Vega : OTTHUMG00000133574 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CDKL4 | |
BioGPS: 344387 | ||
Pathway | NCI Pathway Interaction Database: CDKL4 | |
KEGG: CDKL4 | ||
REACTOME: CDKL4 | ||
Pathway Commons: CDKL4 | ||
Context | iHOP: CDKL4 | |
ligand binding site mutation search in PubMed: CDKL4 | ||
UCL Cancer Institute: CDKL4 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CDKL4 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for CDKL4 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for CDKL4 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CDKL4 |
TissGeneSNV for CDKL4 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V106I | PAAD | 2 |
p.L91M | PAAD | 1 |
p.I119M | STAD | 1 |
p.A148P | LUAD | 1 |
p.S278F | HNSC | 1 |
p.Q198P | STAD | 1 |
p.Q112* | SKCM | 1 |
p.Y211H | KIRC | 1 |
p.R299H | HNSC | 1 |
p.P240L | SARC | 1 |
p.C143F | STAD | 1 |
p.E241Q | LUAD | 1 |
p.I142F | LUAD | 1 |
p.E249Q | LUSC | 1 |
p.R299H | LGG | 1 |
p.R167X | READ | 1 |
p.E301K | SKCM | 1 |
p.M269I | HNSC | 1 |
p.L133I | UCEC | 1 |
p.G232R | SKCM | 1 |
p.D254A | UCEC | 1 |
p.Q309X | PAAD | 1 |
p.V310L | LUAD | 1 |
p.G302E | SKCM | 1 |
p.P95Q | THYM | 1 |
p.H85N | READ | 1 |
p.N231K | LIHC | 1 |
p.R223I | LUAD | 1 |
p.E249Q | HNSC | 1 |
p.H77N | ESCA | 1 |
p.A31P | HNSC | 1 |
p.L63V | BRCA | 1 |
p.I52M | UCEC | 1 |
p.M269V | UCEC | 1 |
p.Q290* | SKCM | 1 |
p.S181L | BRCA | 1 |
p.Q290X | SKCM | 1 |
p.Q309H | LUAD | 1 |
p.V328L | KIRC | 1 |
p.G174E | ESCA | 1 |
p.G146E | SKCM | 1 |
p.I103M | OV | 1 |
p.D159N | SKCM | 1 |
p.Q309* | PAAD | 1 |
p.V106I | COAD | 1 |
p.T247A | STAD | 1 |
p.E193Q | STAD | 1 |
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TissGeneCNV for CDKL4 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CDKL4 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF885809 | CDKL4-SP3 | chr2:39431642 | chr2:174773462 |
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TissGeneNet for CDKL4 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CDKL4 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CDKL4 |
TissGeneDrug for CDKL4 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CDKL4 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0035372 | Rett Syndrome | 1 | GAD |
umls:C0036572 | Seizures | 1 | GAD |
umls:C0162635 | Angelman Syndrome | 1 | GAD |