 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for HSD17B13 |
 Gene summary |
| Basic gene information | Gene symbol | HSD17B13 |
| Gene name | hydroxysteroid (17-beta) dehydrogenase 13 | |
| Synonyms | NIIL497|SCDR9|SDR16C3 | |
| Cytomap | UCSC genome browser: 4q22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001136230.2, NM_178135.4, | |
| Description | 17-beta hydroxysteroid dehydrogenase17-beta-HSD 1317-beta-hydroxysteroid dehydrogenase 13short chain dehydrogenase/reductase family 16C, member 3short-chain dehydrogenase/reductase 9 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612127 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000170509 | ||
| HPRD : 18023 | ||
| Vega : OTTHUMG00000130602 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HSD17B13 | |
| BioGPS: 345275 | ||
| Pathway | NCI Pathway Interaction Database: HSD17B13 | |
| KEGG: HSD17B13 | ||
| REACTOME: HSD17B13 | ||
| Pathway Commons: HSD17B13 | ||
| Context | iHOP: HSD17B13 | |
| ligand binding site mutation search in PubMed: HSD17B13 | ||
| UCL Cancer Institute: HSD17B13 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of HSD17B13 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0046889 | positive regulation of lipid biosynthetic process | 25028495 | GO:0046889 | positive regulation of lipid biosynthetic process | 25028495 |
| Top |
| TissGeneExp for HSD17B13 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | 1.104696407 | 3.870498131 | -2.765801724 | 9.05E-12 | 6.36E-11 |
| LUSC | 0.066511451 | 3.661715373 | -3.595203922 | 7.10E-18 | 6.32E-17 |
| KICH | -1.328140627 | -0.056236627 | -1.271904 | 1.43E-05 | 4.39E-05 |
| LIHC | 5.862691373 | 11.52665737 | -5.663966 | 2.16E-12 | 4.00E-11 |
| BRCA | -0.703674978 | 3.983884671 | -4.687559649 | 2.14E-50 | 1.46E-48 |
| KIRP | -1.082475252 | 0.610287248 | -1.6927625 | 2.07E-07 | 1.19E-06 |
| BLCA | -0.235510943 | 1.334741688 | -1.570252632 | 0.00389 | 0.021791839 |
| HNSC | -1.15529393 | 0.161968861 | -1.317262791 | 0.000724 | 0.0025573 |
| PRAD | 2.465961526 | 4.565551911 | -2.099590385 | 0.000134 | 0.000548984 |
| Top |
| TissGene-miRNA for HSD17B13 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for HSD17B13 |
| TissGeneSNV for HSD17B13 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R81Q | LUAD | 1 |
| p.V85I | BRCA | 1 |
| p.R247C | SKCM | 1 |
| p.R102C | GBM | 1 |
| p.S17P | PAAD | 1 |
| p.D92N | COAD | 1 |
| p.E20Q | LUAD | 1 |
| p.E6X | COAD | 1 |
| p.I137V | LGG | 1 |
| p.R197K | ESCA | 1 |
| p.G43A | HNSC | 1 |
| p.E75G | LIHC | 1 |
| p.S165L | SKCM | 1 |
| p.F225L | SKCM | 1 |
| p.R197K | CESC | 1 |
| p.V168I | STAD | 1 |
| p.M256I | ESCA | 1 |
| p.S201L | SKCM | 1 |
| p.G158S | COAD | 1 |
| p.E136K | BLCA | 1 |
| p.L10R | SKCM | 1 |
| p.P224S | COAD | 1 |
| p.I211M | ESCA | 1 |
| p.M220I | COAD | 1 |
| p.R283C | SKCM | 1 |
| p.S261L | PAAD | 1 |
| p.T223S | LUSC | 1 |
| p.E136D | BLCA | 1 |
| p.I68N | STAD | 1 |
| p.D93H | ESCA | 1 |
| p.Y90C | BLCA | 1 |
| p.S158P | UCEC | 1 |
| p.F113L | COAD | 1 |
| p.E100D | COAD | 1 |
| p.S61N | STAD | 1 |
| p.R102C | SKCM | 1 |
| Top |
| TissGeneCNV for HSD17B13 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for HSD17B13 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Top |
| TissGeneNet for HSD17B13 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| Top |
| TissGeneProg for HSD17B13 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for HSD17B13 |
| TissGeneDrug for HSD17B13 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for HSD17B13 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0376358 | Malignant neoplasm of prostate | 5 | BeFree |
| umls:C0600139 | Prostate carcinoma | 5 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree |
| umls:C0008497 | Choriocarcinoma | 3 | BeFree |
| umls:C0014175 | Endometriosis | 3 | BeFree |
| umls:C0678222 | Breast Carcinoma | 3 | BeFree |
| umls:C0028754 | Obesity | 2 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
| umls:C0238395 | Male Pseudohermaphroditism | 2 | BeFree |
| umls:C2751824 | 46, XY Disorders of Sex Development | 2 | BeFree |
| umls:C0018051 | Gonadal Dysgenesis | 1 | BeFree |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0029928 | Ovarian Diseases | 1 | BeFree |
| umls:C0031511 | Pheochromocytoma | 1 | BeFree |
| umls:C0036572 | Seizures | 1 | BeFree |
| umls:C0041408 | Turner Syndrome | 1 | BeFree |
| umls:C0042755 | Virilism | 1 | BeFree |
| umls:C0206667 | Adrenal Cortical Adenoma | 1 | BeFree |
| umls:C0266362 | Ambiguous Genitalia | 1 | BeFree |
| umls:C0269102 | Endometrioma | 1 | BeFree |
| umls:C0555232 | pseudohermaphrodite (non-specific) | 1 | BeFree |
| umls:C0677776 | Hereditary Breast and Ovarian Cancer Syndrome | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C0848558 | Hypospadias | 1 | BeFree |
| umls:C1134719 | Invasive Ductal Breast Carcinoma | 1 | BeFree |
| umls:C1336076 | Sporadic Breast Carcinoma | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
| umls:C1691215 | Penile hypospadias | 1 | BeFree |
| umls:C1846502 | Mammographic Density | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |