TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for PLCXD3

Gene summary

Basic gene information	Gene symbol	PLCXD3
	Gene name	phosphatidylinositol-specific phospholipase C, X domain containing 3
	Synonyms	-
	Cytomap	UCSC genome browser: 5p13.1
	Type of gene	protein-coding
	RefGenes	NM_001005473.2,
	Description	PI-PLC X domain-containing protein 3
	Modification date	20141207
dbXrefs	HGNC : HGNC
	Ensembl : ENSG00000182836
	HPRD : 17860
	Vega : OTTHUMG00000162076
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_PLCXD3
	BioGPS: 345557
Pathway	NCI Pathway Interaction Database: PLCXD3
	KEGG: PLCXD3
	REACTOME: PLCXD3
	Pathway Commons: PLCXD3
Context	iHOP: PLCXD3
	ligand binding site mutation search in PubMed: PLCXD3
	UCL Cancer Institute: PLCXD3
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	OvaryPancreas
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	OVPAAD
Reference showing the relevant tissue of PLCXD3
Description by TissGene annotations	Have significant anti-correlated miRNA

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO term

PubMed ID

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TissGeneExp for PLCXD3

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
BRCA	-1.62113254	1.392127986	-3.013260526	6.14E-30	8.19E-29
LUAD	-0.351702625	1.806530134	-2.158232759	8.32E-12	5.87E-11
KIRP	-1.404700577	2.916849423	-4.32155	2.18E-14	5.36E-13
LUSC	-1.067588629	1.763668234	-2.831256863	9.94E-12	4.15E-11
COAD	-3.295324375	-0.165697452	-3.129626923	2.34E-11	4.15E-10
HNSC	-3.874547452	-1.345503266	-2.529044186	1.47E-11	3.68E-10
LIHC	-1.183845452	1.641694548	-2.82554	2.67E-10	3.29E-09
THCA	-0.623766096	0.851028819	-1.474794915	7.38E-08	3.27E-07
STAD	-1.475703702	1.785099423	-3.260803125	1.10E-11	2.21E-09
KIRC	0.282759492	3.151466437	-2.868706944	3.43E-17	2.07E-16
BLCA	-1.082000084	0.581126232	-1.663126316	0.00876	0.040634333
ESCA	-1.726556543	3.217525275	-4.944081818	0.000137	0.004062507

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TissGene-miRNA for PLCXD3

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type	miRNA id	miRNA accession	P-val.	Coeff.	# samples
UVM	hsa-miR-200c-3p	MIMAT0000617	0.016	-0.27	80
UCS	hsa-miR-26a-5p	MIMAT0000082	0.034	-0.29	56
LUAD	hsa-miR-429	MIMAT0001536	0.0094	-0.34	60
UCS	hsa-miR-30c-5p	MIMAT0000244	0.012	-0.34	56
UCS	hsa-miR-30e-5p	MIMAT0000692	0.0095	-0.35	56

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TissGeneMut for PLCXD3

TissGeneSNV for PLCXD3

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.M82I	SKCM	2
p.S241L	SKCM	2
p.D296N	SKCM	2
p.H154Y	SKCM	2
p.V280D	SKCM	1
p.S254R	LUAD	1
p.T267P	LGG	1
p.H154Y	BLCA	1
p.M211I	KICH	1
p.F84V	COAD	1
p.K152*	LGG	1
p.D188Y	LUSC	1
p.S3L	LUAD	1
p.K169E	COAD	1
p.V248L	LUAD	1
p.R93C	SKCM	1
p.F95L	SKCM	1
p.K258N	LUAD	1
p.V62F	LUAD	1
p.Q87H	UCS	1
p.G6R	LUSC	1
p.T255N	LUAD	1
p.N122D	STAD	1
p.W76R	LIHC	1
p.K120N	STAD	1
p.R98*	SKCM	1
p.R98*	BRCA	1
p.S262R	DLBC	1
p.G286A	HNSC	1
p.P103S	STAD	1
p.D38N	SKCM	1
p.A231S	LGG	1
p.D107E	LUSC	1
p.S36F	SKCM	1
p.R237K	SKCM	1
p.Q190E	ESCA	1
p.F117L	HNSC	1
p.H37Y	BLCA	1
p.D188N	COAD	1
p.R74Q	UCEC	1
p.R98*	BLCA	1
p.Y153C	LUSC	1
p.T321P	HNSC	1
p.V139I	SKCM	1
p.F141L	COAD	1
p.L310I	LGG	1
p.E109K	BLCA	1
p.T282K	LUSC	1
p.E178K	SKCM	1
p.L125F	SKCM	1
p.G209R	SKCM	1
p.R265K	COAD	1
p.N108I	LUAD	1
p.G317V	LUAD	1
p.E318K	SKCM	1
p.Q5*	CESC	1
p.H196Y	SKCM	1
p.S262I	ESCA	1
p.T250N	HNSC	1
p.E109*	BLCA	1
p.S241*	LUAD	1
p.L229P	LIHC	1
p.V280D	GBM	1
p.K102R	STAD	1
p.F131L	GBM	1
p.E266*	UCEC	1
p.D296N	HNSC	1
p.K102M	LUSC	1
p.F303I	SARC	1
p.T81A	LIHC	1
p.P106L	SKCM	1
p.P27L	SKCM	1
p.D96N	SKCM	1
p.S245Y	GBM	1
p.G259E	LUAD	1
p.R74Q	LGG	1
p.E126Q	BLCA	1
p.P285L	SKCM	1
p.E316*	OV	1
p.H154Y	STAD	1
p.L88P	LUAD	1
p.R98Q	SKCM	1
p.F65Y	SKCM	1
p.H114N	LUAD	1
p.W76*	SKCM	1
p.R281C	SKCM	1
p.P103H	HNSC	1
p.N83S	SKCM	1
p.Y183C	STAD	1
p.E202K	SKCM	1
p.W76X	SKCM	1
p.Q87K	LUSC	1
p.S245Y	UCEC	1
p.Q278H	LUAD	1
p.F84C	UCS	1
p.E223K	SKCM	1
p.M276I	SKCM	1
p.D296Y	PRAD	1
p.R98*	GBM	1

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TissGeneCNV for PLCXD3

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for PLCXD3

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	FusionScan	BRCA	TCGA-D8-A13Z-01A	PRLR-PLCXD3	5'UTR-CDS	chr5:35230369	chr5:41382636
Chimerdb3.0	FusionScan	BRCA	TCGA-AR-A0TW-01A	WDR70-PLCXD3	In-Frame	chr5:37516692	chr5:41313872
TCGAfusionPortal	PRADA	BRCA	TCGA-AR-A0TW-01A	WDR70-PLCXD3	In-frame	Chr5:37516692	Chr5:41313872
TCGAfusionPortal	PRADA	BRCA	TCGA-D8-A13Z-01A	PRLR-PLCXD3	5UTR-CDS	Chr5:35230370	Chr5:41382636

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TissGeneNet for PLCXD3

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

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TissGeneProg for PLCXD3

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for PLCXD3

TissGeneDrug for PLCXD3

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for PLCXD3

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0005586	Bipolar Disorder	1	BeFree
umls:C0021655	Insulin Resistance	1	GAD
umls:C0040336	Tobacco Use Disorder	1	GAD