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TissGeneSummary for APOC4 |
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Basic gene information | Gene symbol | APOC4 |
Gene name | apolipoprotein C-IV | |
Synonyms | APO-CIV|APOC-IV | |
Cytomap | UCSC genome browser: 19q13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001646.2, | |
Description | apolipoprotein C4 | |
Modification date | 20141207 | |
dbXrefs | MIM : 600745 | |
HGNC : HGNC | ||
Ensembl : ENSG00000267467 | ||
HPRD : 02848 | ||
Vega : OTTHUMG00000180845 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_APOC4 | |
BioGPS: 346 | ||
Pathway | NCI Pathway Interaction Database: APOC4 | |
KEGG: APOC4 | ||
REACTOME: APOC4 | ||
Pathway Commons: APOC4 | ||
Context | iHOP: APOC4 | |
ligand binding site mutation search in PubMed: APOC4 | ||
UCL Cancer Institute: APOC4 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of APOC4 | ||
Description by TissGene annotations | TissgsKTS CNV gained TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for APOC4 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -1.58358554 | -0.57166201 | -1.011923529 | 2.92E-08 | 8.71E-08 |
KIRP | -1.041127758 | -2.197249633 | 1.156121875 | 1.13E-06 | 5.66E-06 |
KICH | -0.795121383 | -2.250477383 | 1.455356 | 9.66E-09 | 5.18E-08 |
LUAD | -1.522003728 | -0.406039934 | -1.115963793 | 4.67E-09 | 2.18E-08 |
LIHC | 8.999836617 | 10.91067462 | -1.910838 | 0.00011 | 0.000377022 |
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TissGene-miRNA for APOC4 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for APOC4 |
TissGeneSNV for APOC4 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.L102I | STAD | 1 |
p.G68R | COAD | 1 |
p.L90R | COAD | 1 |
p.S107N | KIRP | 1 |
p.L102F | SKCM | 1 |
p.D106H | BLCA | 1 |
p.M82I | STAD | 1 |
p.S2F | SKCM | 1 |
p.P12S | UCEC | 1 |
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TissGeneCNV for APOC4 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for APOC4 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AA345841 | APOC4-DLG3 | chr19:45452048 | chrX:69723377 |
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TissGeneNet for APOC4 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for APOC4 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for APOC4 |
TissGeneDrug for APOC4 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for APOC4 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0010068 | Coronary heart disease | 4 | BeFree,GAD |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | GAD |
umls:C0019196 | Hepatitis C | 2 | BeFree,GAD |
umls:C0007222 | Cardiovascular Diseases | 1 | GAD |
umls:C0015695 | Fatty Liver | 1 | BeFree |
umls:C0021368 | Inflammation | 1 | GAD |
umls:C0021655 | Insulin Resistance | 1 | GAD |
umls:C0023903 | Liver neoplasms | 1 | BeFree |
umls:C0524620 | Metabolic Syndrome X | 1 | BeFree |
umls:C1956346 | Coronary Artery Disease | 1 | GAD |
umls:C2239176 | Liver carcinoma | 1 | BeFree |
umls:C2711227 | Steatohepatitis | 1 | BeFree |
umls:C3714619 | Insulin resistance syndrome | 1 | BeFree |