TissGeneSummary for IGFBPL1 |
Gene summary |
Basic gene information | Gene symbol | IGFBPL1 |
Gene name | insulin-like growth factor binding protein-like 1 | |
Synonyms | IGFBP-RP4|IGFBPRP4|bA113O24.1 | |
Cytomap | UCSC genome browser: 9p13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001007563.2, | |
Description | IGFBP-related protein 10insulin-like growth factor binding protein related protein 4insulin-like growth factor-binding protein-like 1insulin-like growth factor-binding-related protein 4 | |
Modification date | 20141207 | |
dbXrefs | MIM : 610413 | |
HGNC : HGNC | ||
HPRD : 17138 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IGFBPL1 | |
BioGPS: 347252 | ||
Pathway | NCI Pathway Interaction Database: IGFBPL1 | |
KEGG: IGFBPL1 | ||
REACTOME: IGFBPL1 | ||
Pathway Commons: IGFBPL1 | ||
Context | iHOP: IGFBPL1 | |
ligand binding site mutation search in PubMed: IGFBPL1 | ||
UCL Cancer Institute: IGFBPL1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Thyroid gland | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | THCA | |
Reference showing the relevant tissue of IGFBPL1 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for IGFBPL1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -0.712495059 | -1.885802953 | 1.173307895 | 1.42E-13 | 6.70E-13 |
THCA | 0.705632476 | 4.825025697 | -4.11939322 | 5.24E-24 | 5.52E-22 |
LUAD | 1.575774119 | -0.016777606 | 1.592551724 | 3.48E-08 | 1.46E-07 |
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TissGene-miRNA for IGFBPL1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for IGFBPL1 |
TissGeneSNV for IGFBPL1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P195S | SKCM | 2 |
p.V258M | HNSC | 1 |
p.R234Q | BLCA | 1 |
p.W227C | BLCA | 1 |
p.E238* | UCS | 1 |
p.E238X | UCS | 1 |
p.V172M | SKCM | 1 |
p.A180V | PRAD | 1 |
p.G169V | LUAD | 1 |
p.A252T | THYM | 1 |
p.E223Q | SKCM | 1 |
p.A245V | STAD | 1 |
p.T225S | LUAD | 1 |
p.P160S | HNSC | 1 |
p.T259M | LGG | 1 |
p.P155L | SKCM | 1 |
p.E177D | UCEC | 1 |
p.R267K | SKCM | 1 |
p.A224D | LGG | 1 |
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TissGeneCNV for IGFBPL1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for IGFBPL1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | LUAD | TCGA-05-5425-01A | IGFBPL1-SHB | Out-of-Frame | chr9:38423961 | chr9:37920001 |
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TissGeneNet for IGFBPL1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for IGFBPL1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for IGFBPL1 |
TissGeneDrug for IGFBPL1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for IGFBPL1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0011570 | Mental Depression | 1 | BeFree |
umls:C0011581 | Depressive disorder | 1 | BeFree |
umls:C0020538 | Hypertensive disease | 1 | GAD |
umls:C0041696 | Unipolar Depression | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C1269683 | Major Depressive Disorder | 1 | BeFree |
umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |