TissGeneSummary for DCAF8L2 |
Gene summary |
Basic gene information | Gene symbol | DCAF8L2 |
Gene name | DDB1 and CUL4 associated factor 8-like 2 | |
Synonyms | WDR42C | |
Cytomap | UCSC genome browser: Xp21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001136533.1, | |
Description | DDB1- and CUL4-associated factor 8-like protein 2WD repeat domain 42CWD repeat-containing protein 42C | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000189186 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DCAF8L2 | |
BioGPS: 347442 | ||
Pathway | NCI Pathway Interaction Database: DCAF8L2 | |
KEGG: DCAF8L2 | ||
REACTOME: DCAF8L2 | ||
Pathway Commons: DCAF8L2 | ||
Context | iHOP: DCAF8L2 | |
ligand binding site mutation search in PubMed: DCAF8L2 | ||
UCL Cancer Institute: DCAF8L2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of DCAF8L2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for DCAF8L2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 0.654664569 | -1.123517431 | 1.778182 | 1.12E-05 | 4.68E-05 |
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TissGene-miRNA for DCAF8L2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for DCAF8L2 |
TissGeneSNV for DCAF8L2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D445N | SKCM | 2 |
p.R564Q | SKCM | 2 |
p.R219C | UCEC | 2 |
p.R242Q | STAD | 1 |
p.T345A | COAD | 1 |
p.R201C | UCEC | 1 |
p.F236Y | LUAD | 1 |
p.P153T | UCEC | 1 |
p.R585H | PAAD | 1 |
p.S611C | HNSC | 1 |
p.P331L | LUAD | 1 |
p.H227R | TGCT | 1 |
p.Q350E | BLCA | 1 |
p.T271K | SARC | 1 |
p.L437M | PRAD | 1 |
p.G210V | UCEC | 1 |
p.A213D | GBM | 1 |
p.M290I | HNSC | 1 |
p.M290V | UCEC | 1 |
p.D256Y | UCEC | 1 |
p.S460G | LUAD | 1 |
p.G15R | LUAD | 1 |
p.Q276K | LUAD | 1 |
p.R392K | SARC | 1 |
p.G474V | KIRC | 1 |
p.A170V | COAD | 1 |
p.N476T | READ | 1 |
p.A29D | LUAD | 1 |
p.N469D | DLBC | 1 |
p.P630T | UCEC | 1 |
p.T412P | SKCM | 1 |
p.G552R | BLCA | 1 |
p.R625Q | UCEC | 1 |
p.A601G | HNSC | 1 |
p.T16A | SKCM | 1 |
p.L182M | ACC | 1 |
p.E619X | ESCA | 1 |
p.E339K | ESCA | 1 |
p.G406C | LUAD | 1 |
p.P521L | SKCM | 1 |
p.I39V | UCEC | 1 |
p.A439V | SARC | 1 |
p.G385C | GBM | 1 |
p.P521H | UCEC | 1 |
p.P153S | LIHC | 1 |
p.A341D | LUAD | 1 |
p.R71* | CESC | 1 |
p.A529V | LUAD | 1 |
p.S44L | CESC | 1 |
p.E513* | UCEC | 1 |
p.L243Q | LUAD | 1 |
p.W257C | LUAD | 1 |
p.E619* | ESCA | 1 |
p.F477L | UCEC | 1 |
p.T345A | LUAD | 1 |
p.L583F | UCEC | 1 |
p.L519H | SKCM | 1 |
p.K538R | CESC | 1 |
p.H414R | UCEC | 1 |
p.G591S | UCEC | 1 |
p.G385V | LUAD | 1 |
p.K558T | CESC | 1 |
p.T373A | PAAD | 1 |
p.R223H | LGG | 1 |
p.E25V | LUAD | 1 |
p.T588M | KIRC | 1 |
p.D576Y | HNSC | 1 |
p.V417G | SKCM | 1 |
p.S608L | UCEC | 1 |
p.G406F | LUAD | 1 |
p.L550I | LUAD | 1 |
p.E403K | HNSC | 1 |
p.R219H | UCEC | 1 |
p.W497R | LUAD | 1 |
p.G488S | DLBC | 1 |
p.D329G | UCEC | 1 |
p.A439G | BLCA | 1 |
p.R184* | GBM | 1 |
p.R352W | CESC | 1 |
p.V485L | LUAD | 1 |
p.F411L | COAD | 1 |
p.A377T | UVM | 1 |
p.D65N | SARC | 1 |
p.A377S | LUAD | 1 |
p.R239H | KIRP | 1 |
p.R217H | CESC | 1 |
p.E607K | BLCA | 1 |
p.A244S | CHOL | 1 |
p.R592C | SKCM | 1 |
p.E5K | BRCA | 1 |
p.R201S | SARC | 1 |
p.L224F | CESC | 1 |
p.S598N | LUAD | 1 |
p.I446V | UCEC | 1 |
p.Q296K | COAD | 1 |
p.R184Q | COAD | 1 |
p.V358L | THCA | 1 |
p.G406V | LUAD | 1 |
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TissGeneCNV for DCAF8L2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DCAF8L2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BU568503 | SKP1-DCAF8L2 | chr5:133512641 | chrX:27765547 |
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TissGeneNet for DCAF8L2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DCAF8L2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DCAF8L2 |
TissGeneDrug for DCAF8L2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DCAF8L2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |