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| TissGeneSummary for CXorf66 |
 Gene summary |
| Basic gene information | Gene symbol | CXorf66 |
| Gene name | chromosome X open reading frame 66 | |
| Synonyms | SGPX | |
| Cytomap | UCSC genome browser: Xq27.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001013403.2, | |
| Description | RP11-35F15.2secreted glycoprotein, X-linkeduncharacterized protein CXorf66 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000203933 | ||
| HPRD : 18139 | ||
| Vega : OTTHUMG00000022539 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CXorf66 | |
| BioGPS: 347487 | ||
| Pathway | NCI Pathway Interaction Database: CXorf66 | |
| KEGG: CXorf66 | ||
| REACTOME: CXorf66 | ||
| Pathway Commons: CXorf66 | ||
| Context | iHOP: CXorf66 | |
| ligand binding site mutation search in PubMed: CXorf66 | ||
| UCL Cancer Institute: CXorf66 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of CXorf66 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CXorf66 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | -0.366959808 | 0.873022192 | -1.239982 | 1.71E-07 | 1.13E-06 |
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| TissGene-miRNA for CXorf66 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CXorf66 |
| TissGeneSNV for CXorf66 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R311C | SKCM | 3 |
| p.S258F | SKCM | 2 |
| p.D117V | HNSC | 1 |
| p.C105S | BRCA | 1 |
| p.V60D | COAD | 1 |
| p.S287T | LUAD | 1 |
| p.S122A | READ | 1 |
| p.T345M | SARC | 1 |
| p.K166M | LUAD | 1 |
| p.C346R | STAD | 1 |
| p.S170* | LUSC | 1 |
| p.S151C | STAD | 1 |
| p.K40E | UCEC | 1 |
| p.R316S | LUSC | 1 |
| p.P210H | KIRC | 1 |
| p.E224Q | LUAD | 1 |
| p.K270N | UCEC | 1 |
| p.E335* | LUAD | 1 |
| p.S287Y | LUAD | 1 |
| p.A130T | SKCM | 1 |
| p.R163M | SARC | 1 |
| p.K166T | UCEC | 1 |
| p.S309Y | HNSC | 1 |
| p.H220N | LUAD | 1 |
| p.D285H | BLCA | 1 |
| p.I50S | COAD | 1 |
| p.L9F | UCEC | 1 |
| p.D117N | LUAD | 1 |
| p.S176X | THYM | 1 |
| p.D117F | HNSC | 1 |
| p.M18I | LUAD | 1 |
| p.S187N | SARC | 1 |
| p.K238T | LGG | 1 |
| p.K331I | UCEC | 1 |
| p.G25V | LUAD | 1 |
| p.S165F | SKCM | 1 |
| p.G153E | SKCM | 1 |
| p.S260C | BLCA | 1 |
| p.I343T | SKCM | 1 |
| p.L274I | THYM | 1 |
| p.S27C | LUSC | 1 |
| p.Y350N | LUSC | 1 |
| p.D117Y | HNSC | 1 |
| p.K277E | SKCM | 1 |
| p.S309F | SKCM | 1 |
| p.T294S | LUSC | 1 |
| p.A88S | LUAD | 1 |
| p.K40E | READ | 1 |
| p.D31H | BLCA | 1 |
| p.S187N | LGG | 1 |
| p.R280M | LUAD | 1 |
| p.E224K | SKCM | 1 |
| p.P281H | LUAD | 1 |
| p.P268L | SKCM | 1 |
| p.G30E | SKCM | 1 |
| p.S228P | UCS | 1 |
| p.K93T | UCEC | 1 |
| p.R157M | LUAD | 1 |
| p.G321S | KICH | 1 |
| p.A237S | LUSC | 1 |
| p.A88V | UCEC | 1 |
| p.G153R | SKCM | 1 |
| p.P239L | LUAD | 1 |
| p.Q104* | CESC | 1 |
| p.K14N | SKCM | 1 |
| p.L137I | UCEC | 1 |
| p.E180K | BLCA | 1 |
| p.Q295K | HNSC | 1 |
| p.E189K | LUAD | 1 |
| p.M112L | PAAD | 1 |
| p.K304N | LUSC | 1 |
| p.S168L | LUAD | 1 |
| p.N360H | COAD | 1 |
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| TissGeneCNV for CXorf66 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CXorf66 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BRCA | TCGA-A8-A06U-01A | MFSD6-CXorf66 | Out-of-frame | Chr2:191302287 | ChrX:139040376 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-S3-A6ZF-01A | CD99L2-CXorf66 | In-frame | ChrX:150066995 | ChrX:139040376 |
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| TissGeneNet for CXorf66 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for CXorf66 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CXorf66 |
| TissGeneDrug for CXorf66 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CXorf66 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0004936 | Mental disorders | 1 | GAD |
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