TissGeneSummary for CLEC18A |
Gene summary |
Basic gene information | Gene symbol | CLEC18A |
Gene name | C-type lectin domain family 18, member A | |
Synonyms | MRCL|MRCL1|MRLP2 | |
Cytomap | UCSC genome browser: 16q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001136214.2, NM_001271197.1,NM_182619.3, | |
Description | C-type lectin domain family 18 member Amannose receptor-like 1mannose receptor-like protein 2mannose receptor-like protein 3 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000157322 | ||
HPRD : 17360 | ||
Vega : OTTHUMG00000137574 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CLEC18A | |
BioGPS: 348174 | ||
Pathway | NCI Pathway Interaction Database: CLEC18A | |
KEGG: CLEC18A | ||
REACTOME: CLEC18A | ||
Pathway Commons: CLEC18A | ||
Context | iHOP: CLEC18A | |
ligand binding site mutation search in PubMed: CLEC18A | ||
UCL Cancer Institute: CLEC18A | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of CLEC18A | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CLEC18A |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | -0.451261434 | -1.536909434 | 1.085648 | 7.19E-07 | 3.99E-06 |
KIRC | 6.506571677 | 4.440223066 | 2.066348611 | 1.22E-08 | 3.67E-08 |
KIRP | 2.990910566 | 5.799123066 | -2.8082125 | 5.96E-06 | 2.59E-05 |
KICH | 1.372806566 | 4.466986566 | -3.09418 | 2.21E-08 | 1.11E-07 |
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TissGene-miRNA for CLEC18A |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CLEC18A |
TissGeneSNV for CLEC18A |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.N109K | SKCM | 1 |
p.G139E | KIRP | 1 |
p.P92L | SKCM | 1 |
p.T151M | COAD | 1 |
p.Q422H | PRAD | 1 |
p.G116S | SKCM | 1 |
p.H136Y | SKCM | 1 |
p.T148S | UVM | 1 |
p.A97V | STAD | 1 |
p.G139R | KIRP | 1 |
p.V409M | UCEC | 1 |
p.A435V | UCEC | 1 |
p.L88P | KIRP | 1 |
p.V409M | STAD | 1 |
p.P94L | SKCM | 1 |
p.W101C | PAAD | 1 |
p.R423C | UCEC | 1 |
p.D421N | BRCA | 1 |
p.Y150C | LUAD | 1 |
p.T148S | PCPG | 1 |
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TissGeneCNV for CLEC18A |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CLEC18A |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF081982 | RPS20-CLEC18A | chr8:56985763 | chr16:70194360 | |
Chimerdb3.0 | ChiTaRs | NA | BE504888 | NXF1-CLEC18A | chr11:62559952 | chr16:70192469 | |
Chimerdb3.0 | ChiTaRs | NA | BI061823 | WWC3-CLEC18A | chrX:10073274 | chr16:70152794 | |
Chimerdb3.0 | ChiTaRs | NA | BE551533 | NXF1-CLEC18A | chr11:62559952 | chr16:70192419 | |
Chimerdb3.0 | ChiTaRs | NA | BF904585 | CLEC18A-LOC283922 | chr16:70190594 | chr16:74401491 | |
Chimerdb3.0 | ChiTaRs | NA | BC038107 | CLEC18A-LTBP1 | chr16:70099756 | chr2:33525516 | |
Chimerdb3.0 | ChiTaRs | NA | BC051464 | CLEC18A-LTBP1 | chr16:70099748 | chr2:33525516 | |
Chimerdb3.0 | ChiTaRs | NA | BI027290 | CLEC18A-AMPD3 | chr16:70152597 | chr11:10518039 | |
Chimerdb3.0 | ChiTaRs | NA | AU144432 | CLEC18A-CLEC18A | chr16:70191555 | chr16:70190986 | |
Chimerdb3.0 | ChiTaRs | NA | W22578 | CLEC18A-CLEC18A | chr16:70192678 | chr16:70193406 | |
Chimerdb3.0 | ChiTaRs | NA | BF931966 | CLEC18A-PRRC2B | chr16:70043692 | chr9:134364824 | |
Chimerdb3.0 | ChiTaRs | NA | BE179774 | TP53BP1-CLEC18A | chr15:43748577 | chr16:70195784 |
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TissGeneNet for CLEC18A |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CLEC18A |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CLEC18A |
TissGeneDrug for CLEC18A |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CLEC18A |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |