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| TissGeneSummary for APOH |
 Gene summary |
| Basic gene information | Gene symbol | APOH |
| Gene name | apolipoprotein H (beta-2-glycoprotein I) | |
| Synonyms | B2G1|B2GP1|BG | |
| Cytomap | UCSC genome browser: 17q24.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000042.2, | |
| Description | APC inhibitorB2GPIactivated protein C-binding proteinanticardiolipin cofactorapo-Hbeta(2)GPIbeta-2-glycoprotein 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 138700 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000091583 | ||
| HPRD : 00728 | ||
| Vega : OTTHUMG00000179530 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_APOH | |
| BioGPS: 350 | ||
| Pathway | NCI Pathway Interaction Database: APOH | |
| KEGG: APOH | ||
| REACTOME: APOH | ||
| Pathway Commons: APOH | ||
| Context | iHOP: APOH | |
| ligand binding site mutation search in PubMed: APOH | ||
| UCL Cancer Institute: APOH | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of APOH | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0001937 | negative regulation of endothelial cell proliferation | 17872974 | GO:0006641 | triglyceride metabolic process | 7417307 | GO:0007597 | blood coagulation, intrinsic pathway | 4052628 | GO:0010596 | negative regulation of endothelial cell migration | 17872974 | GO:0016525 | negative regulation of angiogenesis | 17872974 | GO:0030195 | negative regulation of blood coagulation | 4052628 | GO:0031639 | plasminogen activation | 16480936 | GO:0033033 | negative regulation of myeloid cell apoptotic process | 15534879 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process | 15534879 | GO:0051006 | positive regulation of lipoprotein lipase activity | 7417307 | GO:0051917 | regulation of fibrinolysis | 16480936 | GO:0051918 | negative regulation of fibrinolysis | 14726399 | GO:0001937 | negative regulation of endothelial cell proliferation | 17872974 | GO:0006641 | triglyceride metabolic process | 7417307 | GO:0007597 | blood coagulation, intrinsic pathway | 4052628 | GO:0010596 | negative regulation of endothelial cell migration | 17872974 | GO:0016525 | negative regulation of angiogenesis | 17872974 | GO:0030195 | negative regulation of blood coagulation | 4052628 | GO:0031639 | plasminogen activation | 16480936 | GO:0033033 | negative regulation of myeloid cell apoptotic process | 15534879 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process | 15534879 | GO:0051006 | positive regulation of lipoprotein lipase activity | 7417307 | GO:0051917 | regulation of fibrinolysis | 16480936 | GO:0051918 | negative regulation of fibrinolysis | 14726399 |
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| TissGeneExp for APOH |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 13.60829594 | 15.53252594 | -1.92423 | 2.24E-05 | 8.74E-05 |
| KICH | -2.097856062 | 2.160099938 | -4.257956 | 5.63E-07 | 2.22E-06 |
| LUSC | -0.87529967 | 4.812990526 | -5.688290196 | 2.57E-32 | 1.70E-30 |
| LUAD | 2.512990627 | 4.746061317 | -2.23307069 | 3.07E-08 | 1.30E-07 |
| KIRP | -0.285120687 | 4.011973063 | -4.29709375 | 1.62E-08 | 1.20E-07 |
| COAD | -0.377176216 | 0.920354553 | -1.297530769 | 0.000219 | 0.000737065 |
| KIRC | 1.462119938 | 3.303357438 | -1.8412375 | 0.000338 | 0.000669724 |
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| TissGene-miRNA for APOH |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for APOH |
| TissGeneSNV for APOH |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S146F | SKCM | 2 |
| p.G161E | SKCM | 2 |
| p.P85S | SKCM | 2 |
| p.T149M | STAD | 1 |
| p.G128E | SKCM | 1 |
| p.K269N | STAD | 1 |
| p.W335S | COAD | 1 |
| p.M1V | SKCM | 1 |
| p.P148T | KIRC | 1 |
| p.S239F | SKCM | 1 |
| p.E321K | COAD | 1 |
| p.D341N | SKCM | 1 |
| p.G277R | SKCM | 1 |
| p.T223P | KIRC | 1 |
| p.E284K | SKCM | 1 |
| p.E45* | UCEC | 1 |
| p.C315* | LUSC | 1 |
| p.G113R | KIRC | 1 |
| p.G93E | SKCM | 1 |
| p.E245* | UCEC | 1 |
| p.M180I | STAD | 1 |
| p.F286I | COAD | 1 |
| p.D317E | BRCA | 1 |
| p.D317A | LIHC | 1 |
| p.C51X | THYM | 1 |
| p.P43A | HNSC | 1 |
| p.Q314L | LUSC | 1 |
| p.G242C | BLCA | 1 |
| p.P208S | SKCM | 1 |
| p.E304K | SKCM | 1 |
| p.E311* | LUAD | 1 |
| p.E245K | SKCM | 1 |
| p.D184N | SKCM | 1 |
| p.D312E | LUAD | 1 |
| p.E284* | UCEC | 1 |
| p.S297F | SKCM | 1 |
| p.D184Y | UCEC | 1 |
| p.C307Y | CESC | 1 |
| p.G214E | SKCM | 1 |
| p.R58* | UCEC | 1 |
| p.W130R | STAD | 1 |
| p.P53L | ESCA | 1 |
| p.C205Y | THYM | 1 |
| p.A160D | DLBC | 1 |
| p.E91K | PAAD | 1 |
| p.E46K | ESCA | 1 |
| p.S164F | SKCM | 1 |
| p.T152I | CESC | 1 |
| p.R21Q | SKCM | 1 |
| p.P85S | LIHC | 1 |
| p.Y156* | LUAD | 1 |
| p.P176S | STAD | 1 |
| p.R154C | HNSC | 1 |
| p.K229T | COAD | 1 |
| p.R58Q | STAD | 1 |
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| TissGeneCNV for APOH |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for APOH |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BG469920 | MTMR3-APOH | chr22:30279348 | chr17:64212981 | |
| Chimerdb3.0 | ChiTaRs | NA | BG824141 | MTMR3-APOH | chr22:30279348 | chr17:64216676 |
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| TissGeneNet for APOH |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (tumor) | APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (normal) |
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| COAD (tumor) | COAD (normal) |
| APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (tumor) | APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (tumor) | APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (normal) |
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| KICH (tumor) | KICH (normal) |
| APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (tumor) | APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (tumor) | APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (tumor) | APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (tumor) | APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (tumor) | APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (tumor) | APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (tumor) | APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (normal) |
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| STAD (tumor) | STAD (normal) |
| APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (tumor) | APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (normal) |
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| THCA (tumor) | THCA (normal) |
| APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (tumor) | APOH, TP53, HNF4A, ONECUT1, GRB2, RBBP6, CDC42, GEM, ANXA2, PLG, AKT1, HNF1A, LRP8, LPA, F10, CLEC4G, LRP2, LDLR, F12 (normal) |
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| TissGeneProg for APOH |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for APOH |
| TissGeneDrug for APOH |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for APOH |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0085278 | Antiphospholipid Syndrome | 39 | BeFree,GAD,LHGDN |
| umls:C0085409 | Polyendocrinopathies, Autoimmune | 22 | BeFree |
| umls:C0024141 | Lupus Erythematosus, Systemic | 14 | BeFree,GAD |
| umls:C0040053 | Thrombosis | 7 | GAD,LHGDN,RGD |
| umls:C0004153 | Atherosclerosis | 5 | BeFree,LHGDN |
| umls:C0151942 | Arterial thrombosis | 4 | BeFree |
| umls:C0311370 | Lupus anticoagulant disorder | 4 | BeFree |
| umls:C0584960 | Factor V Leiden mutation | 4 | BeFree |
| umls:C0007785 | Cerebral Infarction | 3 | BeFree,GAD,LHGDN |
| umls:C0038454 | Cerebrovascular accident | 3 | BeFree,GAD |
| umls:C0003850 | Arteriosclerosis | 2 | BeFree |
| umls:C0004364 | Autoimmune Diseases | 2 | BeFree |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 2 | BeFree |
| umls:C0023903 | Liver neoplasms | 2 | BeFree |
| umls:C0024131 | Lupus Vulgaris | 2 | BeFree |
| umls:C0024138 | Lupus Erythematosus, Discoid | 2 | BeFree |
| umls:C0027051 | Myocardial Infarction | 2 | BeFree,RGD |
| umls:C0398623 | Thrombophilia | 2 | BeFree |
| umls:C0409974 | Lupus Erythematosus | 2 | BeFree |
| umls:C0553692 | Brain hemorrhage | 2 | GAD |
| umls:C0860207 | Drug-Induced Liver Injury | 2 | CTD_human,RGD |
| umls:C1562585 | Leprosy, Multibacillary | 2 | BeFree,GAD |
| umls:C2239176 | Liver carcinoma | 2 | BeFree |
| umls:C0004943 | Behcet Syndrome | 1 | LHGDN |
| umls:C0005779 | Blood Coagulation Disorders | 1 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
| umls:C0007282 | Carotid Stenosis | 1 | GAD |
| umls:C0009324 | Ulcerative Colitis | 1 | LHGDN |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0012739 | Disseminated Intravascular Coagulation | 1 | LHGDN |
| umls:C0019196 | Hepatitis C | 1 | BeFree |
| umls:C0020445 | Hypercholesterolemia, Familial | 1 | BeFree |
| umls:C0020538 | Hypertensive disease | 1 | BeFree |
| umls:C0022661 | Kidney Failure, Chronic | 1 | GAD |
| umls:C0023487 | Acute Promyelocytic Leukemia | 1 | BeFree |
| umls:C0023890 | Liver Cirrhosis | 1 | LHGDN |
| umls:C0024143 | Lupus Nephritis | 1 | GAD |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | LHGDN |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0039614 | Tetanus | 1 | BeFree |
| umls:C0042373 | Vascular Diseases | 1 | BeFree |
| umls:C0042769 | Virus Diseases | 1 | BeFree |
| umls:C0156149 | Gastrointestinal tract vascular insufficiency | 1 | BeFree |
| umls:C0242422 | Parkinsonian Disorders | 1 | LHGDN |
| umls:C0242666 | Protein S Deficiency | 1 | BeFree |
| umls:C0272285 | Heparin-induced thrombocytopenia | 1 | BeFree |
| umls:C0524620 | Metabolic Syndrome X | 1 | BeFree |
| umls:C0600433 | Activated Protein C Resistance | 1 | LHGDN |
| umls:C0836924 | Thrombocytosis | 1 | BeFree |
| umls:C0856169 | Endothelial dysfunction | 1 | BeFree |
| umls:C0948008 | Ischemic stroke | 1 | BeFree |
| umls:C1527336 | Sjogren's Syndrome | 1 | LHGDN |
| umls:C1562908 | Leprosy, Paucibacillary | 1 | GAD |
| umls:C1704436 | Peripheral Arterial Diseases | 1 | BeFree |
| umls:C2004435 | Vascular insufficiency of intestine | 1 | BeFree |
| umls:C2937358 | Cerebral Hemorrhage | 1 | LHGDN |
| umls:C3714514 | Infection | 1 | LHGDN |
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