TissGeneSummary for LCE1B |
Gene summary |
Basic gene information | Gene symbol | LCE1B |
Gene name | late cornified envelope 1B | |
Synonyms | LEP2|SPRL2A | |
Cytomap | UCSC genome browser: 1q21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_178349.1, | |
Description | late cornified envelope protein 1Blate envelope protein 2small proline rich-like (epidermal differentiation complex) 2Asmall proline-rich-like epidermal differentiation complex protein 2A | |
Modification date | 20141207 | |
dbXrefs | MIM : 612604 | |
HGNC : HGNC | ||
Ensembl : ENSG00000196734 | ||
HPRD : 17259 | ||
Vega : OTTHUMG00000014402 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_LCE1B | |
BioGPS: 353132 | ||
Pathway | NCI Pathway Interaction Database: LCE1B | |
KEGG: LCE1B | ||
REACTOME: LCE1B | ||
Pathway Commons: LCE1B | ||
Context | iHOP: LCE1B | |
ligand binding site mutation search in PubMed: LCE1B | ||
UCL Cancer Institute: LCE1B | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
Reference showing the relevant tissue of LCE1B | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for LCE1B |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for LCE1B |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for LCE1B |
TissGeneSNV for LCE1B |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S42F | SKCM | 1 |
p.G73S | SKCM | 1 |
p.L25I | UCEC | 1 |
p.T26N | UCEC | 1 |
p.G115E | SKCM | 1 |
p.G108E | SARC | 1 |
p.C51F | SKCM | 1 |
p.P34H | STAD | 1 |
p.P22S | SKCM | 1 |
p.G102C | LUSC | 1 |
p.P22L | SKCM | 1 |
p.G71E | SKCM | 1 |
p.I17M | SKCM | 1 |
p.P12S | STAD | 1 |
p.Q91X | SKCM | 1 |
p.H113Y | UCEC | 1 |
p.P13H | SKCM | 1 |
p.S97G | LUAD | 1 |
p.C105S | STAD | 1 |
p.S70F | LIHC | 1 |
p.C51X | COAD | 1 |
p.G102V | LUAD | 1 |
p.P14S | SKCM | 1 |
p.Q7K | LUSC | 1 |
p.S64T | SKCM | 1 |
p.G61A | KIRC | 1 |
p.R28I | UCEC | 1 |
p.S97N | STAD | 1 |
p.G49E | SKCM | 1 |
p.R84M | LUAD | 1 |
p.V40F | LIHC | 1 |
p.R82C | LUAD | 1 |
p.P13S | SKCM | 1 |
p.Q91* | SKCM | 1 |
p.Q112H | LUSC | 1 |
p.S56C | CESC | 1 |
p.G49* | LAML | 1 |
p.P34L | SKCM | 1 |
p.R82H | ESCA | 1 |
p.P38H | STAD | 1 |
p.S45G | LUAD | 1 |
p.Q8L | LUAD | 1 |
p.S100F | SKCM | 1 |
p.I17T | CESC | 1 |
p.P27A | LIHC | 1 |
p.P35H | SARC | 1 |
p.V46D | LUAD | 1 |
p.Q5H | LUSC | 1 |
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TissGeneCNV for LCE1B |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for LCE1B |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for LCE1B |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for LCE1B |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for LCE1B |
TissGeneDrug for LCE1B |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for LCE1B |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |