TissGeneSummary for BMP8A |
Gene summary |
Basic gene information | Gene symbol | BMP8A |
Gene name | bone morphogenetic protein 8a | |
Synonyms | - | |
Cytomap | UCSC genome browser: 1p34.3 | |
Type of gene | protein-coding | |
RefGenes | NM_181809.3, | |
Description | BMP-8Abone morphogenetic protein 8A | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
HPRD : 16555 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_BMP8A | |
BioGPS: 353500 | ||
Pathway | NCI Pathway Interaction Database: BMP8A | |
KEGG: BMP8A | ||
REACTOME: BMP8A | ||
Pathway Commons: BMP8A | ||
Context | iHOP: BMP8A | |
ligand binding site mutation search in PubMed: BMP8A | ||
UCL Cancer Institute: BMP8A | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Thyroid gland | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | THCA | |
Reference showing the relevant tissue of BMP8A | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0002024 | diet induced thermogenesis | 22579288 | GO:0046676 | negative regulation of insulin secretion | 22579288 | GO:2000505 | regulation of energy homeostasis | 22579288 | GO:0002024 | diet induced thermogenesis | 22579288 | GO:0046676 | negative regulation of insulin secretion | 22579288 | GO:2000505 | regulation of energy homeostasis | 22579288 |
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TissGeneExp for BMP8A |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
STAD | 2.22817246 | 0.29696621 | 1.93120625 | 3.46E-10 | 3.24E-08 |
HNSC | 0.783704 | -1.688865767 | 2.472569767 | 6.02E-18 | 2.26E-15 |
LUAD | 1.510237761 | -0.811839825 | 2.322077586 | 1.32E-18 | 1.96E-17 |
BRCA | 1.716699981 | -0.775905282 | 2.492605263 | 2.25E-51 | 1.95E-49 |
THCA | 1.568129345 | 6.346963243 | -4.778833898 | 3.21E-22 | 1.92E-20 |
LIHC | -1.02802679 | -2.34300279 | 1.314976 | 3.90E-06 | 1.85E-05 |
LUSC | 1.447421602 | -0.466150947 | 1.913572549 | 3.10E-13 | 1.52E-12 |
BLCA | 0.985730683 | -0.657721948 | 1.643452632 | 2.53E-07 | 1.10E-05 |
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TissGene-miRNA for BMP8A |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for BMP8A |
TissGeneSNV for BMP8A |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G400S | COAD | 1 |
p.M106I | LUAD | 1 |
p.G297D | HNSC | 1 |
p.D312N | SKCM | 1 |
p.R293H | COAD | 1 |
p.D339N | SKCM | 1 |
p.F180L | UCEC | 1 |
p.A361T | UCEC | 1 |
p.G294S | STAD | 1 |
p.M357T | LUAD | 1 |
p.E278K | SKCM | 1 |
p.R392H | UCEC | 1 |
p.A361T | COAD | 1 |
p.Y307F | SARC | 1 |
p.R293H | CESC | 1 |
p.C366S | COAD | 1 |
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TissGeneCNV for BMP8A |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for BMP8A |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AW836221 | BMP8A-PPIEL | chr1:39992694 | chr1:40007763 | |
Chimerdb3.0 | ChiTaRs | NA | AW836213 | BMP8A-PPIEL | chr1:39992707 | chr1:40007763 |
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TissGeneNet for BMP8A |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for BMP8A |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for BMP8A |
TissGeneDrug for BMP8A |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for BMP8A |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0020503 | Hyperparathyroidism, Secondary | 1 | GAD |