TissGDB
Tissglogo

Home

Download

 Statistics

 Landscape

Help

Contact
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

bullet point

TissGeneSummary

bullet point

TissGeneExp

bullet point

TissGene-miRNA

bullet point

TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

bullet point

TissGeneNet

bullet point

TissGeneProg

bullet point

TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for KLK3
check button Gene summary
Basic gene informationGene symbolKLK3
Gene namekallikrein-related peptidase 3
SynonymsAPS|KLK2A1|PSA|hK3
CytomapUCSC genome browser: 19q13.41
Type of geneprotein-coding
RefGenesNM_001030047.1,
NM_001030048.1,NM_001648.2,NM_001030049.1,NM_001030050.1,
DescriptionP-30 antigengamma-seminoproteinkallikrein-3prostate specific antigenprostate-specific antigensemenogelaseseminin
Modification date20141212
dbXrefs MIM : 176820
HGNC : HGNC
Ensembl : ENSG00000142515
HPRD : 01461
Vega : OTTHUMG00000182867
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KLK3
BioGPS: 354
PathwayNCI Pathway Interaction Database: KLK3
KEGG: KLK3
REACTOME: KLK3
Pathway Commons: KLK3
ContextiHOP: KLK3
ligand binding site mutation search in PubMed: KLK3
UCL Cancer Institute: KLK3
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Prostate
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PRAD
Reference showing the relevant tissue of KLK3Subgroups of Castration-resistant Prostate Cancer Bone Metastases Defined Through an Inverse Relationship Between Androgen Receptor Activity and Immune Response. Ylitalo EB, Thysell E, Jernberg E, Lundholm M, Crnalic S, Egevad L, Stattin P, Widmark A, Bergh A, Wikström P. Eur Urol. 2017 May;71(5):776-787. doi: 10.1016/j.eururo.2016.07.033. Epub 2016 Aug 3. (pmid:27497761)
go to article
Description by TissGene annotationsProtective TissGene in OS
Cancer gene
TissgsKTS
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


Top
TissGeneExp for KLK3

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRC-1.49310708-0.112462636-1.3806444442.06E-117.77E-11
COAD0.8615903562.919090356-2.05751.76E-057.59E-05
THCA-0.2244488881.752166366-1.9766152541.16E-096.60E-09
KICH6.0667915860.0511755866.0156161.15E-163.67E-15
BRCA-0.7676921681.481221867-2.2489140355.18E-142.53E-13
PRAD16.8103384315.138428821.6719096150.0003890.001410597
KIRP-0.3663122891.487165836-1.8534781250.0002830.000880008


Top
TissGene-miRNA for KLK3

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


Top
TissGeneMut for KLK3
TissGeneSNV for KLK3

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
bullet point


check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.P237LSKCM2
p.E32KSKCM1
p.G28CSTAD1
p.A235VHNSC1
p.M225LKIRC1
p.R125HHNSC1
p.F96LHNSC1
p.E164GLIHC1
p.W229RHNSC1
p.T227MHNSC1
p.W234*SKCM1
p.E195KCOAD1
p.K169NCESC1
p.P83SSKCM1
p.H65NHNSC1
p.L89ICOAD1
p.P261TLUAD1
p.D182APRAD1
p.G87SSKCM1
p.G225SSKCM1
p.P129LPRAD1
p.G156VLUAD1
p.R201CLGG1
p.C173FLUAD1
p.G230DUCEC1
p.N260SSKCM1
p.H78QOV1
p.V72MSARC1
p.E32DUCEC1
p.W159RSKCM1
p.S180FSKCM1
p.P19LSKCM1
p.E131KSKCM1
p.W234XSKCM1
p.A192VSKCM1
p.G182SSKCM1
p.A235VSKCM1
p.V42LPRAD1
p.G149WLUSC1
p.R77GCESC1
p.M196LLUAD1
p.A63SKIRP1
p.E32GLUSC1
p.N217SSKCM1
p.V12GSKCM1
p.S127LBLCA1
p.D102EPRAD1
p.W202RSKCM1
p.C209YBRCA1
p.R77WSKCM1
p.V55MLUAD1


Top
TissGeneCNV for KLK3

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


Top
TissGeneFusions for KLK3

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABE835094VPS4A-KLK3chr16:69358477chr19:51361161
Chimerdb3.0ChiTaRsNADA874433KLK3-CDC42EP4chr19:51361401chr17:71282002
Chimerdb3.0ChiTaRsNABF858256KLK3-PSMD7chr19:51361508chr16:74330845
Chimerdb3.0ChiTaRsNAAI686170KLK3-GSNchr19:51364020chr9:124074745
Chimerdb3.0ChiTaRsNABF680981KLK3-MALAT1chr19:51363831chr11:65266528
Chimerdb3.0ChiTaRsNAAA226360KLK3-KLK3chr19:51363418chr19:51361523
Chimerdb3.0ChiTaRsNABF858891RORA-KLK3chr15:61372006chr19:51363680
Chimerdb3.0ChiTaRsNABF222031KLK3-CACNB2chr19:51364020chr10:18484079
Chimerdb3.0ChiTaRsNAAA226359KLK3-KLK3chr19:51363332chr19:51363335
Chimerdb3.0ChiTaRsNABI046989FBRS-KLK3chr16:30674023chr19:51360463
Chimerdb3.0ChiTaRsNAAI826974KLK3-LOC646329chr19:51364020chr7:130581373
Chimerdb3.0FusionScanPRADTCGA-QU-A6IO-01APOLR2J3-KLK33'UTR-3'UTRchr7:102180461chr19:51363227
Chimerdb3.0TopHat-FusionPRADTCGA-J4-A83M-01AKLK3-KLK23'UTR-3'UTRchr19:51363858chr19:51382283
Chimerdb3.0TopHat-FusionPRADTCGA-VN-A88P-01AKLK3-KLK23'UTR-3'UTRchr19:51363771chr19:51381971
Chimerdb3.0TopHat-FusionPRADTCGA-CH-5767-01AKLK3-KLK23'UTR-3'UTRchr19:51363467chr19:51381972
Chimerdb3.0TopHat-FusionPRADTCGA-HC-A6AO-01AKLK3-KLK23'UTR-3'UTRchr19:51363467chr19:51381972
Chimerdb3.0TopHat-FusionPRADTCGA-YL-A8HL-01AKLK3-KLK23'UTR-3'UTRchr19:51363771chr19:51381971
Chimerdb3.0TopHat-FusionPRADTCGA-G9-6499-11AKLK3-KLK23'UTR-3'UTRchr19:51363801chr19:51382016
Chimerdb3.0TopHat-FusionPRADTCGA-HC-A8CY-01AKLK3-KLK23'UTR-3'UTRchr19:51363771chr19:51381971
Chimerdb3.0TopHat-FusionPRADTCGA-EJ-A7NF-01AKLK3-KLK23'UTR-3'UTRchr19:51363801chr19:51382309
Chimerdb3.0TopHat-FusionPRADTCGA-QU-A6IO-01AKLK3-KLK23'UTR-3'UTRchr19:51363467chr19:51381972
Chimerdb3.0TopHat-FusionPRADTCGA-QU-A6IO-01AKLK3-KLK23'UTR-3'UTRchr19:51363850chr19:51382293
Chimerdb3.0TopHat-FusionPRADTCGA-KK-A6E2-01AKLK3-KLK23'UTR-3'UTRchr19:51363467chr19:51381972
Chimerdb3.0TopHat-FusionPRADTCGA-CH-5753-01AKLK3-KLK23'UTR-3'UTRchr19:51363870chr19:51382326
Chimerdb3.0TopHat-FusionPRADTCGA-CH-5763-01AKLK3-KLK2In-Framechr19:51361301chr19:51379780
Chimerdb3.0TopHat-FusionPRADTCGA-CH-5767-01AKLK3-KLK2In-Framechr19:51361301chr19:51379780
Chimerdb3.0TopHat-FusionPRADTCGA-EJ-5522-01AKLK3-KLK2In-Framechr19:51361289chr19:51379819
Chimerdb3.0TopHat-FusionPRADTCGA-CH-5789-01AKLK3-KLK2Out-of-Framechr19:51361296chr19:51379774
Chimerdb3.0TopHat-FusionPRADTCGA-EJ-A65F-01AKLK3-KLK2In-Framechr19:51361301chr19:51379780
Chimerdb3.0TopHat-FusionPRADTCGA-CH-5766-01AKLK3-KLK2Out-of-Framechr19:51361290chr19:51379818
Chimerdb3.0TopHat-FusionPRADTCGA-CH-5766-01AKLK3-KLK2In-Framechr19:51361301chr19:51379780
Chimerdb3.0TopHat-FusionPRADTCGA-EJ-A8FO-01AKLK3-KLK2In-Framechr19:51361301chr19:51379780
Chimerdb3.0TopHat-FusionPRADTCGA-EJ-5509-01AKLK3-KLK2Out-of-Framechr19:51361296chr19:51379774
Chimerdb3.0TopHat-FusionPRADTCGA-EJ-5504-01AKLK3-KLK2In-Framechr19:51361301chr19:51379780
Chimerdb3.0TopHat-FusionPRADTCGA-EJ-5503-01AKLK3-KLK2In-Framechr19:51361282chr19:51378088
Chimerdb3.0TopHat-FusionPRADTCGA-EJ-5516-01AKLK3-KLK2In-Framechr19:51361301chr19:51379780
Chimerdb3.0TopHat-FusionPRADTCGA-HC-7821-01AKLK3-KLK2In-Framechr19:51361301chr19:51379780
Chimerdb3.0TopHat-FusionPRADTCGA-EJ-A7NF-01AKLK3-KLK2Out-of-Framechr19:51361296chr19:51379774
Chimerdb3.0TopHat-FusionPRADTCGA-EJ-7785-11AKLK3-KLK2Out-of-Framechr19:51361333chr19:51379737
Chimerdb3.0TopHat-FusionPRADTCGA-EJ-5496-01AKLK3-KLK2Out-of-Framechr19:51361341chr19:51379740
Chimerdb3.0TopHat-FusionPRADTCGA-KK-A8IJ-01AKLK3-KLK2Out-of-Framechr19:51361341chr19:51379740
Chimerdb3.0TopHat-FusionPRADTCGA-EJ-5499-01AKLK3-KLK2Out-of-Framechr19:51361296chr19:51379774
Chimerdb3.0TopHat-FusionPRADTCGA-EJ-5499-01AKLK3-KLK2In-Framechr19:51361301chr19:51379780
Chimerdb3.0TopHat-FusionPRADTCGA-J4-A83L-01AKLK3-KLK2In-Framechr19:51361337chr19:51379744
Chimerdb3.0TopHat-FusionPRADTCGA-CH-5744-01AKLK3-KLK2In-Framechr19:51361289chr19:51379819
Chimerdb3.0TopHat-FusionPRADTCGA-EJ-5502-01AKLK3-KLK2In-Framechr19:51361301chr19:51379780
Chimerdb3.0TopHat-FusionPRADTCGA-HC-8213-01AKLK3-KLK2In-Framechr19:51361301chr19:51379780
Chimerdb3.0TopHat-FusionPRADTCGA-EJ-8474-01AKLK3-KLK2In-Framechr19:51361295chr19:51376737
Chimerdb3.0TopHat-FusionPRADTCGA-G9-6371-01AKLK3-KLK2Out-of-Framechr19:51361296chr19:51379785
TCGAfusionPortalPRADABRCATCGA-AC-A5XU-01AZC3H3-KLK3Out-of-frameChr8:144547887Chr19:51359496


Top
TissGeneNet for KLK3

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
KLK3, XRCC5, SERPINA1, FN1, CTNNB1, CREBBP, AR, KAT2B, REL, SERPINA3, ALB, A2M, PTHLH, SERPINA5, GRIP1, PRKDC, MYSM1, IGFBP3, ERG, SLPI, PZP (tumor)KLK3, XRCC5, AR, REL, SERPINA3, ALB, HIST1H1B, A2M, PTHLH, PARP1, SERPINA5, PRKDC, IGFBP3, XRCC6, SEMG1, ERG, EPOR, RNF6, SLPI, PZP, SEMG2 (normal)
bullet pointbullet point
COAD (tumor)COAD (normal)
KLK3, XRCC5, SERPINA1, FN1, CTNNB1, CREBBP, AR, KAT2B, REL, PLG, ALB, A2M, PTHLH, PARP1, GRIP1, PRKDC, MYSM1, ERG, EPOR, RNF6, SLPI (tumor)KLK3, XRCC5, HIST3H3, SERPINA1, FN1, CTNNB1, AR, KAT2B, SERPINA3, PLG, ALB, HIST1H1B, A2M, SERPINA5, GRIP1, PRKDC, IGFBP3, SEMG1, ERG, EPOR, RNF6 (normal)
bullet pointbullet point
HNSC (tumor)HNSC (normal)
KLK3, HIST3H3, SERPINA1, FN1, CTNNB1, CREBBP, AR, KAT2B, SERPINA3, PLG, HIST1H1B, A2M, PTHLH, PARP1, SERPINA5, PRKDC, IGFBP3, XRCC6, EPOR, RNF6, PZP (tumor)KLK3, XRCC5, HIST3H3, FN1, CREBBP, AR, REL, SERPINA3, PLG, ALB, A2M, PARP1, SERPINA5, GRIP1, PRKDC, IGFBP3, SEMG1, ERG, EPOR, SLPI, SEMG2 (normal)
bullet pointbullet point
KICH (tumor)KICH (normal)
KLK3, XRCC5, HIST3H3, SERPINA1, FN1, AR, KAT2B, REL, PLG, ALB, HIST1H1B, PTHLH, GRIP1, PRKDC, MYSM1, IGFBP3, SEMG1, EPOR, RNF6, SLPI, PZP (tumor)KLK3, XRCC5, SERPINA1, FN1, AR, KAT2B, REL, SERPINA3, HIST1H1B, A2M, PARP1, GRIP1, PRKDC, MYSM1, IGFBP3, XRCC6, ERG, EPOR, RNF6, SLPI, SEMG2 (normal)
bullet pointbullet point
KIRC (tumor)KIRC (normal)
KLK3, XRCC5, SERPINA1, FN1, CREBBP, AR, KAT2B, PLG, ALB, A2M, PARP1, SERPINA5, GRIP1, PRKDC, IGFBP3, XRCC6, SEMG1, EPOR, RNF6, SLPI, SEMG2 (tumor)KLK3, XRCC5, SERPINA1, FN1, CTNNB1, AR, REL, PLG, A2M, PTHLH, PARP1, SERPINA5, GRIP1, MYSM1, IGFBP3, XRCC6, SEMG1, ERG, EPOR, PZP, SEMG2 (normal)
bullet pointbullet point
KIRP (tumor)KIRP (normal)
KLK3, SERPINA1, CTNNB1, CREBBP, AR, REL, PLG, ALB, HIST1H1B, A2M, PARP1, GRIP1, PRKDC, IGFBP3, XRCC6, ERG, EPOR, RNF6, SLPI, PZP, SEMG2 (tumor)KLK3, XRCC5, HIST3H3, SERPINA1, CTNNB1, AR, REL, SERPINA3, PLG, ALB, HIST1H1B, A2M, PARP1, SERPINA5, GRIP1, IGFBP3, XRCC6, SEMG1, EPOR, SLPI, SEMG2 (normal)
bullet pointbullet point
LIHC (tumor)LIHC (normal)
KLK3, XRCC5, SERPINA1, CTNNB1, CREBBP, AR, SERPINA3, ALB, A2M, PTHLH, PARP1, SERPINA5, GRIP1, PRKDC, MYSM1, IGFBP3, XRCC6, SEMG1, EPOR, SLPI, PZP (tumor)KLK3, XRCC5, SERPINA1, FN1, CTNNB1, CREBBP, KAT2B, REL, SERPINA3, ALB, HIST1H1B, A2M, SERPINA5, GRIP1, PRKDC, IGFBP3, SEMG1, ERG, RNF6, PZP, SEMG2 (normal)
bullet pointbullet point
LUAD (tumor)LUAD (normal)
KLK3, XRCC5, SERPINA1, CTNNB1, CREBBP, AR, KAT2B, SERPINA3, ALB, HIST1H1B, PTHLH, PARP1, SERPINA5, GRIP1, PRKDC, MYSM1, IGFBP3, XRCC6, EPOR, RNF6, PZP (tumor)KLK3, XRCC5, HIST3H3, SERPINA1, FN1, CTNNB1, KAT2B, ALB, PTHLH, PARP1, SERPINA5, GRIP1, MYSM1, IGFBP3, XRCC6, SEMG1, EPOR, RNF6, SLPI, PZP, SEMG2 (normal)
bullet pointbullet point
LUSC (tumor)LUSC (normal)
KLK3, XRCC5, HIST3H3, SERPINA1, FN1, CREBBP, REL, PLG, ALB, A2M, PARP1, GRIP1, MYSM1, IGFBP3, XRCC6, SEMG1, EPOR, RNF6, SLPI, PZP, SEMG2 (tumor)KLK3, XRCC5, HIST3H3, CREBBP, AR, KAT2B, REL, ALB, HIST1H1B, PTHLH, PARP1, SERPINA5, GRIP1, PRKDC, IGFBP3, XRCC6, SEMG1, ERG, EPOR, RNF6, SLPI (normal)
bullet pointbullet point
PRAD (tumor)PRAD (normal)
KLK3, HIST3H3, SERPINA1, FN1, CTNNB1, AR, KAT2B, PLG, ALB, A2M, PTHLH, PARP1, SERPINA5, GRIP1, PRKDC, XRCC6, SEMG1, EPOR, SLPI, PZP, SEMG2 (tumor)KLK3, XRCC5, HIST3H3, SERPINA1, FN1, CTNNB1, CREBBP, AR, REL, SERPINA3, ALB, HIST1H1B, A2M, PTHLH, PARP1, GRIP1, PRKDC, IGFBP3, XRCC6, EPOR, PZP (normal)
bullet pointbullet point
STAD (tumor)STAD (normal)
KLK3, XRCC5, HIST3H3, SERPINA1, CTNNB1, CREBBP, AR, KAT2B, REL, SERPINA3, PLG, PTHLH, SERPINA5, PRKDC, IGFBP3, SEMG1, ERG, EPOR, RNF6, SLPI, SEMG2 (tumor)KLK3, HIST3H3, CTNNB1, CREBBP, AR, KAT2B, REL, SERPINA3, PLG, ALB, HIST1H1B, PTHLH, SERPINA5, MYSM1, IGFBP3, XRCC6, SEMG1, ERG, SLPI, PZP, SEMG2 (normal)
bullet pointbullet point
THCA (tumor)THCA (normal)
KLK3, XRCC5, SERPINA1, CTNNB1, CREBBP, AR, KAT2B, REL, SERPINA3, ALB, A2M, PTHLH, PARP1, SERPINA5, GRIP1, PRKDC, MYSM1, XRCC6, ERG, RNF6, SLPI (tumor)KLK3, XRCC5, SERPINA1, FN1, CTNNB1, CREBBP, AR, KAT2B, PLG, ALB, PTHLH, PARP1, GRIP1, PRKDC, IGFBP3, XRCC6, SEMG1, EPOR, RNF6, SLPI, SEMG2 (normal)
bullet pointbullet point


Top
TissGeneProg for KLK3

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

Top
TissGeneClin for KLK3
TissGeneDrug for KLK3

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


Top
TissGeneDisease for KLK3

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0376358Malignant neoplasm of prostate781BeFree,GAD,GWASCAT
umls:C0600139Prostate carcinoma776BeFree
umls:C0033578Prostatic Neoplasms75BeFree,CTD_human,GAD,LHGDN
umls:C0027627Neoplasm Metastasis71BeFree,GAD
umls:C1704272Benign Prostatic Hyperplasia53BeFree
umls:C0006142Malignant neoplasm of breast31BeFree,GAD
umls:C0678222Breast Carcinoma31BeFree
umls:C0007112Adenocarcinoma of prostate19BeFree
umls:C1458155Mammary Neoplasms17BeFree,LHGDN
umls:C0178874Tumor Progression14BeFree
umls:C0001418Adenocarcinoma11BeFree
umls:C0033575Prostatic Diseases11BeFree,LHGDN
umls:C0686619Secondary malignant neoplasm of lymph node10BeFree
umls:C1328504Hormone refractory prostate cancer10BeFree
umls:C0153690Secondary malignant neoplasm of bone9BeFree
umls:C0936223Metastatic Prostate Carcinoma9BeFree
umls:C1654637androgen independent prostate cancer9BeFree
umls:C1519176Salivary Gland Pleomorphic Adenoma8BeFree
umls:C0034341Pyruvate Carboxylase Deficiency Disease7BeFree
umls:C0278838Prostate cancer recurrent7BeFree
umls:C0029925Ovarian Carcinoma6BeFree
umls:C2931456Prostate cancer, familial6BeFree
umls:C0521158Recurrent tumor5BeFree
umls:C0596263Carcinogenesis5BeFree
umls:C1140680Malignant neoplasm of ovary5BeFree
umls:C2937421Prostatic Hyperplasia5CTD_human,GAD,LHGDN
umls:C0019348Herpes Simplex Infections4BeFree
umls:C0024141Lupus Erythematosus, Systemic4BeFree
umls:C0280280stage, prostate cancer4BeFree
umls:C0574785Lower Urinary Tract Symptoms4BeFree
umls:C0003469Anxiety Disorders3BeFree
umls:C0009402Colorectal Carcinoma3BeFree
umls:C0038587Substance Withdrawal Syndrome3BeFree
umls:C0085110Severe Combined Immunodeficiency3BeFree
umls:C0085278Antiphospholipid Syndrome3BeFree
umls:C1527249Colorectal Cancer3BeFree
umls:C1739363Prostatic Hypertrophy3BeFree
umls:C0004364Autoimmune Diseases2BeFree
umls:C0007104Female Breast Carcinoma2BeFree
umls:C0007134Renal Cell Carcinoma2BeFree
umls:C0016629Fowlpox2BeFree
umls:C0022661Kidney Failure, Chronic2BeFree
umls:C0022735Klinefelter Syndrome2BeFree
umls:C0024115Lung diseases2BeFree
umls:C0024121Lung Neoplasms2BeFree
umls:C0024143Lupus Nephritis2BeFree
umls:C0032002Pituitary Diseases2BeFree
umls:C0032460Polycystic Ovary Syndrome2LHGDN
umls:C0033581prostatitis2BeFree
umls:C0035078Kidney Failure2BeFree
umls:C0042029Urinary tract infection2BeFree
umls:C0085860Autoimmune Syndrome Type II, Polyglandular2BeFree
umls:C0151514Atrophic condition of skin2BeFree
umls:C0235653Malignant neoplasm of female breast2BeFree
umls:C0238339Hereditary pancreatitis2BeFree
umls:C0272138Erythroblastosis2BeFree
umls:C0282612Prostatic Intraepithelial Neoplasias2BeFree
umls:C0398623Thrombophilia2BeFree
umls:C0432474Klinefelter's syndrome - male with more than two X chromosomes2BeFree
umls:C0677932Progressive Neoplastic Disease2BeFree
umls:C1168327High-Grade Prostatic Intraepithelial Neoplasia2BeFree
umls:C1516170Cancer Cell Growth2BeFree
umls:C1519680Tumor Immunity2BeFree
umls:C1520166Xenograft Model2BeFree
umls:C1558141Urinary Retention Adverse Event2BeFree
umls:C3539781Progressive cGVHD2BeFree
umls:C0002395Alzheimer's Disease1BeFree
umls:C0002793Anaplasia1BeFree
umls:C0004277Tooth Attrition1BeFree
umls:C0005779Blood Coagulation Disorders1BeFree
umls:C0006118Brain Neoplasms1BeFree
umls:C0007138Carcinoma, Transitional Cell1BeFree
umls:C0008354Cholera1BeFree
umls:C0009319Colitis1BeFree
umls:C0010046Corn of toe1BeFree
umls:C0012546Diphtheria1BeFree
umls:C0014836Escherichia coli Infections1BeFree
umls:C0015230Exanthema1BeFree
umls:C0018204Granulomatous prostatitis1BeFree
umls:C0020507Hyperplasia1LHGDN
umls:C0021051Immunologic Deficiency Syndromes1BeFree
umls:C0022650Kidney Calculi1BeFree
umls:C0024232Lymphatic Metastasis1GAD
umls:C0024305Lymphoma, Non-Hodgkin1LHGDN
umls:C0024623Malignant neoplasm of stomach1BeFree
umls:C0024897Mastocytoma1BeFree
umls:C0025202melanoma1BeFree
umls:C0027643Neoplasm Recurrence, Local1CTD_human
umls:C0027708Nephroblastoma1BeFree
umls:C0027819Neuroblastoma1BeFree
umls:C0030201Pain, Postoperative1BeFree
umls:C0032580Adenomatous Polyposis Coli1BeFree
umls:C0033579Prostate nodule1BeFree
umls:C0033860Psoriasis1BeFree
umls:C0035222Respiratory Distress Syndrome, Adult1BeFree
umls:C0036875Disorders of Sex Development1BeFree
umls:C0037286Skin Neoplasms1BeFree
umls:C0085215Ovarian Failure, Premature1BeFree
umls:C0152013Adenocarcinoma of lung (disorder)1BeFree
umls:C0153633Malignant neoplasm of brain1BeFree
umls:C0162311Androgenetic Alopecia1BeFree
umls:C0221406Pituitary-dependent Cushing's disease1LHGDN
umls:C0242594Residual Cancer1BeFree
umls:C0242656Disease Progression1CTD_human
umls:C0242966Systemic Inflammatory Response Syndrome1BeFree
umls:C0262584Carcinoma, Small Cell1BeFree
umls:C0263361Psoriasis vulgaris1BeFree
umls:C0263978Disorder of soft tissue1BeFree
umls:C0278996Cancer of Head and Neck1BeFree
umls:C0279672Cervical Adenocarcinoma1BeFree
umls:C0334664Mast Cell Neoplasm1BeFree
umls:C0346255Oncocytoma, renal1BeFree
umls:C0549379Recurrent Carcinoma1BeFree
umls:C0600502Vascular Hemostatic Disorders1BeFree
umls:C0677886Epithelial ovarian cancer1BeFree
umls:C0677949Stage III Colorectal Cancer1BeFree
umls:C0677984Locally Advanced Malignant Neoplasm1BeFree
umls:C0699791Stomach Carcinoma1BeFree
umls:C0700095Central neuroblastoma1BeFree
umls:C0796563Localized Malignant Neoplasm1BeFree
umls:C0848332Spots on skin1BeFree
umls:C0877373Advanced cancer1BeFree
umls:C0919267ovarian neoplasm1BeFree
umls:C0920420cancer recurrence1BeFree
umls:C1261473Sarcoma1BeFree
umls:C1266042Chromophobe Renal Cell Carcinoma1BeFree
umls:C1334407Localized Carcinoma1BeFree
umls:C1334615Malignant Phyllodes Tumor of Prostate1CTD_human
umls:C1335729Refractory Neoplasm1BeFree
umls:C1658953tumor vasculature1BeFree
umls:C1853195Prostate Cancer, Hereditary, 71BeFree
umls:C1861355Syndactyly, Type IV1BeFree
umls:C2242987Benign Mastocytoma1BeFree
umls:C2316810Chronic kidney disease stage 51BeFree
umls:C2945759aggressive cancer1BeFree
umls:C3146250Stage III Colorectal Cancer AJCC v71BeFree
umls:C3146265Prostate cancer stage D1BeFree
umls:C3273239Proliferative Inflammatory Atrophy1BeFree