TissGeneSummary for IGLL1 |
Gene summary |
Basic gene information | Gene symbol | IGLL1 |
Gene name | immunoglobulin lambda-like polypeptide 1 | |
Synonyms | 14.1|AGM2|CD179b|IGL1|IGL5|IGLJ14.1|IGLL|IGO|IGVPB|VPREB2 | |
Cytomap | UCSC genome browser: 22q11.23 | |
Type of gene | protein-coding | |
RefGenes | NM_020070.3, NM_152855.2, | |
Description | CD179 antigen-like family member BCD179b antigenPre-B lymphocyte-specific protein-2ig lambda-5immunoglobulin omega polypeptide chainimmunoglobulin-related 14.1 proteinimmunoglobulin-related protein 14.1lambda5 | |
Modification date | 20141221 | |
dbXrefs | MIM : 146770 | |
HGNC : HGNC | ||
Ensembl : ENSG00000128322 | ||
HPRD : 00905 | ||
Vega : OTTHUMG00000150673 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IGLL1 | |
BioGPS: 3543 | ||
Pathway | NCI Pathway Interaction Database: IGLL1 | |
KEGG: IGLL1 | ||
REACTOME: IGLL1 | ||
Pathway Commons: IGLL1 | ||
Context | iHOP: IGLL1 | |
ligand binding site mutation search in PubMed: IGLL1 | ||
UCL Cancer Institute: IGLL1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrowTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAMLTGCT | |
Reference showing the relevant tissue of IGLL1 | ||
Description by TissGene annotations | High usage of specific isoform |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for IGLL1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for IGLL1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for IGLL1 |
TissGeneSNV for IGLL1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P120L | PAAD | 3 |
p.S115L | SKCM | 3 |
p.G143E | SKCM | 1 |
p.V33L | SKCM | 1 |
p.G9C | LIHC | 1 |
p.S177R | ACC | 1 |
p.Y173C | PRAD | 1 |
p.P155S | SKCM | 1 |
p.H96N | ESCA | 1 |
p.P80A | PRAD | 1 |
p.G153V | COAD | 1 |
p.G75S | STAD | 1 |
p.M162K | COAD | 1 |
p.V207M | SKCM | 1 |
p.S89C | ESCA | 1 |
p.S79F | LUAD | 1 |
p.S108G | LUAD | 1 |
p.R189C | SKCM | 1 |
p.G200V | LUAD | 1 |
p.M162I | HNSC | 1 |
p.M1V | KIRP | 1 |
p.L126P | STAD | 1 |
p.S45L | LUSC | 1 |
p.W77* | SKCM | 1 |
p.E161D | HNSC | 1 |
p.S180N | UCEC | 1 |
p.G86V | LUSC | 1 |
p.A82S | LUAD | 1 |
p.S193R | UCEC | 1 |
p.S122F | SKCM | 1 |
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TissGeneCNV for IGLL1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for IGLL1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-PE-A5DE-01A | SNAP29-IGLL1 | In-frame | Chr22:21224821 | Chr22:23917269 |
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TissGeneNet for IGLL1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for IGLL1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for IGLL1 |
TissGeneDrug for IGLL1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for IGLL1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C1292769 | Precursor B-cell lymphoblastic leukemia | 5 | BeFree |
umls:C0221026 | X-linked agammaglobulinemia | 3 | BeFree |
umls:C0001768 | Agammaglobulinemia | 1 | BeFree,CTD_human |
umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | BeFree |
umls:C0085404 | POEMS Syndrome | 1 | BeFree |
umls:C0338480 | Common Migraine | 1 | GAD |
umls:C3150750 | AGAMMAGLOBULINEMIA 2, AUTOSOMAL RECESSIVE | 1 | CLINVAR,UNIPROT |