TissGeneSummary for IHH |
Gene summary |
Basic gene information | Gene symbol | IHH |
Gene name | indian hedgehog | |
Synonyms | BDA1|HHG2 | |
Cytomap | UCSC genome browser: 2q33-q35 | |
Type of gene | protein-coding | |
RefGenes | NM_002181.3, | |
Description | HHG-2Indian hedgehog homologindian hedgehog protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 600726 | |
HGNC : HGNC | ||
Ensembl : ENSG00000163501 | ||
HPRD : 02839 | ||
Vega : OTTHUMG00000154631 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IHH | |
BioGPS: 3549 | ||
Pathway | NCI Pathway Interaction Database: IHH | |
KEGG: IHH | ||
REACTOME: IHH | ||
Pathway Commons: IHH | ||
Context | iHOP: IHH | |
ligand binding site mutation search in PubMed: IHH | ||
UCL Cancer Institute: IHH | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Colon | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COAD | |
Reference showing the relevant tissue of IHH | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0007224 | smoothened signaling pathway | 21537345 | GO:0007224 | smoothened signaling pathway | 21537345 |
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TissGeneExp for IHH |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | 0.635855402 | 3.249652277 | -2.613796875 | 1.06E-06 | 5.40E-06 |
THCA | -3.237507415 | -0.983848093 | -2.253659322 | 2.78E-15 | 3.69E-14 |
LUAD | -0.994413348 | 2.939641825 | -3.934055172 | 1.22E-21 | 3.01E-20 |
LUSC | -2.117306485 | 2.634466064 | -4.751772549 | 4.08E-29 | 1.53E-27 |
KICH | 0.259168652 | 2.499960652 | -2.240792 | 5.50E-05 | 0.000151715 |
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TissGene-miRNA for IHH |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for IHH |
TissGeneSNV for IHH |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E261K | GBM | 1 |
p.R211H | STAD | 1 |
p.V223A | LGG | 1 |
p.H355Y | LUAD | 1 |
p.D134N | LGG | 1 |
p.R42C | BLCA | 1 |
p.R211C | HNSC | 1 |
p.E285K | SKCM | 1 |
p.R168H | COAD | 1 |
p.A219T | SKCM | 1 |
p.E250* | LUAD | 1 |
p.E379K | SKCM | 1 |
p.V298M | UCEC | 1 |
p.G327R | LGG | 1 |
p.V56A | COAD | 1 |
p.R73H | BLCA | 1 |
p.R224G | LUSC | 1 |
p.T376S | SKCM | 1 |
p.A216V | STAD | 1 |
p.P331S | SKCM | 1 |
p.T279A | STAD | 1 |
p.H11R | PRAD | 1 |
p.D93E | PCPG | 1 |
p.T200M | STAD | 1 |
p.F290S | KIRP | 1 |
p.R224G | ESCA | 1 |
p.R7W | SKCM | 1 |
p.G201V | KIRP | 1 |
p.P377S | SKCM | 1 |
p.A274D | ESCA | 1 |
p.R249H | STAD | 1 |
p.R217L | SKCM | 1 |
p.E379G | UCEC | 1 |
p.R160L | HNSC | 1 |
p.D281G | CESC | 1 |
p.G380S | STAD | 1 |
p.F240L | LUAD | 1 |
p.A206V | BLCA | 1 |
p.T284M | STAD | 1 |
p.P331L | SKCM | 1 |
p.S156L | SKCM | 1 |
p.G98S | COAD | 1 |
p.S195L | SKCM | 1 |
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TissGeneCNV for IHH |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for IHH |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for IHH |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for IHH |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for IHH |
TissGeneDrug for IHH |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for IHH |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C1862151 | BRACHYDACTYLY, TYPE A1 (disorder) | 8 | BeFree,CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT |
umls:C0596263 | Carcinogenesis | 6 | BeFree |
umls:C0008479 | Chondrosarcoma | 5 | BeFree,LHGDN |
umls:C0024623 | Malignant neoplasm of stomach | 4 | BeFree |
umls:C0029408 | Degenerative polyarthritis | 4 | BeFree,GAD |
umls:C0010278 | Craniosynostosis | 3 | BeFree |
umls:C0162809 | Kallmann Syndrome | 3 | BeFree |
umls:C0221357 | Brachydactyly | 3 | BeFree |
umls:C0699791 | Stomach Carcinoma | 3 | BeFree |
umls:C1527249 | Colorectal Cancer | 3 | BeFree |
umls:C0000768 | Congenital Abnormality | 2 | BeFree |
umls:C0007102 | Malignant tumor of colon | 2 | BeFree |
umls:C0029423 | Cartilaginous exostosis | 2 | BeFree |
umls:C0032580 | Adenomatous Polyposis Coli | 2 | BeFree |
umls:C0039075 | Syndactyly | 2 | BeFree |
umls:C0149521 | Pancreatitis, Chronic | 2 | BeFree |
umls:C0699790 | Colon Carcinoma | 2 | BeFree |
umls:C1843096 | Acrocapitofemoral Dysplasia | 2 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
umls:C0001418 | Adenocarcinoma | 1 | BeFree |
umls:C0001430 | Adenoma | 1 | BeFree |
umls:C0005940 | Bone Diseases | 1 | LHGDN |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0010346 | Crohn Disease | 1 | GAD |
umls:C0010709 | Cyst | 1 | BeFree |
umls:C0013336 | Dwarfism | 1 | BeFree |
umls:C0014175 | Endometriosis | 1 | CTD_human |
umls:C0018273 | Growth Disorders | 1 | GAD |
umls:C0019569 | Hirschsprung Disease | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | LHGDN |
umls:C0029927 | Ovarian Cysts | 1 | CTD_human |
umls:C0030297 | Pancreatic Neoplasm | 1 | LHGDN |
umls:C0032584 | polyps | 1 | BeFree |
umls:C0035344 | Retinopathy of Prematurity | 1 | BeFree |
umls:C0149955 | Annular pancreas | 1 | BeFree,MGD |
umls:C0152427 | Polydactyly | 1 | BeFree |
umls:C0205874 | Papilloma, Squamous Cell | 1 | BeFree |
umls:C0206637 | Chondrosarcoma, Mesenchymal | 1 | LHGDN |
umls:C0206762 | Limb Deformities, Congenital | 1 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0279628 | Adenocarcinoma Of Esophagus | 1 | BeFree |
umls:C0333983 | Hyperplastic Polyp | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0410530 | Metachondromatosis | 1 | BeFree |
umls:C0432282 | Dysplasia epiphysealis hemimelica | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
umls:C0796147 | Acrocallosal Syndrome | 1 | BeFree |
umls:C0796154 | SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 1 | 1 | BeFree |
umls:C1302401 | Adenoma of large intestine | 1 | BeFree |
umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
umls:C1704356 | Enchondroma | 1 | BeFree |
umls:C1705254 | Neonatal Deformity | 1 | BeFree |
umls:C1737329 | Dysmorphism | 1 | BeFree |
umls:C1862112 | BRACHYDACTYLY, TYPE B1 | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | BeFree |
umls:C2732618 | Sessile Serrated Adenoma/Polyp | 1 | BeFree |
umls:C2931876 | Hirschsprung disease 1 | 1 | BeFree |
umls:C3536714 | Renal dysplasia | 1 | BeFree |