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| TissGeneSummary for IL13RA2 |
 Gene summary |
| Basic gene information | Gene symbol | IL13RA2 |
| Gene name | interleukin 13 receptor, alpha 2 | |
| Synonyms | CD213A2|CT19|IL-13R|IL13BP | |
| Cytomap | UCSC genome browser: Xq23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000640.2, | |
| Description | IL-13 receptor subunit alpha-2IL-13R subunit alpha-2IL-13R-alpha-2IL-13RA2cancer/testis antigen 19interleukin 13 binding proteininterleukin 13 receptor alpha 2 chaininterleukin-13 receptor subunit alpha-2interleukin-13-binding protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 300130 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000123496 | ||
| HPRD : 02132 | ||
| Vega : OTTHUMG00000022229 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_IL13RA2 | |
| BioGPS: 3598 | ||
| Pathway | NCI Pathway Interaction Database: IL13RA2 | |
| KEGG: IL13RA2 | ||
| REACTOME: IL13RA2 | ||
| Pathway Commons: IL13RA2 | ||
| Context | iHOP: IL13RA2 | |
| ligand binding site mutation search in PubMed: IL13RA2 | ||
| UCL Cancer Institute: IL13RA2 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of IL13RA2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for IL13RA2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -3.332689166 | 0.729262834 | -4.061952 | 9.82E-12 | 9.37E-11 |
| LIHC | -1.631011166 | 2.092610834 | -3.723622 | 2.66E-15 | 8.32E-14 |
| THCA | -1.816671268 | -0.588356013 | -1.228315254 | 1.04E-06 | 3.91E-06 |
| KIRP | -3.254302041 | 0.973854209 | -4.22815625 | 1.58E-13 | 2.95E-12 |
| STAD | -1.630833291 | -3.165517666 | 1.534684375 | 0.000912 | 0.0049305 |
| ESCA | 0.910694834 | -3.088186984 | 3.998881818 | 9.71E-05 | 0.003175741 |
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| TissGene-miRNA for IL13RA2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for IL13RA2 |
| TissGeneSNV for IL13RA2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q183H | SARC | 1 |
| p.T380R | LUSC | 1 |
| p.I314S | ESCA | 1 |
| p.W325C | LUAD | 1 |
| p.D209Y | READ | 1 |
| p.E118D | STAD | 1 |
| p.L89V | LUAD | 1 |
| p.F344L | COAD | 1 |
| p.R309G | UCEC | 1 |
| p.L89Q | LIHC | 1 |
| p.S323G | BRCA | 1 |
| p.H106R | COAD | 1 |
| p.S121R | STAD | 1 |
| p.Y201N | LUAD | 1 |
| p.S317L | LUAD | 1 |
| p.L342I | UCEC | 1 |
| p.R74Q | UCEC | 1 |
| p.Q36E | LUAD | 1 |
| p.C145Y | SARC | 1 |
| p.E332K | LUAD | 1 |
| p.R343H | HNSC | 1 |
| p.E29K | LUAD | 1 |
| p.N194Y | COAD | 1 |
| p.S156F | SKCM | 1 |
| p.P266L | SKCM | 1 |
| p.E68Q | BRCA | 1 |
| p.R364H | STAD | 1 |
| p.F344L | ESCA | 1 |
| p.L354S | UCEC | 1 |
| p.T359A | HNSC | 1 |
| p.E375K | HNSC | 1 |
| p.I223M | ESCA | 1 |
| p.P200L | SKCM | 1 |
| p.R248L | LUAD | 1 |
| p.C197Y | CESC | 1 |
| p.E275G | COAD | 1 |
| p.W150R | UCEC | 1 |
| p.E291K | SKCM | 1 |
| p.L336P | STAD | 1 |
| p.Q329K | BRCA | 1 |
| p.A103V | READ | 1 |
| p.C10Y | UCEC | 1 |
| p.K63M | LUAD | 1 |
| p.A124T | GBM | 1 |
| p.X381R | COAD | 1 |
| p.K296T | UCEC | 1 |
| p.T294I | BRCA | 1 |
| p.P200S | SKCM | 1 |
| p.P261H | SKCM | 1 |
| p.W123L | LUAD | 1 |
| p.E375D | STAD | 1 |
| p.W111L | UCEC | 1 |
| p.E334K | HNSC | 1 |
| p.P35L | LUAD | 1 |
| p.R343H | STAD | 1 |
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| TissGeneCNV for IL13RA2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for IL13RA2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for IL13RA2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| IL13RA2, IL4, IL13 (tumor) | IL13RA2, IL4, IL13 (normal) |
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| COAD (tumor) | COAD (normal) |
| IL13RA2, IL4, IL13 (tumor) | IL13RA2, IL4, IL13 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| IL13RA2, IL4, IL13 (tumor) | IL13RA2, IL4, IL13 (normal) |
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| KICH (tumor) | KICH (normal) |
| IL13RA2, IL4, IL13 (tumor) | IL13RA2, IL4, IL13 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| IL13RA2, IL4, IL13 (tumor) | IL13RA2, IL4, IL13 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| IL13RA2, IL4, IL13 (tumor) | IL13RA2, IL4, IL13 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| IL13RA2, IL4, IL13 (tumor) | IL13RA2, IL4, IL13 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| IL13RA2, IL4, IL13 (tumor) | IL13RA2, IL4, IL13 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| IL13RA2, IL4, IL13 (tumor) | IL13RA2, IL4, IL13 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| IL13RA2, IL4, IL13 (tumor) | IL13RA2, IL4, IL13 (normal) |
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| STAD (tumor) | STAD (normal) |
| IL13RA2, IL4, IL13 (tumor) | IL13RA2, IL4, IL13 (normal) |
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| THCA (tumor) | THCA (normal) |
| IL13RA2, IL4, IL13 (tumor) | IL13RA2, IL4, IL13 (normal) |
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| TissGeneProg for IL13RA2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for IL13RA2 |
| TissGeneDrug for IL13RA2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for IL13RA2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0017638 | Glioma | 14 | BeFree,LHGDN |
| umls:C0017636 | Glioblastoma | 8 | BeFree,LHGDN |
| umls:C0004096 | Asthma | 5 | BeFree,GAD |
| umls:C0006118 | Brain Neoplasms | 5 | BeFree |
| umls:C1621958 | Glioblastoma Multiforme | 4 | BeFree |
| umls:C0004114 | Astrocytoma | 2 | LHGDN |
| umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
| umls:C0278996 | Cancer of Head and Neck | 2 | BeFree |
| umls:C0280100 | Solid tumour | 2 | BeFree |
| umls:C0555198 | Malignant Glioma | 2 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 2 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 2 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0006274 | Bronchiolitis, Viral | 1 | GAD |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
| umls:C0008495 | Chorioamnionitis | 1 | GAD |
| umls:C0009319 | Colitis | 1 | BeFree |
| umls:C0011615 | Dermatitis, Atopic | 1 | BeFree |
| umls:C0013595 | Eczema | 1 | BeFree |
| umls:C0015695 | Fatty Liver | 1 | BeFree,RGD |
| umls:C0015944 | Fetal Membranes, Premature Rupture | 1 | GAD |
| umls:C0018621 | Hay fever | 1 | BeFree |
| umls:C0018671 | Head and Neck Neoplasms | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0021051 | Immunologic Deficiency Syndromes | 1 | BeFree |
| umls:C0022568 | Keratitis | 1 | BeFree |
| umls:C0022876 | Premature Obstetric Labor | 1 | GAD |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
| umls:C0025500 | Mesothelioma | 1 | BeFree |
| umls:C0026946 | Mycoses | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0032914 | Pre-Eclampsia | 1 | GAD |
| umls:C0033578 | Prostatic Neoplasms | 1 | BeFree,LHGDN |
| umls:C0033860 | Psoriasis | 1 | LHGDN |
| umls:C0035235 | Respiratory Syncytial Virus Infections | 1 | GAD |
| umls:C0036421 | Systemic Scleroderma | 1 | BeFree,GAD,LHGDN |
| umls:C0040592 | Trachoma | 1 | BeFree |
| umls:C0151526 | Premature Birth | 1 | GAD |
| umls:C0152268 | Hodgkin's disease, nodular sclerosis (clinical) | 1 | BeFree |
| umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0278688 | Stage IV Ovarian Carcinoma | 1 | BeFree |
| umls:C0345967 | Malignant mesothelioma | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0699949 | airway disease | 1 | BeFree |
| umls:C0919267 | ovarian neoplasm | 1 | BeFree,LHGDN |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
| umls:C2919032 | Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 1 | GAD |
| umls:C3241937 | Nonalcoholic Steatohepatitis | 1 | BeFree |
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