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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for IL13RA2
check button Gene summary
Basic gene informationGene symbolIL13RA2
Gene nameinterleukin 13 receptor, alpha 2
SynonymsCD213A2|CT19|IL-13R|IL13BP
CytomapUCSC genome browser: Xq23
Type of geneprotein-coding
RefGenesNM_000640.2,
DescriptionIL-13 receptor subunit alpha-2IL-13R subunit alpha-2IL-13R-alpha-2IL-13RA2cancer/testis antigen 19interleukin 13 binding proteininterleukin 13 receptor alpha 2 chaininterleukin-13 receptor subunit alpha-2interleukin-13-binding protein
Modification date20141207
dbXrefs MIM : 300130
HGNC : HGNC
Ensembl : ENSG00000123496
HPRD : 02132
Vega : OTTHUMG00000022229
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_IL13RA2
BioGPS: 3598
PathwayNCI Pathway Interaction Database: IL13RA2
KEGG: IL13RA2
REACTOME: IL13RA2
Pathway Commons: IL13RA2
ContextiHOP: IL13RA2
ligand binding site mutation search in PubMed: IL13RA2
UCL Cancer Institute: IL13RA2
Assigned class in TissGDB*B
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCT
Reference showing the relevant tissue of IL13RA2
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for IL13RA2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH-3.3326891660.729262834-4.0619529.82E-129.37E-11
LIHC-1.6310111662.092610834-3.7236222.66E-158.32E-14
THCA-1.816671268-0.588356013-1.2283152541.04E-063.91E-06
KIRP-3.2543020410.973854209-4.228156251.58E-132.95E-12
STAD-1.630833291-3.1655176661.5346843750.0009120.0049305
ESCA0.910694834-3.0881869843.9988818189.71E-050.003175741


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TissGene-miRNA for IL13RA2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for IL13RA2
TissGeneSNV for IL13RA2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.Q183HSARC1
p.T380RLUSC1
p.I314SESCA1
p.W325CLUAD1
p.D209YREAD1
p.E118DSTAD1
p.L89VLUAD1
p.F344LCOAD1
p.R309GUCEC1
p.L89QLIHC1
p.S323GBRCA1
p.H106RCOAD1
p.S121RSTAD1
p.Y201NLUAD1
p.S317LLUAD1
p.L342IUCEC1
p.R74QUCEC1
p.Q36ELUAD1
p.C145YSARC1
p.E332KLUAD1
p.R343HHNSC1
p.E29KLUAD1
p.N194YCOAD1
p.S156FSKCM1
p.P266LSKCM1
p.E68QBRCA1
p.R364HSTAD1
p.F344LESCA1
p.L354SUCEC1
p.T359AHNSC1
p.E375KHNSC1
p.I223MESCA1
p.P200LSKCM1
p.R248LLUAD1
p.C197YCESC1
p.E275GCOAD1
p.W150RUCEC1
p.E291KSKCM1
p.L336PSTAD1
p.Q329KBRCA1
p.A103VREAD1
p.C10YUCEC1
p.K63MLUAD1
p.A124TGBM1
p.X381RCOAD1
p.K296TUCEC1
p.T294IBRCA1
p.P200SSKCM1
p.P261HSKCM1
p.W123LLUAD1
p.E375DSTAD1
p.W111LUCEC1
p.E334KHNSC1
p.P35LLUAD1
p.R343HSTAD1


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TissGeneCNV for IL13RA2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for IL13RA2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for IL13RA2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
IL13RA2, IL4, IL13 (tumor)IL13RA2, IL4, IL13 (normal)
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COAD (tumor)COAD (normal)
IL13RA2, IL4, IL13 (tumor)IL13RA2, IL4, IL13 (normal)
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HNSC (tumor)HNSC (normal)
IL13RA2, IL4, IL13 (tumor)IL13RA2, IL4, IL13 (normal)
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KICH (tumor)KICH (normal)
IL13RA2, IL4, IL13 (tumor)IL13RA2, IL4, IL13 (normal)
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KIRC (tumor)KIRC (normal)
IL13RA2, IL4, IL13 (tumor)IL13RA2, IL4, IL13 (normal)
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KIRP (tumor)KIRP (normal)
IL13RA2, IL4, IL13 (tumor)IL13RA2, IL4, IL13 (normal)
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LIHC (tumor)LIHC (normal)
IL13RA2, IL4, IL13 (tumor)IL13RA2, IL4, IL13 (normal)
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LUAD (tumor)LUAD (normal)
IL13RA2, IL4, IL13 (tumor)IL13RA2, IL4, IL13 (normal)
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LUSC (tumor)LUSC (normal)
IL13RA2, IL4, IL13 (tumor)IL13RA2, IL4, IL13 (normal)
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PRAD (tumor)PRAD (normal)
IL13RA2, IL4, IL13 (tumor)IL13RA2, IL4, IL13 (normal)
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STAD (tumor)STAD (normal)
IL13RA2, IL4, IL13 (tumor)IL13RA2, IL4, IL13 (normal)
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THCA (tumor)THCA (normal)
IL13RA2, IL4, IL13 (tumor)IL13RA2, IL4, IL13 (normal)
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TissGeneProg for IL13RA2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for IL13RA2
TissGeneDrug for IL13RA2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for IL13RA2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0017638Glioma14BeFree,LHGDN
umls:C0017636Glioblastoma8BeFree,LHGDN
umls:C0004096Asthma5BeFree,GAD
umls:C0006118Brain Neoplasms5BeFree
umls:C1621958Glioblastoma Multiforme4BeFree
umls:C0004114Astrocytoma2LHGDN
umls:C0029925Ovarian Carcinoma2BeFree
umls:C0278996Cancer of Head and Neck2BeFree
umls:C0280100Solid tumour2BeFree
umls:C0555198Malignant Glioma2BeFree
umls:C1140680Malignant neoplasm of ovary2BeFree
umls:C1168401Squamous cell carcinoma of the head and neck2BeFree
umls:C0006142Malignant neoplasm of breast1BeFree
umls:C0006274Bronchiolitis, Viral1GAD
umls:C0007134Renal Cell Carcinoma1BeFree
umls:C0008495Chorioamnionitis1GAD
umls:C0009319Colitis1BeFree
umls:C0011615Dermatitis, Atopic1BeFree
umls:C0013595Eczema1BeFree
umls:C0015695Fatty Liver1BeFree,RGD
umls:C0015944Fetal Membranes, Premature Rupture1GAD
umls:C0018621Hay fever1BeFree
umls:C0018671Head and Neck Neoplasms1BeFree
umls:C0019693HIV Infections1BeFree
umls:C0021051Immunologic Deficiency Syndromes1BeFree
umls:C0022568Keratitis1BeFree
umls:C0022876Premature Obstetric Labor1GAD
umls:C0024117Chronic Obstructive Airway Disease1GAD
umls:C0025500Mesothelioma1BeFree
umls:C0026946Mycoses1BeFree
umls:C0027627Neoplasm Metastasis1BeFree
umls:C0032914Pre-Eclampsia1GAD
umls:C0033578Prostatic Neoplasms1BeFree,LHGDN
umls:C0033860Psoriasis1LHGDN
umls:C0035235Respiratory Syncytial Virus Infections1GAD
umls:C0036421Systemic Scleroderma1BeFree,GAD,LHGDN
umls:C0040592Trachoma1BeFree
umls:C0151526Premature Birth1GAD
umls:C0152268Hodgkin's disease, nodular sclerosis (clinical)1BeFree
umls:C0153594Malignant neoplasm of testis1BeFree
umls:C0235974Pancreatic carcinoma1BeFree
umls:C0278688Stage IV Ovarian Carcinoma1BeFree
umls:C0345967Malignant mesothelioma1BeFree
umls:C0346647Malignant neoplasm of pancreas1BeFree
umls:C0376358Malignant neoplasm of prostate1BeFree
umls:C0600139Prostate carcinoma1BeFree
umls:C0678222Breast Carcinoma1BeFree
umls:C0699949airway disease1BeFree
umls:C0919267ovarian neoplasm1BeFree,LHGDN
umls:C1458155Mammary Neoplasms1BeFree
umls:C2919032Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified1GAD
umls:C3241937Nonalcoholic Steatohepatitis1BeFree