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| TissGeneSummary for EIF3E |
 Gene summary |
| Basic gene information | Gene symbol | EIF3E |
| Gene name | eukaryotic translation initiation factor 3, subunit E | |
| Synonyms | EIF3-P48|EIF3S6|INT6|eIF3-p46 | |
| Cytomap | UCSC genome browser: 8q22-q23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001568.2, | |
| Description | eIF-3 p48eukaryotic translation initiation factor 3 subunit 6eukaryotic translation initiation factor 3 subunit Eeukaryotic translation initiation factor 3, subunit 6 (48kD)eukaryotic translation initiation factor 3, subunit 6 48kDamammary tumor-asso | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 602210 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000104408 | ||
| HPRD : 03734 | ||
| Vega : OTTHUMG00000164858 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_EIF3E | |
| BioGPS: 3646 | ||
| Pathway | NCI Pathway Interaction Database: EIF3E | |
| KEGG: EIF3E | ||
| REACTOME: EIF3E | ||
| Pathway Commons: EIF3E | ||
| Context | iHOP: EIF3E | |
| ligand binding site mutation search in PubMed: EIF3E | ||
| UCL Cancer Institute: EIF3E | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrowOvary | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAMLOV | |
| Reference showing the relevant tissue of EIF3E | ||
| Description by TissGene annotations | Cancer gene TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006413 | translational initiation | 17581632 | GO:0006413 | translational initiation | 17581632 |
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| TissGeneExp for EIF3E |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for EIF3E |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for EIF3E |
| TissGeneSNV for EIF3E |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q428* | UCEC | 3 |
| p.D183G | LUAD | 1 |
| p.Y152H | BLCA | 1 |
| p.D230H | LIHC | 1 |
| p.E89K | UCEC | 1 |
| p.L6F | KIRC | 1 |
| p.T7A | BLCA | 1 |
| p.D276N | ESCA | 1 |
| p.H12P | HNSC | 1 |
| p.E194D | OV | 1 |
| p.A336T | LIHC | 1 |
| p.I10M | CESC | 1 |
| p.P251S | SKCM | 1 |
| p.L173P | LUSC | 1 |
| p.S168L | SKCM | 1 |
| p.N49I | UCEC | 1 |
| p.V273F | LIHC | 1 |
| p.R268X | COAD | 1 |
| p.G394D | UCEC | 1 |
| p.K407R | THYM | 1 |
| p.N49H | LUAD | 1 |
| p.K59N | UCEC | 1 |
| p.A148S | COAD | 1 |
| p.R191Q | STAD | 1 |
| p.A327S | STAD | 1 |
| p.A174S | LUSC | 1 |
| p.P98S | ESCA | 1 |
| p.I351V | LIHC | 1 |
| p.D234Y | LUAD | 1 |
| p.T161A | LUSC | 1 |
| p.E366K | BRCA | 1 |
| p.N421H | COAD | 1 |
| p.L374X | SKCM | 1 |
| p.N224S | GBM | 1 |
| p.L70F | HNSC | 1 |
| p.K407T | UCEC | 1 |
| p.R229C | UCEC | 1 |
| p.Q428* | STAD | 1 |
| p.R74S | CESC | 1 |
| p.H390Y | LUAD | 1 |
| p.V280F | UCEC | 1 |
| p.K407N | LUSC | 1 |
| p.K41T | HNSC | 1 |
| p.R155_V156delinsX | COAD | 1 |
| p.S399L | BLCA | 1 |
| p.G171R | LUSC | 1 |
| p.Q309L | COAD | 1 |
| p.Q428X | DLBC | 1 |
| p.L23F | SKCM | 1 |
| p.K383E | OV | 1 |
| p.L61F | SKCM | 1 |
| p.M420I | THCA | 1 |
| p.L319I | UCEC | 1 |
| p.L205H | OV | 1 |
| p.V391L | LUAD | 1 |
| p.N373T | BLCA | 1 |
| p.Q209* | LUAD | 1 |
| p.Q428X | STAD | 1 |
| p.A165T | LUSC | 1 |
| p.D43A | BLCA | 1 |
| p.D230N | UCEC | 1 |
| p.L219M | UCEC | 1 |
| p.S412F | SKCM | 1 |
| p.L374* | SKCM | 1 |
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| TissGeneCNV for EIF3E |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for EIF3E |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChimerDB 2.0 | NA | NA | EIF3J-EIF3E | chr15:42634084 | chr8:109284880 | |
| Chimerdb3.0 | ChiTaRs | NA | DA000478 | EIF3E-GTSE1 | chr8:109260942 | chr22:46693275 | |
| Chimerdb3.0 | ChiTaRs | NA | BF799939 | EIF3E-PRSS23 | chr8:109240524 | chr11:86519299 | |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-L7-A6VZ-01A | TTC35-EIF3E | Out-of-Frame | chr8:109455927 | chr8:109241424 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A4A6-01A | FZD6-EIF3E | In-Frame | chr8:104312512 | chr8:109254142 |
| Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2978-03A | EIF3E-KHDC1 | Out-of-Frame | chr8:109229566 | chr6:74002623 |
| Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2803-03A | KHDC1-EIF3E | In-Frame | chr6:74002839 | chr8:109226937 |
| Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-KK-A7AZ-01A | PVT1-EIF3E | 5'UTR-CDS | chr8:128806979 | chr8:109215731 |
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| TissGeneNet for EIF3E |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| EIF3E, SUMO2, EIF3J, CSN3, EIF1B, YWHAE, EPAS1, TRIM27, EIF4ENIF1, EIF3I, EIF3F, NPM1, FBXW7, ARF6, COPS2, EIF3H, NDRG1, EIF3L, EIF3D, COPS7B, GPBP1L1 (tumor) | EIF3E, SUMO2, EIF3J, RGS2, MYC, TNFRSF14, SMURF2, EIF3I, EIF3F, EIF3B, NPM1, FBXW7, PRKAB1, COPS2, EIF3H, NDRG1, USP20, EIF3L, EIF3D, EIF3K, GPAA1 (normal) |
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| COAD (tumor) | COAD (normal) |
| EIF3E, SIRT7, NCOA3, COPS6, UBC, SUMO2, EIF3J, EPAS1, EIF3I, EIF3F, ATG12, NPM1, COPS2, DDX3X, EIF3H, COPS8, EIF3L, COPS7A, EIF3D, COPS7B, EIF3G (tumor) | EIF3E, COPS6, SUMO2, EIF3J, EIF1B, MYC, TNFRSF14, EPAS1, EIF3I, EIF3F, NPM1, PSMC6, COPS2, SAP18, EIF3H, COPS8, EIF6, EIF3L, EIF3D, EIF3G, GPAA1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| EIF3E, SUMO2, CSN3, YWHAE, EPAS1, TRIM63, EIF3I, EIF3F, NPM1, PRKAB1, COPS2, DDX24, SAP18, EIF3H, NDRG1, USP20, EIF3L, COPS7A, EIF3D, GPBP1L1, DEGS1 (tumor) | EIF3E, SUMO2, EIF3J, EIF1B, YWHAE, MYC, TNFRSF14, EIF3I, EIF3F, EIF3B, ATG12, NPM1, PSMC6, COPS2, SAP18, EIF3H, NDRG1, EIF3L, EIF3D, EIF3G, GPAA1 (normal) |
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| KICH (tumor) | KICH (normal) |
| EIF3E, COPS6, EIF3A, YWHAE, EIF3I, EIF3F, ATG12, HAP1, NPM1, PSMC6, COPS2, DDX24, SAP18, EIF3H, EIF3C, COPS8, USP20, EIF6, EIF3L, COPS7A, EIF3D (tumor) | EIF3E, NCOA3, COPS6, EIF3A, EIF1B, MYC, RANBP2, EIF3I, ATG12, HAP1, NPM1, SMAD9, COPS2, ATM, EIF3H, IFIT1, EIF3L, EIF3D, COPS7B, EIF3G, GPAA1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| EIF3E, EIF3A, TNFRSF14, TRIM63, TRIM27, EIF4ENIF1, ATG12, HAP1, NPM1, PRKAB1, PSMC6, COPS2, DDX24, EIF3H, COPS8, USP20, EIF6, EIF3L, MAGED1, COPS7B, DEGS1 (tumor) | EIF3E, SUMO2, EIF3J, EIF1B, PSMD12, YWHAE, MYC, SHBG, TRIM63, MYL12A, EIF3I, EIF3F, ATG12, NPM1, PSMC6, COPS2, EIF3H, COPS8, USP20, EIF3L, EIF3D (normal) |
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| KIRP (tumor) | KIRP (normal) |
| EIF3E, EIF3J, MYC, TRIM63, EIF3I, EIF3F, ATG12, HAP1, NPM1, SMAD9, PSMC6, COPS2, DDX24, SAP18, EIF3H, USP20, EIF6, EIF3L, EIF3D, COPS7B, DEGS1 (tumor) | EIF3E, UBC, SUMO2, EIF3J, EIF1B, PSMD12, MYC, EIF4ENIF1, EIF3I, EIF3F, ATG12, NPM1, PSMC6, COPS2, EIF3H, NDRG1, COPS8, EIF3L, EIF3D, EIF3K, EIF3G (normal) |
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| LIHC (tumor) | LIHC (normal) |
| EIF3E, SIRT7, COPS6, SUMO2, EIF1B, YWHAE, EIF3F, HAP1, NPM1, SMAD9, FBXW7, PSMC6, COPS2, EIF3H, EIF3C, NSF, EIF6, EIF3L, MAGED1, EIF3D, EIF3G (tumor) | EIF3E, SIRT7, SUMO2, EIF3J, EIF1B, MYC, EPAS1, TRIM27, MYL12A, EIF3F, EIF3B, NPM1, PRKAB1, EIF3H, NDRG1, EIF6, EIF3L, EIF3D, EIF3K, EIF3G, GPAA1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| EIF3E, COPS6, SUMO2, EIF3A, YWHAE, MYL12A, EIF3I, EIF3F, ATG12, NPM1, PSMC6, COPS2, SAP18, EIF3H, EIF3C, COPS8, EIF3L, COPS7A, EIF3D, EIF3K, EIF3G (tumor) | EIF3E, SUMO2, EIF3J, EIF1B, YWHAE, MYC, TNFRSF14, EIF3I, EIF3F, ATG12, NPM1, PSMC6, COPS2, SAP18, EIF3H, COPS8, USP20, EIF3L, EIF3D, EIF3K, EIF3G (normal) |
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| LUSC (tumor) | LUSC (normal) |
| EIF3E, SUMO2, EIF3A, YWHAE, MYL12A, EIF3I, EIF3F, EIF3B, ATG12, NPM1, PSMC6, COPS2, DDX24, SAP18, EIF3H, COPS8, EIF3L, EIF3D, EIF3K, GPBP1L1, DEGS1 (tumor) | EIF3E, COPS6, SUMO2, EIF1B, YWHAE, MYC, EPAS1, RANBP2, EIF3I, EIF3F, ATG12, NPM1, PSMC6, COPS2, SAP18, EIF3H, COPS8, USP20, EIF3L, EIF3D, EIF3K (normal) |
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| PRAD (tumor) | PRAD (normal) |
| EIF3E, COPS6, SUMO2, EIF3J, YWHAE, RANBP2, MYL12A, EIF3I, EIF3F, HAP1, NPM1, PSMC6, COPS2, SAP18, EIF3H, COPS8, USP20, EIF6, EIF3L, EIF3D, EIF3K (tumor) | EIF3E, UBC, SUMO2, EIF3J, MYC, TNFRSF14, EPAS1, SHBG, EIF3I, EIF3F, EIF3B, HAP1, NPM1, PSMC6, COPS2, DDX24, EIF3H, IFIT1, EIF3L, MAGED1, EIF3D (normal) |
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| STAD (tumor) | STAD (normal) |
| EIF3E, SIRT7, COPS6, SUMO2, EIF3J, EIF1B, PSMD12, TNFRSF14, SHBG, TRIM27, NPM1, PSMC6, COPS2, EIF3H, COPS8, DCC, EIF3L, COPS7A, DEGS1, CNTF, GPAA1 (tumor) | EIF3E, UBC, SUMO2, YWHAE, MYC, EPAS1, MYL12A, EIF3I, EIF3F, ATG12, NPM1, SMAD9, PSMC6, COPS2, SAP18, EIF3H, COPS8, USP20, EIF3L, MAGED1, EIF3D (normal) |
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| THCA (tumor) | THCA (normal) |
| EIF3E, SUMO2, SHBG, EIF3I, EIF3F, ATG12, HAP1, NPM1, FBXW7, PRKAB1, COPS2, DDX24, EIF3H, NSF, EIF3L, COPS7A, MAGED1, EIF3D, EIF3G, CNTF, GPAA1 (tumor) | EIF3E, TRAF6, SUMO2, EIF1B, EPAS1, MYL12A, EIF4ENIF1, EIF3I, EIF3F, HAP1, NPM1, SMAD9, PSMC6, COPS2, EIF3H, NSF, EIF3L, MAGED1, EIF3D, EIF3G, DEGS1 (normal) |
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| TissGeneProg for EIF3E |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for EIF3E |
| TissGeneDrug for EIF3E |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for EIF3E |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0678222 | Breast Carcinoma | 6 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 6 | BeFree |
| umls:C0596263 | Carcinogenesis | 5 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree |
| umls:C0007786 | Brain Ischemia | 3 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 2 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0013312 | Dupuytren Contracture | 1 | GAD,GWASCAT |
| umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0278504 | Non-small cell lung cancer stage I | 1 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0919267 | ovarian neoplasm | 1 | BeFree |
| umls:C1368683 | Epithelioma | 1 | BeFree |
| umls:C1512981 | Mammary Tumorigenesis | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
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