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| TissGeneSummary for ISL1 |
 Gene summary |
| Basic gene information | Gene symbol | ISL1 |
| Gene name | ISL LIM homeobox 1 | |
| Synonyms | ISLET1|Isl-1 | |
| Cytomap | UCSC genome browser: 5q11.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002202.2, | |
| Description | ISL1 transcription factor, LIM/homeodomaininsulin gene enhancer protein ISL-1islet-1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600366 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000016082 | ||
| HPRD : 02650 | ||
| Vega : OTTHUMG00000162281 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ISL1 | |
| BioGPS: 3670 | ||
| Pathway | NCI Pathway Interaction Database: ISL1 | |
| KEGG: ISL1 | ||
| REACTOME: ISL1 | ||
| Pathway Commons: ISL1 | ||
| Context | iHOP: ISL1 | |
| ligand binding site mutation search in PubMed: ISL1 | ||
| UCL Cancer Institute: ISL1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ProstateEye | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRADUVM | |
| Reference showing the relevant tissue of ISL1 | ||
| Description by TissGene annotations | Protective TissGene in OS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0060913 | cardiac cell fate determination | 19571884 | GO:0060913 | cardiac cell fate determination | 19571884 |
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| TissGeneExp for ISL1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| HNSC | -0.959480692 | 1.04544489 | -2.004925581 | 3.48E-06 | 2.28E-05 |
| THCA | -2.795564728 | -1.18243422 | -1.613130508 | 4.21E-09 | 2.22E-08 |
| KICH | -1.846975575 | -3.180731576 | 1.333756 | 0.0241 | 0.04002743 |
| LUAD | -1.523920748 | -2.608569024 | 1.084648276 | 0.00295 | 0.005923769 |
| BLCA | -2.023231365 | 0.364679161 | -2.387910526 | 0.000634 | 0.004862124 |
| LUSC | -1.19432734 | -2.667884203 | 1.473556863 | 5.08E-05 | 0.000108335 |
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| TissGene-miRNA for ISL1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ISL1 |
| TissGeneSNV for ISL1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S326I | ESCA | 2 |
| p.L220F | LUAD | 2 |
| p.L299S | BLCA | 1 |
| p.M210I | BLCA | 1 |
| p.A121V | LUAD | 1 |
| p.E190Q | CESC | 1 |
| p.T255A | STAD | 1 |
| p.Q258* | SARC | 1 |
| p.S333P | BRCA | 1 |
| p.H175L | HNSC | 1 |
| p.R69G | THYM | 1 |
| p.K254E | OV | 1 |
| p.A139S | THYM | 1 |
| p.L141R | LUAD | 1 |
| p.S15Y | UCEC | 1 |
| p.Q177* | KIRC | 1 |
| p.Q250H | LUAD | 1 |
| p.R31W | SKCM | 1 |
| p.R185W | STAD | 1 |
| p.A307V | BRCA | 1 |
| p.R69I | READ | 1 |
| p.D70N | SKCM | 1 |
| p.Y66N | LUAD | 1 |
| p.D302V | HNSC | 1 |
| p.D274E | STAD | 1 |
| p.E119K | COAD | 1 |
| p.G317E | COAD | 1 |
| p.S286R | SKCM | 1 |
| p.A169V | STAD | 1 |
| p.S87T | LUSC | 1 |
| p.R138M | COAD | 1 |
| p.V174I | SKCM | 1 |
| p.F91L | LUAD | 1 |
| p.P264L | SKCM | 1 |
| p.E190K | UCEC | 1 |
| p.H39P | ACC | 1 |
| p.R61M | LGG | 1 |
| p.I347T | LUAD | 1 |
| p.C79S | LUAD | 1 |
| p.D118N | UCEC | 1 |
| p.A208V | KIRC | 1 |
| p.G275C | KIRP | 1 |
| p.E212Q | KIRC | 1 |
| p.N22D | KIRP | 1 |
| p.G5R | SKCM | 1 |
| p.P222H | LIHC | 1 |
| p.G262* | STAD | 1 |
| p.A250T | UCEC | 1 |
| p.P319L | HNSC | 1 |
| p.A268S | HNSC | 1 |
| p.G259E | SKCM | 1 |
| p.S111R | LUSC | 1 |
| p.L156Q | LUAD | 1 |
| p.E119K | UCEC | 1 |
| p.Q177X | KIRC | 1 |
| p.R138S | LUAD | 1 |
| p.D134N | LUAD | 1 |
| p.G262E | SKCM | 1 |
| p.D134N | SKCM | 1 |
| p.K254T | SKCM | 1 |
| p.K237N | BLCA | 1 |
| p.Q23H | READ | 1 |
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| TissGeneCNV for ISL1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ISL1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BI047516 | ISL1-PFKFB3 | chr5:50689409 | chr10:6253071 |
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| TissGeneNet for ISL1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (tumor) | ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (normal) |
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| COAD (tumor) | COAD (normal) |
| ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (tumor) | ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (tumor) | ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (normal) |
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| KICH (tumor) | KICH (normal) |
| ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (tumor) | ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (tumor) | ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (tumor) | ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (tumor) | ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (tumor) | ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (tumor) | ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (normal) |
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| PRAD (tumor) | PRAD (normal) |
| ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (tumor) | ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (normal) |
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| STAD (tumor) | STAD (normal) |
| ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (tumor) | ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (normal) |
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| THCA (tumor) | THCA (normal) |
| ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (tumor) | ISL1, SSBP4, LDB1, SMAD3, RELA, ESR1, CDK6, COPS5, LMO2, RLIM, NR2F1, CDKN2B, LHX4, LMX1A, LHX3, LDB2, ISL2, LHX1, PECR (normal) |
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| TissGeneProg for ISL1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ISL1 |
| TissGeneDrug for ISL1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ISL1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 6 | BeFree,GAD |
| umls:C0152021 | Congenital heart disease | 5 | BeFree |
| umls:C0000768 | Congenital Abnormality | 3 | BeFree |
| umls:C0027819 | Neuroblastoma | 3 | BeFree |
| umls:C0596263 | Carcinogenesis | 3 | BeFree |
| umls:C0700095 | Central neuroblastoma | 3 | BeFree |
| umls:C0010068 | Coronary heart disease | 2 | BeFree |
| umls:C0018818 | Ventricular Septal Defects | 2 | BeFree |
| umls:C0028754 | Obesity | 2 | BeFree |
| umls:C0349788 | Arrhythmogenic Right Ventricular Dysplasia | 2 | BeFree |
| umls:C1520166 | Xenograft Model | 2 | BeFree |
| umls:C0002448 | Ameloblastoma | 1 | BeFree |
| umls:C0002871 | Anemia | 1 | BeFree |
| umls:C0005689 | Bladder Exstrophy | 1 | BeFree,ORPHANET |
| umls:C0005695 | Bladder Neoplasm | 1 | CTD_human |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0017185 | Gastrointestinal Neoplasms | 1 | BeFree |
| umls:C0018798 | Congenital Heart Defects | 1 | GAD |
| umls:C0018801 | Heart failure | 1 | BeFree,GAD |
| umls:C0018802 | Congestive heart failure | 1 | BeFree |
| umls:C0019829 | Hodgkin Disease | 1 | BeFree |
| umls:C0021670 | insulinoma | 1 | BeFree |
| umls:C0024299 | Lymphoma | 1 | BeFree |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
| umls:C0028756 | Obesity, Morbid | 1 | BeFree |
| umls:C0032002 | Pituitary Diseases | 1 | BeFree |
| umls:C0040517 | Gilles de la Tourette syndrome | 1 | GAD |
| umls:C0041207 | Truncus Arteriosus, Persistent | 1 | BeFree |
| umls:C0085648 | Synovial Cyst | 1 | BeFree |
| umls:C0242855 | Congenital atresia of pulmonary valve | 1 | BeFree |
| umls:C0278701 | Gastric Adenocarcinoma | 1 | BeFree |
| umls:C0342276 | Maturity onset diabetes mellitus in young | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0750952 | Biliary Tract Cancer | 1 | BeFree |
| umls:C1258666 | Myxoid cyst | 1 | BeFree |
| umls:C1263846 | Attention deficit hyperactivity disorder | 1 | GAD |
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