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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for ABCC6
check button Gene summary
Basic gene informationGene symbolABCC6
Gene nameATP-binding cassette, sub-family C (CFTR/MRP), member 6
SynonymsABC34|ARA|EST349056|GACI2|MLP1|MOAT-E|MOATE|MRP6|PXE|PXE1|URG7
CytomapUCSC genome browser: 16p13.1
Type of geneprotein-coding
RefGenesNM_001079528.3,
NM_001171.5,
DescriptionATP-binding cassette sub-family C member 6anthracycline resistance-associated proteinmulti-specific organic anion transporter Emultidrug resistance-associated protein 6
Modification date20141219
dbXrefs MIM : 603234
HGNC : HGNC
Ensembl : ENSG00000091262
HPRD : 04453
Vega : OTTHUMG00000129967
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ABCC6
BioGPS: 368
PathwayNCI Pathway Interaction Database: ABCC6
KEGG: ABCC6
REACTOME: ABCC6
Pathway Commons: ABCC6
ContextiHOP: ABCC6
ligand binding site mutation search in PubMed: ABCC6
UCL Cancer Institute: ABCC6
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)KidneyLiver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICHLIHC
Reference showing the relevant tissue of ABCC6
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for ABCC6

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC-1.4167795592.746194951-4.162974513.92E-258.83E-24
BRCA-0.9956757921.143147015-2.1388228075.46E-193.62E-18
KICH-1.0849427752.325565225-3.4105085.14E-103.45E-09
LUAD1.3448398462.933250191-1.5884103453.06E-132.52E-12
KIRP2.4763749753.574649975-1.0982750.02230.044759714
HNSC-3.736788542-2.406704821-1.3300837210.000440.001666667


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TissGene-miRNA for ABCC6

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for ABCC6
TissGeneSNV for ABCC6

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R87WSKCM3
p.E255KSKCM2
p.P895SSKCM2
p.E242*UCEC2
p.Q593*SKCM2
p.R1141QSKCM2
p.L1313MUCEC1
p.S66FUCEC1
p.E690KCOAD1
p.G226ESKCM1
p.R526WPAAD1
p.L946IDLBC1
p.V1055ISKCM1
p.K392*SKCM1
p.A730VCOAD1
p.A302VSKCM1
p.E641DSKCM1
p.R290WSTAD1
p.E1037QHNSC1
p.R1468GKIRP1
p.H1336PLIHC1
p.S706FBLCA1
p.G1327EDLBC1
p.V596MSKCM1
p.E1427KSTAD1
p.G429VSTAD1
p.D627NSKCM1
p.R769KSKCM1
p.R807QSKCM1
p.R807QBLCA1
p.S238LSKCM1
p.G741ESKCM1
p.R1235QUCEC1
p.A271PTGCT1
p.Y171*UCEC1
p.W347*SKCM1
p.I1422LBRCA1
p.T364MCESC1
p.R64QTHCA1
p.R297CSTAD1
p.S397FSKCM1
p.Q593XSKCM1
p.G276CLUAD1
p.V693MCOAD1
p.E242KSKCM1
p.D1368NSKCM1
p.L358FSTAD1
p.T806AUCEC1
p.E253QLUAD1
p.W506XSKCM1
p.G863RSKCM1
p.R1164XPRAD1
p.A700DSKCM1
p.E609*UCEC1
p.L1272ISARC1
p.L81QTHYM1
p.R899GLUAD1
p.G663SSKCM1
p.G755RGBM1
p.V1202MUCEC1
p.K892XSKCM1
p.D1397GSTAD1
p.R1164*PRAD1
p.G666ESKCM1
p.G741RSKCM1
p.L677FSKCM1
p.G992ESKCM1
p.P644SSKCM1
p.R1314QREAD1
p.S670FSKCM1
p.W721LLUAD1
p.G1475ESKCM1
p.G861ESKCM1
p.R473KSKCM1
p.R1114HSTAD1
p.W638*UCEC1
p.D1058ETHYM1
p.R487LLUSC1
p.A1428DSKCM1
p.P329SSKCM1
p.D235YACC1
p.E422KSKCM1
p.S1065FSKCM1
p.R1114CUCEC1
p.V442ISTAD1
p.V435ISTAD1
p.K484MSKCM1
p.Y43*UCEC1
p.R987HSTAD1
p.W506*SKCM1
p.V1202LSTAD1
p.R1268QCOAD1
p.S1343RKIRC1
p.P1329APAAD1
p.L425VOV1
p.D898NSKCM1
p.N95KBRCA1
p.L374FSKCM1
p.G529SKIRC1
p.A972VREAD1
p.G863ESKCM1
p.S1157IACC1
p.G1042SPRAD1
p.E1369ALIHC1
p.E1320KBLCA1
p.T630SSKCM1
p.R1141QHNSC1
p.P913RLUAD1
p.A76VTHYM1
p.V1463LLIHC1
p.P644ALUAD1
p.W1026*SKCM1
p.G621ESKCM1
p.G755ESKCM1
p.E1427KCESC1
p.M1006TBLCA1
p.V1202RSTAD1
p.P909SSKCM1
p.Q1421HOV1
p.A728VPAAD1
p.V1191GLIHC1
p.L168VLIHC1
p.R1015QDLBC1
p.R241KHNSC1
p.K892*SKCM1
p.L1417FSKCM1
p.E1266KBLCA1
p.E1266KPAAD1
p.K1407ELIHC1
p.F1035LUCEC1
p.P450LSKCM1
p.V1154ISTAD1
p.G917XKIRP1
p.A624VOV1
p.E1437KBLCA1
p.S836FSKCM1
p.G61CBRCA1
p.L1097IDLBC1
p.V1298ISKCM1
p.A1014VSKCM1
p.N259SSTAD1
p.E1129*LUAD1
p.L1171FBRCA1
p.G917*LUAD1
p.K375NSKCM1
p.G276SSTAD1
p.R64WLGG1
p.G1322RSKCM1
p.V534LCOAD1
p.P664LSKCM1
p.G1405CSTAD1


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TissGeneCNV for ABCC6

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for ABCC6

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAW79014ABCC6-SEMA4Gchr16:16249736chr10:102743741
TCGAfusionPortalPRADALAMLTCGA-AB-2846-03AABCC6-C16orf70In-frameChr16:16253339Chr16:67165189


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TissGeneNet for ABCC6

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (tumor)ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (normal)
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COAD (tumor)COAD (normal)
ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (tumor)ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (normal)
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HNSC (tumor)HNSC (normal)
ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (tumor)ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (normal)
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KICH (tumor)KICH (normal)
ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (tumor)ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (normal)
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KIRC (tumor)KIRC (normal)
ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (tumor)ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (normal)
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KIRP (tumor)KIRP (normal)
ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (tumor)ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (normal)
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LIHC (tumor)LIHC (normal)
ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (tumor)ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (normal)
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LUAD (tumor)LUAD (normal)
ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (tumor)ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (normal)
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LUSC (tumor)LUSC (normal)
ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (tumor)ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (normal)
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PRAD (tumor)PRAD (normal)
ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (tumor)ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (normal)
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STAD (tumor)STAD (normal)
ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (tumor)ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (normal)
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THCA (tumor)THCA (normal)
ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (tumor)ABCC6, HNF4A, CEBPB, FURIN, VCL, NR4A1, A1BG, AK2, CRYL1 (normal)
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TissGeneProg for ABCC6

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for ABCC6
TissGeneDrug for ABCC6

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for ABCC6

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0033847Pseudoxanthoma Elasticum129BeFree,CLINVAR,CTD_human,GAD,LHGDN,MGD,ORPHANET,UNIPROT
umls:C0473583Nevus elasticus53BeFree
umls:C0010068Coronary heart disease8BeFree,GAD
umls:C0010054Coronary Arteriosclerosis7BeFree,GAD
umls:C0023467Leukemia, Myelocytic, Acute7BeFree
umls:C1956346Coronary Artery Disease7BeFree,LHGDN
umls:C3276161ARTERIAL CALCIFICATION, GENERALIZED, OF INFANCY, 26CLINVAR,UNIPROT
umls:C0006663Calcinosis5BeFree,GAD
umls:C0025517Metabolic Diseases4BeFree
umls:C1859727Arterial calcification of infancy4BeFree,ORPHANET
umls:C0002982Angioid Streaks3BeFree,GAD
umls:C0003873Rheumatoid Arthritis3BeFree
umls:C0009782Connective Tissue Diseases2BeFree
umls:C0024141Lupus Erythematosus, Systemic2BeFree
umls:C0410787Hereditary Connective Tissue Disorder2BeFree
umls:C0524909Hepatitis B, Chronic2BeFree
umls:C0001418Adenocarcinoma1LHGDN
umls:C0005779Blood Coagulation Disorders1BeFree
umls:C0007222Cardiovascular Diseases1BeFree
umls:C0008312Primary biliary cirrhosis1BeFree
umls:C0009404Colorectal Neoplasms1CTD_human
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1BeFree
umls:C0015393Eye Abnormalities1BeFree
umls:C0017638Glioma1BeFree
umls:C0020538Hypertensive disease1BeFree
umls:C0021368Inflammation1GAD
umls:C0021655Insulin Resistance1GAD
umls:C0023418leukemia1BeFree
umls:C0024138Lupus Erythematosus, Discoid1BeFree
umls:C0025312Meningomyelocele1BeFree
umls:C0029456Osteoporosis1BeFree
umls:C0031069Familial Mediterranean Fever1LHGDN
umls:C0031117Peripheral Neuropathy1CTD_human
umls:C0035309Retinal Diseases1GAD
umls:C0037274Dermatologic disorders1BeFree,LHGDN
umls:C0042373Vascular Diseases1BeFree
umls:C0151744Myocardial Ischemia1BeFree
umls:C0155626Acute myocardial infarction1BeFree
umls:C0239849Harlequin Fetus1BeFree
umls:C0242339Dyslipidemias1BeFree
umls:C0242656Disease Progression1CTD_human
umls:C0272315Coagulation factor deficiency syndrome1BeFree
umls:C0524620Metabolic Syndrome X1GAD
umls:C0559758Multisystem disorder1BeFree
umls:C0746556metabolic disturbance1BeFree
umls:C0877104Retinal toxicity1BeFree
umls:C0948008Ischemic stroke1BeFree
umls:C1397307Cardiac fibrosis1BeFree
umls:C1859372Calcification of Joints and Arteries1BeFree
umls:C1861502COLCHICINE RESISTANCE1BeFree
umls:C3272363Ischemic Cerebrovascular Accident1BeFree
umls:C3665346Unspecified visual loss1BeFree
umls:C0264955Idiopathic arterial calcification of infancy0ORPHANET
umls:C1867450Pseudoxanthoma Elasticum, Incomplete0CLINVAR