TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for ITGB3

Gene summary

Basic gene information	Gene symbol	ITGB3
	Gene name	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
	Synonyms	BDPLT16\|BDPLT2\|CD61\|GP3A\|GPIIIa\|GT
	Cytomap	UCSC genome browser: 17q21.32
	Type of gene	protein-coding
	RefGenes	NM_000212.2,
	Description	integrin beta-3platelet membrane glycoprotein IIIa
	Modification date	20141222
dbXrefs	MIM : 173470
	HGNC : HGNC
	Ensembl : ENSG00000259207
	HPRD : 01428
	Vega : OTTHUMG00000171956
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_ITGB3
	BioGPS: 3690
Pathway	NCI Pathway Interaction Database: ITGB3
	KEGG: ITGB3
	REACTOME: ITGB3
	Pathway Commons: ITGB3
Context	iHOP: ITGB3
	ligand binding site mutation search in PubMed: ITGB3
	UCL Cancer Institute: ITGB3
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	KidneyThyroid gland
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	KIRC,KIRP,KICHTHCA
Reference showing the relevant tissue of ITGB3
Description by TissGene annotations	Cancer gene Fused withTSGene

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0006457	protein folding	12204115
GO:0007160	cell-matrix adhesion	22505472
GO:0007229	integrin-mediated signaling pathway	23382103
GO:0034446	substrate adhesion-dependent cell spreading	24658351
GO:0006457	protein folding	12204115
GO:0007160	cell-matrix adhesion	22505472
GO:0007229	integrin-mediated signaling pathway	23382103
GO:0034446	substrate adhesion-dependent cell spreading	24658351

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TissGeneExp for ITGB3

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
PRAD	-0.184132182	0.976440895	-1.160573077	5.72E-07	4.32E-06
BLCA	-0.940593923	0.942774498	-1.883368421	0.00375	0.02127551
COAD	-0.134305259	1.23627551	-1.370580769	0.000233	0.000780586
KICH	1.027783972	2.505783972	-1.478	4.05E-05	0.000114292

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TissGene-miRNA for ITGB3

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for ITGB3

TissGeneSNV for ITGB3

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.S395F	SKCM	2
p.R441C	SKCM	2
p.W406*	SKCM	1
p.C64S	LUAD	1
p.D205A	STAD	1
p.E697K	SKCM	1
p.E501K	BLCA	1
p.R750Q	READ	1
p.V691I	STAD	1
p.R750Q	SKCM	1
p.S393P	LIHC	1
p.M144I	LUAD	1
p.S411Y	UCEC	1
p.P377T	SKCM	1
p.R505H	LUSC	1
p.S638G	LGG	1
p.G273R	SKCM	1
p.I170V	LIHC	1
p.R505C	SKCM	1
p.P105S	SKCM	1
p.N597D	BRCA	1
p.R505L	ESCA	1
p.R378C	UCEC	1
p.R169*	LGG	1
p.E200K	SKCM	1
p.E548K	CESC	1
p.D54N	LUAD	1
p.L600Q	LUAD	1
p.L744P	LIHC	1
p.F396L	CESC	1
p.L350P	LGG	1
p.L343F	SKCM	1
p.G637R	KIRC	1
p.R524W	DLBC	1
p.S47F	SKCM	1
p.D653N	SKCM	1
p.S507F	SKCM	1
p.E338K	THCA	1
p.S536N	STAD	1
p.P111H	COAD	1
p.S194F	SKCM	1
p.R487C	LUSC	1
p.P628Q	LUAD	1
p.G418E	HNSC	1
p.K558N	LIHC	1
p.E81K	BLCA	1
p.R176W	UCEC	1
p.W406*	HNSC	1
p.P155S	LUAD	1
p.R514*	STAD	1
p.S348N	UCEC	1
p.R63H	PAAD	1
p.W477*	SKCM	1
p.A289T	UCEC	1
p.S61L	HNSC	1
p.S563*	LUAD	1
p.A164E	LUAD	1
p.G605S	TGCT	1
p.K410E	UCEC	1
p.R750*	SKCM	1
p.S326F	SKCM	1
p.D647G	LGG	1
p.R63H	THYM	1
p.Q454P	UCEC	1
p.D122Y	LUSC	1
p.R386C	STAD	1
p.W492*	UCEC	1
p.D135N	SKCM	1
p.H300Y	ESCA	1
p.S123L	BRCA	1
p.P366S	SKCM	1
p.D152N	SKCM	1
p.L731V	BLCA	1
p.R386C	BLCA	1
p.A754T	SARC	1
p.H138Y	SKCM	1
p.K124Q	SKCM	1
p.S439F	KIRP	1
p.N365S	BRCA	1
p.A283P	HNSC	1
p.R750X	SKCM	1
p.R750Q	UCEC	1
p.D749H	CESC	1
p.R742C	LUAD	1
p.S127C	LUAD	1
p.A478T	SKCM	1
p.W554*	SKCM	1
p.I744V	SKCM	1
p.Y344*	LIHC	1
p.P628H	LUAD	1
p.R34L	MESO	1
p.H349Y	SKCM	1
p.R515W	STAD	1
p.G418E	SKCM	1
p.R589C	GBM	1
p.E752*	UCEC	1
p.Y773H	BLCA	1
p.E608K	SKCM	1
p.A255D	LUAD	1
p.T590S	LUAD	1
p.P389S	SKCM	1
p.D184E	KIRP	1
p.T784M	BLCA	1
p.G172R	SKCM	1
p.R589C	BLCA	1
p.R740G	STAD	1
p.E664K	UCEC	1
p.Q108R	SKCM	1
p.D362Y	HNSC	1
p.G566S	SKCM	1
p.R648Q	BLCA	1
p.S79F	SKCM	1
p.D510N	SKCM	1
p.E654K	SKCM	1
p.I252T	LIHC	1
p.H617N	LUAD	1
p.Y578*	LUAD	1
p.E68D	READ	1
p.R422S	HNSC	1
p.S363T	LUSC	1
p.G435D	SKCM	1
p.R786Q	COAD	1
p.H145Y	HNSC	1
p.E511K	SKCM	1
p.D749N	SKCM	1
p.T420M	HNSC	1

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TissGeneCNV for ITGB3

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for ITGB3

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	ChiTaRs	NA	BI059143	GOLGA1-ITGB3		chr9:127642395	chr17:45335169
Chimerdb3.0	ChiTaRs	NA	AI655822	KIF4A-ITGB3		chrX:69542274	chr17:45390262
Chimerdb3.0	ChiTaRs	NA	AU116912	ITGB3-INADL		chr17:45389761	chr1:62617829
Chimerdb3.0	ChiTaRs	NA	BC015906	ITGB3-FMN1		chr17:45390031	chr15:33062085
Chimerdb3.0	ChiTaRs	NA	BF800064	ITGB3-TTC12		chr17:45421652	chr11:113230098
Chimerdb3.0	ChiTaRs	NA	T11184	SCG3-ITGB3		chr15:51973975	chr17:45381930
Chimerdb3.0	FusionScan	ESCA	TCGA-L5-A4OH-01A	SPOP-ITGB3	5'UTR-CDS	chr17:47755294	chr17:45351784
Chimerdb3.0	FusionScan	OV	TCGA-24-1103-01A	ITGB3-DYNLRB1	In-Frame	chr17:45331306	chr20:33122431

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TissGeneNet for ITGB3

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
ITGB3, NID1, FN1, PTPN11, KDR, ITGAV, NFATC2, EPS8, PECAM1, DAB2, PDGFRB, COL1A2, PBX2, TGM2, CD36, TLN1, TENC1, FBLN2, PDGFRA, ITGA5, THY1 (tumor)	ITGB3, NID1, FN1, FLNA, PTPN11, KDR, ITGAV, NFATC2, THBS1, EPS8, DAB2, PDGFRB, COL1A2, TLN1, NUMB, PDPK1, FBLN2, PDGFRA, GULP1, ITGA5, THY1 (normal)

COAD (tumor)	COAD (normal)
ITGB3, NID1, FN1, FLNA, PTPN11, AKT1, ILK, PDGFRB, COL1A2, MAPK8IP1, RABGAP1, PBX2, CIB1, TLN1, NUMB, ANKS1B, TENC1, PTPRZ1, ITGA5, P2RY2, THY1 (tumor)	ITGB3, NID1, FN1, FLNA, KDR, ITGAV, NFATC2, THBS1, PECAM1, PDGFRB, COL1A2, TGM2, CD36, TLN1, TENC1, NFATC1, FBLN2, PDGFRA, PTPRZ1, ITGA5, THY1 (normal)

HNSC (tumor)	HNSC (normal)
ITGB3, NID1, SYK, FN1, KDR, ITGAV, THBS1, PECAM1, DAB2, PDGFRB, COL1A2, CDCA8, CD36, TLN1, CAPN1, ANKS1B, TENC1, NFATC1, FBLN2, PDGFRA, ITGA5 (tumor)	ITGB3, NID1, FN1, FLNA, PTPN11, KDR, ITGAV, NFATC2, THBS1, EPS8, DAB2, PDGFRB, COL1A2, TGM2, TLN1, TENC1, FBLN2, PDGFRA, ITGA5, THY1, MYO10 (normal)

KICH (tumor)	KICH (normal)
ITGB3, SRC, SHC1, FLNA, PTPN1, PTPN11, YES1, ITGAV, THBS1, DAB2, PTK2B, PDGFRB, COL1A2, FGA, VTN, CD36, TLN1, FGG, RGS12, ITGA2B, P2RY2 (tumor)	ITGB3, FLNB, NID1, FN1, FLNA, PTPN11, ITGAV, PTK2, THBS1, EPS8, DAB2, PTK2B, TGM2, CD36, PDPK1, FGG, NFATC1, ITGA2B, FBLN2, GULP1, ITGA5 (normal)

KIRC (tumor)	KIRC (normal)
ITGB3, NID1, SYK, SHC1, FLNA, PTPN1, PTPN11, KDR, ITGAV, THBS1, EPS8, DAB2, PDGFRB, COL1A2, PXN, FGA, TLN1, CEACAM1, ITGA2B, GULP1, ITGA5 (tumor)	ITGB3, NID1, FN1, FLNA, PTPN1, PTPN11, LYN, YES1, ITGAV, NFATC2, PTK2, THBS1, EPS8, COL1A2, MAPK8IP1, TGM2, TLN1, PDPK1, FBLN2, ITGA5, MYO10 (normal)

KIRP (tumor)	KIRP (normal)
ITGB3, NID1, SYK, SHC1, PTPN1, PTPN11, KDR, ITGAV, THBS1, EPS8, DAB2, PDGFRB, PXN, MAPK8IP1, FGA, MAP3K13, TLN1, FGG, ITGA2B, FBLN2, GULP1 (tumor)	ITGB3, NID1, SHC1, FN1, FLNA, PTPN1, ITGAV, NFATC2, PTK2, THBS1, EPS8, RABGAP1, TGM2, CIB1, FGA, MAP3K13, TLN1, ANKS1B, PDPK1, FGG, GULP1 (normal)

LIHC (tumor)	LIHC (normal)
ITGB3, NID1, SYK, PTPN1, PTPN11, KDR, YES1, ITGAV, NFATC2, PTK2, EPS8, DAB2, RABGAP1, CIB1, VTN, CD36, MAP3K13, TLN1, NUMB, PDGFRA, MYO10 (tumor)	ITGB3, NID1, FN1, FLNA, PTPN1, PTPN11, KDR, YES1, ITGAV, NFATC2, AKT1, EPS8, PTK2B, COL1A2, CIB1, DAB1, MAP3K13, TLN1, NUMB, PDPK1, FBLN2 (normal)

LUAD (tumor)	LUAD (normal)
ITGB3, FLNB, NID1, FN1, FLNA, PTPN11, KDR, ITGAV, NFATC2, THBS1, PDGFRB, PXN, TLN1, ANKS1B, DOK1, NFATC1, ITGA2B, FBLN2, PDGFRA, PTPRZ1, ITGA5 (tumor)	ITGB3, NID1, FN1, FLNA, LYN, KDR, ITGAV, NFATC2, THBS1, DAB2, PDGFRB, COL1A2, TGM2, FGA, MAP3K13, TLN1, NFATC1, FBLN2, PDGFRA, ITGA5, THY1 (normal)

LUSC (tumor)	LUSC (normal)
ITGB3, NID1, SHC1, FN1, FLNA, PTPN11, KDR, ITGAV, NFATC2, THBS1, DAB2, PDGFRB, COL1A2, TGM2, CIB1, TLN1, NFATC1, ITGA2B, FBLN2, ITGA5, MYO10 (tumor)	ITGB3, NID1, FN1, FLNA, KDR, ITGAV, NFATC2, THBS1, ILK, PECAM1, DAB2, PDGFRB, COL1A2, PXN, TGM2, TLN1, TENC1, FBLN2, PDGFRA, ITGA5, THY1 (normal)

PRAD (tumor)	PRAD (normal)
ITGB3, NID1, FN1, FLNA, PTPN11, KDR, NFATC2, ILK, DAB2, PDGFRB, COL1A2, RABGAP1, CIB1, DAB1, CD36, TLN1, ANKS1B, TENC1, PDGFRA, ITGA5, THY1 (tumor)	ITGB3, NID1, FN1, FLNA, PTPN11, KDR, NFATC2, THBS1, EPS8, DAB2, PDGFRB, COL1A2, RABGAP1, CIB1, DAB1, TLN1, NUMB, FBLN2, PDGFRA, ITGA5, P2RY2 (normal)

STAD (tumor)	STAD (normal)
ITGB3, NID1, FN1, FLNA, PTPN11, ITGAV, PTK2, AKT1, ILK, PDGFRB, COL1A2, CDCA8, MAPK8IP1, TGM2, TLN1, TENC1, NFATC1, FBLN2, PDGFRA, ITGA5, THY1 (tumor)	ITGB3, NID1, FN1, FLNA, KDR, ITGAV, THBS1, ILK, PECAM1, DAB2, PDGFRB, CDCA8, CD36, TLN1, ANKS1B, TENC1, ITGB3BP, NFATC1, FBLN2, PDGFRA, ITGA5 (normal)

THCA (tumor)	THCA (normal)
ITGB3, FLNB, PTPN11, YES1, ITGAV, NFATC2, PTK2, ILK, EPS8, PECAM1, RABGAP1, CIB1, MAP3K13, TLN1, NUMB, ANKS1B, PDPK1, DOK1, GULP1, P2RY2, MYO10 (tumor)	ITGB3, FLNA, PTPN1, PTPN11, LYN, YES1, ITGAV, NFATC2, PTK2, AKT1, EPS8, PECAM1, RABGAP1, TGM2, CIB1, MAP3K13, TLN1, CAPN1, PDPK1, P2RY2, THY1 (normal)

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TissGeneProg for ITGB3

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for ITGB3

TissGeneDrug for ITGB3

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID	Drug name	Drug activity	Drug type	Drug status
DB00098	Anti-thymocyte Globulin (Rabbit)		Biotech	Approved
DB00775	Tirofiban	Antagonist	Small molecule	Approved
DB00063	Eptifibatide		Biotech	Approved\|Investigational

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TissGeneDisease for ITGB3

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0040015	Thrombasthenia	46	BeFree,CLINVAR,CTD_human,GAD,LHGDN,MGD,ORPHANET,UNIPROT
umls:C0027051	Myocardial Infarction	44	BeFree,CLINVAR,CTD_human,GAD,LHGDN,RGD
umls:C0038454	Cerebrovascular accident	26	BeFree,CTD_human,GAD,LHGDN,RGD
umls:C0010054	Coronary Arteriosclerosis	21	BeFree,GAD
umls:C1956346	Coronary Artery Disease	19	BeFree,GAD,LHGDN
umls:C0007222	Cardiovascular Diseases	16	BeFree,GAD
umls:C0010068	Coronary heart disease	14	BeFree,GAD
umls:C0010072	Coronary Thrombosis	11	BeFree,CTD_human,GAD
umls:C0040053	Thrombosis	11	GAD,LHGDN
umls:C0006142	Malignant neoplasm of breast	10	BeFree,GAD
umls:C0027627	Neoplasm Metastasis	10	BeFree,LHGDN
umls:C1458155	Mammary Neoplasms	10	BeFree,LHGDN
umls:C0948089	Acute Coronary Syndrome	9	BeFree,CTD_human,GAD,LHGDN
umls:C0004352	Autistic Disorder	8	BeFree,CTD_human,GAD,LHGDN
umls:C0020538	Hypertensive disease	8	BeFree,GAD
umls:C0333186	Restenosis	8	BeFree,GAD
umls:C0004153	Atherosclerosis	7	BeFree,GAD
umls:C0033578	Prostatic Neoplasms	7	CTD_human,LHGDN
umls:C0398623	Thrombophilia	7	BeFree,GAD
umls:C0678222	Breast Carcinoma	7	BeFree
umls:C0004096	Asthma	6	BeFree,GAD,LHGDN
umls:C0007786	Brain Ischemia	6	GAD
umls:C0025202	melanoma	6	BeFree,LHGDN
umls:C0151744	Myocardial Ischemia	6	GAD
umls:C0155626	Acute myocardial infarction	6	BeFree
umls:C0040034	Thrombocytopenia	5	CTD_human,GAD,LHGDN
umls:C0948008	Ischemic stroke	5	BeFree,GAD
umls:C1842372	ASPIRIN RESISTANCE	5	GAD
umls:C0011860	Diabetes Mellitus, Non-Insulin-Dependent	4	BeFree,GAD
umls:C0024314	Lymphoproliferative Disorders	4	GAD
umls:C0040038	Thromboembolism	4	BeFree,GAD
umls:C0242379	Malignant neoplasm of lung	4	BeFree,GAD
umls:C0836924	Thrombocytosis	4	BeFree
umls:C0001418	Adenocarcinoma	3	BeFree,LHGDN
umls:C0003850	Arteriosclerosis	3	BeFree,GAD
umls:C0009402	Colorectal Carcinoma	3	BeFree
umls:C0018817	Atrial Septal Defects	3	BeFree
umls:C0021368	Inflammation	3	GAD
umls:C0023418	leukemia	3	BeFree
umls:C0024141	Lupus Erythematosus, Systemic	3	GAD,LHGDN
umls:C0029925	Ovarian Carcinoma	3	BeFree
umls:C0035326	Retinal vascular occlusion	3	GAD
umls:C0038525	Subarachnoid Hemorrhage	3	BeFree,GAD,LHGDN
umls:C0042373	Vascular Diseases	3	BeFree,GAD
umls:C0398650	Immune thrombocytopenic purpura	3	BeFree,LHGDN
umls:C0687675	Pregnancy loss	3	GAD
umls:C0919267	ovarian neoplasm	3	LHGDN
umls:C0948201	Alloimmunisation	3	BeFree
umls:C1140680	Malignant neoplasm of ovary	3	BeFree,GAD
umls:C1264031	Alloimmune thrombocytopenia	3	BeFree
umls:C1527249	Colorectal Cancer	3	BeFree,GAD
umls:C3853779	Neonatal Alloimmune Thrombocytopenia	3	CTD_human,GAD,LHGDN
umls:C0000786	Spontaneous abortion	2	GAD,LHGDN
umls:C0000809	Abortion, Habitual	2	GAD
umls:C0002895	Anemia, Sickle Cell	2	GAD
umls:C0005818	Blood Platelet Disorders	2	BeFree,GAD
umls:C0007131	Non-Small Cell Lung Carcinoma	2	BeFree
umls:C0007787	Transient Ischemic Attack	2	GAD,RGD
umls:C0011881	Diabetic Nephropathy	2	BeFree
umls:C0017327	Generalized atherosclerosis	2	GAD
umls:C0019080	Hemorrhage	2	CTD_human,GAD
umls:C0019087	Hemorrhagic Disorders	2	GAD
umls:C0019101	Hemorrhagic Fever with Renal Syndrome	2	GAD,LHGDN
umls:C0019693	HIV Infections	2	BeFree
umls:C0021361	Female infertility	2	GAD
umls:C0021390	Inflammatory Bowel Diseases	2	BeFree,GAD
umls:C0022661	Kidney Failure, Chronic	2	GAD
umls:C0028754	Obesity	2	GAD
umls:C0031117	Peripheral Neuropathy	2	CTD_human,GAD
umls:C0032914	Pre-Eclampsia	2	GAD
umls:C0040028	Thrombocythemia, Essential	2	BeFree
umls:C0085096	Peripheral Vascular Diseases	2	GAD
umls:C0085298	Sudden Cardiac Death	2	GAD
umls:C0149931	Migraine Disorders	2	GAD
umls:C0684249	Carcinoma of lung	2	BeFree
umls:C0686619	Secondary malignant neoplasm of lymph node	2	BeFree
umls:C0751633	Carotid Artery Plaque	2	BeFree
umls:C1510586	Autism Spectrum Disorders	2	BeFree
umls:C1561955	Fibrinogen Adverse Event	2	GAD
umls:C1861172	Venous Thromboembolism	2	GAD
umls:C1868251	Neonatal alloimmune thrombocytopenia (NAIT)	2	BeFree
umls:C0001925	Albuminuria	1	GAD
umls:C0002736	Amyotrophic Lateral Sclerosis	1	GAD
umls:C0002874	Aplastic Anemia	1	LHGDN
umls:C0002962	Angina Pectoris	1	GAD
umls:C0002965	Angina, Unstable	1	LHGDN
umls:C0003130	Anoxia	1	LHGDN
umls:C0003838	Arterial Occlusive Diseases	1	RGD
umls:C0003873	Rheumatoid Arthritis	1	BeFree
umls:C0004238	Atrial Fibrillation	1	GAD
umls:C0004626	Pneumonia, Bacterial	1	RGD
umls:C0004936	Mental disorders	1	BeFree
umls:C0004943	Behcet Syndrome	1	BeFree
umls:C0005283	beta Thalassemia	1	GAD
umls:C0007137	Squamous cell carcinoma	1	GAD
umls:C0007273	Carotid Artery Diseases	1	GAD
umls:C0007274	Carotid Artery Thrombosis	1	CTD_human
umls:C0007282	Carotid Stenosis	1	GAD
umls:C0007766	Intracranial Aneurysm	1	GAD
umls:C0007772	Intracranial Arteriovenous Malformation	1	LHGDN
umls:C0007789	Cerebral Palsy	1	GAD
umls:C0007820	Cerebrovascular Disorders	1	GAD
umls:C0008074	Child Development Disorders, Pervasive	1	CTD_human
umls:C0008479	Chondrosarcoma	1	LHGDN
umls:C0008495	Chorioamnionitis	1	GAD
umls:C0008924	Cleft Lip	1	BeFree
umls:C0009404	Colorectal Neoplasms	1	GAD
umls:C0010346	Crohn Disease	1	BeFree
umls:C0011057	Hearing Loss, Sudden	1	GAD
umls:C0011644	Scleroderma	1	BeFree
umls:C0011853	Diabetes Mellitus, Experimental	1	RGD
umls:C0011854	Diabetes Mellitus, Insulin-Dependent	1	BeFree
umls:C0011884	Diabetic Retinopathy	1	BeFree
umls:C0014121	Bacterial Endocarditis	1	BeFree
umls:C0014175	Endometriosis	1	LHGDN
umls:C0014591	Epistaxis	1	GAD
umls:C0015944	Fetal Membranes, Premature Rupture	1	GAD
umls:C0015967	Fever	1	LHGDN
umls:C0017181	Gastrointestinal Hemorrhage	1	GAD
umls:C0017638	Glioma	1	BeFree
umls:C0017639	Gliosis	1	CTD_human
umls:C0017658	Glomerulonephritis	1	RGD
umls:C0018128	Graft Occlusion, Vascular	1	GAD
umls:C0018784	Sensorineural Hearing Loss (disorder)	1	GAD
umls:C0018799	Heart Diseases	1	GAD
umls:C0019061	Hemolytic-Uremic Syndrome	1	GAD
umls:C0019100	Severe Dengue	1	GAD
umls:C0019196	Hepatitis C	1	GAD
umls:C0019829	Hodgkin Disease	1	LHGDN
umls:C0020445	Hypercholesterolemia, Familial	1	BeFree
umls:C0020473	Hyperlipidemia	1	GAD
umls:C0020517	Hypersensitivity	1	GAD
umls:C0020732	Iatrogenic Disease	1	GAD
umls:C0021308	Infarction	1	LHGDN
umls:C0021775	Intermittent Claudication	1	GAD
umls:C0022658	Kidney Diseases	1	GAD
umls:C0022876	Premature Obstetric Labor	1	GAD
umls:C0023473	Myeloid Leukemia, Chronic	1	BeFree
umls:C0024121	Lung Neoplasms	1	LHGDN
umls:C0024305	Lymphoma, Non-Hodgkin	1	BeFree,GAD
umls:C0024668	Mammary Neoplasms, Experimental	1	RGD
umls:C0026269	Mitral Valve Stenosis	1	GAD
umls:C0026640	Mouth Neoplasms	1	GAD
umls:C0026764	Multiple Myeloma	1	LHGDN
umls:C0029134	Optic Neuritis	1	GAD,LHGDN
umls:C0029463	Osteosarcoma	1	LHGDN
umls:C0030805	Bullous pemphigoid	1	LHGDN
umls:C0030920	Peptic Ulcer	1	GAD
umls:C0032460	Polycystic Ovary Syndrome	1	GAD
umls:C0032963	Pregnancy Complications, Cardiovascular	1	GAD
umls:C0032964	Pregnancy Complications, Hematologic	1	GAD
umls:C0033027	Preleukemia	1	BeFree
umls:C0035126	Reperfusion Injury	1	RGD
umls:C0035302	Retinal Artery Occlusion	1	GAD
umls:C0035328	Retinal Vein Occlusion	1	GAD
umls:C0036220	Kaposi Sarcoma	1	BeFree
umls:C0036341	Schizophrenia	1	BeFree
umls:C0036421	Systemic Scleroderma	1	BeFree
umls:C0039263	Takayasu Arteritis	1	LHGDN
umls:C0039483	Giant Cell Arteritis	1	BeFree,GAD,LHGDN
umls:C0040336	Tobacco Use Disorder	1	GAD
umls:C0042345	Varicosity	1	BeFree
umls:C0042755	Virilism	1	GAD
umls:C0042974	von Willebrand Disease	1	GAD
umls:C0043194	Wiskott-Aldrich Syndrome	1	BeFree
umls:C0079487	Helicobacter Infections	1	GAD
umls:C0079731	B-Cell Lymphomas	1	BeFree
umls:C0079745	Lymphoma, Large-Cell, Follicular	1	BeFree
umls:C0085110	Severe Combined Immunodeficiency	1	BeFree
umls:C0085278	Antiphospholipid Syndrome	1	GAD
umls:C0149871	Deep Vein Thrombosis	1	BeFree
umls:C0151526	Premature Birth	1	GAD
umls:C0151950	Deep thrombophlebitis	1	BeFree
umls:C0152013	Adenocarcinoma of lung (disorder)	1	BeFree
umls:C0155305	Optic Neuropathy, Ischemic	1	GAD
umls:C0155668	Old myocardial infarction	1	BeFree
umls:C0162869	Aneurysm, Ruptured	1	GAD
umls:C0232197	Fibrillation	1	BeFree
umls:C0242231	Coronary Stenosis	1	BeFree
umls:C0242339	Dyslipidemias	1	GAD
umls:C0242383	Age related macular degeneration	1	GAD
umls:C0242584	Autoimmune thrombocytopenia	1	BeFree
umls:C0264683	Coronary artery atheroma	1	BeFree
umls:C0265808	Cyanotic congenital heart disease	1	BeFree
umls:C0280141	Acute Undifferentiated Leukemia	1	BeFree
umls:C0338656	Impaired cognition	1	BeFree
umls:C0342257	Complications of Diabetes Mellitus	1	GAD
umls:C0376358	Malignant neoplasm of prostate	1	GAD
umls:C0376618	Endotoxemia	1	RGD
umls:C0398356	Abdominal aortic atherosclerosis	1	BeFree
umls:C0553692	Brain hemorrhage	1	GAD
umls:C0577698	Exercise-induced angina	1	BeFree
umls:C0596263	Carcinogenesis	1	BeFree
umls:C0598608	Hyperhomocysteinemia	1	GAD
umls:C0598766	Leukemogenesis	1	BeFree
umls:C0598935	Tumor Initiation	1	BeFree
umls:C0740457	Malignant neoplasm of kidney	1	GAD
umls:C0741923	cardiac event	1	BeFree
umls:C0750145	vascular disease occlusive	1	BeFree
umls:C0750151	Vaso-occlusive crisis	1	GAD
umls:C0751711	Anterior Ischemic Optic Neuropathy	1	BeFree
umls:C0752140	Intracranial Embolism	1	GAD
umls:C0752143	Intracranial Thrombosis	1	GAD
umls:C0752351	Embryo Loss	1	GAD
umls:C0852077	Blood Coagulation Disorders, Inherited	1	GAD
umls:C0872054	latent infection	1	BeFree
umls:C0993582	Arthritis, Experimental	1	RGD
umls:C1272641	Systemic arterial pressure	1	GAD
umls:C1273976	First myocardial infarction	1	BeFree
umls:C1319200	Postoperative confusion	1	BeFree
umls:C1378511	Undifferentiated leukemia	1	BeFree
umls:C1541923	Infective endocarditis	1	BeFree
umls:C1857941	Brooke-Spiegler syndrome	1	BeFree
umls:C1861185	THROMBOCYTOPENIA 2 (disorder)	1	BeFree
umls:C1861195	Glanzmann Thrombasthenia, Autosomal Dominant	1	CLINVAR,MGD,UNIPROT
umls:C1956391	Temporal Arteritis	1	GAD
umls:C2349404	Heparin induced thrombocytopenia (HIT)	1	BeFree
umls:C2919032	Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified	1	GAD
umls:C2921106	Recurrent pregnancy loss	1	GAD
umls:C2937358	Cerebral Hemorrhage	1	CTD_human
umls:C3178801	Stroke, Lacunar	1	GAD
umls:C3272363	Ischemic Cerebrovascular Accident	1	BeFree
umls:C3463824	MYELODYSPLASTIC SYNDROME	1	BeFree
umls:C3539878	Triple Negative Breast Neoplasms	1	BeFree
umls:C3539909	Allergic disposition	1	BeFree
umls:C0398648	Posttransfusion purpura	0	CLINVAR
umls:C2674640	FRACTURE, HIP, SUSCEPTIBILITY TO (finding)	0	CLINVAR