TissGeneSummary for ITIH4 |
Gene summary |
Basic gene information | Gene symbol | ITIH4 |
Gene name | inter-alpha-trypsin inhibitor heavy chain family, member 4 | |
Synonyms | GP120|H4P|IHRP|ITI-HC4|ITIHL1|PK-120|PK120 | |
Cytomap | UCSC genome browser: 3p21.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001166449.1, NM_002218.4, | |
Description | ITI heavy chain H4inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)inter-alpha-inhibitor heavy chain 4inter-alpha-trypsin inhibitor family heavy chain-related proteininter-alpha-trypsin inhibitor heavy chain H4inter-alpha | |
Modification date | 20141207 | |
dbXrefs | MIM : 600564 | |
HGNC : HGNC | ||
Ensembl : ENSG00000055955 | ||
HPRD : 02781 | ||
Vega : OTTHUMG00000159023 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ITIH4 | |
BioGPS: 3700 | ||
Pathway | NCI Pathway Interaction Database: ITIH4 | |
KEGG: ITIH4 | ||
REACTOME: ITIH4 | ||
Pathway Commons: ITIH4 | ||
Context | iHOP: ITIH4 | |
ligand binding site mutation search in PubMed: ITIH4 | ||
UCL Cancer Institute: ITIH4 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of ITIH4 | ||
Description by TissGene annotations | Cancer gene TissgsKTS Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ITIH4 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -0.99768451 | 0.660629215 | -1.658313725 | 2.18E-09 | 7.23E-09 |
BRCA | -1.006451177 | 0.223195314 | -1.229646491 | 4.49E-13 | 2.07E-12 |
LIHC | 9.73851349 | 11.58675349 | -1.84824 | 2.06E-08 | 1.69E-07 |
KICH | -1.76158851 | -0.50198051 | -1.259608 | 4.52E-06 | 1.52E-05 |
KIRP | -1.499412635 | -0.43054076 | -1.068871875 | 0.00568 | 0.013223842 |
KIRC | -0.655401177 | -1.692765066 | 1.037363889 | 0.00289 | 0.00518534 |
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TissGene-miRNA for ITIH4 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ITIH4 |
TissGeneSNV for ITIH4 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V802A | UCEC | 1 |
p.E799Q | HNSC | 1 |
p.P395T | HNSC | 1 |
p.Q765R | HNSC | 1 |
p.G651R | GBM | 1 |
p.G611V | LUAD | 1 |
p.G418S | GBM | 1 |
p.E528K | LUSC | 1 |
p.T51K | OV | 1 |
p.E909K | CESC | 1 |
p.T192I | LUAD | 1 |
p.L150F | UCEC | 1 |
p.R910H | STAD | 1 |
p.R409Q | HNSC | 1 |
p.Q182H | LGG | 1 |
p.P324Q | COAD | 1 |
p.T594A | UCEC | 1 |
p.L860F | SKCM | 1 |
p.D567Y | BLCA | 1 |
p.D34N | UCEC | 1 |
p.R805W | COAD | 1 |
p.T9I | LIHC | 1 |
p.Q127* | HNSC | 1 |
p.D762Y | LUAD | 1 |
p.Q554L | LUAD | 1 |
p.A783V | LUSC | 1 |
p.V334M | UCEC | 1 |
p.E784K | BLCA | 1 |
p.P587H | UCEC | 1 |
p.Q253* | KIRC | 1 |
p.M285I | BLCA | 1 |
p.E295* | THYM | 1 |
p.S810F | LGG | 1 |
p.V402M | STAD | 1 |
p.P710S | SKCM | 1 |
p.R214W | SKCM | 1 |
p.E148D | BRCA | 1 |
p.Q877* | LGG | 1 |
p.N472S | PRAD | 1 |
p.A563T | UCEC | 1 |
p.A563T | STAD | 1 |
p.P676S | SKCM | 1 |
p.G876V | LIHC | 1 |
p.T723I | SKCM | 1 |
p.A531V | SARC | 1 |
p.R439H | ESCA | 1 |
p.E295X | THYM | 1 |
p.P679S | SKCM | 1 |
p.P739S | BLCA | 1 |
p.L505I | HNSC | 1 |
p.R245Q | COAD | 1 |
p.E158K | HNSC | 1 |
p.A246V | SKCM | 1 |
p.R409L | BLCA | 1 |
p.A264T | STAD | 1 |
p.Q877X | LGG | 1 |
p.R245W | READ | 1 |
p.R164W | STAD | 1 |
p.P918S | SKCM | 1 |
p.E147* | SKCM | 1 |
p.P181S | STAD | 1 |
p.E784K | SKCM | 1 |
p.V314I | UCS | 1 |
p.A77T | SKCM | 1 |
p.R240C | SKCM | 1 |
p.P919L | ACC | 1 |
p.K75N | COAD | 1 |
p.P395S | SKCM | 1 |
p.R753C | SARC | 1 |
p.R908I | UCEC | 1 |
p.R164Q | STAD | 1 |
p.V53I | STAD | 1 |
p.S781* | BLCA | 1 |
p.E295D | PRAD | 1 |
p.M721I | BLCA | 1 |
p.Q182R | LIHC | 1 |
p.L379H | KIRC | 1 |
p.T141A | STAD | 1 |
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TissGeneCNV for ITIH4 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ITIH4 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | D38535 | ONECUT1-ITIH4 | chr15:53082210 | chr3:52847302 | |
Chimerdb3.0 | ChiTaRs | NA | DA281687 | ARHGEF1-ITIH4 | chr19:42392102 | chr3:52853567 | |
Chimerdb3.0 | ChiTaRs | NA | AI133253 | SART1-ITIH4 | chr11:65746532 | chr3:52858446 |
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TissGeneNet for ITIH4 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ITIH4 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ITIH4 |
TissGeneDrug for ITIH4 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ITIH4 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0019693 | HIV Infections | 537 | BeFree |
umls:C0042769 | Virus Diseases | 11 | BeFree |
umls:C0276199 | Canarypox (disorder) | 6 | BeFree |
umls:C0001849 | AIDS Dementia Complex | 5 | BeFree |
umls:C0027819 | Neuroblastoma | 4 | BeFree |
umls:C0497169 | hiv-infection/aids | 4 | BeFree |
umls:C0497327 | Dementia | 4 | BeFree |
umls:C0700095 | Central neuroblastoma | 4 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
umls:C0011265 | Presenile dementia | 3 | BeFree |
umls:C0014038 | Encephalitis | 3 | BeFree |
umls:C0039614 | Tetanus | 3 | BeFree |
umls:C0085584 | Encephalopathies | 3 | BeFree |
umls:C0266999 | Vesicular Stomatitis | 3 | BeFree |
umls:C0678222 | Breast Carcinoma | 3 | BeFree |
umls:C0001175 | Acquired Immunodeficiency Syndrome | 2 | BeFree |
umls:C0004114 | Astrocytoma | 2 | BeFree |
umls:C0005586 | Bipolar Disorder | 2 | BeFree |
umls:C0019163 | Hepatitis B | 2 | BeFree |
umls:C0023418 | leukemia | 2 | BeFree |
umls:C0026936 | Mycoplasma Infections | 2 | BeFree |
umls:C0027796 | Neuralgia | 2 | BeFree |
umls:C0036341 | Schizophrenia | 2 | GAD,GWASCAT |
umls:C0038826 | Superinfection | 2 | BeFree |
umls:C0206019 | HIV Encephalopathy | 2 | BeFree |
umls:C0948192 | Primary infection NOS | 2 | BeFree |
umls:C0003175 | Anthrax disease | 1 | BeFree |
umls:C0004565 | Melanoma, B16 | 1 | BeFree |
umls:C0004623 | Bacterial Infections | 1 | BeFree |
umls:C0010692 | Cystitis | 1 | LHGDN |
umls:C0012546 | Diphtheria | 1 | BeFree |
umls:C0015230 | Exanthema | 1 | BeFree |
umls:C0016034 | Breast Fibrocystic Disease | 1 | BeFree |
umls:C0016629 | Fowlpox | 1 | BeFree |
umls:C0019348 | Herpes Simplex Infections | 1 | BeFree |
umls:C0020443 | Hypercholesterolemia | 1 | BeFree,GAD |
umls:C0024266 | Lymphocytic Choriomeningitis | 1 | BeFree |
umls:C0036220 | Kaposi Sarcoma | 1 | BeFree |
umls:C0039128 | Syphilis | 1 | BeFree |
umls:C0042109 | Urticaria | 1 | BeFree |
umls:C0078911 | AIDS-Associated Nephropathy | 1 | BeFree |
umls:C0153014 | Non-arthropod borne lymphocytic choriomeningitis | 1 | BeFree |
umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
umls:C0221026 | X-linked agammaglobulinemia | 1 | BeFree |
umls:C0221232 | Welts | 1 | BeFree |
umls:C0276548 | HIV encephalitis | 1 | BeFree |
umls:C0338656 | Impaired cognition | 1 | BeFree |
umls:C0404521 | Infective vaginitis | 1 | BeFree |
umls:C0677936 | Refractory cancer | 1 | BeFree |
umls:C0848332 | Spots on skin | 1 | BeFree |
umls:C1262091 | Lymphocytic infiltration | 1 | BeFree |
umls:C1707758 | Direct Contact Transmission Infection | 1 | BeFree |
umls:C1744558 | T-lymphocyte deficiency | 1 | BeFree |
umls:C2936719 | Mechanical Allodynia | 1 | BeFree |
umls:C3826758 | AIDS (Disease) | 1 | BeFree |
umls:C0745103 | Hyperlipoproteinemia Type IIa | 0 | CTD_human |