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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for ITIH4
check button Gene summary
Basic gene informationGene symbolITIH4
Gene nameinter-alpha-trypsin inhibitor heavy chain family, member 4
SynonymsGP120|H4P|IHRP|ITI-HC4|ITIHL1|PK-120|PK120
CytomapUCSC genome browser: 3p21.1
Type of geneprotein-coding
RefGenesNM_001166449.1,
NM_002218.4,
DescriptionITI heavy chain H4inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)inter-alpha-inhibitor heavy chain 4inter-alpha-trypsin inhibitor family heavy chain-related proteininter-alpha-trypsin inhibitor heavy chain H4inter-alpha
Modification date20141207
dbXrefs MIM : 600564
HGNC : HGNC
Ensembl : ENSG00000055955
HPRD : 02781
Vega : OTTHUMG00000159023
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ITIH4
BioGPS: 3700
PathwayNCI Pathway Interaction Database: ITIH4
KEGG: ITIH4
REACTOME: ITIH4
Pathway Commons: ITIH4
ContextiHOP: ITIH4
ligand binding site mutation search in PubMed: ITIH4
UCL Cancer Institute: ITIH4
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,TiGER
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of ITIH4
Description by TissGene annotationsCancer gene
TissgsKTS
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for ITIH4

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC-0.997684510.660629215-1.6583137252.18E-097.23E-09
BRCA-1.0064511770.223195314-1.2296464914.49E-132.07E-12
LIHC9.7385134911.58675349-1.848242.06E-081.69E-07
KICH-1.76158851-0.50198051-1.2596084.52E-061.52E-05
KIRP-1.499412635-0.43054076-1.0688718750.005680.013223842
KIRC-0.655401177-1.6927650661.0373638890.002890.00518534


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TissGene-miRNA for ITIH4

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for ITIH4
TissGeneSNV for ITIH4

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.V802AUCEC1
p.E799QHNSC1
p.P395THNSC1
p.Q765RHNSC1
p.G651RGBM1
p.G611VLUAD1
p.G418SGBM1
p.E528KLUSC1
p.T51KOV1
p.E909KCESC1
p.T192ILUAD1
p.L150FUCEC1
p.R910HSTAD1
p.R409QHNSC1
p.Q182HLGG1
p.P324QCOAD1
p.T594AUCEC1
p.L860FSKCM1
p.D567YBLCA1
p.D34NUCEC1
p.R805WCOAD1
p.T9ILIHC1
p.Q127*HNSC1
p.D762YLUAD1
p.Q554LLUAD1
p.A783VLUSC1
p.V334MUCEC1
p.E784KBLCA1
p.P587HUCEC1
p.Q253*KIRC1
p.M285IBLCA1
p.E295*THYM1
p.S810FLGG1
p.V402MSTAD1
p.P710SSKCM1
p.R214WSKCM1
p.E148DBRCA1
p.Q877*LGG1
p.N472SPRAD1
p.A563TUCEC1
p.A563TSTAD1
p.P676SSKCM1
p.G876VLIHC1
p.T723ISKCM1
p.A531VSARC1
p.R439HESCA1
p.E295XTHYM1
p.P679SSKCM1
p.P739SBLCA1
p.L505IHNSC1
p.R245QCOAD1
p.E158KHNSC1
p.A246VSKCM1
p.R409LBLCA1
p.A264TSTAD1
p.Q877XLGG1
p.R245WREAD1
p.R164WSTAD1
p.P918SSKCM1
p.E147*SKCM1
p.P181SSTAD1
p.E784KSKCM1
p.V314IUCS1
p.A77TSKCM1
p.R240CSKCM1
p.P919LACC1
p.K75NCOAD1
p.P395SSKCM1
p.R753CSARC1
p.R908IUCEC1
p.R164QSTAD1
p.V53ISTAD1
p.S781*BLCA1
p.E295DPRAD1
p.M721IBLCA1
p.Q182RLIHC1
p.L379HKIRC1
p.T141ASTAD1


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TissGeneCNV for ITIH4

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for ITIH4

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAD38535ONECUT1-ITIH4chr15:53082210chr3:52847302
Chimerdb3.0ChiTaRsNADA281687ARHGEF1-ITIH4chr19:42392102chr3:52853567
Chimerdb3.0ChiTaRsNAAI133253SART1-ITIH4chr11:65746532chr3:52858446


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TissGeneNet for ITIH4

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (tumor)ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (normal)
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COAD (tumor)COAD (normal)
ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (tumor)ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (normal)
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HNSC (tumor)HNSC (normal)
ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (tumor)ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (normal)
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KICH (tumor)KICH (normal)
ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (tumor)ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (normal)
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KIRC (tumor)KIRC (normal)
ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (tumor)ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (normal)
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KIRP (tumor)KIRP (normal)
ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (tumor)ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (normal)
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LIHC (tumor)LIHC (normal)
ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (tumor)ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (normal)
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LUAD (tumor)LUAD (normal)
ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (tumor)ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (normal)
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LUSC (tumor)LUSC (normal)
ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (tumor)ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (normal)
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PRAD (tumor)PRAD (normal)
ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (tumor)ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (normal)
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STAD (tumor)STAD (normal)
ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (tumor)ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (normal)
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THCA (tumor)THCA (normal)
ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (tumor)ITIH4, TP63, HNF4A, GRB2, LGALS3, HNF1A, LGALS8, DNAJC1 (normal)
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TissGeneProg for ITIH4

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for ITIH4
TissGeneDrug for ITIH4

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for ITIH4

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0019693HIV Infections537BeFree
umls:C0042769Virus Diseases11BeFree
umls:C0276199Canarypox (disorder)6BeFree
umls:C0001849AIDS Dementia Complex5BeFree
umls:C0027819Neuroblastoma4BeFree
umls:C0497169hiv-infection/aids4BeFree
umls:C0497327Dementia4BeFree
umls:C0700095Central neuroblastoma4BeFree
umls:C0006142Malignant neoplasm of breast3BeFree
umls:C0011265Presenile dementia3BeFree
umls:C0014038Encephalitis3BeFree
umls:C0039614Tetanus3BeFree
umls:C0085584Encephalopathies3BeFree
umls:C0266999Vesicular Stomatitis3BeFree
umls:C0678222Breast Carcinoma3BeFree
umls:C0001175Acquired Immunodeficiency Syndrome2BeFree
umls:C0004114Astrocytoma2BeFree
umls:C0005586Bipolar Disorder2BeFree
umls:C0019163Hepatitis B2BeFree
umls:C0023418leukemia2BeFree
umls:C0026936Mycoplasma Infections2BeFree
umls:C0027796Neuralgia2BeFree
umls:C0036341Schizophrenia2GAD,GWASCAT
umls:C0038826Superinfection2BeFree
umls:C0206019HIV Encephalopathy2BeFree
umls:C0948192Primary infection NOS2BeFree
umls:C0003175Anthrax disease1BeFree
umls:C0004565Melanoma, B161BeFree
umls:C0004623Bacterial Infections1BeFree
umls:C0010692Cystitis1LHGDN
umls:C0012546Diphtheria1BeFree
umls:C0015230Exanthema1BeFree
umls:C0016034Breast Fibrocystic Disease1BeFree
umls:C0016629Fowlpox1BeFree
umls:C0019348Herpes Simplex Infections1BeFree
umls:C0020443Hypercholesterolemia1BeFree,GAD
umls:C0024266Lymphocytic Choriomeningitis1BeFree
umls:C0036220Kaposi Sarcoma1BeFree
umls:C0039128Syphilis1BeFree
umls:C0042109Urticaria1BeFree
umls:C0078911AIDS-Associated Nephropathy1BeFree
umls:C0153014Non-arthropod borne lymphocytic choriomeningitis1BeFree
umls:C0153676Secondary malignant neoplasm of lung1BeFree
umls:C0221026X-linked agammaglobulinemia1BeFree
umls:C0221232Welts1BeFree
umls:C0276548HIV encephalitis1BeFree
umls:C0338656Impaired cognition1BeFree
umls:C0404521Infective vaginitis1BeFree
umls:C0677936Refractory cancer1BeFree
umls:C0848332Spots on skin1BeFree
umls:C1262091Lymphocytic infiltration1BeFree
umls:C1707758Direct Contact Transmission Infection1BeFree
umls:C1744558T-lymphocyte deficiency1BeFree
umls:C2936719Mechanical Allodynia1BeFree
umls:C3826758AIDS (Disease)1BeFree
umls:C0745103Hyperlipoproteinemia Type IIa0CTD_human