TissGeneSummary for KCNA2 |
Gene summary |
Basic gene information | Gene symbol | KCNA2 |
Gene name | potassium voltage-gated channel, shaker-related subfamily, member 2 | |
Synonyms | HBK5|HK4|HUKIV|KV1.2|MK2|NGK1|RBK2 | |
Cytomap | UCSC genome browser: 1p13 | |
Type of gene | protein-coding | |
RefGenes | NM_001204269.1, NM_004974.3, | |
Description | potassium voltage-gated channel subfamily A member 2voltage-gated K(+) channel HuKIVvoltage-gated potassium channel HBK5voltage-gated potassium channel protein Kv1.2voltage-gated potassium channel subunit Kv1.2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 176262 | |
HGNC : HGNC | ||
Ensembl : ENSG00000177301 | ||
HPRD : 01443 | ||
Vega : OTTHUMG00000011567 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KCNA2 | |
BioGPS: 3737 | ||
Pathway | NCI Pathway Interaction Database: KCNA2 | |
KEGG: KCNA2 | ||
REACTOME: KCNA2 | ||
Pathway Commons: KCNA2 | ||
Context | iHOP: KCNA2 | |
ligand binding site mutation search in PubMed: KCNA2 | ||
UCL Cancer Institute: KCNA2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGUVM | |
Reference showing the relevant tissue of KCNA2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KCNA2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -0.38486864 | 1.824211021 | -2.209079661 | 4.58E-14 | 4.92E-13 |
HNSC | -1.356231233 | 0.177059464 | -1.533290698 | 1.79E-10 | 3.48E-09 |
BRCA | -1.153319279 | 0.994057037 | -2.147376316 | 2.61E-28 | 3.10E-27 |
STAD | -0.095006669 | 2.273296456 | -2.368303125 | 4.28E-08 | 1.38E-06 |
BLCA | -1.582012262 | -0.331764893 | -1.250247368 | 3.77E-05 | 0.000514385 |
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TissGene-miRNA for KCNA2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KCNA2 |
TissGeneSNV for KCNA2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R80L | UCEC | 1 |
p.V301I | SKCM | 1 |
p.A262V | STAD | 1 |
p.R294L | KIRP | 1 |
p.E191K | HNSC | 1 |
p.V170A | HNSC | 1 |
p.R73X | READ | 1 |
p.P405L | SKCM | 1 |
p.T483I | SKCM | 1 |
p.G41A | LUAD | 1 |
p.P105R | KIRP | 1 |
p.Q285L | LIHC | 1 |
p.P265L | SKCM | 1 |
p.Y155* | BLCA | 1 |
p.N38S | SKCM | 1 |
p.L106S | HNSC | 1 |
p.K437T | LUAD | 1 |
p.R82S | READ | 1 |
p.A323V | SKCM | 1 |
p.G95W | BLCA | 1 |
p.E135K | CESC | 1 |
p.F237L | READ | 1 |
p.T401P | SKCM | 1 |
p.T320N | THYM | 1 |
p.R419Q | STAD | 1 |
p.R65Q | UCEC | 1 |
p.R294C | LUAD | 1 |
p.A395V | READ | 1 |
p.R73X | STAD | 1 |
p.E128K | SKCM | 1 |
p.V225I | READ | 1 |
p.W150C | GBM | 1 |
p.R82H | STAD | 1 |
p.G6R | HNSC | 1 |
p.E130K | BLCA | 1 |
p.Y489C | BLCA | 1 |
p.D129N | HNSC | 1 |
p.R189P | LUAD | 1 |
p.E121K | BLCA | 1 |
p.K455T | STAD | 1 |
p.G6R | LUAD | 1 |
p.G197C | LUAD | 1 |
p.E279Q | OV | 1 |
p.T483A | LUAD | 1 |
p.S289L | LUSC | 1 |
p.R100Q | COAD | 1 |
p.I402F | BLCA | 1 |
p.R294S | LUAD | 1 |
p.Y68F | STAD | 1 |
p.E136G | SKCM | 1 |
p.F241L | COAD | 1 |
p.V390A | PRAD | 1 |
p.R114W | LIHC | 1 |
p.R138H | STAD | 1 |
p.R82L | LUAD | 1 |
p.K445N | LUAD | 1 |
p.S449G | SKCM | 1 |
p.E144V | LIHC | 1 |
p.A329V | COAD | 1 |
p.F109I | SKCM | 1 |
p.G17V | PAAD | 1 |
p.G313C | HNSC | 1 |
p.F413L | KIRC | 1 |
p.P105T | LUSC | 1 |
p.R73* | STAD | 1 |
p.T320I | SKCM | 1 |
p.V301I | BLCA | 1 |
p.Q20R | LUAD | 1 |
p.T216I | STAD | 1 |
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TissGeneCNV for KCNA2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KCNA2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for KCNA2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KCNA2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KCNA2 |
TissGeneDrug for KCNA2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KCNA2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0036572 | Seizures | 3 | BeFree,CTD_human |
umls:C0004134 | Ataxia | 2 | BeFree |
umls:C0027796 | Neuralgia | 2 | BeFree |
umls:C1720983 | Channelopathies | 2 | BeFree |
umls:C0007758 | Cerebellar Ataxia | 1 | BeFree |
umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
umls:C0014544 | Epilepsy | 1 | BeFree |
umls:C0014550 | Epilepsies, Myoclonic | 1 | BeFree |
umls:C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
umls:C0022116 | Ischemia | 1 | BeFree |
umls:C0023014 | Language Development Disorders | 1 | CTD_human |
umls:C0024141 | Lupus Erythematosus, Systemic | 1 | BeFree |
umls:C0027854 | Neurologic Manifestations | 1 | LHGDN |
umls:C0038454 | Cerebrovascular accident | 1 | BeFree |
umls:C0184567 | Acute onset pain | 1 | BeFree |
umls:C0234366 | Ataxic | 1 | BeFree |
umls:C0543888 | Epileptic encephalopathy | 1 | BeFree |
umls:C1535926 | Neurodevelopmental Disorders | 1 | BeFree |
umls:C3714756 | Intellectual Disability | 1 | CTD_human |