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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for KCNA2
check button Gene summary
Basic gene informationGene symbolKCNA2
Gene namepotassium voltage-gated channel, shaker-related subfamily, member 2
SynonymsHBK5|HK4|HUKIV|KV1.2|MK2|NGK1|RBK2
CytomapUCSC genome browser: 1p13
Type of geneprotein-coding
RefGenesNM_001204269.1,
NM_004974.3,
Descriptionpotassium voltage-gated channel subfamily A member 2voltage-gated K(+) channel HuKIVvoltage-gated potassium channel HBK5voltage-gated potassium channel protein Kv1.2voltage-gated potassium channel subunit Kv1.2
Modification date20141207
dbXrefs MIM : 176262
HGNC : HGNC
Ensembl : ENSG00000177301
HPRD : 01443
Vega : OTTHUMG00000011567
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KCNA2
BioGPS: 3737
PathwayNCI Pathway Interaction Database: KCNA2
KEGG: KCNA2
REACTOME: KCNA2
Pathway Commons: KCNA2
ContextiHOP: KCNA2
ligand binding site mutation search in PubMed: KCNA2
UCL Cancer Institute: KCNA2
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,TiGER
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)BrainEye
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)GBM,LGGUVM
Reference showing the relevant tissue of KCNA2
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for KCNA2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
THCA-0.384868641.824211021-2.2090796614.58E-144.92E-13
HNSC-1.3562312330.177059464-1.5332906981.79E-103.48E-09
BRCA-1.1533192790.994057037-2.1473763162.61E-283.10E-27
STAD-0.0950066692.273296456-2.3683031254.28E-081.38E-06
BLCA-1.582012262-0.331764893-1.2502473683.77E-050.000514385


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TissGene-miRNA for KCNA2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for KCNA2
TissGeneSNV for KCNA2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R80LUCEC1
p.V301ISKCM1
p.A262VSTAD1
p.R294LKIRP1
p.E191KHNSC1
p.V170AHNSC1
p.R73XREAD1
p.P405LSKCM1
p.T483ISKCM1
p.G41ALUAD1
p.P105RKIRP1
p.Q285LLIHC1
p.P265LSKCM1
p.Y155*BLCA1
p.N38SSKCM1
p.L106SHNSC1
p.K437TLUAD1
p.R82SREAD1
p.A323VSKCM1
p.G95WBLCA1
p.E135KCESC1
p.F237LREAD1
p.T401PSKCM1
p.T320NTHYM1
p.R419QSTAD1
p.R65QUCEC1
p.R294CLUAD1
p.A395VREAD1
p.R73XSTAD1
p.E128KSKCM1
p.V225IREAD1
p.W150CGBM1
p.R82HSTAD1
p.G6RHNSC1
p.E130KBLCA1
p.Y489CBLCA1
p.D129NHNSC1
p.R189PLUAD1
p.E121KBLCA1
p.K455TSTAD1
p.G6RLUAD1
p.G197CLUAD1
p.E279QOV1
p.T483ALUAD1
p.S289LLUSC1
p.R100QCOAD1
p.I402FBLCA1
p.R294SLUAD1
p.Y68FSTAD1
p.E136GSKCM1
p.F241LCOAD1
p.V390APRAD1
p.R114WLIHC1
p.R138HSTAD1
p.R82LLUAD1
p.K445NLUAD1
p.S449GSKCM1
p.E144VLIHC1
p.A329VCOAD1
p.F109ISKCM1
p.G17VPAAD1
p.G313CHNSC1
p.F413LKIRC1
p.P105TLUSC1
p.R73*STAD1
p.T320ISKCM1
p.V301IBLCA1
p.Q20RLUAD1
p.T216ISTAD1


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TissGeneCNV for KCNA2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for KCNA2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for KCNA2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (tumor)KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (normal)
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COAD (tumor)COAD (normal)
KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (tumor)KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (normal)
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HNSC (tumor)HNSC (normal)
KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (tumor)KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (normal)
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KICH (tumor)KICH (normal)
KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (tumor)KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (normal)
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KIRC (tumor)KIRC (normal)
KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (tumor)KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (normal)
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KIRP (tumor)KIRP (normal)
KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (tumor)KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (normal)
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LIHC (tumor)LIHC (normal)
KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (tumor)KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (normal)
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LUAD (tumor)LUAD (normal)
KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (tumor)KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (normal)
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LUSC (tumor)LUSC (normal)
KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (tumor)KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (normal)
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PRAD (tumor)PRAD (normal)
KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (tumor)KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (normal)
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STAD (tumor)STAD (normal)
KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (tumor)KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (normal)
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THCA (tumor)THCA (normal)
KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (tumor)KCNA2, RTN4, DLG4, RHOA, CTTN, PTK2B, KCNA5, KCNA3, DLG1, KCNA1, CNTNAP2, CNTNAP1, PTPRA, ETV1, KCNAB2, KCNAB1, KCNA4 (normal)
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TissGeneProg for KCNA2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for KCNA2
TissGeneDrug for KCNA2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for KCNA2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0036572Seizures3BeFree,CTD_human
umls:C0004134Ataxia2BeFree
umls:C0027796Neuralgia2BeFree
umls:C1720983Channelopathies2BeFree
umls:C0007758Cerebellar Ataxia1BeFree
umls:C0011853Diabetes Mellitus, Experimental1RGD
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1BeFree
umls:C0014544Epilepsy1BeFree
umls:C0014550Epilepsies, Myoclonic1BeFree
umls:C0019284Diaphragmatic Hernia1CTD_human
umls:C0022116Ischemia1BeFree
umls:C0023014Language Development Disorders1CTD_human
umls:C0024141Lupus Erythematosus, Systemic1BeFree
umls:C0027854Neurologic Manifestations1LHGDN
umls:C0038454Cerebrovascular accident1BeFree
umls:C0184567Acute onset pain1BeFree
umls:C0234366Ataxic1BeFree
umls:C0543888Epileptic encephalopathy1BeFree
umls:C1535926Neurodevelopmental Disorders1BeFree
umls:C3714756Intellectual Disability1CTD_human