TissGeneSummary for C12orf42 |
Gene summary |
Basic gene information | Gene symbol | C12orf42 |
Gene name | chromosome 12 open reading frame 42 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 12q23.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001099336.2, NM_001278419.1,NM_001278420.1,NM_198521.3,NR_103526.1, | |
Description | uncharacterized protein C12orf42 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000179088 | ||
HPRD : 13393 | ||
Vega : OTTHUMG00000169988 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C12orf42 | |
BioGPS: 374470 | ||
Pathway | NCI Pathway Interaction Database: C12orf42 | |
KEGG: C12orf42 | ||
REACTOME: C12orf42 | ||
Pathway Commons: C12orf42 | ||
Context | iHOP: C12orf42 | |
ligand binding site mutation search in PubMed: C12orf42 | ||
UCL Cancer Institute: C12orf42 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of C12orf42 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C12orf42 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
STAD | -0.26879061 | -1.385774985 | 1.116984375 | 0.00106 | 0.005582998 |
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TissGene-miRNA for C12orf42 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C12orf42 |
TissGeneSNV for C12orf42 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S98L | SKCM | 2 |
p.E13* | UCEC | 2 |
p.R340Q | SKCM | 1 |
p.A201V | BLCA | 1 |
p.L16Q | LIHC | 1 |
p.L16Q | LUAD | 1 |
p.R273Q | SKCM | 1 |
p.N96D | ACC | 1 |
p.W95* | HNSC | 1 |
p.H237Y | SKCM | 1 |
p.E152Q | LUSC | 1 |
p.I190V | LIHC | 1 |
p.R226W | LIHC | 1 |
p.Q160L | LUAD | 1 |
p.E12K | SKCM | 1 |
p.H36Y | SKCM | 1 |
p.P170S | SKCM | 1 |
p.N209K | STAD | 1 |
p.S123N | UCEC | 1 |
p.P43H | PAAD | 1 |
p.P33S | SKCM | 1 |
p.A310V | STAD | 1 |
p.S263R | COAD | 1 |
p.R56I | UCEC | 1 |
p.P29L | HNSC | 1 |
p.R293W | LIHC | 1 |
p.V114E | LUSC | 1 |
p.G317S | STAD | 1 |
p.L83Q | LIHC | 1 |
p.P272S | SKCM | 1 |
p.A214T | CESC | 1 |
p.G203E | SKCM | 1 |
p.E58A | UCS | 1 |
p.S324Y | HNSC | 1 |
p.S333L | BRCA | 1 |
p.S7F | SKCM | 1 |
p.S165L | SKCM | 1 |
p.A281V | COAD | 1 |
p.Q93L | LUAD | 1 |
p.W162* | HNSC | 1 |
p.P237S | SKCM | 1 |
p.E11D | CESC | 1 |
p.R61H | LGG | 1 |
p.E85* | LUAD | 1 |
p.P110H | PAAD | 1 |
p.S257Y | HNSC | 1 |
p.G154S | UCS | 1 |
p.N23I | STAD | 1 |
p.M68I | COAD | 1 |
p.V109D | LUAD | 1 |
p.P205S | SKCM | 1 |
p.K69N | COAD | 1 |
p.F127S | UCEC | 1 |
p.R128S | BRCA | 1 |
p.K329Q | UCEC | 1 |
p.E139K | BLCA | 1 |
p.S74F | SKCM | 1 |
p.A281V | OV | 1 |
p.P19S | SKCM | 1 |
p.K132N | LUAD | 1 |
p.S28F | SKCM | 1 |
p.S210Y | UCEC | 1 |
p.S265F | LUAD | 1 |
p.P225S | SKCM | 1 |
p.D53Y | LUAD | 1 |
p.A201T | PRAD | 1 |
p.R91M | UCEC | 1 |
p.P19L | SKCM | 1 |
p.R226W | STAD | 1 |
p.A268V | BLCA | 1 |
p.I32S | HNSC | 1 |
p.Q255* | CESC | 1 |
p.H343Y | LUSC | 1 |
p.T17N | COAD | 1 |
p.K207E | STAD | 1 |
p.E72K | BLCA | 1 |
p.M1I | UCEC | 1 |
p.A140T | READ | 1 |
p.S210F | KIRP | 1 |
p.P107H | SARC | 1 |
p.V42D | LUAD | 1 |
p.L232V | CESC | 1 |
p.G250D | SKCM | 1 |
p.G122C | LUAD | 1 |
p.S212F | CESC | 1 |
p.D42N | SKCM | 1 |
p.Q169H | UCEC | 1 |
p.N96K | SARC | 1 |
p.G221S | UCS | 1 |
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TissGeneCNV for C12orf42 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C12orf42 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-C8-A12M-01A | CORO1C-C12orf42 | Out-of-frame | Chr12:109072048 | Chr12:103696337 |
TCGAfusionPortal | PRADA | GBM | TCGA-06-0129-01A | TM7SF3-C12orf42 | Out-of-frame | Chr12:27156169 | Chr12:103670988 |
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TissGeneNet for C12orf42 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C12orf42 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C12orf42 |
TissGeneDrug for C12orf42 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C12orf42 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0948480 | Coronary Restenosis | 1 | GAD |