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| TissGeneSummary for TEPP |
 Gene summary |
| Basic gene information | Gene symbol | TEPP |
| Gene name | testis, prostate and placenta expressed | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 16q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_199046.2, NM_199456.2, | |
| Description | testis, prostate and placenta-expressed proteintestis/prostate/placenta-expressed protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 610264 | |
| HGNC : HGNC | ||
| HPRD : 15486 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TEPP | |
| BioGPS: 374739 | ||
| Pathway | NCI Pathway Interaction Database: TEPP | |
| KEGG: TEPP | ||
| REACTOME: TEPP | ||
| Pathway Commons: TEPP | ||
| Context | iHOP: TEPP | |
| ligand binding site mutation search in PubMed: TEPP | ||
| UCL Cancer Institute: TEPP | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ProstateTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRADTGCT | |
| Reference showing the relevant tissue of TEPP | TEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates. Biochem Biophys Res Commun. 2003 Dec 26;312(4):1209-15. (pmid:14652002) go to articleTEPP, a new gene specifically expressed in testis, prostate, and placenta and well conserved in chordates. Biochem Biophys Res Commun. 2003 Dec 26;312(4):1209-15. (pmid:14652002) go to article | |
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for TEPP |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -1.834223927 | -0.155683927 | -1.67854 | 1.11E-08 | 5.87E-08 |
| BRCA | -1.603458734 | 0.557189512 | -2.160648246 | 3.66E-32 | 5.43E-31 |
| PRAD | -0.842572465 | 0.955221766 | -1.797794231 | 1.30E-11 | 4.08E-10 |
| LUSC | -0.13721828 | 1.666995446 | -1.804213725 | 7.80E-10 | 2.71E-09 |
| LUAD | 0.30485028 | 1.76359166 | -1.458741379 | 6.49E-06 | 1.95E-05 |
| HNSC | -0.660703369 | 0.857745469 | -1.518448837 | 1.71E-06 | 1.21E-05 |
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| TissGene-miRNA for TEPP |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for TEPP |
| TissGeneSNV for TEPP |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R290C | BRCA | 1 |
| p.F193L | HNSC | 1 |
| p.A77V | UCEC | 1 |
| p.A90V | UCEC | 1 |
| p.V224A | STAD | 1 |
| p.L278M | UCEC | 1 |
| p.S286Y | BLCA | 1 |
| p.R128H | STAD | 1 |
| p.D108N | SKCM | 1 |
| p.A135S | UCEC | 1 |
| p.P181H | LUAD | 1 |
| p.K113Q | TGCT | 1 |
| p.E188Q | BLCA | 1 |
| p.D67N | UCEC | 1 |
| p.T34A | SKCM | 1 |
| p.M107I | SKCM | 1 |
| p.G214S | STAD | 1 |
| p.P40H | COAD | 1 |
| p.A90E | LUSC | 1 |
| p.Y38* | BLCA | 1 |
| p.S259C | HNSC | 1 |
| p.L116R | SKCM | 1 |
| p.S259Y | BLCA | 1 |
| p.R84Q | SKCM | 1 |
| p.C253Y | CHOL | 1 |
| p.S286C | HNSC | 1 |
| p.G198R | PAAD | 1 |
| p.W270X | COAD | 1 |
| p.A197T | STAD | 1 |
| p.C8Y | ESCA | 1 |
| p.F248L | STAD | 1 |
| p.G141E | SKCM | 1 |
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| TissGeneCNV for TEPP |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for TEPP |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for TEPP |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for TEPP |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for TEPP |
| TissGeneDrug for TEPP |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for TEPP |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |
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