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| TissGeneSummary for IGFL1 |
 Gene summary |
| Basic gene information | Gene symbol | IGFL1 |
| Gene name | IGF-like family member 1 | |
| Synonyms | APRG644|UNQ644 | |
| Cytomap | UCSC genome browser: 19q13.32 | |
| Type of gene | protein-coding | |
| RefGenes | NM_198541.1, | |
| Description | insulin growth factor-like family member 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 610544 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000188293 | ||
| HPRD : 17139 | ||
| Vega : OTTHUMG00000182501 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_IGFL1 | |
| BioGPS: 374918 | ||
| Pathway | NCI Pathway Interaction Database: IGFL1 | |
| KEGG: IGFL1 | ||
| REACTOME: IGFL1 | ||
| Pathway Commons: IGFL1 | ||
| Context | iHOP: IGFL1 | |
| ligand binding site mutation search in PubMed: IGFL1 | ||
| UCL Cancer Institute: IGFL1 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | EsophagusUterus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCAUCEC,UCS | |
| Reference showing the relevant tissue of IGFL1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for IGFL1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 2.823783458 | -1.370306739 | 4.194090196 | 8.80E-13 | 4.08E-12 |
| BLCA | 5.588270867 | 1.613128762 | 3.975142105 | 0.00207 | 0.013115897 |
| KICH | -1.846250817 | -0.755382817 | -1.090868 | 0.00137 | 0.002892222 |
| KIRP | -1.703646567 | -0.651677817 | -1.05196875 | 0.000968 | 0.00267549 |
| COAD | -0.623783586 | -1.932602817 | 1.308819231 | 7.54E-05 | 0.000283364 |
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| TissGene-miRNA for IGFL1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for IGFL1 |
| TissGeneSNV for IGFL1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.D49N | SKCM | 2 |
| p.Q52K | LUAD | 1 |
| p.R104K | SKCM | 1 |
| p.E79K | SKCM | 1 |
| p.F86L | LUAD | 1 |
| p.A64P | STAD | 1 |
| p.E79Q | BLCA | 1 |
| p.M1K | LIHC | 1 |
| p.E79K | BLCA | 1 |
| p.L20F | COAD | 1 |
| p.S101* | LUSC | 1 |
| p.A98V | UCEC | 1 |
| p.M87K | LUAD | 1 |
| p.T68A | LIHC | 1 |
| p.R18K | SKCM | 1 |
| p.D58G | UCEC | 1 |
| p.P83S | SKCM | 1 |
| p.D58Y | COAD | 1 |
| p.L19F | SKCM | 1 |
| p.N92D | LIHC | 1 |
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| TissGeneCNV for IGFL1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| Top |
| TissGeneFusions for IGFL1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for IGFL1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for IGFL1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for IGFL1 |
| TissGeneDrug for IGFL1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for IGFL1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0033860 | Psoriasis | 1 | BeFree |
| umls:C0037274 | Dermatologic disorders | 1 | BeFree |
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