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| TissGeneSummary for KCNJ15 |
 Gene summary |
| Basic gene information | Gene symbol | KCNJ15 |
| Gene name | potassium inwardly-rectifying channel, subfamily J, member 15 | |
| Synonyms | IRKK|KIR1.3|KIR4.2 | |
| Cytomap | UCSC genome browser: 21q22.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001276435.1, NM_001276436.1,NM_001276437.1,NM_001276438.1,NM_001276439.1, NM_002243.4,NM_170736.2,NM_170737.2, | |
| Description | ATP-sensitive inward rectifier potassium channel 15inward rectifier K(+) channel Kir1.3inward rectifier K(+) channel Kir4.2inward rectifier K+ channel KIR4.2potassium channel, inwardly rectifying subfamily J member 15 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602106 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000157551 | ||
| HPRD : 03659 | ||
| Vega : OTTHUMG00000090609 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KCNJ15 | |
| BioGPS: 3772 | ||
| Pathway | NCI Pathway Interaction Database: KCNJ15 | |
| KEGG: KCNJ15 | ||
| REACTOME: KCNJ15 | ||
| Pathway Commons: KCNJ15 | ||
| Context | iHOP: KCNJ15 | |
| ligand binding site mutation search in PubMed: KCNJ15 | ||
| UCL Cancer Institute: KCNJ15 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
| Reference showing the relevant tissue of KCNJ15 | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for KCNJ15 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | 1.714808304 | 3.702978993 | -1.98817069 | 9.81E-15 | 9.91E-14 |
| LIHC | -2.672031007 | -0.940723007 | -1.731308 | 6.05E-09 | 5.60E-08 |
| KIRC | 3.507356771 | 5.014938716 | -1.507581944 | 1.39E-10 | 4.85E-10 |
| KICH | 1.063878993 | 4.290874993 | -3.226996 | 6.71E-08 | 3.17E-07 |
| LUSC | 1.589375072 | 3.567731935 | -1.978356863 | 6.83E-11 | 2.63E-10 |
| PRAD | -2.464121007 | 0.137921301 | -2.602042308 | 3.16E-12 | 1.39E-10 |
| STAD | -1.431646007 | 0.633394618 | -2.065040625 | 0.000757 | 0.0042669 |
| COAD | -2.764855622 | -4.20294793 | 1.438092308 | 0.000396 | 0.001250196 |
| KIRP | 3.892591493 | 5.006188368 | -1.113596875 | 0.00029 | 0.000898039 |
| Top |
| TissGene-miRNA for KCNJ15 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| LUAD | hsa-miR-425-5p | MIMAT0003393 | 0.026 | -0.29 | 60 |
| ACC | hsa-miR-200c-3p | MIMAT0000617 | 0.0047 | -0.34 | 78 |
| ACC | hsa-miR-200c-3p | MIMAT0000617 | 0.0047 | -0.34 | 78 |
| Top |
| TissGeneMut for KCNJ15 |
| TissGeneSNV for KCNJ15 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R334W | UCEC | 2 |
| p.P337S | SKCM | 1 |
| p.T242I | SKCM | 1 |
| p.R154C | PAAD | 1 |
| p.S124F | SKCM | 1 |
| p.P27L | SKCM | 1 |
| p.S197G | LIHC | 1 |
| p.C139Y | MESO | 1 |
| p.L155F | BRCA | 1 |
| p.S102* | BLCA | 1 |
| p.S242F | SKCM | 1 |
| p.S245N | SKCM | 1 |
| p.V75M | BLCA | 1 |
| p.E177D | KIRP | 1 |
| p.E123Q | SKCM | 1 |
| p.X263C | SKCM | 1 |
| p.T154S | PAAD | 1 |
| p.K124I | SKCM | 1 |
| p.D44G | STAD | 1 |
| p.S213C | COAD | 1 |
| p.R133H | BRCA | 1 |
| p.N103K | KIRC | 1 |
| p.L317F | SKCM | 1 |
| p.A89T | LUSC | 1 |
| p.Y326N | STAD | 1 |
| p.Q189H | HNSC | 1 |
| p.H141Y | SKCM | 1 |
| p.T187A | STAD | 1 |
| p.M173I | LIHC | 1 |
| p.L155S | STAD | 1 |
| p.G5C | ESCA | 1 |
| p.L327F | SKCM | 1 |
| p.Y86C | LUAD | 1 |
| p.H256Y | SKCM | 1 |
| p.G308D | LGG | 1 |
| p.H182N | BRCA | 1 |
| p.R203S | LUSC | 1 |
| p.F132L | STAD | 1 |
| p.Q332H | HNSC | 1 |
| p.K275E | SKCM | 1 |
| p.R337X | SKCM | 1 |
| p.A117V | GBM | 1 |
| p.Q155P | STAD | 1 |
| p.C133Y | LIHC | 1 |
| p.T11N | SARC | 1 |
| p.P54T | STAD | 1 |
| p.A166V | COAD | 1 |
| p.P107L | THYM | 1 |
| p.Y44C | STAD | 1 |
| p.L114V | KIRC | 1 |
| p.Q27H | SKCM | 1 |
| p.D326N | STAD | 1 |
| p.T174N | SKCM | 1 |
| p.F52L | SKCM | 1 |
| p.K37N | STAD | 1 |
| p.R203S | SKCM | 1 |
| p.T336A | LIHC | 1 |
| p.R174Q | STAD | 1 |
| p.E260* | SARC | 1 |
| p.G321E | SKCM | 1 |
| p.Y275D | SKCM | 1 |
| p.G97X | ESCA | 1 |
| p.C107Y | BLCA | 1 |
| p.G98D | COAD | 1 |
| p.E358K | SKCM | 1 |
| p.W6C | STAD | 1 |
| p.Y187D | STAD | 1 |
| p.E256X | SKCM | 1 |
| p.W114G | KIRC | 1 |
| p.G162R | SKCM | 1 |
| p.F111L | SKCM | 1 |
| p.P106L | SKCM | 1 |
| p.D266Y | LUAD | 1 |
| p.D12E | KIRP | 1 |
| p.A117V | LGG | 1 |
| p.A20V | STAD | 1 |
| p.Q27L | SKCM | 1 |
| p.E362K | SKCM | 1 |
| p.Y306F | HNSC | 1 |
| p.T106I | SKCM | 1 |
| p.R174Q | SKCM | 1 |
| p.P263S | SKCM | 1 |
| p.S291N | SKCM | 1 |
| p.L54M | STAD | 1 |
| p.I197V | LIHC | 1 |
| p.T253A | COAD | 1 |
| p.E304K | SKCM | 1 |
| p.H5Y | ESCA | 1 |
| p.H104D | HNSC | 1 |
| p.V239E | LIHC | 1 |
| p.P97S | ESCA | 1 |
| p.S117I | LGG | 1 |
| Top |
| TissGeneCNV for KCNJ15 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KCNJ15 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BE182927 | KCNJ15-KCNJ15 | chr21:39673529 | chr21:39673504 | |
| Chimerdb3.0 | ChiTaRs | NA | AJ311492 | KCNJ15-ZFPM1 | chr21:39619483 | chr16:88587216 | |
| TCGAfusionPortal | PRADA | LUAD | TCGA-38-4632-01A | CHST8-KCNJ15 | CDS-5UTR | Chr19:34180297 | Chr21:39668848 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-50-5944-01A | WRB-KCNJ15 | 3UTR-5UTR | Chr21:40782863 | Chr21:39668848 |
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| TissGeneNet for KCNJ15 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor) | KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal) |
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| COAD (tumor) | COAD (normal) |
| KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor) | KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor) | KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal) |
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| KICH (tumor) | KICH (normal) |
| KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor) | KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor) | KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor) | KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor) | KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor) | KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor) | KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor) | KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal) |
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| STAD (tumor) | STAD (normal) |
| KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor) | KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal) |
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| THCA (tumor) | THCA (normal) |
| KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor) | KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal) |
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| Top |
| TissGeneProg for KCNJ15 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Top |
| TissGeneClin for KCNJ15 |
| TissGeneDrug for KCNJ15 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KCNJ15 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 3 | BeFree,GAD |
| umls:C0013080 | Down Syndrome | 2 | CTD_human,LHGDN |
| umls:C0020459 | Hyperinsulinism | 1 | BeFree |
| umls:C0021670 | insulinoma | 1 | BeFree |
| umls:C0151786 | Muscle Weakness | 1 | CTD_human |
| umls:C3495559 | Juvenile arthritis | 1 | CTD_human |
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