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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for KCNJ15
check button Gene summary
Basic gene informationGene symbolKCNJ15
Gene namepotassium inwardly-rectifying channel, subfamily J, member 15
SynonymsIRKK|KIR1.3|KIR4.2
CytomapUCSC genome browser: 21q22.2
Type of geneprotein-coding
RefGenesNM_001276435.1,
NM_001276436.1,NM_001276437.1,NM_001276438.1,NM_001276439.1,
NM_002243.4,NM_170736.2,NM_170737.2,
DescriptionATP-sensitive inward rectifier potassium channel 15inward rectifier K(+) channel Kir1.3inward rectifier K(+) channel Kir4.2inward rectifier K+ channel KIR4.2potassium channel, inwardly rectifying subfamily J member 15
Modification date20141207
dbXrefs MIM : 602106
HGNC : HGNC
Ensembl : ENSG00000157551
HPRD : 03659
Vega : OTTHUMG00000090609
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KCNJ15
BioGPS: 3772
PathwayNCI Pathway Interaction Database: KCNJ15
KEGG: KCNJ15
REACTOME: KCNJ15
Pathway Commons: KCNJ15
ContextiHOP: KCNJ15
ligand binding site mutation search in PubMed: KCNJ15
UCL Cancer Institute: KCNJ15
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Kidney
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICH
Reference showing the relevant tissue of KCNJ15
Description by TissGene annotationsHave significant anti-correlated miRNA
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for KCNJ15

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUAD1.7148083043.702978993-1.988170699.81E-159.91E-14
LIHC-2.672031007-0.940723007-1.7313086.05E-095.60E-08
KIRC3.5073567715.014938716-1.5075819441.39E-104.85E-10
KICH1.0638789934.290874993-3.2269966.71E-083.17E-07
LUSC1.5893750723.567731935-1.9783568636.83E-112.63E-10
PRAD-2.4641210070.137921301-2.6020423083.16E-121.39E-10
STAD-1.4316460070.633394618-2.0650406250.0007570.0042669
COAD-2.764855622-4.202947931.4380923080.0003960.001250196
KIRP3.8925914935.006188368-1.1135968750.000290.000898039


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TissGene-miRNA for KCNJ15

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
LUADhsa-miR-425-5pMIMAT00033930.026-0.2960
ACChsa-miR-200c-3pMIMAT00006170.0047-0.3478
ACChsa-miR-200c-3pMIMAT00006170.0047-0.3478


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TissGeneMut for KCNJ15
TissGeneSNV for KCNJ15

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R334WUCEC2
p.P337SSKCM1
p.T242ISKCM1
p.R154CPAAD1
p.S124FSKCM1
p.P27LSKCM1
p.S197GLIHC1
p.C139YMESO1
p.L155FBRCA1
p.S102*BLCA1
p.S242FSKCM1
p.S245NSKCM1
p.V75MBLCA1
p.E177DKIRP1
p.E123QSKCM1
p.X263CSKCM1
p.T154SPAAD1
p.K124ISKCM1
p.D44GSTAD1
p.S213CCOAD1
p.R133HBRCA1
p.N103KKIRC1
p.L317FSKCM1
p.A89TLUSC1
p.Y326NSTAD1
p.Q189HHNSC1
p.H141YSKCM1
p.T187ASTAD1
p.M173ILIHC1
p.L155SSTAD1
p.G5CESCA1
p.L327FSKCM1
p.Y86CLUAD1
p.H256YSKCM1
p.G308DLGG1
p.H182NBRCA1
p.R203SLUSC1
p.F132LSTAD1
p.Q332HHNSC1
p.K275ESKCM1
p.R337XSKCM1
p.A117VGBM1
p.Q155PSTAD1
p.C133YLIHC1
p.T11NSARC1
p.P54TSTAD1
p.A166VCOAD1
p.P107LTHYM1
p.Y44CSTAD1
p.L114VKIRC1
p.Q27HSKCM1
p.D326NSTAD1
p.T174NSKCM1
p.F52LSKCM1
p.K37NSTAD1
p.R203SSKCM1
p.T336ALIHC1
p.R174QSTAD1
p.E260*SARC1
p.G321ESKCM1
p.Y275DSKCM1
p.G97XESCA1
p.C107YBLCA1
p.G98DCOAD1
p.E358KSKCM1
p.W6CSTAD1
p.Y187DSTAD1
p.E256XSKCM1
p.W114GKIRC1
p.G162RSKCM1
p.F111LSKCM1
p.P106LSKCM1
p.D266YLUAD1
p.D12EKIRP1
p.A117VLGG1
p.A20VSTAD1
p.Q27LSKCM1
p.E362KSKCM1
p.Y306FHNSC1
p.T106ISKCM1
p.R174QSKCM1
p.P263SSKCM1
p.S291NSKCM1
p.L54MSTAD1
p.I197VLIHC1
p.T253ACOAD1
p.E304KSKCM1
p.H5YESCA1
p.H104DHNSC1
p.V239ELIHC1
p.P97SESCA1
p.S117ILGG1


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TissGeneCNV for KCNJ15

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for KCNJ15

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABE182927KCNJ15-KCNJ15chr21:39673529chr21:39673504
Chimerdb3.0ChiTaRsNAAJ311492KCNJ15-ZFPM1chr21:39619483chr16:88587216
TCGAfusionPortalPRADALUADTCGA-38-4632-01ACHST8-KCNJ15CDS-5UTRChr19:34180297Chr21:39668848
TCGAfusionPortalPRADALUADTCGA-50-5944-01AWRB-KCNJ153UTR-5UTRChr21:40782863Chr21:39668848


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TissGeneNet for KCNJ15

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor)KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal)
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COAD (tumor)COAD (normal)
KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor)KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal)
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HNSC (tumor)HNSC (normal)
KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor)KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal)
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KICH (tumor)KICH (normal)
KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor)KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal)
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KIRC (tumor)KIRC (normal)
KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor)KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal)
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KIRP (tumor)KIRP (normal)
KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor)KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal)
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LIHC (tumor)LIHC (normal)
KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor)KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal)
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LUAD (tumor)LUAD (normal)
KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor)KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal)
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LUSC (tumor)LUSC (normal)
KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor)KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal)
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PRAD (tumor)PRAD (normal)
KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor)KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal)
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STAD (tumor)STAD (normal)
KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor)KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal)
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THCA (tumor)THCA (normal)
KCNJ15, IL16, INADL, SNTA1, KCNJ16 (tumor)KCNJ15, IL16, INADL, SNTA1, KCNJ16 (normal)
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TissGeneProg for KCNJ15

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for KCNJ15
TissGeneDrug for KCNJ15

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for KCNJ15

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent3BeFree,GAD
umls:C0013080Down Syndrome2CTD_human,LHGDN
umls:C0020459Hyperinsulinism1BeFree
umls:C0021670insulinoma1BeFree
umls:C0151786Muscle Weakness1CTD_human
umls:C3495559Juvenile arthritis1CTD_human